The evolutionary ecology of bacterial immune mechanisms

Project Information

EVOIMMECH

Grant agreement ID: 714478

DOI

10.3030/714478

Project closed

EC signature date 28 October 2016

Start date 1 January 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 337,00

EU contribution

€ 1 498 337,00

Coordinated by

THE UNIVERSITY OF EXETER
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (20)

Phage gene expression and host responses lead to infection-dependent costs of CRISPR immunity

Author(s): Sean Meaden, Loris Capria, Ellinor Alseth, Sylvain Gandon, Ambarish Biswas, Luca Lenzi, Stineke van Houte, Edze R. Westra
Published in: The ISME Journal, Issue 15/2, 2021, Page(s) 534-544, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-020-00794-w

Coevolution between bacterial CRISPR-Cas systems and their bacteriophages

Author(s): Bridget N.J. Watson, Jurre A. Steens, Raymond H.J. Staals, Edze R. Westra, Stineke van Houte
Published in: Cell Host & Microbe, Issue 29/5, 2021, Page(s) 715-725, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2021.03.018

Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity

Author(s): Mariann Landsberger, Sylvain Gandon, Sean Meaden, Clare Rollie, Anne Chevallereau, Hélène Chabas, Angus Buckling, Edze R. Westra, Stineke van Houte
Published in: Cell, Issue 174/4, 2018, Page(s) 908-916.e12, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.05.058

The effect of bacterial mutation rate on the evolution of CRISPR-Cas adaptive immunity

Author(s): Anne Chevallereau, Sean Meaden, Stineke van Houte, Edze R. Westra, Clare Rollie
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1772, 2019, Page(s) 20180094, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0094

Variability in the durability of CRISPR-Cas immunity

Author(s): Hélène Chabas, Antoine Nicot, Sean Meaden, Edze R. Westra, Denise M. Tremblay, Léa Pradier, Sébastien Lion, Sylvain Moineau, Sylvain Gandon
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1772, 2019, Page(s) 20180097, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0097

Evolutionary emergence of infectious diseases in heterogeneous host populations

Author(s): Hélène Chabas, Sébastien Lion, Antoine Nicot, Sean Meaden, Stineke van Houte, Sylvain Moineau, Lindi M. Wahl, Edze R. Westra, Sylvain Gandon
Published in: PLOS Biology, Issue 16/9, 2018, Page(s) e2006738, ISSN 1545-7885
Publisher: PLoS
DOI: 10.1371/journal.pbio.2006738

CRISPR-Cas immunity leads to a coevolutionary arms race between Streptococcus thermophilus and lytic phage

Author(s): Jack Common, Daniel Morley, Edze R. Westra, Stineke van Houte
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1772, 2019, Page(s) 20180098, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0098

CRISPR-Cas antimicrobials: Challenges and future prospects

Author(s): Elizabeth Pursey, David Sünderhauf, William H. Gaze, Edze R. Westra, Stineke van Houte
Published in: PLOS Pathogens, Issue 14/6, 2018, Page(s) e1006990, ISSN 1553-7374
Publisher: PLoS
DOI: 10.1371/journal.ppat.1006990

CRISPR evolution and bacteriophage persistence in the context of population bottlenecks

Author(s): Jack Common, Edze R. Westra
Published in: RNA Biology, Issue 16/4, 2018, Page(s) 588-594, ISSN 1547-6286
Publisher: Landes Bioscience
DOI: 10.1080/15476286.2019.1578608

Recombination between phages and CRISPR−cas loci facilitates horizontal gene transfer in staphylococci

Author(s): Andrew Varble, Sean Meaden, Rodolphe Barrangou, Edze R. Westra, Luciano A. Marraffini
Published in: Nature Microbiology, Issue 4/6, 2019, Page(s) 956-963, ISSN 2058-5276
Publisher: Nature press
DOI: 10.1038/s41564-019-0400-2

Addiction systems antagonize bacterial adaptive immunity

Author(s): Lisa van Sluijs, Stineke van Houte, John van der Oost, Stan JJ Brouns, Angus Buckling, Edze R Westra
Published in: FEMS Microbiology Letters, Issue 366/5, 2019, ISSN 1574-6968
Publisher: Oxford academic
DOI: 10.1093/femsle/fnz047

Exploitation of the Cooperative Behaviors of Anti-CRISPR Phages

Author(s): Anne Chevallereau, Sean Meaden, Olivier Fradet, Mariann Landsberger, Alice Maestri, Ambarish Biswas, Sylvain Gandon, Stineke van Houte, Edze R. Westra
Published in: Cell Host & Microbe, 2019, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2019.12.004

The effect of phage genetic diversity on bacterial resistance evolution

Author(s): Jenny M. Broniewski, Sean Meaden, Steve Paterson, Angus Buckling, Edze R. Westra
Published in: The ISME Journal, 2020, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-019-0577-7

Targeting of temperate phages drives loss of type I CRISPR–Cas systems

Author(s): Clare Rollie, Anne Chevallereau, Bridget N. J. Watson, Te-yuan Chyou, Olivier Fradet, Isobel McLeod, Peter C. Fineran, Chris M. Brown, Sylvain Gandon, Edze R. Westra
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-1936-2

Bacterial biodiversity drives the evolution of CRISPR-based phage resistance

Author(s): Ellinor O. Alseth, Elizabeth Pursey, Adela M. Luján, Isobel McLeod, Clare Rollie, Edze R. Westra
Published in: Nature, Issue 574/7779, 2019, Page(s) 549-552, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1662-9

It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements

Author(s): Edze R. Westra, Bruce R. Levin
Published in: Proceedings of the National Academy of Sciences, Issue 117/45, 2020, Page(s) 27777-27785, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1915966117

Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems

Author(s): Tatiana Dimitriu, Mark D. Szczelkun, Edze R. Westra
Published in: Current Biology, Issue 30/19, 2020, Page(s) R1189-R1202, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.08.028

Avoidance of Self during CRISPR Immunization

Author(s): Jake L. Weissman, Arlin Stoltzfus, Edze R. Westra, Philip L.F. Johnson
Published in: Trends in Microbiology, Issue 28/7, 2020, Page(s) 543-553, ISSN 0966-842X
Publisher: Elsevier BV
DOI: 10.1016/j.tim.2020.02.005

The effect of Quorum sensing inhibitors on the evolution of CRISPR-based phage immunity in Pseudomonas aeruginosa

Author(s): Jenny M. Broniewski, Matthew A. W. Chisnall, Nina Molin Høyland-Kroghsbo, Angus Buckling, Edze R. Westra
Published in: The ISME Journal, 2021, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-021-00946-6

Diversity in CRISPR‐based immunity protects susceptible genotypes by restricting phage spread and evolution

Author(s): Jack Common, David Walker‐Sünderhauf, Stineke Houte, Edze R. Westra
Published in: Journal of Evolutionary Biology, Issue 33/8, 2020, Page(s) 1097-1108, ISSN 1010-061X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jeb.13638

Non-peer reviewed articles (1)

The ecology and evolution of microbial CRISPR-Cas adaptive immune systems

Author(s): Edze R. Westra, Stineke van Houte, Sylvain Gandon, Rachel Whitaker
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1772, 2019, Page(s) 20190101, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2019.0101