Macrophage aging and rejuvenation

Project Information

MacAGE

Grant agreement ID: 695093

DOI

10.3030/695093

Project closed

EC signature date 19 September 2016

Start date 1 January 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 994,00

EU contribution

€ 2 499 994,00

Coordinated by

TECHNISCHE UNIVERSITAET DRESDEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

Author(s): Bérengère de Laval, Julien Maurizio, Prashanth K. Kandalla, Gabriel Brisou, Louise Simonnet, Caroline Huber, Gregory Gimenez, Orit Matcovitch-Natan, Susanne Reinhardt, Eyal David, Alexander Mildner, Achim Leutz, Bertrand Nadel, Christophe Bordi, Ido Amit, Sandrine Sarrazin, Michael H. Sieweke
Published in: Cell Stem Cell, Issue 26/5, 2020, Page(s) 657-674.e8, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.01.017

Autofluorescence identifies highly phagocytic tissue-resident macrophages in mouse and human skin and cutaneous squamous cell carcinoma

Author(s): Pierre Bourdely, Luciana Petti, Sokchea Khou, Aida Meghraoui-Kheddar, Roxane Elaldi, Julie Cazareth, Noushine Mossadegh-Keller, Julien Boyer, Michael H Sieweke, Gilles Poissonnet, Anne Sudaka, Veronique M Braud, Fabienne Anjuère
Published in: Frontiers in Immunology, Issue Volume 13, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.903069

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo

Author(s): Sethuraman Subramanian, Clara Jana-Lui Busch, Kaaweh Molawi, Laufey Geirsdottir, Julien Maurizio, Stephanie Vargas Aguilar, Hassiba Belahbib, Gregory Gimenez, Ridzky Anis Advent Yuda, Michaela Burkon, Jérémy Favret, Sara Gholamhosseinian Najjar, Bérengère de Laval, Prashanth Kumar Kandalla, Sandrine Sarrazin, Lena Alexopoulou, Michael H. Sieweke
Published in: Nature Immunology, Issue 23(3), 2022, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-022-01146-w

Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain

Author(s): C. Siret, M. van Lessen, J. Bavais, H. W. Jeong, S. K. Reddy Samawar, K. Kapupara, S. Wang, M. Simic, L. de Fabritus, A. Tchoghandjian, M. Fallet, H. Huang, S. Sarrazin, M. H. Sieweke, R. Stumm, L. Sorokin, R. H. Adams, S. Schulte-Merker, F. Kiefer, S. A. van de Pavert
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35166-9

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

Author(s): Anders Etzerodt, Morgane Moulin, Thomas Koed Doktor, Marcello Delfini, Noushine Mossadegh-Keller, Marc Bajenoff, Michael H. Sieweke, Søren Kragh Moestrup, Nathalie Auphan-Anezin, Toby Lawrence
Published in: Journal of Experimental Medicine, Issue 217/4, 2020, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20191869

ImmGen at 15

Author(s): Stephanie Vargas Aguilar, Oscar Aguilar, Rhys Allan, El Ad David Amir, Veronique Angeli, Maxim N. Artyomov, Natasha Asinovski, Jilian Astarita, K. Frank Austen, Geetika Bajpai, Nora Barrett, Alev Baysoy, Christophe Benoist, Angelique Bellemare-Pelletier, Brad Berg, Adam Best, Natalie Bezman, David Blair, Julie M. Blander, Milena Bogunovic, Patrick Brennan, Michael Brenner, Brian Brown, Matthew Bue
Published in: Nature Immunology, Issue 21/7, 2020, Page(s) 700-703, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0687-4

Developmental origin and maintenance of distinct testicular macrophage populations

Author(s): Noushin Mossadegh-Keller, Rebecca Gentek, Gregory Gimenez, Sylvain Bigot, Sebastien Mailfert, Michael H. Sieweke
Published in: The Journal of Experimental Medicine, Issue 214/10, 2017, Page(s) 2829-2841, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20170829

Characterization of Mouse Adult Testicular Macrophage Populations by Immunofluorescence Imaging and Flow Cytometry

Author(s): Noushin Mossadegh-Keller, Michael Sieweke
Published in: BIO-PROTOCOL, Issue 9/5, 2019, ISSN 2331-8325
Publisher: Bio-protocol LLC
DOI: 10.21769/bioprotoc.3178

