Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine

Project Information

MEL-PLEX

Grant agreement ID: 642295

DOI

10.3030/642295

Project closed

EC signature date 16 December 2014

Start date 1 December 2014

End date 30 November 2018

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 583 870,17

EU contribution

€ 3 583 870,17

Coordinated by

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (4)

Dissemination report 2

Annual dissemination and outreach report (events, talks, publications, posters, public engagement, etc.)

Dissemination report 1

Dissemination and outreach report (events, talks, publications, posters, public engagement etc.)

Dissemination report 3

Report on events, talks, publications, posters, public engagement, demonstrations etc.

Final dissemination report

Final dissemination and outreach report (events, talks, publications, posters, public engagement etc.)

Other (1)

MEL-PLEX conference

Open MEL-PLEX conference, dissemination

Websites, patent fillings, videos etc. (1)

Website

Project website and brochure

Publications

Peer reviewed articles (17)

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells

Author(s): Erminia Romano, Nicole Rufo, Hannelie Korf, Chantal Mathieu, Abhishek D. Garg, Patrizia Agostinis
Published in: Oncotarget, Issue 9/25, 2018, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.24815

Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment

Author(s): Kotryna Seip, Kjetil Jørgensen, Marco Vincent Haselager, Marco Albrecht, Mads Haugland Haugen, Eivind Valen Egeland, Philippe Lucarelli, Olav Engebraaten, Thomas Sauter, Gunhild Mari Mælandsmo, Lina Prasmickaite
Published in: Cancer Letters, Issue 439, 2018, Page(s) 1-13, ISSN 0304-3835
Publisher: Elsevier BV
DOI: 10.1016/j.canlet.2018.09.023

Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma

Author(s): Jan Rožanc, Theodore Sakellaropoulos, Asier Antoranz, Cristiano Guttà, Biswajit Podder, Vesna Vetma, Nicole Rufo, Patrizia Agostinis, Vaia Pliaka, Thomas Sauter, Dagmar Kulms, Markus Rehm, Leonidas G. Alexopoulos
Published in: Cell Death & Differentiation, 2018, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-018-0210-8

Epigenetics of malignant melanoma

Author(s): Bruce Moran, Romina Silva, Antoinette S. Perry, William M. Gallagher
Published in: Seminars in Cancer Biology, Issue 51, 2018, Page(s) 80-88, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2017.10.006

Using Regularization to Infer Cell Line Specificity in Logical Network Models of Signaling Pathways

Author(s): Sébastien De Landtsheer, Philippe Lucarelli, Thomas Sauter
Published in: Frontiers in Physiology, Issue 9, 2018, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.00550

Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

Author(s): Greta Del Mistro, Philippe Lucarelli, Ines Müller, Sébastien De Landtsheer, Anna Zinoveva, Meike Hutt, Martin Siegemund, Roland E. Kontermann, Stefan Beissert, Thomas Sauter, Dagmar Kulms
Published in: npj Systems Biology and Applications, Issue 4/1, 2018, ISSN 2056-7189
Publisher: Systems Biology Institute
DOI: 10.1038/s41540-018-0075-y

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

Author(s): Oleksii S. Rukhlenko, Fahimeh Khorsand, Aleksandar Krstic, Jan Rozanc, Leonidas G. Alexopoulos, Nora Rauch, Keesha E. Erickson, William S. Hlavacek, Richard G. Posner, Silvia Gómez-Coca, Edina Rosta, Cheree Fitzgibbon, David Matallanas, Jens Rauch, Walter Kolch, Boris N. Kholodenko
Published in: Cell Systems, Issue 7/2, 2018, Page(s) 161-179.e14, ISSN 2405-4712
Publisher: Elsevier B.V.
DOI: 10.1016/j.cels.2018.06.002

Multiplex Staining by Sequential Immunostaining and Antibody Removal on Routine Tissue Sections

