Nanomedicine upscaling for early clinical phases of multimodal cancer therapy

Informazioni relative al progetto

NoCanTher

ID dell’accordo di sovvenzione: 685795

DOI

10.3030/685795

Progetto chiuso

Data della firma CE 8 Marzo 2016

Data di avvio 1 Aprile 2016

Data di completamento 30 Settembre 2021

Finanziato da

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Costo totale

€ 7 113 778,75

Contributo UE

€ 7 113 778,75

Coordinato da

FUNDACION IMDEA NANOCIENCIA
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (2)

Exploitation & Dissemination Workshop I

International workshops with main stakeholders and players, including representatives of the EC (around 80 participants)

Exploitation and dissemination Workshop II

International workshop with main stakeholders and players, including representatives of the EC (around 80 participants)

Documents, reports (2)

White paper on good practices for Nanotherapies scale up

This file will contain all the good practices, potential contribution standards and lessons learned in certified nanoparticle production scale up, to contribute to the deployment of nanotherapies in the EU

Submission of scientific paper for publication and thereby bringing trial results into the public domain

After collection of all clinical data and data cleaning a scientific report will be delivered and submitted to a peer-reviewed journal to make all data available in the public domain

Websites, patent fillings, videos etc. (1)

Public Web Site and Project Presentation

Design and maintenance of dedicated project web site with an offering of the typical electronic dissemination facilities

Pubblicazioni

Peer reviewed articles (37)

Optomagnetic Nanoplatforms for In Situ Controlled Hyperthermia

Autori: Dirk H. Ortgies, Francisco J. Teran, Uéslen Rocha, Leonor de la Cueva, Gorka Salas, David Cabrera, Alexander S. Vanetsev, Mihkel Rähn, Väino Sammelselg, Yurii V. Orlovskii, Daniel Jaque
Pubblicato in: Advanced Functional Materials, Numero 28/11, 2018, Pagina/e 1704434, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201704434

Iron oxide-manganese oxide nanoparticles with tunable morphology and switchable MRI contrast mode triggered by intracellular conditions

Autori: García-Soriano, D., Milán-Rois, P., Lafuente-Gómez, N., Navío, C., Gutiérrez, L., Cussó, L., Desco, M., Calle, D., Somoza, Á., Salas, G.
Pubblicato in: Journal of Colloid and Interface Science, 2022, Pagina/e 447-460, ISSN 0021-9797
Editore: Academic Press
DOI: 10.1016/j.jcis.2022.01.070

Stimuli-responsive nanomaterials for cancer treatment: boundaries, opportunities and applications

Autori: Nuria Lafuente-Gómez; Ana Latorre; Paula Milán-Rois; Ciro Rodriguez Diaz; Álvaro Somoza
Pubblicato in: Chemical Communications, Numero 1, 2021, Pagina/e 13662-13677, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cc05056g

In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments

Autori: Irene Rubia-Rodríguez; Luca Zilberti; Alessandro Arduino; Oriano Bottauscio; Mario Chiampi; Daniel Ortega; Daniel Ortega
Pubblicato in: International Journal of Hyperthermia, Numero 1, 2021, Pagina/e 846-861, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.6084/m9.figshare.16780691.v1

Smartphone‐Based Colorimetric Method to Quantify Iron Concentration and to Determine the Nanoparticle Size from Suspensions of Magnetic Nanoparticles

Autori: Yilian Fernández‐Afonso, Gorka Salas, Irene Fernández‐Barahona, Fernando Herranz, Cordula Grüttner, Jesús Martínez de la Fuente, María Puerto Morales, Lucía Gutiérrez
Pubblicato in: Particle & Particle Systems Characterization, Numero 37/7, 2020, Pagina/e 2000032, ISSN 0934-0866
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ppsc.202000032

Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance

Autori: S. Inder, M. Bates, N. Ni Labhrai, N. McDermott, J. Schneider, G. Erdmann, T. Jamerson, A. N. Flores, A. Prina-Mello, P. Thirion, P. R. Manecksha, D. Cormican, S. Finn, T. Lynch, L. Marignol
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-53799-7

Iron oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: impact and future perspectives

Autori: Susann Piehler; Heidi Dähring; Julia Grandke; Julia Göring; Pierre Couleaud; Antonio Aires; Aitziber L. Cortajarena; Aitziber L. Cortajarena; José Courty; Alfonso Latorre; Álvaro Somoza; Ulf Teichgräber; Ingrid Hilger
Pubblicato in: Nanomaterials, Numero 1, 2021, Pagina/e 1016, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano10061016

Tumor-Selective Immune Active Mild Hyperthermia Associated with Chemotherapy in Colon Peritoneal Metastasis by Photoactivation of Fluorouracil – Gold Nanoparticle Complexes

Autori: Gazeau Florence
Pubblicato in: ACS Nano, Numero 6, 2021, Pagina/e 3330-3348, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.0c10276

Physical oncology: New targets for nanomedicine

Autori: Nicolas-Boluda, A., Silva, A.K.A., Fournel, S., Gazeau, F.
Pubblicato in: Biomaterials, 2018, Pagina/e 87-99, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.10.014

Effect of Matrix-Modulating Enzymes on the Cellular Uptake of Magnetic Nanoparticles and on Magnetic Hyperthermia Treatment of Pancreatic Cancer Models In Vivo

Autori: Felista L. Tansi; Filipp Fröbel; Wisdom O. Maduabuchi; Frank Steiniger; Martin Westermann; Rainer Quaas; Ulf Teichgräber; Ingrid Hilger
Pubblicato in: Nanomaterials, Numero 1, 2021, Pagina/e 438, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano11020438

Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications

Autori: Geoffrey Cotin; Cristina Blanco-Andujar; Francis Perton; Laura Asín; Jesús M. de la Fuente; Wilfried Reichardt; Wilfried Reichardt; Denise Schaffner; Dinh-Vu Ngyen; Damien Mertz; Céline Kiefer; Florent Meyer; Simo Spassov; Ovidiu Ersen; Michael Chatzidakis; Gianluigi A. Botton; Céline Henoumont; Sophie Laurent; Jean-Marc Greneche; Francisco J. Teran; Francisco J. Teran; Daniel Ortega; Daniel O
Pubblicato in: Nanoscale, Numero 1, 2021, Pagina/e 14552-14571, ISSN 2040-3372
Editore: RSC
DOI: 10.1039/d1nr03335b

Deep-tissue localization of magnetic field hyperthermia using pulse sequencing

Autori: Tansi, F.L., Maduabuchi, W.O., Hirsch, M., Southern, P., Hattersley, S., Quaas, R., Teichgräber, U., Pankhurst, Q.A., Hilger, I.
Pubblicato in: International Journal of Hypertermia, 2021, Pagina/e 743-754, ISSN 1464-5157
Editore: Taylor Francis
DOI: 10.1080/02656736.2021.1912412

Unraveling viscosity effects on the hysteresis losses of magnetic nanocubes

Autori: D. Cabrera, A. Lak, T. Yoshida, M. E. Materia, D. Ortega, F. Ludwig, P. Guardia, A. Sathya, T. Pellegrino, F. J. Teran
Pubblicato in: Nanoscale, Numero 9/16, 2017, Pagina/e 5094-5101, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/c7nr00810d

Introduction to Nanomaterials Applied to Life Sciences

Autori: Espinosa, A., Teran, F.J., Ortega, D.
Pubblicato in: Nanoscale Advances, 2021, ISSN 2516-0230
Editore: RSC
DOI: 10.1039/d1na90011k

Endotoxin contamination of engineered nanomaterials: Overcoming the hurdles associated with endotoxin testing

Autori: Hannon, G., Prina-Mello, A.
Pubblicato in: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021, Pagina/e e1738, ISSN 1939-0041
Editore: John Wiley & Sons Inc.
DOI: 10.1002/wnan.1738

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma

Autori: Alba Nicolás-Boluda, Javier Vaquero, Gautier Laurent, Gilles Renault, Rana Bazzi, Emmanuel Donnadieu, Stéphane Roux, Laura Fouassier, Florence Gazeau
Pubblicato in: ACS Nano, Numero 14/5, 2020, Pagina/e 5738-5753, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.0c00417

The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

Autori: David García-Soriano, Rebeca Amaro, Nuria Lafuente-Gómez, Paula Milán-Rois, Álvaro Somoza, Cristina Navío, Fernando Herranz, Lucía Gutiérrez, Gorka Salas
Pubblicato in: Journal of Colloid and Interface Science, Numero 578, 2020, Pagina/e 510-521, ISSN 0021-9797
Editore: Academic Press
DOI: 10.1016/j.jcis.2020.06.011

Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells

Autori: Gary Hannon, Anna Bogdanska, Yuri Volkov, Adriele Prina-Mello
Pubblicato in: Nanomaterials, Numero 10/3, 2020, Pagina/e 593, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano10030593

Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells

Autori: David Cabrera, Annelies Coene, Jonathan Leliaert, Emilio J. Artés-Ibáñez, Luc Dupré, Neil D. Telling, Francisco J. Teran
Pubblicato in: ACS Nano, Numero 12/3, 2018, Pagina/e 2741-2752, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.7b08995

Nanoparticle-based hyperthermia, a local treatment modulating the tumor extracellular matrix

Autori: Jelena Kolosnjaj-Tabi, Iris Marangon, Alba Nicolas-Boluda, Amanda K.A. Silva, Florence Gazeau
Pubblicato in: Pharmacological Research, Numero 126, 2017, Pagina/e 123-137, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2017.07.010

Overcoming the tumor microenvironment: the role of nanohyperthermia

Autori: Amanda K Silva, Alba Nicolas-Boluda, Laura Fouassier, Florence Gazeau
Pubblicato in: Nanomedicine, Numero 12/11, 2017, Pagina/e 1213-1215, ISSN 1743-5889
Editore: Future Medicine Ltd.
DOI: 10.2217/nnm-2017-0096

How gastrin-releasing peptide receptor (GRPR) and αvβ3 integrin expression reflect reorganization features of tumors after hyperthermia treatments

Autori: Sandra Hallasch, Sindy Frick, Maximilian Jung, Ingrid Hilger
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-06100-7

Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models

Autori: Paul Southern, Quentin A. Pankhurst
Pubblicato in: International Journal of Hyperthermia, Numero 34/6, 2017, Pagina/e 671-686, ISSN 0265-6736
Editore: Taylor & Francis
DOI: 10.1080/02656736.2017.1365953

The Effects of Localized Heat on the Hallmarks of Cancer

Autori: Gary Hannon; Felista L. Tansi; Ingrid Hilger; Adriele Prina-Mello
Pubblicato in: Advanced Therapeutics, Numero 1, 2021, ISSN 2366-3987
Editore: Wiley
DOI: 10.1002/adtp.202000267

Smart model of intrinsic loss power of SPIONs in hyperthermia treatment

Autori: Marco Alberti; Adriele Prina-Mello
Pubblicato in: Journal of Magnetism and Magnetic Materials, Numero 3, 2020, Pagina/e 166493, ISSN 0304-8853
Editore: Elsevier BV
DOI: 10.1016/j.jmmm.2020.166493

Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties.

Autori: Nuria Lafuente-Gómez; Paula Milán-Rois; David García-Soriano; Yurena Luengo; Marco Cordani; Hernán Alarcón-Iniesta; Gorka Salas; Gorka Salas; Álvaro Somoza; Álvaro Somoza
Pubblicato in: Cancers, Numero 4, 2021, Pagina/e 4095, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13164095

Using the ‘dispersion-retention-formulation method’ to estimate clinical and preclinical dosage limits for interstitial nanomedicines or agents

Autori: Paul Southern, Quentin A. Pankhurst
Pubblicato in: Journal of Magnetism and Magnetic Materials, Numero 473, 2019, Pagina/e 74-78, ISSN 0304-8853
Editore: Elsevier BV
DOI: 10.1016/j.jmmm.2018.10.019

Combining Ag and γ-Fe2O3 properties to produce effective antibacterial nanocomposites

Autori: Yurena Luengo, Begoña Sot, Gorka Salas
Pubblicato in: Colloids and Surfaces B: Biointerfaces, Numero 194, 2020, Pagina/e 111178, ISSN 0927-7765
Editore: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111178

Whither Magnetic Hyperthermia? A Tentative Roadmap

Autori: Irene Rubia-Rodríguez; Antonio Santana-Otero; Simo Spassov; Etelka Tombácz; Christer Johansson; Patricia de la Presa; Patricia de la Presa; Francisco J. Teran; María del Puerto Morales; Sabino Veintemillas-Verdaguer; Nguyen T. K. Thanh; Maximilian O. Besenhard; Claire Wilhelm; Florence Gazeau; Quentin John Harmer; Eric Mayes; Bella B. Manshian; Stefaan J. Soenen; Yuanyu Gu; Ángel Millán; Elen
Pubblicato in: Materials, Numero 1, 2021, Pagina/e 706, ISSN 1996-1944
Editore: MDPI Open Access Publishing
DOI: 10.3390/ma14040706

