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CORDIS - EU research results
CORDIS

Integrating Epidemiology and Experimental Biology to Improve Risk Assessment of Exposure to Mixtures of Endocrine Disruptive Compounds

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Project guideline document (opens in new window)
3rd Report from the Scientific Advisory Board meeting (opens in new window)

Report from the SAB regarding the project's progress during the third year.

Report on critical EDC mixtures I (opens in new window)

Report on critical EDC mixtures for the three health domains in the SELMA and the Life Child study modelled with covariates and potential confounders (mixtures I).

Report on doses and exposure regiments for experimental studies with mixtures 0 (opens in new window)

Report on doses and exposure regiments for experimental studies with mixtures 0. Mixture 0 is based on a Bio-statistical model (pre-study on existing data) including prenatal EDC exposure for a subset of EDCs (10 phthalate metabolites, 2 phenols and 8 PFCs) and health outcomes at 2.5 years of age in the three health domains.

1st Report from Scientific Advisory Board meeting (opens in new window)

Report from the SAB regarding the project's progress during the first year.

Report on inclusive strategies for the regulatory implementation of risk assessment tools for EDC mixtures (opens in new window)
2nd Dissemination activity and quality report (opens in new window)

Report on the activity and quality of dissemination during the second half of the project.

Report EDC mixtures III (opens in new window)

Report on final biostatistical models for identifying critical EDC mixtures including covariates and potential confounders, new biomarkers, genetic/epigenetic analyses and new biomarkers (mixtures III).

1st Dissemination activity and quality report (opens in new window)

Report on the activity and quality of dissemination during the first half of the project.

Report on how to ensure workability of the IPCS definition of EDCs (opens in new window)

Report on how to ensure workability of the IPCS definition of EDCs.

Report on chemical levels in SELMA and Life Child. (opens in new window)

Report on measured levels of chemicals in serumplasma and urine of mothers in SELMA and Life Child

Report on a novel framework for risk assessment of mixtures (opens in new window)
Dissemination guideline (opens in new window)

Guideline on the dissemination of information and results generated within EDC-MixRisk.

Meeting report of the WHO Chemical Risk Assessment Network (opens in new window)
Whitepaper on EDCs and health risks (opens in new window)
4th Report from the Scientific Advisory Board meeting (opens in new window)

Report from the SAB regarding the project's progress during the fourth year.

Internal communication plan document (opens in new window)

Document about the internal communication plan

Report on doses and exposure regiments for experimental studies with mixtures I (opens in new window)

Report on doses and exposure regiments for experimental studies with mixtures I. Mixture I on a Bio-statistical model including prenatal EDC exposure (full data set), and health outcome data at 7 years of age, and potential confounders in SELMA and LIFE Child.

2nd Report from the Scientific Advisory Board meeting (opens in new window)

Report from the SAB regarding the project's progress during the second year.

Publications

Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals (opens in new window)

Author(s): Miriam N. Jacobs, Emma L. Marczylo, Carlos Guerrero-Bosagna, Joëlle Rüegg
Published in: Annual Review of Environment and Resources, Issue 42/1, 2017, Page(s) 105-160, ISSN 1543-5938
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-environ-102016-061111

Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: From Mechanisms to Novel Test Methods (opens in new window)

Author(s): Ali Alavian-Ghavanini, Joëlle Rüegg
Published in: Basic & Clinical Pharmacology & Toxicology, Issue 122/1, 2018, Page(s) 38-45, ISSN 1742-7835
Publisher: Nordic Pharmacological Society
DOI: 10.1111/bcpt.12878

Endokrine Modulatoren (opens in new window)

Author(s): M. Hoffmann, S. Gebauer, M. Nüchter, R. Baber, J. Ried, M. von Bergen, W. Kiess
Published in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, Issue 60/6, 2017, Page(s) 640-648, ISSN 1436-9990
Publisher: Springer Verlag
DOI: 10.1007/s00103-017-2551-8

Androgenic potential of human fetal adrenals at the end of the first trimester (opens in new window)

Author(s): I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder, K Svechnikov
Published in: Endocrine Connections, Issue 6/6, 2017, Page(s) 348-359, ISSN 2049-3614
Publisher: BioScientifica Ltd.
DOI: 10.1530/EC-17-0085

Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos (opens in new window)

Author(s): Jean-Baptiste Fini, Bilal B. Mughal, Sébastien Le Mével, Michelle Leemans, Mélodie Lettmann, Petra Spirhanzlova, Pierre Affaticati, Arnim Jenett, Barbara A. Demeneix
Published in: Scientific Reports, Issue 7, 2017, Page(s) 43786, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep43786

Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic (opens in new window)

Author(s): Lars Lind, P. Monica Lind, Margareta H. Lejonklou, Linda Dunder, Åke Bergman, Carlos Guerrero-Bosagna, Erik Lampa, Hong Kyu Lee, Juliette Legler, Angel Nadal, Youngmi Kim Pak, Richard P. Phipps, Laura N. Vandenberg, Daniel Zalko, Marlene Ågerstrand, Mattias Öberg, Bruce Blumberg, Jerrold J. Heindel, Linda S. Birnbaum
Published in: Environmental Health Perspectives, Issue 124/5, 2016, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp.1511115

Effects of pre- and post-natal exposure to bisphenol A on the stress system (opens in new window)

Author(s): E. Kitraki, I. Nalvarte, A. Alavian-Ghavanini, J. Rüegg
Published in: Endocrine Disruptors, Issue 4/1, 2016, Page(s) e1184775, ISSN 2327-3747
Publisher: Taylor & Francis
DOI: 10.1080/23273747.2016.1184775

Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement (opens in new window)

Author(s): Roland Solecki, Andreas Kortenkamp, Åke Bergman, Ibrahim Chahoud, Gisela H. Degen, Daniel Dietrich, Helmut Greim, Helen Håkansson, Ulla Hass, Trine Husoy, Miriam Jacobs, Susan Jobling, Alberto Mantovani, Philip Marx-Stoelting, Aldert Piersma, Vera Ritz, Remy Slama, Ralf Stahlmann, Martin van den Berg, R. Thomas Zoeller, Alan R. Boobis
Published in: Archives of Toxicology, 2016, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-016-1866-9

Thyroid-disrupting chemicals and brain development: an update (opens in new window)

Author(s): Bilal B Mughal, Jean-Baptiste Fini, Barbara A Demeneix
Published in: Endocrine Connections, Issue 7/4, 2018, Page(s) R160-R186, ISSN 2049-3614
Publisher: BioScientifica Ltd.
DOI: 10.1530/EC-18-0029

Prenatal Bisphenol A Exposure is Linked to Epigenetic Changes in Glutamate Receptor Subunit Gene Grin2b in Female Rats and Humans (opens in new window)

Author(s): Ali Alavian-Ghavanini, Ping-I Lin, P. Monica Lind, Sabina Risén Rimfors, Margareta Halin Lejonklou, Linda Dunder, Mandy Tang, Christian Lindh, Carl-Gustaf Bornehag, Joëlle Rüegg
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-29732-9

Current EU research activities on combined exposure to multiple chemicals (opens in new window)

Author(s): Stephanie K. Bopp, Robert Barouki, Werner Brack, Silvia Dalla Costa, Jean-Lou C.M. Dorne, Paula E. Drakvik, Michael Faust, Tuomo K. Karjalainen, Stylianos Kephalopoulos, Jacob van Klaveren, Marike Kolossa-Gehring, Andreas Kortenkamp, Erik Lebret, Teresa Lettieri, Sofie Nørager, Joëlle Rüegg, Jose V. Tarazona, Xenia Trier, Bob van de Water, Jos van Gils, Åke Bergman
Published in: Environment International, Issue 120, 2018, Page(s) 544-562, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2018.07.037

Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes (opens in new window)

Author(s): Anastasia Repouskou, Emily Panagiotidou, Lydia Panagopoulou, Pernilla Larsdotter Bisting, Astrud R. Tuck, Marcus O. D. Sjödin, Johan Lindberg, Evangelos Bozas, Joëlle Rüegg, Chris Gennings, Carl-Gustaf Bornehag, Pauliina Damdimopoulou, Antonios Stamatakis, Efthymia Kitraki
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-42377-6

A Novel Approach to Chemical Mixture Risk Assessment—Linking Data from Population‐Based Epidemiology and Experimental Animal Tests (opens in new window)

Author(s): Carl‐Gustaf Bornehag, Efthymia Kitraki, Antonios Stamatakis, Emily Panagiotidou, Christina Rudén, Huan Shu, Christian Lindh, Joelle Ruegg, Chris Gennings
Published in: Risk Analysis, 2019, ISSN 0272-4332
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/risa.13323

Following Endocrine-Disrupting Effects on Gene Expression in Xenopus laevis (opens in new window)

Author(s): Petra Spirhanzlova, Michelle Leemans, Barbara A. Demeneix, Jean-Baptiste Fini
Published in: Cold Spring Harbor Protocols, Issue 2019/7, 2019, Page(s) pdb.prot098301, ISSN 1559-6095
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/pdb.prot098301

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