HIV-1 sensing and signaling in dendritic cells

Informazioni relative al progetto

SENTINEL

ID dell’accordo di sovvenzione: 670424

DOI

10.3030/670424

Progetto chiuso

Data della firma CE 27 Agosto 2015

Data di avvio 1 Ottobre 2015

Data di completamento 30 Settembre 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 156,25

Contributo UE

€ 2 499 156,00

Coordinato da

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (22)

MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals

Autori: Melissa Stunnenberg, Lisa van Pul, Joris K. Sprokholt, Karel A. van Dort, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek, Neeltje A. Kootstra
Pubblicato in: Viruses, Numero 12/7, 2020, Pagina/e 764, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12070764

Separate signaling events control TCR downregulation and T cell activation in primary human T cells

Autori: Lieve E. H. Donk, Louis S. Ates, Jet Spek, Laura M. Tukker, Teunis B. H. Geijtenbeek, Jeroen W. J. Heijst
Pubblicato in: Immunity, Inflammation and Disease, Numero 9/1, 2021, Pagina/e 223-238, ISSN 2050-4527
Editore: Wiley
DOI: 10.1002/iid3.383

RIG-I–like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and T H 1 Differentiation

Autori: Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, Ronald J. Overmars, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Pubblicato in: The Journal of Immunology, Numero 198/12, 2017, Pagina/e 4764-4771, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1602121

DDX3 in HIV-1 infection and sensing: A paradox

Autori: Melissa Stunnenberg, Teunis B.H. Geijtenbeek, Sonja I. Gringhuis
Pubblicato in: Cytokine & Growth Factor Reviews, Numero 40, 2018, Pagina/e 32-39, ISSN 1359-6101
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.cytogfr.2018.03.001

C-Type Lectin Receptors in Antiviral Immunity and Viral Escape

Autori: Marta Bermejo-Jambrina, Julia Eder, Leanne C. Helgers, Nina Hertoghs, Bernadien M. Nijmeijer, Melissa Stunnenberg, Teunis B. H. Geijtenbeek
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2018.00590

RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production

Autori: Joris K. Sprokholt, Tanja M. Kaptein, John L. van Hamme, Ronald J. Overmars, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Pubblicato in: PLOS Pathogens, Numero 13/11, 2017, Pagina/e e1006738, ISSN 1553-7374
Editore: PLOS
DOI: 10.1371/journal.ppat.1006738

DCs facilitate B cell responses against microbial DNA via DC-SIGN

Autori: Joris K. Sprokholt, Marieke H. Heineke, Tanja M. Kaptein, John L. van Hamme, Teunis B. H. Geijtenbeek
Pubblicato in: PLOS ONE, Numero 12/10, 2017, Pagina/e e0185580, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0185580

C-type lectin receptors in the control of T helper cell differentiation

Autori: Teunis B. H. Geijtenbeek, Sonja I. Gringhuis
Pubblicato in: Nature Reviews Immunology, Numero 16/7, 2016, Pagina/e 433-448, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/nri.2016.55

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets

Autori: Carla M. S. Ribeiro, Ramin Sarrami-Forooshani, Laurentia C. Setiawan, Esther M. Zijlstra-Willems, John L. van Hamme, Wikky Tigchelaar, Nicole N. van der Wel, Neeltje A. Kootstra, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Pubblicato in: Nature, Numero 540/7633, 2016, Pagina/e 448-452, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature20567

Interplay between HIV-1 innate sensing and restriction in mucosal dendritic cells: balancing defense and viral transmission

Autori: Nina Hertoghs, Teunis B.H. Geijtenbeek, Carla M.S. Ribeiro
Pubblicato in: Current Opinion in Virology, Numero 22, 2017, Pagina/e 112-119, ISSN 1879-6257
Editore: Elsevier BV
DOI: 10.1016/j.coviro.2017.01.001

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

Autori: Sonja I Gringhuis, Nina Hertoghs, Tanja M Kaptein, Esther M Zijlstra-Willems, Ramin Sarrami-Fooroshani, Joris K Sprokholt, Nienke H van Teijlingen, Neeltje A Kootstra, Thijs Booiman, Karel A van Dort, Carla M S Ribeiro, Agata Drewniak, Teunis B H Geijtenbeek
Pubblicato in: Nature Immunology, Numero 18/2, 2016, Pagina/e 225-235, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/ni.3647

Syndecan 4 Upregulation on Activated Langerhans Cells Counteracts Langerin Restriction to Facilitate Hepatitis C Virus Transmission

Autori: Bernadien M. Nijmeijer, Julia Eder, Catharina J. M. Langedijk, Tanja M. Kaptein, Sofie Meeussen, Pascale Zimmermann, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.00503

