Intra Erythrocyte Dexamethasone in the treatment of Ataxia Telangiectasia

Project Information

IEDAT

Grant agreement ID: 667946

DOI

10.3030/667946

Project closed

EC signature date 9 December 2015

Start date 1 January 2016

End date 31 August 2021

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 5 871 825,00

EU contribution

€ 5 871 825,00

Coordinated by

ERYDEL SPA
Italy

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Deliverables

Documents, reports (5)

First evaluation workshop
Report on AT NEST definition, guidelines and SOPs
Registration number of clinical study in approved registry

Registration number of clinical study in approved registry Informed Consents Forms and/or Data Protection Forms (in their final version) will be included here. The authorisation for the use of personal data for specified purposes for a specified duration, and if applicable data transfers to third countries will be part of the content of these forms. Mandatory deliverable

Statistical report of comparison
Final evaluation workshop

Websites, patent fillings, videos etc. (2)

Project website (IEDAT)
Dissemination materials

Other (1)

Registry database

Publications

Peer reviewed articles (7)

DDIT4 gene expression is switched on by a new HDAC4 function in ataxia telangiectasia

Author(s): Anastasia Ricci, Luca Galluzzi, Mauro Magnani, Michele Menotta
Published in: The FASEB Journal, Issue 34/1, 2020, Page(s) 1802-1818, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201902039r

The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone

Author(s): Anastasia Ricci, Sara Orazi, Federica Biancucci, Mauro Magnani, Michele Menotta
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-89608-3

Proteomics and transcriptomics analyses of ataxia telangiectasia cells treated with Dexamethasone

Author(s): Michele Menotta, Sara Orazi, Anna Maria Gioacchini, Chiara Spapperi, Anastasia Ricci, Luciana Chessa, Mauro Magnani
Published in: PLOS ONE, Issue 13/4, 2018, Page(s) e0195388, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0195388

ATM splicing variants as biomarkers for low dose dexamethasone treatment of A-T

Author(s): Michele Menotta, Sara Biagiotti, Chiara Spapperi, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D’Agnano, Annarosa Soresina, Roberto Micheli, Mauro Magnani
Published in: Orphanet Journal of Rare Diseases, Issue 12/1, 2017, ISSN 1750-1172
Publisher: BioMed Central
DOI: 10.1186/s13023-017-0669-2

Ex vivo encapsulation of dexamethasone sodium phosphate into human autologous erythrocytes using fully automated biomedical equipment

Author(s): Giovanni Mambrini, Marco Mandolini, Luigia Rossi, Francesca Pierigè, Giovanni Capogrossi, Patricia Salvati, Sonja Serafini, Luca Benatti, Mauro Magnani
Published in: International Journal of Pharmaceutics, Issue 517/1-2, 2017, Page(s) 175-184, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2016.12.011

In vivo effects of dexamethasone on blood gene expression in ataxia telangiectasia

Author(s): Michele Menotta, Sara Biagiotti, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D’Agnano, Alessandro Plebani, Annarosa Soresina, Mauro Magnani
Published in: Molecular and Cellular Biochemistry, Issue 438/1-2, 2018, Page(s) 153-166, ISSN 0300-8177
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11010-017-3122-x

Transcriptomic profile of ataxia telangiectasia cells treated for 30 days with a low dose of dexamethasone

Author(s): Anastasia Ricci, Federica Biancucci, Mauro Magnani, Michele Menotta
Published in: All Life, Issue 14/1, 2021, Page(s) 277-286, ISSN 2689-5293
Publisher: all life
DOI: 10.1080/26895293.2021.1911863