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CORDIS - EU research results
CORDIS

Nanostructured molecular decoders for the quantitative, multiplexed, layer-by-layer detection of disease-associated proteins

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

D6.1.3 (opens in new window)

Minute conference calls for coordination of visiting periods

D2.7 (opens in new window)

The deliverable lead is the partner Temple University. Lecture notes on computational docking.

D1.7 (opens in new window)

Lecture notes on high performance computing.

D6.1.4 (opens in new window)

Minute conference calls for coordination of visiting periods

D6.1.1 (opens in new window)

Minute conference calls for coordination of visiting periods

D6.1.7 (opens in new window)

Minute conference calls for coordination of visiting periods

D6.1.6 (opens in new window)

Minute conference calls for coordination of visiting periods

D6.3.1 (opens in new window)

Submitted grant proposals to European Community, NSF and NIH (USA), etc.

D6.1.5 (opens in new window)

Minute conference calls for coordination of visiting periods

D6.1.2 (opens in new window)

Minute conference calls for coordination of visiting periods

D3.3 (opens in new window)

Enabling technique for the decoration of DNA nanostructures with proteins.

D2.8 (opens in new window)

The deliverable lead is the partner Temple University. Computational codes to analyse long MD trajectories.

D5.3 (opens in new window)

Standardized protocols for the use of the immune-device for the study of GAA and autophagy associated proteins in cultured cells.

D4.2 (opens in new window)

The deliverable lead is the partner CONICET. Feedback on the functions of large nanodecoders (5-30 fluorescent dyes) for detecting MAGE proteins in cells and histological tissue samples.

D5.2 (opens in new window)

Feedback on the functions of large nanodecoders (5-30 fluorescent dyes) for detecting glycogenosis type II-related proteins in cells.

D1.8 (opens in new window)

Computational codes to setup coarse-grain simulations.

D4.1 (opens in new window)

The deliverable lead is the partner CONICET. Feedback on the functions of small nanodecoders (1-5 fluorescent dyes) for detecting MAGE proteins in cells and histological tissues samples.

D5.1 (opens in new window)

Feedback on the functions of small nanodecoders (1-5 fluorescent dyes) for detecting glycogenosis type II-related proteins in cells.

D5.4 (opens in new window)

Identification of possible therapeutic small molecules able to restore GAA expression and revert the pathological cellular phenotype.

D3.1 (opens in new window)

Protocols and sequences for the synthesis of a universal DNA-protein linker for nanodecoders based on DNA nanoparticles.

D3.2 (opens in new window)

Protocols and sequences for the synthesis of a universal DNA-protein linker for nanodecoders based on DNA origami.

D5.5 (opens in new window)

Training of young researchers on cell culture-related techniques and advanced cells imaging.

D1.1 (opens in new window)

Immuno-nanodecoders based on a single DNA probe functioning with hybridization reactions.

D6.4.1 (opens in new window)

Seminars held at industries and SME.

D1.2 (opens in new window)

Immuno-nanodecoders based on complex DNA nanostructure, comprising several DNA probes, and functioning with hybridization reactions.

D2.6 (opens in new window)

The deliverable lead is the partner Temple University. Characterization of the molecular factors affecting catalytic efficiency of RNase H

D2.3 (opens in new window)

The deliverable lead is the partner Temple University. Training young scientist on experimental methods for studying the behaviour of DNA:RNA nanostructures in solution.

D2.5 (opens in new window)

The deliverable lead is the partner Temple University. Structure of the catalytically active complex between RNase H and the nanodecoder

D4.3 (opens in new window)

The deliverable lead is the partner CONICET. Training and exchange-I for researches not involved in biomedical issues (by M.12). The availability of the device is scheduled for month 18, so the results obtained from task 4.1 and 4.2 are expected for months 24-30.

D2.2 (opens in new window)

The deliverable lead is the partner Temple University. Immuno-nanodecoders based on complex DNA:RNA nanostructures, comprising several DNA probes, and functioning with DNA:RNA hybridization and RNase H enzymatic reactions.

D1.5 (opens in new window)

Characterization of the global structural constraints to design nanodecoders.

D3.4 (opens in new window)

Training junior researcher in sequence selective conjugation of protein-DNA nanostructures.

D1.6 (opens in new window)

Characterization of the molecular factors affecting accessibility of the stem-loop to on- and off-code.

D2.4 (opens in new window)

The deliverable lead is the partner Temple University. Training young scientist on experimental methods for studying the behaviour of DNA:RNA nanostructures on surfaces.

D1.4 (opens in new window)

Training young scientist on experimental methods for studying the behaviour of DNA nanostructures on surfaces.

D2.1 (opens in new window)

The deliverable lead is the partner Temple University. Immuno-nanodecoders based on a single DNA probe, and functioning with DNA:RNA hybridization and enzymatic reactions.

D4.4 (opens in new window)

The deliverable lead is the partner CONICET. Training and exchange-II for researches involved in WP5.

D1.3 (opens in new window)

Training young scientist on experimental methods for studying the behaviour of DNA nanostructures in solution.

Publications

Modular assembly of proteins on nanoparticles (opens in new window)

Author(s): Wenwei Ma, Angela Saccardo, Danilo Roccatano, Dorothy Aboagye-Mensah, Mohammad Alkaseem, Matthew Jewkes, Francesca Di Nezza, Mark Baron, Mikhail Soloviev, Enrico Ferrari
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03931-4

Protein Conjugation to Nanoparticles by Designer Affinity Tags (opens in new window)

Author(s): W. Ma, D. Aboagye-Mensah, M. Soloviev, B. Davletov, E. Ferrari
Published in: Materials Today: Proceedings, Issue 4/7, 2017, Page(s) 6923-6929, ISSN 2214-7853
Publisher: Elsevier
DOI: 10.1016/j.matpr.2017.07.021

Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding (opens in new window)

Author(s): Anish Parmar, Abhishek Iyer, Stephen H. Prior, Daniel G. Lloyd, Eunice Tze Leng Goh, Charlotte S. Vincent, Timea Palmai-Pallag, Csanad Z. Bachrati, Eefjan Breukink, Annemieke Madder, Rajamani Lakshminarayanan, Edward J. Taylor, Ishwar Singh
Published in: Chemical Science, Issue 8/12, 2017, Page(s) 8183-8192, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7sc03241b

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