Author(s): Maddalena Maria Bolognesi, Marco Manzoni, Carla Rossana Scalia, Stefano Zannella, Francesca Maria Bosisio, Mario Faretta, Giorgio Cattoretti
Published in: Journal of Histochemistry & Cytochemistry, Issue 65/8, 2017, Page(s) 431-444, ISSN 0022-1554
Publisher: Histochemical Society
DOI: 10.1369/0022155417719419

Immunoplasticity in cutaneous melanoma: beyond pure morphology

Author(s): Joost J van den Oord; Bosisio, Francesca Maria
Published in: Virchows Archiv, Issue 1, 2016, ISSN 0945-6317
Publisher: Springer Verlag
DOI: 10.1007/s00428-016-2058-y

Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation

Author(s): A D Garg, E Romano, N Rufo, P Agostinis
Published in: Cell Death and Differentiation, Issue 23/6, 2016, Page(s) 938-951, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/cdd.2016.5

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Author(s): Abhishek D. Garg, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B. Birge, José Manuel Bravo-San Pedro, Karine Breckpot, David Brough, Ricardo Chaurio, Mara Cirone, An Coosemans, Pierre G. Coulie, Dirk De Ruysscher, Luciana Dini, Peter de Witte, Aleksandra M. Dudek-Peric, Alberto Faggioni, Jitka Fucikova, Udo S. Gaipl, Jakub Golab, Marie-Lise Gougeon, Michael R. Hamblin, Akseli Hemminki, M
Published in: Frontiers in Immunology, Issue 6, 2015, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2015.00588

TTCA: an R package for the identification of differentially expressed genes in time course microarray data

Author(s): Marco Albrecht, Damian Stichel, Benedikt Müller, Ruth Merkle, Carsten Sticht, Norbert Gretz, Ursula Klingmüller, Kai Breuhahn and Franziska Matthäus
Published in: BMC Bioinformatics, 2017, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-016-1440-8

Examining the In-Vitro Efficacy of the IAP Antagonist Birinapant as a Single-Agent or in Combination with Dacarbazine to Induce Melanoma Cell Death

Author(s): Vesna Vetma, Jan Rožanc, Emilie M Charles, Christian T Hellwig, Leonidas G Alexopoulos, Markus Rehm
Published in: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2017, ISSN 0965-0407
Publisher: Cognizant Communication Corp.
DOI: 10.3727/096504017X14897145996933

Plasma cells in primary melanoma. Prognostic significance and possible role of IgA

Author(s): Francesca M Bosisio, James S Wilmott, Nathalie Volders, Marjorie Mercier, Jasper Wouters, Marguerite Stas, Willeke AM Blokx, Daniela Massi, John F Thompson, Richard A Scolyer, Nicolas van Baren, Joost J van den Oord
Published in: Modern Pathology, Issue 29/4, 2016, Page(s) 347-358, ISSN 0893-3952
Publisher: Nature Publishing Group
DOI: 10.1038/modpathol.2016.28

Master Transcriptional Regulators in Cancer: Discovery via Reverse Engineering Approaches and Subsequent Validation

Author(s): Bruce Moran, Arman Rahman, Katja Palonen, Fiona T. Lanigan, William M. Gallagher
Published in: Cancer Research, Issue 77/9, 2017, Page(s) 2186-2190, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-16-1813

FALCON: a toolbox for the fast contextualization of logical networks

Author(s): Sébastien De Landtsheer, Panuwat Trairatphisan, Philippe Lucarelli, Thomas Sauter
Published in: Bioinformatics, 2017, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btx380

The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy

Author(s): Nicole Rufo, Abhishek D. Garg, Patrizia Agostinis
Published in: Trends in Cancer, 2017, ISSN 2405-8033
Publisher: Elsevier B.V.
DOI: 10.1016/j.trecan.2017.07.002

Conference proceedings (1)

Thermodynamically constrained averaging theory for cancer growth modelling

Author(s): Marco Albrecht, Giuseppe Sciume, Philippe Lucarelli, Thomas Sauter
Published in: IFAC Papers Online, Issue 49/26, 2016
Publisher: Elsevier
DOI: 10.1016/j.ifacol.2016.12.141