Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union

Informazioni relative al progetto

PERFORM

ID dell’accordo di sovvenzione: 668303

DOI 10.3030/668303

Progetto chiuso

Data della firma CE 1 Dicembre 2015

Data di avvio 1 Gennaio 2016

Data di completamento 30 Giugno 2021

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale € 18 467 697,76

Contributo UE € 17 997 665,50

Coordinato da

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

Risultati finali

Documents, reports (33)

3rd Annual Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.

Project Handbook

The Project Handbook is to be taken as a collated support document covering all deadlines and procedures related with decision-making structure, financial reporting, corrective actions, and all aspects involved with managing the project. Partners will be provided a copy and it will be periodically reviewed and updated if necessary

Report on Pilot Studies with Quantum Dot Technology

Results of pilot studies detecting multi transcript signatures by quantum dot technology.

Report on results from multi transcript signature detection via electronic sensors

Results of alternative approaches to detect multi transcript signatures using electro sensors. Evaluation of results from studies in collaboration with POC-ID.

All Approvals Package

Copies of all approvals from ethics committees and national or regional ethics boards/bodies/administrations to be submitted to the European commission. These include approvals for transfer of biological samples and data between parties and any third party. Ethics approvals must cover approval of local institutions where samples are collected as well as overall national approval

Impact Model of Diagnostic on Antimicrobial resistance

Conceptual model of impact of diagnostic on antimicrobial resistance

Report on Rna-Seq and Microarray Studies

Summary report on RNAseq and microarray studies for Discovery group

Mid-Term Recruitment Report

Overview of recruitment by study site including numbers, recruiting problems and any measures made to compensate if recruitment delays occurred. (Per study)

2nd Annual Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.

Final Ethics Review

Final report from Ethics Review Board on study conduction

Consent and Child Assent Forms

Copies of consent forms and child assent forms (in each partner language) submitted to confirm compliance with Article 29 workgroup paper WP131 on processing personal data in health records, and confirming that the consent forms cover the right to withdraw from studies including withdrawal of samples and data.

Ethics Review Report

Independent ethics review board submits second report on ethical issues and conduct of the study

4th Final Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.

Tool-server Platforms

Tool-server platforms: allowing computational tools and workflows to be deployed on the integrated data including custom ones developed by project

PERFORM Dissemination & Communnication Strategy

Will outline the approach PERFORM will take towards the communication of its activities and results to relevant audiences, end-users, policy-makers and stakeholders. The document will include the strategic approach the consortium has selected to maximize the effectiveness and impact of its expected outcomes. It will also include all chosen communication channels and platforms to be developed and used across the duration of the project.

Transcriptomic and proteomic signatures of bacterial and viral infections

Report on transcriptomic and proteomic signatures that distinguish bacterial and viral infections in the discovery cohort

Provider, Parent and Costing Studies

Reports on provider, parent and costing studies

Performance of RNA and protein expression models

Report on performance of RNA and protein expression models in validation of prospective cohorts from emergency departments PICU and inpatient cohorts

Ethics Board Report (Preliminary)

Initial report of independent ethics review board on the documents for patient consent and the procedures for patient data and sample collection and overall ethical procedures submitted

Report on Feasibility and Implementation of Novel Diagnostics

Report on feasibility and implementation assessment of novel diagnostic

Recruitment Completion Review

Completion of recruitment and patient assignment for all prospective studies (BIVABI, BIVA- ED, BIVA-PIC, BIVA-INF and MOFICHE); samples and patient data sent for analysis. Includes report on updating the status of study registry.

report on protein biomarkers

Report on the performance of individual biomarker proteins

selection of platform

report on the selection of platform to develop prototype diagnostic

Transcriptomic Markers for bacterial and viral infections

Report studies of transcriptomic markers to differentiate febrile patients with bacterial and viral infection in the validation cohorts

Models of novel proteomic and genomic markers

Delivery of a range of options based on models on how a novel proteomic or genomic marker would influence patient care flows

report on molecular diagnostics

report on the outcome of molecular bacterial and viral diagnostic studies

Operational Database

Delivery of operational database, housing clinical and laboratory data

Final Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.