Various Tastes of Sugar: The Potential of Glycosylation in Targeting and Modulating Human Immunity via C-Type Lectin Receptors

Autori: Stefanie Busold, Noémi A. Nagy, Sander W. Tas, Ronald van Ree, Esther C. de Jong, Teunis B. H. Geijtenbeek
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: frontiers
DOI: 10.3389/fimmu.2020.00134

Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity

Autori: Melissa Stunnenberg, Joris K. Sprokholt, John L. van Hamme, Tanja M. Kaptein, Esther M. Zijlstra-Willems, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.00008

Vaginal dysbiosis associated-bacteria Megasphaera elsdenii and Prevotella timonensis induce immune activation via dendritic cells

Autori: Nienke H. van Teijlingen, Leanne C. Helgers, Esther M. Zijlstra - Willems, John L. van Hamme, Carla M.S. Ribeiro, Karin Strijbis, Teunis B.H. Geijtenbeek
Pubblicato in: Journal of Reproductive Immunology, Numero 138, 2020, Pagina/e 103085, ISSN 0165-0378
Editore: Elsevier BV
DOI: 10.1016/j.jri.2020.103085

Sexually transmitted founder HIV-1 viruses are relatively resistant to Langerhans cell-mediated restriction

Autori: Nina Hertoghs, Bernadien M. Nijmeijer, Nienke H. van Teijlingen, Angharad E. Fenton-May, Tanja M. Kaptein, John L. van Hamme, John C. Kappes, Neeltje A. Kootstra, Beatrice H. Hahn, Persephone Borrow, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek
Pubblicato in: PLOS ONE, Numero 14/12, 2019, Pagina/e e0226651, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0226651

Borrelia miyamotoi Activates Human Dendritic Cells and Elicits T Cell Responses

Autori: Lauren M. K. Mason, Joris Koetsveld, Jos J. A. Trentelman, Tanja M. Kaptein, Dieuwertje Hoornstra, Alex Wagemakers, Michelle M. Fikrig, Jasmin I. Ersoz, Anneke Oei, Teunis B. H. Geijtenbeek, Joppe W. R. Hovius
Pubblicato in: The Journal of Immunology, Numero 204/2, 2020, Pagina/e 386-393, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1801589

Sexually transmitted hepatitis C virus infections: current trends, and recent advances in understanding the spread in men who have sex with men

Autori: Bernadien M Nijmeijer, Jelle Koopsen, Janke Schinkel, Maria Prins, Teunis BH Geijtenbeek
Pubblicato in: Journal of the International AIDS Society, Numero 22/S6, 2019, ISSN 1758-2652
Editore: International AIDS Society
DOI: 10.1002/jia2.25348

Negative and Positive Selection Pressure During Sexual Transmission of Transmitted Founder HIV-1

Autori: Bernadien M. Nijmeijer, Teunis B. H. Geijtenbeek
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2019.01599

HIV ‐1 exposure and immune activation enhance sexual transmission of Hepatitis C virus by primary Langerhans cells

Autori: Bernadien M Nijmeijer, Ramin Sarrami‐Forooshani, Gaby S Steba, Renée RCE Schreurs, Sylvie M Koekkoek, Richard Molenkamp, Janke Schinkel, Peter Reiss, Matthijs L Siegenbeek van Heukelom, Marc Valk, Carla MS Ribeiro, Teunis BH Geijtenbeek
Pubblicato in: Journal of the International AIDS Society, Numero 22/3, 2019, Pagina/e e25268, ISSN 1758-2652
Editore: International AIDS Society
DOI: 10.1002/jia2.25268

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

Autori: Renée R.C.E. Schreurs, Martin E. Baumdick, Adrian F. Sagebiel, Max Kaufmann, Michal Mokry, Paul L. Klarenbeek, Nicola Schaltenberg, Fenja L. Steinert, Jorik M. van Rijn, Agata Drewniak, Sarah-May M.L. The, Roel Bakx, Joep P.M. Derikx, Niek de Vries, Willemijn E. Corpeleijn, Steven T. Pals, Nicola Gagliani, Manuel A. Friese, Sabine Middendorp, Edward E.S. Nieuwenhuis, Konrad Reinshagen, Teunis B.H
Pubblicato in: Immunity, Numero 50/2, 2019, Pagina/e 462-476.e8, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2018.12.010

Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22–Specific Th Cells

Autori: Yohei Otsuka, Eri Watanabe, Eiji Shinya, Sadayuki Okura, Hidehisa Saeki, Teunis B. H. Geijtenbeek, Hidemi Takahashi
Pubblicato in: The Journal of Immunology, Numero 201/10, 2018, Pagina/e 3006-3016, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1701402