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

Author(s): Leona Gabryšová, Marisol Alvarez-Martinez, Raphaëlle Luisier, Luke S. Cox, Jan Sodenkamp, Caroline Hosking, Damián Pérez-Mazliah, Charlotte Whicher, Yashaswini Kannan, Krzysztof Potempa, Xuemei Wu, Leena Bhaw, Hagen Wende, Michael H. Sieweke, Greg Elgar, Mark Wilson, James Briscoe, Vicki Metzis, Jean Langhorne, Nicholas M. Luscombe, Anne O’Garra
Published in: Nature Immunology, Issue 19/5, 2018, Page(s) 497-507, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-018-0083-5

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self‐renewal and identity

Author(s): René Rauschmeier, Charlotte Gustafsson, Annika Reinhardt, Noelia A‐Gonzalez, Luigi Tortola, Dilay Cansever, Sethuraman Subramanian, Reshma Taneja, Moritz J Rossner, Michael H Sieweke, Melanie Greter, Robert Månsson, Meinrad Busslinger, Taras Kreslavsky
Published in: The EMBO Journal, 2019, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018101233

Testicular macrophages: Guardians of fertility

Author(s): Noushin Mossadegh-Keller, Michael H. Sieweke
Published in: Cellular Immunology, Issue 330, 2018, Page(s) 120-125, ISSN 0008-8749
Publisher: Academic Press
DOI: 10.1016/j.cellimm.2018.03.009

Trained macrophages support hygiene hypothesis

Author(s): Bérengère de Laval, Michael H Sieweke
Published in: Nature Immunology, Issue 18/12, 2017, Page(s) 1279-1280, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3874

SIRT1 regulates macrophage self‐renewal

Author(s): Francesco Imperatore, Julien Maurizio, Stephanie Vargas Aguilar, Clara J Busch, Jérémy Favret, Elisabeth Kowenz‐Leutz, Wilfried Cathou, Rebecca Gentek, Pierre Perrin, Achim Leutz, Carole Berruyer, Michael H Sieweke
Published in: The EMBO Journal, Issue 36/16, 2017, Page(s) 2353-2372, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201695737

Isolation and Long-term Cultivation of Mouse Alveolar Macrophages

Author(s): Clara Busch, Jérémy Favret, Laufey Geirsdóttir, Kaaweh Molawi, Michael Sieweke
Published in: BIO-PROTOCOL, Issue 9/14, 2019, ISSN 2331-8325
Publisher: Bio-protocol LLC
DOI: 10.21769/bioprotoc.3302

TLR7 Signaling Drives the Development of Sjögren’s Syndrome

Author(s): Yawen Wang, Annie Roussel-Queval, Lionel Chasson, Noël Hanna Kazazian, Laetitia Marcadet, Andrianos Nezos, Michael H. Sieweke, Clio Mavragani, Lena Alexopoulou
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.676010

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Author(s): Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B. Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R. DiNardo, Jorge Dominguez-Andres, Raphael Duivenvoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L. Jeffrey, Nargis Khan, Leo A. B. Joosten, Eva Kaufmann, Eicke Latz, Giuseppe Matarese, Jos W. M. van der Meer, Musa Mhl
Published in: Nature Immunology, Issue 22/1, 2021, Page(s) 2-6, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-00845-6

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes

Author(s): Anastasiia Gainullina, Denis A Mogilenko, Li-Hao Huang, Helena Todorov, Vipin Narang, Ki-Wook Kim, Lim Sheau Yng, Andrew Kent, Baosen Jia, Kumba Seddu, Karen Krchma, Jun Wu, Karine Crozat, Elena Tomasello, Regine Dress, Peter See, Charlotte Scott, Sophie Gibbings, Geetika Bajpai, Jigar V Desai, Barbara Maier, Sébastien This, Peter Wang, Stephanie Vargas Aguilar, Lucie Poupel, Sébastien Dussaud,
Published in: Cell Reports, Issue 42(2), 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112046

Intellectual Property Rights

Patent (1)

METHODS FOR EXPANDING A POPULATION OF ALVEOLAR MACROPHAGES IN A LONG TERM CULTURE

Application/Publication number: 16 808635
Date: 2016-12-08
Applicant(s): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS