From fast food to healthy diet: Addressing the dynamic molecular mechanism of sequential diet switch-induced T cell plasticity for the purpose of developing new treatments for immuno-mediated diseases

Project Information

Diet-namic

Grant agreement ID: 715271

DOI

10.3030/715271

Project closed

EC signature date 16 November 2016

Start date 1 December 2016

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 695,00

EU contribution

€ 1 499 695,00

Coordinated by

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

A Gas Chromatography Mass Spectrometry-Based Method for the Quantification of Short Chain Fatty Acids

Author(s): Rohde JK, Fuh MM, Evangelakos I, Pauly MJ, Schaltenberg N, Siracusa F, Gagliani N, Tödter K, Heeren J, Worthmann A.
Published in: Metabolites, 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12020170

Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH

Author(s): Woestemeier A, Scognamiglio P, Zhao Y, Wagner J, Muscate F, Casar C, Siracusa F, Cortesi F, Agalioti T, Müller S, Sagebiel A, Konczalla L, Wahib R, Karstens KF, Giannou AD, Duprée A, Wolter S, Wong MN, Mühlig AK, Bielecka AA, Bansal V, Zhang T, Mann O, Puelles VG, Huber TB, Lohse AW, Izbicki JR, Palm NW, Bonn S, Huber S, Gagliani N.
Published in: JCI Insight, 2023, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.153831

Single-cell atlas of hepatic T cells reveals expansion of liver-resident naïve-like CD4+ T cells in primary sclerosing cholangitis

Author(s): Poch T, Krause J, Casar C, Liwinski T, Glau L, Kaufmann M, Ahrenstorf AE, Hess LU, Ziegler AE, Martrus G, Lunemann S, Sebode M, Li J, Schwinge D, Krebs CF, Franke A, Friese MA, Oldhafer KJ, Fischer L, Altfeld M, Lohse AW, Huber S, Tolosa E, Gagliani N*, Schramm C
Published in: Journal of Hepatology, 2021, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.03.016

Efferocytosis fuels malignant pleural effusion through TIMP1

Author(s): Lilan Zhao; Lilan Zhao; Anastasios D. Giannou; Yang Xu; Ahmad Mustafa Shiri; Imke Liebold; Imke Liebold; Babett Steglich; Babett Steglich; Tanja Bedke; Tao Zhang; Jöran Lücke; Pasquale Scognamiglio; Jan Kempski; Anna Woestemeier; Jing Chen; Theodora Agalioti; Dimitra E. Zazara; Diana Lindner; Diana Lindner; Melanie Janning; Melanie Janning; Melanie Janning; Jan K. Hennigs; Rajesh Jagirdar; Ouran
Published in: Science Advances, Issue 1, 2021, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abd6734

The induction and function of the anti-inflammatory fate of TH17 cells

Author(s): Xu H, Agalioti T, Zhao J, Steglich B, Wahib R, Vesely MCA, Bielecki P, Bailis W, Jackson R, Perez D, Izbicki J, Licona-Limón P, Kaartinen V, Geginat J, Esplugues E, Tolosa E, Huber S, Flavell RA*, Gagliani N*
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17097-5

Title: IL-10-producing T cells and their dual functions.

Author(s): Tanja Bedke; Franziska Muscate; Shiwa Soukou; Nicola Gagliani; Nicola Gagliani; Samuel Huber
Published in: Seminars in Immunology, 2019, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2019.101335

Recipe for IBD: can we use food to control inflammatory bowel disease?

Author(s): Mario Witkowski, Marco Witkowski, Nicola Gagliani, Samuel Huber
Published in: Seminars in Immunopathology, Issue 40/2, 2018, Page(s) 145-156, ISSN 1863-2297
Publisher: Springer Verlag
DOI: 10.1007/s00281-017-0658-5

TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis

Author(s): Jan Kempski, Leonie Brockmann, Nicola Gagliani, Samuel Huber
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.01373

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

Author(s): Leonie Brockmann, Shiwa Soukou, Babett Steglich, Paulo Czarnewski, Lilan Zhao, Sandra Wende, Tanja Bedke, Can Ergen, Carolin Manthey, Theodora Agalioti, Maria Geffken, Oliver Seiz, Sara M. Parigi, Chiara Sorini, Jens Geginat, Keishi Fujio, Thomas Jacobs, Thomas Roesch, Jacob R. Izbicki, Ansgar W. Lohse, Richard A. Flavell, Christian Krebs, Jan-Ake Gustafsson, Per Antonson, Maria Grazia Roncarolo,
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-07581-4

T H 17 cell plasticity: The role of dendritic cells and molecular mechanisms

Author(s): Theodora Agalioti, Eduardo J. Villablanca, Samuel Huber, Nicola Gagliani
Published in: Journal of Autoimmunity, Issue 87, 2018, Page(s) 50-60, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2017.12.003

Dietary Habits and Intestinal Immunity: From Food Intake to CD4+ TH Cells

Author(s): Francesco Siracusa, Nicola Schaltenberg, Eduardo J. Villablanca, Samuel Huber, Nicola Gagliani
Published in: Frontiers in Immunology, Issue 9, 2019, ISSN 1664-3224
Publisher: Holtzbrink publishing group
DOI: 10.3389/fimmu.2018.03177

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Author(s): Tintelnot J, Xu Y, Lesker TR, Schönlein M, Konczalla L, Giannou AD, Pelczar P, Kylies D, Puelles VG, Bielecka AA, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring TS, Trajkovic-Arsic M, Siveke JT, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu FG, Güngör C, Stein A, Izbicki JR, Bokemeyer C, Sinn M, Kimmelman AC, Huber S, Gagliani N
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.3389/fimmu.2022.844401

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Author(s): Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, S
Published in: Immunity, 2023, ISSN 1097-4180
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

Author(s): Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gaglian
Published in: Science Immunology, 2021, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1126/sciimmunol.abf6692