New Management Algorithm Model

Final delivery of proposed new management algorithm including the use of genomic proteomic or clinical biomarkers identified during our programme with evaluation of cost benefit patient safety and overall healthcare benefit which would be obtained if the model were Implemented

1st Annual Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.

Mass Spectrometry Proteomic Analysis

Delivery of Mass spectrometry proteomic analysis on discovery cohort

Models of Novel Diagnostic Tests

Delivery of models describing the performance of the novel diagnostic tests

Clinical Recruitment & Data Collection Documents

Clinical recruitment and data collection documents for all prospective studies (BIVABI, BIVA- ED, BIVA-PIC, BIVA-INF and MOFICHE) finalised and agreed by PERFORM consortium. These documents to include the first study subject approvals package – with the final version of study protocol, registration number in an approved registry, ethics approval for main study site.

Websites, patent fillings, videos etc. (1)

PERFORM Website

The project will develop and use a dedicated website to improve engagement with its end-users and stakeholders. It is the aim of the project to keep its website up to date with the latest activities and outcomes, so as to maximize it's impact with regards to the main interested parties.

Pubblicazioni

Conference proceedings (10)

PATHOGENS DETECTED AMONG FEBRILE CHILDREN PRESENTING TO OUTPATIENT DEPARTMENT IN URBAN GAMBIA

Autori: """U. Effua, F. Secka, I. Sarr, M.A. Zaman, K. Bojang, A. Roca, O. N and on Behalf Of The Perform Consoritum"""
Pubblicato in: ESPID 2020 Abstract Book, 2020
Editore: ESPID 2020 Abstract Book

FEVER IN HIGH-RISK PAEDIATRIC PATIENTS PRESENTING TO EUROPEAN EMERGENCY DEPARTMENTS: THE PERFORM EXPERIENCE

Autori: F. Van Der Velden, P. Agyeman, U. Von Both,, E. Carrol, C. Fink, J. Herberg, T. Kuijpers, F. Martinón-Torres, H. Moll, M. Pokorn, A. Pollard, L. Schlapbach, M. Tsolia, S. Yeung, D. Zavadska, W. Zenz, M. Levin, M. Van Der Flier, M. Emonts, On Behalf Or Perform Consortium
Pubblicato in: ESPID 2021 Abstract book, Numero May 2021, 2021
Editore: ESPID

RESPIRATORY VIRUSES DETECTED FROM FEBRILE GAMBIAN CHILDREN PRESENTING TO HOSPITAL

Autori: """U. Effua, M. Voice, F. Secka, I. Sarr, M.A. Zaman, K. Bojang, A. Roca, N. ‘On Behalf Of The Perform Consortium"""
Pubblicato in: ESPID 2020 Abstract Book, 2020
Editore: ESPID 2020 Abstract Book

ANTIBIOTIC USE IN DEFINITE VIRAL AND DEFINITE BACTERIAL PHENOTYPES FROM THE PERFORM BIVA-STUDY ACROSS EUROPE

Autori: A. Khanijau, L.Kolberg, F. Van Der Velden, J. Herberg, T. Kuijpers, F. Martinón-Torres, H. Moll, M. Pokorn, A. Pollard, L. Schlapbach, M. Tsolia, S. Yeung, D. Zavadska, W. Zenz, M. Van Der Flier, M. Levin, E. Carrol, M. Emonts, U. Von Both, On Behalf Of Perform Consortium
Pubblicato in: ESPID2021, Numero May 2021, 2021
Editore: ESPID

CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS OF >5000 CHILDREN ATTENDING EMERGENCY DEPARTMENTS ACROSS EUROPE (PERFORM PROJECT)

Autori: I. Rivero-Calle, J. Pardo-Seco, M. Cebey-López, F. Martinón-Torres, P. Consortium
Pubblicato in: ESPID 2020 Abstract Book, 2020
Editore: ESPID 2020 Abstract Book

A NICE combination predicting hospitalisation at triage

Autori: Dorine Borensztajn, Nienke Hagedoorn, Ulrich von Both, Enitan D. Carrol, Manuel Dewez, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Herberg, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinon-Torres, Ruud Nijman, Marko Pokorn, Franc Strle, Maria Tsolia, Clementien Vermont, Shunmay Yeung, Dace Zavadska, Werner Zenz, Michael Levin, Henriëtte A Moll
Pubblicato in: European Society for Emergency Medicine abstract book, 2019
Editore: EUSEM

Clinical prediction to target new biomarkers in febrile children at the ED, a European observational study

Autori: Nienke Hagedoorn, Dorine Borensztajn, Ian Maconochie, Ruud Nijman, Federico Martinon-Torres, Jethro Herberg, Enitan Carrol, Emma Lim, Maria Tsolia, Marieke Emonts, Ronald de Groot, Michiel van der Flier, Werner Zenz, Benno Kohlmaier, Franc Strle, Marko Pokorn, Dace Zavadska, Ulrich von Both, Clementien Vermont, Shunmay Yeung, Michael Levin, Henriëtte Moll
Pubblicato in: European Society for Emergency Medicine abstract book, 2019
Editore: EUSEM

PROSPECTIVE EVALUATION OF MANAGEMENT OF >5,000 PAEDIATRIC PATIENTS IN THE EMERGENCY DEPARTMENTS ACROSS EUROPE (PERFORM PROJECT)

Autori: Retrieving data. Wait a few seconds and try to cut or copy again.
Pubblicato in: Retrieving data. Wait a few seconds and try to cut or copy again., 2020
Editore: Retrieving data. Wait a few seconds and try to cut or copy again.

H.INFLUENZA - AN OVERLOOKED CAUSE OF PNEUMONIA IN CHILDREN?

Autori: P. Shah, M. Voice, C. Fink, J.Herberg, L. Calvo-Bado, On Behalf Or Perform Consortium
Pubblicato in: ESPID 2021 Abstract book, 2021
Editore: ESPID 2021 Abstract book

THE AVAILABILITY AND USE OF RAPID POINT-OF-CARE TESTS FOR THE MANAGEMENT OF ACUTE CHILDHOOD INFECTIONS IN EUROPE: A CROSS SECTIONAL SURVEY OF PAEDIATRICIANS

Autori: J. Dewez, S. Yeung, O.B.O. Perform/eaprasnet Study Group
Pubblicato in: ESPID 2020 Abstract Book, 2020
Editore: ESPID2020

Peer reviewed articles (34)

Defective Neutrophil Transendothelial Migration and Lateral Motility in ARPC1B Deficiency Under Flow Conditions

Autori: Lanette Kempers, Evelien G. G. Sprenkeler, Abraham C. I. van Steen, Jaap D. van Buul, Taco W. Kuijpers
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, Pagina/e 12:2062, ISSN 1664-3224
Editore: frontiers media
DOI: 10.3389/fimmu.2021.678030

Assessment of an Antibody-in-Lymphocyte Supernatant Assay for the Etiological Diagnosis of Pneumococcal Pneumonia in Children

Autori: Michael J. Carter, Pallavi Gurung, Claire Jones, Shristy Rajkarnikar, Rama Kandasamy, Meeru Gurung, Stephen Thorson, Madhav C. Gautam, Krishna G. Prajapati, Bibek Khadka, Anju Maharjan, Julian C. Knight, David R. Murdoch, Thomas C. Darton, Merryn Voysey, Brian Wahl, Katherine L. O'Brien, Sarah Kelly, Imran Ansari, Ganesh Shah, Nina Ekström, Merit Melin, Andrew J. Pollard, Dominic F. Kelly, Shrija
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 9, 2020, Pagina/e 459, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2019.00459

