Defining hormonal cross-talk and the role of mutations in estrogen receptor positive breast cancer

Project Information

ER_disease

Grant agreement ID: 646876

DOI

10.3030/646876

Project closed

EC signature date 27 May 2015

Start date 1 June 2015

End date 31 May 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 987 273,75

EU contribution

€ 1 987 273,75

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers

Author(s): A. A. Serandour, H. Mohammed, A. Miremadi, K. W. Mulder, J. S. Carroll
Published in: Oncogene, 2018, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-018-0312-2

A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes

Author(s): Evangelia K. Papachristou, Kamal Kishore, Andrew N. Holding, Kate Harvey, Theodoros I. Roumeliotis, Chandra Sekhar Reddy Chilamakuri, Soleilmane Omarjee, Kee Ming Chia, Alex Swarbrick, Elgene Lim, Florian Markowetz, Matthew Eldridge, Rasmus Siersbaek, Clive S. D’Santos, Jason S. Carroll
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04619-5

Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity

Author(s): Adam W. Nelson, Arnoud J. Groen, Jodi L. Miller, Anne Y. Warren, Kelly A. Holmes, Gerard A. Tarulli, Wayne D. Tilley, Benita S. Katzenellenbogen, John R. Hawse, Vincent J. Gnanapragasam, Jason S. Carroll
Published in: Molecular and Cellular Endocrinology, Issue 440, 2017, Page(s) 138-150, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2016.11.016

Deciphering the divergent roles of progestogens in breast cancer

Author(s): Jason S. Carroll, Theresa E. Hickey, Gerard A. Tarulli, Michael Williams, Wayne D. Tilley
Published in: Nature Reviews Cancer, Issue 17/1, 2016, Page(s) 54-64, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/nrc.2016.116

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3

Author(s): Kamila M. Jozwik, Igor Chernukhin, Aurelien A. Serandour, Sankari Nagarajan, Jason S. Carroll
Published in: Cell Reports, Issue 17/10, 2016, Page(s) 2715-2723, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.11.028

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

Author(s): Sankari Nagarajan, Shalini V. Rao, Joseph Sutton, Danya Cheeseman, Shanade Dunn, Evangelia K. Papachristou, Jose-Enrique Gonzalez Prada, Dominique-Laurent Couturier, Sanjeev Kumar, Kamal Kishore, Chandra Sekhar Reddy Chilamakuri, Silvia-Elena Glont, Emily Archer Goode, Cara Brodie, Naomi Guppy, Rachael Natrajan, Alejandra Bruna, Carlos Caldas, Alasdair Russell, Rasmus Siersbæk, Kosuke Yusa, Igor
Published in: Nature Genetics, 2020, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0541-5

Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling

Author(s): Silvia-E. Glont, Igor Chernukhin, Jason S. Carroll
Published in: Cell Reports, Issue 26/10, 2019, Page(s) 2558-2565.e3, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.02.036

IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis

Author(s): Rasmus Siersbæk, Valentina Scabia, Sankari Nagarajan, Igor Chernukhin, Evangelia K. Papachristou, Rebecca Broome, Simon J. Johnston, Stacey E.P. Joosten, Andrew R. Green, Sanjeev Kumar, Julia Jones, Soleilmane Omarjee, Ruben Alvarez-Fernandez, Silvia Glont, Sarah J. Aitken, Kamal Kishore, Danya Cheeseman, Emad A. Rakha, Clive D'Santos, Wilbert Zwart, Alasdair Russell, Cathrin Brisken, Jason S. Ca
Published in: Cancer Cell, 2020, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2020.06.007