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Comprehensive identification of host factors involved in the early steps of HIV infection.

Objective

35 million people are currently infected with Human immunodeficiency virus (HIV), causative agent of AIDS. While cocktails of anti-retrovirals can reduce viral loading to undetectable levels, drug resistance can emerge due to the high-mutation rate of the virus. Moreover, no cure is yet achieved. Therefore, it is crucial to explore complementary therapeutic strategies, a challenge that H2020 prioritizes in health. The strict dependency of HIV on host RNA-binding proteins (RBPs) represents a potential step for intervention through host-based therapies, which can be more refractory to the evolution of resistance. In some sporadic cases, host RBPs have been shown to be incorporated into virions and impact downstream early steps of infection. However, no global and systematic studies aimed to determine the scope and biological significance of host RBPs selectively packed with the HIV RNA within the virions have been reported so far. The main goal of this action, referred to as hRBP-virion, is to address this important biological question by developing an unprecedented multidisciplinary approach that combines molecular biology and virology methods with next generation proteomics and data analysis. Hence, this pioneer approach will open new avenues of research in the field of viruses that have major health and socioeconomic impact and will enhance world-class basic and applied European innovation. The hRBP-virion project requires an exclusive mix of competences. I will bring research experience in RNA and molecular virology. My supervisor will train me in cutting-edge, system-wide proteomic methods. The host institution will provide state-of-the-art facilities and pooled expertise in a broad range of disciplines. Together these will create an excellent and unique cross-disciplinary atmosphere that will ensure the successful outcome of hRBP-virion and the appropriate transfer of knowledge among the participants.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2015

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Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 195 454,80
Address
WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD Oxford
United Kingdom

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 195 454,80
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