Objective
The aim of the proposed interdisciplinary project is to design, make and test novel nanoparticles that will have direct and rapid impact in osteoporosis. The unique aspect of these injectable nanoparticles is that they will deliver active therapy locally, to where it is needed, and that the cargo is not a conventional drug, but a sustained delivery of a combination of active inorganic cations and rare earth nanoparticles. Certain cations can promote bone growth and inhibit resorption and nanoceria can scavenge free radicals that would otherwise accelerate osteoporosis. Systemic concentrations of active agents will be much smaller that caused by taking oral drugs. Delivery will be sustained because it is controlled by the dissolution rate of biodegradable mesoporous silica nanoparticles, which will improve over biodegradable polymer capsules that often deliver a burst release of their drug cargo. Beyond the project, long-term impact could include slowing metastasis of tumours into bone (e.g. breast cancer to the sternum). The biodegradable mesoporous silica nanoparticles will be synthesised by sol-gel, while the nanoceria will be synthesized by co-precipitation method and microwave treatment and entrapped within the silica network. Key aspects will be: incorporation of active ions and nanoceria within monodispersed silica nanoparticles of controlled size; ensuring the particles remain dispersed in body fluid (control of surface chemistry); testing efficacy in cell co-culture (uptake and cell stimulation) and investigating the effect of the presence of the particles on immune cells. The effect of process variables on composition, particle size, bioactivity, degradation rate, radical scavenger ability and the cellular response will be investigated.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences nursing
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology breast cancer
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
SW7 2AZ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.