Investigating Host-Microbial Interactions after Bariatric Surgery

Informations projet

EnteroBariatric

N° de convention de subvention: 715662

DOI

10.3030/715662

Projet clôturé

Date de signature de la CE 3 Novembre 2016

Date de début 1 Août 2017

Date de fin 31 Janvier 2025

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 1 499 091,00

Contribution de l’UE

€ 1 499 091,00

Coordonné par

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

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Publications

Peer reviewed articles (30)

Lipid profiling of mouse intestinal organoids for studying <i>APC</i> mutations

Auteurs: Zoë Jukes, Anne Freier, Maria Glymenaki, Richard Brown, Lee Parry, Elizabeth Want, Panagiotis A. Vorkas, Jia V. Li
Publié dans: Bioscience Reports, Numéro 41, 2021, ISSN 0144-8463
Éditeur: Kluwer Academic Publishers
DOI: 10.1042/bsr20202915

Chronic treatment with glucagon-like peptide-1 and glucagon receptor co-agonist causes weight loss-independent improvements in hepatic steatosis in mice with diet-induced obesity

Auteurs: Emma Rose McGlone, David C.D. Hope, Iona Davies, Marian Dore, Rob Goldin, Ben Jones, Zhigang Liu, Jia V. Li, Panagiotis A. Vorkas, Bernard Khoo, David Carling, James Minnion, Stephen R. Bloom, Tricia M-M. Tan
Publié dans: Biomedicine &amp; Pharmacotherapy, Numéro 176, 2024, Page(s) 116888, ISSN 0753-3322
Éditeur: Elsevier Masson
DOI: 10.1016/j.biopha.2024.116888

Tumour Necrosis Factor-Alpha (TNF-α)-Induced Metastatic Phenotype in Colorectal Cancer Epithelial Cells: Mechanistic Support for the Role of MicroRNA-21

Auteurs: Aminah G. Alotaibi, Jia V. Li, Nigel J. Gooderham
Publié dans: Cancers, Numéro 15, 2025, Page(s) 627, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15030627

Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation

Auteurs: Maria Glymenaki, Sophie Curio, Smeeta Shrestha, Qi Zhong, Laura Rushton, Rachael Barry, Mona El-Bahrawy, Julian R. Marchesi, Yulan Wang, Nigel J. Gooderham, Nadia Guerra, Jia V. Li
Publié dans: Microbiome, Numéro 13, 2025, ISSN 2049-2618
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s40168-025-02049-2

Rectal swabs as a viable alternative to faecal sampling for the analysis of gut microbiota functionality and composition

Auteurs: Shiva T. Radhakrishnan, Kate I. Gallagher, Benjamin H. Mullish, Jose I. Serrano-Contreras, James L. Alexander, Jesus Miguens Blanco, Nathan P. Danckert, Maria Valdivia-Garcia, Billy J. Hopkins, Anik Ghai, Azad Ayub, Jia V. Li, Julian R. Marchesi, Horace R. T. Williams
Publié dans: Scientific Reports, Numéro 13, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-27131-9

Improved Quantitation of Short-Chain Carboxylic Acids in Human Biofluids Using 3-Nitrophenylhydrazine Derivatization and Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS)

Auteurs: Maria Valdivia-Garcia, Katie Chappell, Stephane Camuzeaux, Lucía Olmo-García, Verena Horneffer-van der Sluis, Shiva T. Radhakrishnan, Hannah Stephens, Sonia Bouri, Lucia M. de Campos Braz, Horace R.T. Williams, Mathew R. Lewis, Gary Frost, Jia V. Li
Publié dans: SSRN Electronic Journal, 2023, ISSN 1556-5068
Éditeur: Elsevier BV
DOI: 10.2139/ssrn.4163686

Differential effects of L‐ and D‐phenylalanine on pancreatic and gastrointestinal hormone release in humans: A randomized crossover study

Auteurs: Anjali Amin, James Frampton, Zhigang Liu, Georgia Franco‐Becker, Mariana Norton, Aos Alaa, Jia V. Li, Kevin G. Murphy
Publié dans: Diabetes, Obesity and Metabolism, Numéro 23, 2024, Page(s) 147-157, ISSN 1462-8902
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/dom.14204

Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss

Auteurs: Florian Seyfried, Jutarop Phetcharaburanin, Maria Glymenaki, Arno Nordbeck, Mohammed Hankir, Jeremy K Nicholson, Elaine Holmes, Julian R. Marchesi, Jia V. Li
Publié dans: Gut Microbes, Numéro 13, 2025, ISSN 1949-0976
Éditeur: Landes Bioscience
DOI: 10.1080/19490976.2021.1875108

Multiomic features associated with mucosal healing and inflammation in paediatric Crohn’s disease

Auteurs: Henry Taylor, Jose Ivan Serrano‐Contreras, Julie A. K. McDonald, Jenny Epstein, JM Fell, Rocio C. Seoane, Jia V. Li, Julian R. Marchesi, Ailsa L. Hart
Publié dans: Alimentary Pharmacology &amp; Therapeutics, Numéro 52, 2023, Page(s) 1491-1502, ISSN 0269-2813
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/apt.16086

Indole-3-Aldehyde Reduces Inflammatory Responses and Restores Intestinal Epithelial Barrier Function Partially via Aryl Hydrocarbon Receptor (AhR) in Experimental Colitis Models

Auteurs: Mu Wang, Jian Guo, Ailsa L Hart, Jia V Li
Publié dans: Journal of Inflammation Research, Numéro Volume 16, 2023, Page(s) 5845-5864, ISSN 1178-7031
Éditeur: Dove Medical Press Ltd
DOI: 10.2147/jir.s432747

The Metabolomic Effects of Tripeptide Gut Hormone Infusion Compared to Roux-en-Y Gastric Bypass and Caloric Restriction

Auteurs: Ben Jones, Caroline Sands, Kleopatra Alexiadou, James Minnion, George Tharakan, Preeshila Behary, Ahmed R Ahmed, Sanjay Purkayastha, Matthew R Lewis, Stephen Bloom, Jia V Li, Tricia M Tan
Publié dans: The Journal of Clinical Endocrinology &amp; Metabolism, Numéro 107, 2024, Page(s) e767-e782, ISSN 0021-972X
Éditeur: The Endocrine Society
DOI: 10.1210/clinem/dgab608

Derivatization to reduce background interferences for simultaneous quantitation of trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) using liquid chromatography with tandem mass spectrometry

Auteurs: Maria A. Valdivia-Garcia, Yang Bi, Kaoutar Abaakil, Jia V Li
Publié dans: Journal of Pharmaceutical and Biomedical Analysis, Numéro 252, 2024, Page(s) 116480, ISSN 0731-7085
Éditeur: Elsevier BV
DOI: 10.1016/j.jpba.2024.116480

Stability in fecal metabolites amid a diverse gut microbiome composition: a one-month longitudinal study of variability in healthy individuals

Auteurs: Matteo Sangermani, Indri Desiati, Solveig M. Jørgensen, Jia V. Li, Trygve Andreassen, Tone F. Bathen, Guro F. Giskeødegård
Publié dans: Gut Microbes, Numéro 16, 2024, ISSN 1949-0976
Éditeur: Landes Bioscience
DOI: 10.1080/19490976.2024.2427878

The double burden of malnutrition in individuals: Identifying key challenges and re‐thinking research focus

Auteurs: Agklinta Kiosia, Aygul Dagbasi, James A. Berkley, John P. H. Wilding, Andrew J. Prendergast, Jia V. Li, Jon Swann, John C. Mathers, Marko Kerac, Douglas Morrison, Lesley Drake, Andre Briend, Kathryn Maitland, Gary Frost
Publié dans: Nutrition Bulletin, Numéro 49, 2024, Page(s) 132-145, ISSN 1471-9827
Éditeur: Wiley
DOI: 10.1111/nbu.12670

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism

Auteurs: Zhigang Liu, Bing Xia, Jasmina Saric, Jürg Utzinger, Elaine Holmes, Jennifer Keiser, Jia V. Li
Publié dans: Journal of Proteome Research, Numéro 17/10, 2018, Page(s) 3565-3573, ISSN 1535-3893
Éditeur: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00583

