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Model-Driven European Paediatric Digital Repository

Description du projet


Virtual Physiological Human

MD-Paedigree, which stands for Model-Driven European Paediatric Digital Repository (http://www.md-paedigree.eu), provides decision support to medical professionals wherever they treat their young patients. Through disease simulations, requiring the availability of high performance and supercomputer resources, MD-Paedigree improves the diagnostic precision of paediatricians and offers child-specific treatment choices for Europe’s children.
MD-Paedigree follows two previous highly successful projects, Health-e-Child (www.health-e-child.org) and Sim-e-Child (www.sim-e-child.org), making it possible to apply innovative diagnostic tools to routine clinical data. It provides three fundamental functionalities on top of those of an advanced Electronic Health Records registry:
1. similarity search, allowing clinicians to access “patients like mine” (and finding decision support for optimal treatment also based on comparative outcome analysis), and allowing patients to get in touch with “patients exactly like me”
2. model-based patient-specific simulation and prediction
3. patient-specific clinical workflows.
Using MD-Paedigree, doctors can select a highly individualised treatment option and receive on-the-spot support in predicting the likely outcome of such treatments based on each patient’s personal medical data. This leads us into a future where child healthcare will become more effective, more personalised, and even more affordable.

MD-Paedigree is a clinically-led VPH project that addresses both the first and the second actions of part B of Objective ICT-2011.5.2:1. it enhances existing disease models stemming from former EC-funded research (Health-e-Child and Sim-e-Child) and from industry and academia, by developing robust and reusable multi-scale models for more predictive, individualised, effective and safer healthcare in several disease areas;2. it builds on the eHealth platform already developed for Health-e-Child and Sim-e-Child to establish a worldwide advanced paediatric digital repository.Integrating the point of care through state-of-the-art and fast response interfaces, MD-Paedigree services a broad range of off-the-shelf models and simulations to support physicians and clinical researchers in their daily work. MD-Paedigree vertically integrates data, information and knowledge of incoming patients, in participating hospitals from across Europe and the USA, and provides innovative tools to define new workflows of models towards personalised predictive medicine. Conceived of as a part of the "VPH Infostructure" described in the ARGOS, MD-Paedigree encompasses a set of services for storage, sharing, similarity search, outcome analysis, risk stratification, and personalised decision support in paediatrics within its innovative model-driven data and workflow-based digital repository. As a specific implementation of the VPH-Share project, MD-Paedigree fully interoperates with it. It has the ambition to be the dominant tool within its purview. MD-Paedigree integrates methodological approaches from the targeted specialties and consequently analyzes biomedical data derived from a multiplicity of heterogeneous sources (from clinical, genetic and metagenomic analysis, to MRI and US image analytics, to haemodynamics, to real-time processing of musculoskeletal parameters and fibres biomechanical data, and others), as well as specialised biomechanical and imaging VPH simulation models.

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Coordinateur

OSPEDALE PEDIATRICO BAMBINO GESU
Contribution de l’UE
€ 1 415 383,00
Adresse
PIAZZA SANT ONOFRIO 4
00165 Roma
Italie

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Région
Centro (IT) Lazio Roma
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Dernière mise à jour: 7 Août 2017

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Permalink: https://cordis.europa.eu/project/id/600932/fr

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