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A multifunctional self-immolative hydrogel for accelerating the healing of chronic wounds

Objective

"In this Marie Skłodowska-Curie Fellowship project entitled “Multi-SIP Hydrogel” I will design a modular synthetic platform for preparing multifunctional self-immolative polymer (SIP) hydrogels designed to accelerate tissue regeneration in chronic skin wounds. The hydrogels will contain multiple SIP components, each designed to rapidly degrade and deliver a therapeutic payload in response to a specific biochemical stimulus typical of a chronic wound (e.g. reactive oxygen species or enzymatic action). During the two years of this Fellowship, I aim to establish a proof-of-principle SIP-hydrogel system that will undergo sequential stimuli-responsive degradation and promote cell proliferation in vitro. This Fellowship will be undertaken under the supervision of Prof. Molly Stevens in the Division of Biomaterials and Regenerative Medicine at the Karolinska Institute (KI), which has the world-leading expertise in polymer chemistry, biomaterials engineering, cell biology and tissue engineering crucial to the objectives of the proposed work plan. Due to the modular design of the ""Multi-SIP Hydrogel"" platform, there is broad scope for designing SIP-hydrogels matched to different tissue types once a proof-of-principle is established. This will initiate new research areas at the cutting edge of biomaterials science, which will help me to establish my own independent research career following the proposed Fellowship."

Fields of science (EuroSciVoc)

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Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF-EF-ST - Standard EF

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2015

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Coordinator

KAROLINSKA INSTITUTET
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 173 857,20
Address
NOBELS VAG 5
171 77 STOCKHOLM
Sweden

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 173 857,20
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