Treatment of Multisystem Inflammatory Syndrome in Children

Autori: Andrew J. McArdle, Ortensia Vito, Harsita Patel, Eleanor G. Seaby, Priyen Shah, Clare Wilson, Claire Broderick, Ruud Nijman, Adriana H. Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J. Carter, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A. Herberg, Myrsini Kaforou, Aubrey J. Cunnington, Michael Levin
Pubblicato in: New England Journal of Medicine, Numero 385/1, 2021, Pagina/e 11-22, ISSN 0028-4793
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmoa2102968

Variation in hospital admission in febrile children evaluated at the Emergency Department (ED) in Europe: PERFORM, a multicentre prospective observational study

Autori: Dorine M. Borensztajn, Nienke N. Hagedoorn, Irene Rivero Calle, Ian K. Maconochie, Ulrich von Both, Enitan D. Carrol, Juan Emmanuel Dewez, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Herberg, Benno Kohlmaier, Emma Lim, Federico Martinon-Torres, Daan Nieboer, Ruud G. Nijman, Marko Pokorn, Franc Strle, Maria Tsolia, Clementien Vermont, Shunmay Yeung, Dace Zavadska, Werner Zenz, Mi
Pubblicato in: PLOS ONE, Numero 16/1, 2021, Pagina/e e0244810, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0244810

When Actin is Not Actin’ Like It Should: A New Category of Distinct Primary Immunodeficiency Disorders

Autori: Evelien G.G. Sprenkeler, Steven D.S. Webbers, Taco W. Kuijpers
Pubblicato in: Journal of Innate Immunity, Numero 13/1, 2021, Pagina/e 3-25, ISSN 1662-811X
Editore: Karger AG
DOI: 10.1159/000509717

A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin

Autori: Luis G. Leal, Clive Hoggart, Marjo‐Riitta Jarvelin, Karl‐Heinz Herzig, Michael J. E. Sternberg, Alessia David
Pubblicato in: Molecular Genetics & Genomic Medicine, Numero 8/6, 2020, Pagina/e 1-9, ISSN 2324-9269
Editore: Wiley Open Access
DOI: 10.1002/mgg3.1248

Development and validation of a prediction model for invasive bacterial infections in febrile children at European Emergency Departments: MOFICHE, a prospective observational study

Autori: Nienke N Hagedoorn, Dorine Borensztajn, Ruud Gerard Nijman, Daan Nieboer, Jethro Adam Herberg, Anda Balode, Ulrich von Both, Enitan Carrol, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinón-Torres, Marko Pokorn, Franc Strle, Maria Tsolia, Dace Zavadska, Werner Zenz, Michael Levin, Clementien Vermont, Henriette A
Pubblicato in: Archives of Disease in Childhood, Numero 106/7, 2021, Pagina/e 641-647, ISSN 0003-9888
Editore: BMJ Publishing Group
DOI: 10.1136/archdischild-2020-319794

Defective neutrophil development and specific granule deficiency caused by a homozygous splice-site mutation in SMARCD2

Autori: Ina Schim van der Loeff, Evelien G.G. Sprenkeler, Anton T.J. Tool, Mario Abinun, Angela Grainger, Karin R. Engelhardt, Michel van Houdt, Hans Janssen, Taco W. Kuijpers, Sophie Hambleton
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 147/6, 2021, Pagina/e 2381-2385.e2, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2020.11.025

MKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization

Autori: Evelien G. G. Sprenkeler, Stefanie S. V. Henriet, Anton T. J. Tool, Iris C. Kreft, Ivo van der Bijl, Cathelijn E. M. Aarts, Michel van Houdt, Paul J. J. H. Verkuijlen, Koen van Aerde, Gerald Jaspers, Arno van Heijst, Wouter Koole, Thatjana Gardeitchik, Judy Geissler, Martin de Boer, Simon Tol, Christine W. Bruggeman, Floris P. J. van Alphen, Han J. M. P. Verhagen, Emile van den Akker, Hans Janssen
Pubblicato in: Blood, Numero 135/24, 2020, Pagina/e 2171-2181, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019002633

Shock Index in the early assessment of febrile children at the emergency department: a prospective multicentre study

Autori: Nienke N Hagedoorn, Joany M Zachariasse, Dorine Borensztajn, Elise Adriaansens, Ulrich von Both, Enitan D Carrol, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Adam Herberg, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinón-Torres, Ruud Gerard Nijman, Marko Pokorn, Irene Rivero-Calle, Maria Tsolia, Dace Zavadska, Werner Zenz, Michael Levin, Clementie
Pubblicato in: Archives of Disease in Childhood, Numero June 2021, 2021, Pagina/e archdischild-2020-320992, ISSN 0003-9888
Editore: BMJ Publishing Group
DOI: 10.1136/archdischild-2020-320992

Variation in antibiotic prescription rates in febrile children presenting to emergency departments across Europe (MOFICHE): A multicentre observational study

Autori: Nienke N. Hagedoorn, Dorine M. Borensztajn, Ruud Nijman, Anda Balode, Ulrich von Both, Enitan D. Carrol, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Herberg, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinon-Torres, Daan Nieboer, Marko Pokorn, Franc Strle, Maria Tsolia, Shunmay Yeung, Dace Zavadska, Werner Zenz, Clementien Vermont, Michael Levin, He
Pubblicato in: PLOS Medicine, Numero 17/8, 2020, Pagina/e e1003208, ISSN 1549-1676
Editore: Public Library of Science
DOI: 10.1371/journal.pmed.1003208

Current Ceftriaxone Dose Recommendations are Adequate for Most Critically Ill Children: Results of a Population Pharmacokinetic Modeling and Simulation Study

Autori: Stan J. F. Hartman, Parth J. Upadhyay, Nienke N. Hagedoorn, Ron A. A. Mathôt, Henriëtte A. Moll, Michiel van der Flier, Michiel F. Schreuder, Roger J. Brüggemann, Catherijne A. Knibbe, Saskia N. de Wildt
Pubblicato in: Clinical Pharmacokinetics, Numero Elife, 10, e65005., 2021, Pagina/e 1-12, ISSN 0312-5963
Editore: Adis International Ltd.
DOI: 10.1007/s40262-021-01035-9

Impact of a clinical decision rule on antibiotic prescription for children with suspected lower respiratory tract infections presenting to European emergency departments: a simulation study based on routine data

Autori: Nienke N Hagedoorn, Josephine H L Wagenaar, Daan Nieboer, David Bath, Ulrich Von Both, Enitan D Carrol, Irini Eleftheriou, Marieke Emonts, Michiel Van Der Flier, Ronald De Groot, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian Maconochie, Federico Martinon-Torres, Ruud Nijman, Marko Pokorn, Irene Rivero Calle, Maria Tsolia, Shunmay Yeung, Dace Zavadska, Werner Zenz, Clementien L Verm
Pubblicato in: Journal of Antimicrobial Chemotherapy, Numero 76/5, 2021, Pagina/e 1349-1357, ISSN 0305-7453
Editore: Oxford University Press
DOI: 10.1093/jac/dkab023

What matters when managing childhood fever in the emergency department? A discrete-choice experiment comparing the preferences of parents and healthcare professionals in the UK

Autori: Simon Leigh, Jude Robinson, Shunmay Yeung, Frans Coenen, Enitan D Carrol, Louis W Niessen
Pubblicato in: Archives of Disease in Childhood, Numero 105/8, 2020, Pagina/e 765-771, ISSN 0003-9888
Editore: BMJ Publishing Group
DOI: 10.1136/archdischild-2019-318209

Kawasaki Disease Patient Stratification and Pathway Analysis Based on Host Transcriptomic and Proteomic Profiles

Autori: Heather Jackson, Stephanie Menikou, Shea Hamilton, Andrew McArdle, Chisato Shimizu, Rachel Galassini, Honglei Huang, Jihoon Kim, Adriana Tremoulet, Adam Thorne, Roman Fischer, Marien de Jonge, Taco Kuijpers, Victoria Wright, Jane Burns, Climent Casals-Pascual, Jethro Herberg, Mike Levin, Myrsini Kaforou
Pubblicato in: International Journal of Molecular Sciences, Numero 22/11, 2021, Pagina/e 5655, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115655

Identification of disease-associated loci using machine learning for genotype and network data integration

Autori: Luis G Leal, Alessia David, Marjo-Riita Jarvelin, Sylvain Sebert, Minna Männikkö, Ville Karhunen, Eleanor Seaby, Clive Hoggart, Michael J E Sternberg
Pubblicato in: Bioinformatics, Numero 35/24, 2019, Pagina/e 5182-5190, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btz310

The cost of diagnostic uncertainty: a prospective economic analysis of febrile children attending an NHS emergency department

Autori: Simon Leigh, Alison Grant, Nicola Murray, Brian Faragher, Henal Desai, Samantha Dolan, Naeema Cabdi, James B. Murray, Yasmin Rejaei, Stephanie Stewart, Karl Edwardson, Jason Dean, Bimal Mehta, Shunmay Yeung, Frans Coenen, Louis W. Niessen, Enitan D. Carrol
Pubblicato in: BMC Medicine, Numero 17/1, 2019, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-019-1275-z

Integrated Chemometrics and Statistics to Drive Successful Proteomics Biomarker Discovery

Autori: Anouk Suppers, Alain van Gool, Hans Wessels
Pubblicato in: Proteomes, Numero 6/2, 2018, Pagina/e 20, ISSN 2227-7382
Editore: MDPI
DOI: 10.3390/proteomes6020020

Clinical practice guidelines for acute otitis media in children: a systematic review and appraisal of European national guidelines

Autori: Hijiri G Suzuki, Juan Emmanuel Dewez, Ruud G Nijman, Shunmay Yeung
Pubblicato in: BMJ Open, Numero 10/5, 2020, Pagina/e e035343, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2019-035343

Biosynthetic homeostasis and resilience of the complement system in health and infectious disease

Autori: Esther Willems, Wynand Alkema, Jenneke Keizer-Garritsen, Anouk Suppers, Michiel van der Flier, Ria H.L.A. Philipsen, Lambert P. van den Heuvel, Elena Volokhina, Renate G. van der Molen, Jethro A. Herberg, Michael Levin, Victoria J. Wright, Inge M.L. Ahout, Gerben Ferwerda, Marieke Emonts, Navin P. Boeddha, Irene Rivero-Calle, Federico Martinon Torres, Hans J.C.T. Wessels, Ronald de Groot, Alain J.
Pubblicato in: EBioMedicine, Numero 45, 2019, Pagina/e 303-313, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2019.06.008

Fluids in the management of sepsis in children: a review of guidelines in the aftermath of the FEAST trial

Autori: Juan Emmanuel Dewez, Ruud Gerard Nijman, Shunmay Yeung
Pubblicato in: Archives of Disease in Childhood, Numero 104/12, 2019, Pagina/e 1236-1236, ISSN 0003-9888
Editore: BMJ Publishing Group
DOI: 10.1136/archdischild-2019-317595

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

Autori: Elizabeth Whittaker, Alasdair Bamford, Julia Kenny, Myrsini Kaforou, Christine E. Jones, Priyen Shah, Padmanabhan Ramnarayan, Alain Fraisse, Owen Miller, Patrick Davies, Filip Kucera, Joe Brierley, Marilyn McDougall, Michael Carter, Adriana Tremoulet, Chisato Shimizu, Jethro Herberg, Jane C. Burns, Hermione Lyall, Michael Levin
Pubblicato in: JAMA, 2020, ISSN 0098-7484
Editore: American Medical Association
DOI: 10.1001/jama.2020.10369

Diversity in the emergency care for febrile children in Europe: a questionnaire study

Autori: Dorine Borensztajn, Shunmay Yeung, Nienke N Hagedoorn, Anda Balode, Ulrich von Both, Enitan D Carrol, Juan Emmanuel Dewez, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Adam Herberg, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinón-Torres, Ruud Nijman, Marko Pokorn, Franc Strle, Maria Tsolia, Gerald Wendelin, Dace Zavadska, Werner Zenz, Michael Levi
Pubblicato in: BMJ Paediatrics Open, Numero 3/1, 2019, Pagina/e e000456, ISSN 2399-9772
Editore: BMJ
DOI: 10.1136/bmjpo-2019-000456

A comparison of clinical paediatric guidelines for hypotension with population-based lower centiles: a systematic review

Autori: Nienke N. Hagedoorn, Joany M. Zachariasse, Henriette A. Moll
Pubblicato in: Critical Care, Numero 23/1, 2019, ISSN 1364-8535
Editore: BioMed Central Ltd
DOI: 10.1186/s13054-019-2653-9

Biomarkers to predict infection and infection‐related complications during chemotherapy‐induced neutropenia in acute myeloid leukaemia: a pilot study

Autori: Annemarie Geer, Judith Zandstra, Michael W. T. Tanck, Erfan Nur, Gerard Mierlo, Ilse Jongerius, Robin Bruggen, Sacha S. Zeerleder, Taco W. Kuijpers
Pubblicato in: British Journal of Haematology, Numero 193/5, 2021, Pagina/e 1008-1012, ISSN 0007-1048
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjh.17422

Management of non-urgent paediatric emergency department attendances by GPs: a retrospective observational study

Autori: Simon Leigh, Bimal Mehta, Lillian Dummer, Harriet Aird, Sinead McSorley, Venessa Oseyenum, Anna Cumbers, Mary Ryan, Karl Edwardson, Phil Johnston, Jude Robinson, Frans Coenen, David Taylor-Robinson, Louis W Niessen, Enitan D Carrol
Pubblicato in: British Journal of General Practice, Numero 71/702, 2020, Pagina/e e22-e30, ISSN 0960-1643
Editore: Royal College of General Practitioners
DOI: 10.3399/bjgp20x713885

Molecular Mechanisms of Leukocyte Migration and Its Potential Targeting—Lessons Learned From MKL1/SRF-Related Primary Immunodeficiency Diseases

Autori: Evelien G. G. Sprenkeler, Carla Guenther, Imrul Faisal, Taco W. Kuijpers, Susanna C. Fagerholm
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, Pagina/e 12:22., ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2021.615477

Role of point-of-care tests in the management of febrile children: a qualitative study of hospital-based doctors and nurses in England

Autori: Edmond Li, Juan Emmanuel Dewez, Queena Luu, Marieke Emonts, Ian Maconochie, Ruud Nijman, Shunmay Yeung
Pubblicato in: BMJ Open, Numero 11/5, 2021, Pagina/e e044510, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-044510

Biomarkers for the Discrimination of Acute Kawasaki Disease From Infections in Childhood

Autori: Judith Zandstra, Annemarie van de Geer, Michael W. T. Tanck, Diana van Stijn-Bringas Dimitriades, Cathelijn E. M. Aarts, Sanne M. Dietz, Robin van Bruggen, Nina A. Schweintzger, Werner Zenz, Marieke Emonts, Dace Zavadska, Marko Pokorn, Effua Usuf, Henriette A. Moll, Luregn J. Schlapbach, Enitan D. Carrol, Stephane Paulus, Maria Tsolia, Colin Fink, Shunmay Yeung, Chisato Shimizu, Adriana Tremoulet,
Pubblicato in: Frontiers in Pediatrics, Numero 8, 2020, Pagina/e 355, ISSN 2296-2360
Editore: Frontiers Media
DOI: 10.3389/fped.2020.00355

