Objective
Given the ageing population in Europe, it is critical to understand the mechanisms involved in growing old. Our ability to reduce the impact of ageing in humans might be best studied in equally long-lived animals. Predicting future changes in longevity patterns might depend on our ability to develop indicators of how old we really are and how many healthy years we have ahead of us, and how those indicators depend on our health history across decades.
My study will be the first linking lifelong disease history with physiological and molecular measures of ageing in a mammal as long-lived as humans. I will examine how different molecular ageing markers (telomere dynamics, oxidative stress and telomerase activity) interact with lifelong disease and reproductive history, and current endocrinological measures of stress and reproduction. This helps to better grasp both the mechanisms of ageing and their consequences on senescence rates, thus providing exceptional opportunities to identify the exact role of these markers in evolutionary processes and how they determine ageing rates and individual variation in senescence rates. It would also help us to establish which molecular markers best represent individual health history and to understand how health history can predict ageing rates. To do so, I will combine the world's most comprehensive demographic data on Asian elephants with bi-monthly health and disease records across life and with molecular ageing markers and hormonal correlates of stress and reproduction (N~240).
I will determine:
Q1.How does health decline with age?
Q2.How does lifelong disease exposure and current health link with ageing markers?
Q3.How does reproduction affect age-specific declines in health and current ageing markers?
Q4.How does early stress affect age-specific declines in health and current ageing markers?
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- social sciences sociology demography mortality
- humanities history and archaeology history
- natural sciences biological sciences evolutionary biology
- medical and health sciences basic medicine physiology
- natural sciences biological sciences zoology mammalogy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
S10 2TN Sheffield
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.