Objective
The IMPACT project is about improving the lives of brain diseased patients through a novel approach that leaps beyond currently available Deep Brain Stimulation (DBS) devices and procedures. The initial project focus is on Parkinson’s Disease (PD), but further brain-disease indications will be included in the later phase of the project. The personalized approach that IMPACT brings is essential in delivering full therapeutic benefits to DBS patients while preventing the stimulation-induced side-effects that occur with today's DBS implants.
PD is well known for its characteristic symptoms: shaking, rigidity, slowness of movement and postural instability. Millions are suffering from PD including famous people like Michael J. Fox. Drugs are used as first treatment, but as the disease progresses they become ineffective and increasingly higher doses are needed. This leads to many side-effects, while symptoms still persist.
DBS is a ‘pacemaker for the brain’, analogous to the function of pacemakers for the heart: mild electrical stimuli are delivered to brain tissue to suppress unwanted activity and restore desired neuronal functions. When stimulation is optimal, the impact of DBS is spectacular: shaking and rigidity are strongly improved, and medication doses may be lowered significantly.
Despite its successes, DBS is still in its infancy. Programming for optimal therapy is complicated since physicians lack the appropriate tools to support them. Around 15 – 30% of DBS patients suffer from stimulation-induced side-effects resulting from stimulation leaking outside intended target regions. IMPACT addresses these barriers to adoption exploiting the directivity provided by next generation high-resolution implants.
IMPACT delivers a physician tool for tuning the high-resolution implant based on a personalized patient brain stimulation model that takes into account imaging data (MRI, X-ray) as well as pre-operative data (local field potentials).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences basic medicine neurology parkinson
- medical and health sciences medical biotechnology implants
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2012-INNOVATION-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6229GW Maastricht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.