A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies

Autori: Ruud G. Nijman, Rianne Oostenbrink, Henriette A. Moll, Climent Casals-Pascual, Ulrich von Both, Aubrey Cunnington, Tisham De, Irini Eleftheriou, Marieke Emonts, Colin Fink, Michiel van der Flier, Ronald de Groot, Myrsini Kaforou, Benno Kohlmaier, Taco W. Kuijpers, Emma Lim, Ian K. Maconochie, Stephane Paulus, Federico Martinon-Torres, Marko Pokorn, Sam T. Romaine, Irene Rivero Calle, Luregn J. Sch
Pubblicato in: Frontiers in Pediatrics, Numero 9, 2021, Pagina/e 748, ISSN 2296-2360
Editore: Frontiers Media
DOI: 10.3389/fped.2021.688272

Quantitative multiplex profiling of the complement system to diagnose complement‐mediated diseases

Autori: Esther Willems, Laura Lorés‐Motta, Andrea Zanichelli, Chiara Suffritti, Michiel Flier, Renate G Molen, Jeroen D Langereis, Joris Drongelen, Lambert P Heuvel, Elena Volokhina, Nicole CAJ Kar, Jenneke Keizer‐Garritsen, Michael Levin, Jethro A Herberg, Federico Martinon‐Torres, Hans JTC Wessels, Anita Breuk, Sascha Fauser, Carel B Hoyng, Anneke I Hollander, Ronald Groot, Alain J Gool, Jolein G
Pubblicato in: Clinical & Translational Immunology, Numero 9/12, 2020, Pagina/e 2020 Dec 9;9(12):e1225, ISSN 2050-0068
Editore: Wiley Open Access
DOI: 10.1002/cti2.1225

Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE): protocol for a multisite prospective observational study of the causes of fever in Africa and Asia

Autori: Heidi Hopkins, Quique Bassat, Clare IR Chandler, John A Crump, Nicholas A Feasey, Rashida A Ferrand, Katharina Kranzer, David G Lalloo, Mayfong Mayxay, Paul N Newton, David Mabey
Pubblicato in: BMJ Open, Numero 10/7, 2020, Pagina/e e035632, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2019-035632

Loss‐of‐function mutations in CSF3R cause moderate neutropenia with fully mature neutrophils: two novel pedigrees

Autori: Evelien G. G. Sprenkeler, Anton T. J. Tool, Iris C. Kreft, Floris P. J. Alphen, Suranjith L. Seneviratne, Jesmeen Maimaris, Asad Luqmani, Karin Leeuwen, Robin Bruggen, Siobhan O. Burns, Taco W. Kuijpers
Pubblicato in: British Journal of Haematology, Numero 191/5, 2020, Pagina/e 930-934, ISSN 0007-1048
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjh.17081

Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration

Autori: Laura Lorés-Motta, Anna E. van Beek, Esther Willems, Judith Zandstra, Gerard van Mierlo, Alfred Einhaus, Jean-Luc Mary, Corinne Stucki, Bjorn Bakker, Carel B. Hoyng, Sascha Fauser, Simon J. Clark, Marien I. de Jonge, Everson Nogoceke, Elod Koertvely, Ilse Jongerius, Taco W. Kuijpers, Anneke I. den Hollander
Pubblicato in: The American Journal of Human Genetics, Numero 108/8, 2021, Pagina/e 1367-1384, ISSN 0002-9297
Editore: University of Chicago Press
DOI: 10.1016/j.ajhg.2021.06.002