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota

Auteurs: Julie A.K. McDonald, Benjamin H. Mullish, Alexandros Pechlivanis, Zhigang Liu, Jerusa Brignardello, Dina Kao, Elaine Holmes, Jia V. Li, Thomas B. Clarke, Mark R. Thursz, Julian R. Marchesi
Publié dans: Gastroenterology, Numéro 155/5, 2018, Page(s) 1495-1507.e15, ISSN 0016-5085
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.07.014

Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans

Auteurs: L. Katsidzira, S. Ocvirk, A. Wilson, J. Li, C. B. Mahachi, D. Soni, J. DeLany, J. K. Nicholson, E. G. Zoetendal, S. J. D. O’Keefe
Publié dans: Nutrition and Cancer, Numéro 71/8, 2019, Page(s) 1313-1324, ISSN 0163-5581
Éditeur: Lawrence Erlbaum Associates Inc.
DOI: 10.1080/01635581.2019.1602659

Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery

Auteurs: Kiana Ashley West, Chidimma Kanu, Tanya Maric, Julie Anne Kathryn McDonald, Jeremy K Nicholson, Jia V Li, Mark R Johnson, Elaine Holmes, Makrina D Savvidou
Publié dans: Gut, 2020, Page(s) gutjnl-2019-319620, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319620

Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients

Auteurs: Yong Guo, Yingchuan Li, Yinan Zhang, Shudong Fang, Xiaotao Xu, Aihua Zhao, Junfeng Zhang, Jia V Li, Daqing Ma, Wei Jia, Wei Jiang
Publié dans: Age and Ageing, Numéro 49/1, 2019, Page(s) 88-95, ISSN 0002-0729
Éditeur: Oxford University Press
DOI: 10.1093/ageing/afz132

A biochemical comparison of the lung, colonic, brain, renal, and ovarian cancer cell lines using 1H-NMR spectroscopy

Auteurs: Cong Hu, Zhigang Liu, Hailin Zhao, Lingzhi Wu, Qingquan Lian, Daqing Ma, Jia V. Li
Publié dans: Bioscience Reports, Numéro 40/4, 2020, ISSN 0144-8463
Éditeur: Kluwer Academic Publishers
DOI: 10.1042/bsr20194027

Microbiota- and Radiotherapy-Induced Gastrointestinal Side-Effects (MARS) Study: A Large Pilot Study of the Microbiome in Acute and Late-Radiation Enteropathy

Auteurs: Miguel Reis Ferreira, H. Jervoise N. Andreyev, Kabir Mohammed, Lesley Truelove, Sharon M. Gowan, Jia Li, Sarah L. Gulliford, Julian R. Marchesi, David P. Dearnaley
Publié dans: Clinical Cancer Research, Numéro 25/21, 2019, Page(s) 6487-6500, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-19-0960

In vitro metabolomic footprint of the Echinococcus multilocularis metacestode

Auteurs: Dominic Ritler, Reto Rufener, Jia V. Li, Urs Kämpfer, Joachim Müller, Claudia Bühr, Stefan Schürch, Britta Lundström-Stadelmann
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-56073-y

Evaluation of Direct from Sample Metabolomics of Human Feces Using Rapid Evaporative Ionization Mass Spectrometry

Auteurs: Simon J. S. Cameron, James L. Alexander, Frances Bolt, Adam Burke, Hutan Ashrafian, Julian Teare, Julian R. Marchesi, James Kinross, Jia V. Li, Zoltán Takáts
Publié dans: Analytical Chemistry, Numéro 91/21, 2019, Page(s) 13448-13457, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.9b02358

A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer

Auteurs: Soeren Ocvirk, Annette S Wilson, Joram M Posma, Jia V Li, Kathryn R Koller, Gretchen M Day, Christie A Flanagan, Jill Evon Otto, Pam E Sacco, Frank D Sacco, Flora R Sapp, Amy S Wilson, Keith Newton, Faye Brouard, James P DeLany, Marissa Behnning, Corynn N Appolonia, Devavrata Soni, Faheem Bhatti, Barbara Methé, Adam Fitch, Alison Morris, H Rex Gaskins, James Kinross, Jeremy K Nicholson, Timothy K
Publié dans: The American Journal of Clinical Nutrition, Numéro 111/2, 2019, Page(s) 406-419, ISSN 0002-9165
Éditeur: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqz301

Monosodium Glutamate (MSG) Renders Alkalinizing Properties and Its Urinary Metabolic Markers of MSG Consumption in Rats

Auteurs: Nahok, Li, Phetcharaburanin, Abdul, Wongkham, Thanan, Silsirivanit, Anutrakulchai, Selmi, Cha’on
Publié dans: Biomolecules, Numéro 9/10, 2019, Page(s) 542, ISSN 2218-273X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom9100542

Bile salt metabolism is not the only factor contributing to Clostridioides ( Clostridium ) difficile disease severity in the murine model of disease

Auteurs: Caitlin A. Jukes, Umer Zeeshan Ijaz, Anthony Buckley, Janice Spencer, June Irvine, Denise Candlish, Jia V. Li, Julian R. Marchesi, Gillian Douce
Publié dans: Gut Microbes, Numéro 11/3, 2020, Page(s) 481-496, ISSN 1949-0976
Éditeur: Landes Bioscience
DOI: 10.1080/19490976.2019.1678996

Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms

Auteurs: Cong Hu, Bincheng Wang, Zhigang Liu, Qiling Chen, Masashi Ishikawa, Han Lin, Qingquan Lian, Jun Li, Jia V. Li, Daqing Ma, null null
Publié dans: Cell Biology and Toxicology, Numéro 39, 2023, Page(s) 1395-1411, ISSN 0742-2091
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10565-022-09766-6

Improved Spatial Resolution of Metabolites in Tissue Biopsies Using High-Resolution Magic-Angle-Spinning Slice Localization NMR Spectroscopy

Auteurs: Elisabeth V. Vonhof, Martial Piotto, Elaine Holmes, John C. Lindon, Jeremy K. Nicholson, Jia V. Li
Publié dans: Analytical Chemistry, Numéro 92, 2023, Page(s) 11516-11519, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.0c02377

Tumour necrosis factor-α (TNF-α) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway

Auteurs: Aminah G. Alotaibi, Jia V. Li, Nigel J. Gooderham
Publié dans: Toxicology, Numéro 457, 2022, Page(s) 152806, ISSN 0300-483X
Éditeur: Elsevier BV
DOI: 10.1016/j.tox.2021.152806

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype

Auteurs: Jia V. Li, Hutan Ashrafian, Magali Sarafian, Daniel Homola, Laura Rushton, Grace Barker, Paula Momo Cabrera, Matthew R. Lewis, Ara Darzi, Edward Lin, Nana Adwoa Gletsu-Miller, Stephen L. Atkin, Thozhukat Sathyapalan, Nigel J. Gooderham, Jeremy K. Nicholson, Julian R. Marchesi, Thanos Athanasiou, Elaine Holmes
Publié dans: Microbiome, Numéro 9, 2021, ISSN 2049-2618
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s40168-021-01086-x

Book chapters (1)

Metabolic Profiling in IBD

Auteurs: Maria Glymenaki, Jia V. Li, Julian R. Marchesi
Publié dans: Biomarkers in Inflammatory Bowel Diseases, 2019, Page(s) 303-312, ISBN 978-3-030-11445-9
Éditeur: Springer International Publishing
DOI: 10.1007/978-3-030-11446-6_25

Non-peer reviewed articles (1)

Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer

Auteurs: M. C. Ramaboli, S. Ocvirk, M. Khan Mirzaei, B. L. Eberhart, M. Valdivia-Garcia, A. Metwaly, K. Neuhaus, G. Barker, J. Ru, L. T. Nesengani, D. Mahdi-Joest, A. S. Wilson, S. K. Joni, D. C. Layman, J. Zheng, R. Mandal, Q. Chen, M. R. Perez, S. Fortuin, B. Gaunt, D. Wishart, B. Methé, D. Haller, J. V. Li, L. Deng, R. Swart, S. J. D. O’Keefe
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-46265-0

Thesis and dissertations (1)

Investigating the metabolic function of the gut microbiota in colorectal carcinogenesis via choline metabolism

Auteurs: Yang Bi
Publié dans: 2024
Éditeur: Imperial College London