The phenotype of target pancreatic cancer cells influences cell death by magnetic hyperthermia with nanoparticles carrying gemicitabine and the pseudo-peptide NucAnt

Autori: Mourad Sanhaji, Julia Göring, Pierre Couleaud, Antonio Aires, Aitziber L. Cortajarena, José Courty, Adriele Prina-Mello, Marcus Stapf, Robert Ludwig, Yuri Volkov, Alfonso Latorre, Álvaro Somoza, Rodolfo Miranda, Ingrid Hilger
Pubblicato in: Nanomedicine: Nanotechnology, Biology and Medicine, Numero 20, 2019, Pagina/e 101983, ISSN 1549-9634
Editore: Elsevier BV
DOI: 10.1016/j.nano.2018.12.019

A study focused on macrophages modulation induced by the Polymeric Electrospun Matrices (EL-Ms) for application in tissue regeneration: in vitro proof of concept.

Autori: Silvia Pisani; Rossella Dorati; Ida Genta; Marco Benazzo; Bice Conti; Adriele Prina Mello
Pubblicato in: International Journal of Pharmaceutics, Numero 1, 2021, Pagina/e 120712, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2021.120712

Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment

Autori: Marco Cordani, Álvaro Somoza
Pubblicato in: Cellular and Molecular Life Sciences, Numero 76/7, 2019, Pagina/e 1215-1242, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-018-2973-y

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment.

Autori: Alba Nicolas-Boluda; Javier Vaquero; Lene Vimeux; Thomas Guilbert; Sarah Barrin; Chahrazade Kantari-Mimoun; Matteo Ponzo; Gilles Renault; Piotr Deptuła; Katarzyna Pogoda; Robert Bucki; Ilaria Cascone; José Courty; Laura Fouassier; Florence Gazeau; Emmanuel Donnadieu
Pubblicato in: "eLife, eLife Sciences Publication, 2021, 10 (32), pp.322001. ⟨10.7554/eLife.58688⟩", Numero 1, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.58688

Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells

Autori: Ana Lazaro-Carrillo, Macarena Calero, Antonio Aires, Aitziber L. Cortajarena, Bruno M. Simões, Alfonso Latorre, Álvaro Somoza, Robert B. Clarke, Rodolfo Miranda, Angeles Villanueva
Pubblicato in: Cancers, Numero 12/6, 2020, Pagina/e 1397, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061397

Individual particle heating of interacting magnetic nanoparticles at nonzero temperature

Autori: Jonathan Leliaert; Javier Ortega-Julia; Daniel Ortega; Daniel Ortega
Pubblicato in: Nanoscale, 2021, Pagina/e 14734-14744, ISSN 2040-3372
Editore: Royal Society of Chemistry
DOI: 10.1039/d1nr05311f

3D volume segmentation and reconstruction. Supervised image classification and automated quantification of superparamagnetic iron oxide nanoparticles in histology slides for safety assessment.

Autori: Anna Bogdanska; Oliviero L. Gobbo; Yuri Volkov; Adriele Prina-Mello
Pubblicato in: Nanotoxicology, Numero 1, 2021, Pagina/e 1151-1167, ISSN 1743-5390
Editore: Informa Healthcare
DOI: 10.1080/17435390.2021.1991502

Self‐Assemblies of Fe 3 O 4 Nanocrystals: Toward Nanoscale Precision of Photothermal Effects in the Tumor Microenvironment

Autori: Alba Nicolas‐Boluda, Zhijie Yang, Thomas Guilbert, Laura Fouassier, Florent Carn, Florence Gazeau, Marie Paule Pileni
Pubblicato in: Advanced Functional Materials, 2020, Pagina/e 2006824, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202006824

Non-peer reviewed articles (1)

Two step promotion of a hot tumor immune environment by gold decorated iron oxide nanoflowers and light-triggered mild hyperthermia

Autori: Gazeau Florence
Pubblicato in: Nanoscale, Numero 6, 2021, Pagina/e 18483-18497, ISSN 2040-3372
Editore: RSC
DOI: 10.1039/d1nr03201a

Diritti di proprietà intellettuale

Patent (1)

METHOD FOR DETECTION OF AN ANALYTE

Numero candidatura/pubblicazione: 18 796477
Data: 2018-11-08
Candidato/i: FUNDACION IMDEA NANOCIENCIA