Investigating Host-Microbial Interactions after Bariatric Surgery

Informazioni relative al progetto

EnteroBariatric

ID dell’accordo di sovvenzione: 715662

DOI

10.3030/715662

Progetto chiuso

Data della firma CE 3 Novembre 2016

Data di avvio 1 Agosto 2017

Data di completamento 31 Gennaio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 091,00

Contributo UE

€ 1 499 091,00

Coordinato da

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (30)

Lipid profiling of mouse intestinal organoids for studying <i>APC</i> mutations

Autori: Zoë Jukes, Anne Freier, Maria Glymenaki, Richard Brown, Lee Parry, Elizabeth Want, Panagiotis A. Vorkas, Jia V. Li
Pubblicato in: Bioscience Reports, Numero 41, 2021, ISSN 0144-8463
Editore: Kluwer Academic Publishers
DOI: 10.1042/bsr20202915

Chronic treatment with glucagon-like peptide-1 and glucagon receptor co-agonist causes weight loss-independent improvements in hepatic steatosis in mice with diet-induced obesity

Autori: Emma Rose McGlone, David C.D. Hope, Iona Davies, Marian Dore, Rob Goldin, Ben Jones, Zhigang Liu, Jia V. Li, Panagiotis A. Vorkas, Bernard Khoo, David Carling, James Minnion, Stephen R. Bloom, Tricia M-M. Tan
Pubblicato in: Biomedicine &amp; Pharmacotherapy, Numero 176, 2024, Pagina/e 116888, ISSN 0753-3322
Editore: Elsevier Masson
DOI: 10.1016/j.biopha.2024.116888

Tumour Necrosis Factor-Alpha (TNF-α)-Induced Metastatic Phenotype in Colorectal Cancer Epithelial Cells: Mechanistic Support for the Role of MicroRNA-21

Autori: Aminah G. Alotaibi, Jia V. Li, Nigel J. Gooderham
Pubblicato in: Cancers, Numero 15, 2025, Pagina/e 627, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15030627

Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation

Autori: Maria Glymenaki, Sophie Curio, Smeeta Shrestha, Qi Zhong, Laura Rushton, Rachael Barry, Mona El-Bahrawy, Julian R. Marchesi, Yulan Wang, Nigel J. Gooderham, Nadia Guerra, Jia V. Li
Pubblicato in: Microbiome, Numero 13, 2025, ISSN 2049-2618
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s40168-025-02049-2

Rectal swabs as a viable alternative to faecal sampling for the analysis of gut microbiota functionality and composition

Autori: Shiva T. Radhakrishnan, Kate I. Gallagher, Benjamin H. Mullish, Jose I. Serrano-Contreras, James L. Alexander, Jesus Miguens Blanco, Nathan P. Danckert, Maria Valdivia-Garcia, Billy J. Hopkins, Anik Ghai, Azad Ayub, Jia V. Li, Julian R. Marchesi, Horace R. T. Williams
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-27131-9

Improved Quantitation of Short-Chain Carboxylic Acids in Human Biofluids Using 3-Nitrophenylhydrazine Derivatization and Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS)

Autori: Maria Valdivia-Garcia, Katie Chappell, Stephane Camuzeaux, Lucía Olmo-García, Verena Horneffer-van der Sluis, Shiva T. Radhakrishnan, Hannah Stephens, Sonia Bouri, Lucia M. de Campos Braz, Horace R.T. Williams, Mathew R. Lewis, Gary Frost, Jia V. Li
Pubblicato in: SSRN Electronic Journal, 2023, ISSN 1556-5068
Editore: Elsevier BV
DOI: 10.2139/ssrn.4163686

Differential effects of L‐ and D‐phenylalanine on pancreatic and gastrointestinal hormone release in humans: A randomized crossover study

Autori: Anjali Amin, James Frampton, Zhigang Liu, Georgia Franco‐Becker, Mariana Norton, Aos Alaa, Jia V. Li, Kevin G. Murphy
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 23, 2024, Pagina/e 147-157, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.14204

Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss

Autori: Florian Seyfried, Jutarop Phetcharaburanin, Maria Glymenaki, Arno Nordbeck, Mohammed Hankir, Jeremy K Nicholson, Elaine Holmes, Julian R. Marchesi, Jia V. Li
Pubblicato in: Gut Microbes, Numero 13, 2025, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2021.1875108

Multiomic features associated with mucosal healing and inflammation in paediatric Crohn’s disease

Autori: Henry Taylor, Jose Ivan Serrano‐Contreras, Julie A. K. McDonald, Jenny Epstein, JM Fell, Rocio C. Seoane, Jia V. Li, Julian R. Marchesi, Ailsa L. Hart
Pubblicato in: Alimentary Pharmacology &amp; Therapeutics, Numero 52, 2023, Pagina/e 1491-1502, ISSN 0269-2813
Editore: Blackwell Publishing Inc.
DOI: 10.1111/apt.16086

Indole-3-Aldehyde Reduces Inflammatory Responses and Restores Intestinal Epithelial Barrier Function Partially via Aryl Hydrocarbon Receptor (AhR) in Experimental Colitis Models

Autori: Mu Wang, Jian Guo, Ailsa L Hart, Jia V Li
Pubblicato in: Journal of Inflammation Research, Numero Volume 16, 2023, Pagina/e 5845-5864, ISSN 1178-7031
Editore: Dove Medical Press Ltd
DOI: 10.2147/jir.s432747

The Metabolomic Effects of Tripeptide Gut Hormone Infusion Compared to Roux-en-Y Gastric Bypass and Caloric Restriction

Autori: Ben Jones, Caroline Sands, Kleopatra Alexiadou, James Minnion, George Tharakan, Preeshila Behary, Ahmed R Ahmed, Sanjay Purkayastha, Matthew R Lewis, Stephen Bloom, Jia V Li, Tricia M Tan
Pubblicato in: The Journal of Clinical Endocrinology &amp; Metabolism, Numero 107, 2024, Pagina/e e767-e782, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/clinem/dgab608

Derivatization to reduce background interferences for simultaneous quantitation of trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) using liquid chromatography with tandem mass spectrometry

Autori: Maria A. Valdivia-Garcia, Yang Bi, Kaoutar Abaakil, Jia V Li
Pubblicato in: Journal of Pharmaceutical and Biomedical Analysis, Numero 252, 2024, Pagina/e 116480, ISSN 0731-7085
Editore: Elsevier BV
DOI: 10.1016/j.jpba.2024.116480

Stability in fecal metabolites amid a diverse gut microbiome composition: a one-month longitudinal study of variability in healthy individuals

Autori: Matteo Sangermani, Indri Desiati, Solveig M. Jørgensen, Jia V. Li, Trygve Andreassen, Tone F. Bathen, Guro F. Giskeødegård
Pubblicato in: Gut Microbes, Numero 16, 2024, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2024.2427878

The double burden of malnutrition in individuals: Identifying key challenges and re‐thinking research focus

Autori: Agklinta Kiosia, Aygul Dagbasi, James A. Berkley, John P. H. Wilding, Andrew J. Prendergast, Jia V. Li, Jon Swann, John C. Mathers, Marko Kerac, Douglas Morrison, Lesley Drake, Andre Briend, Kathryn Maitland, Gary Frost
Pubblicato in: Nutrition Bulletin, Numero 49, 2024, Pagina/e 132-145, ISSN 1471-9827
Editore: Wiley
DOI: 10.1111/nbu.12670

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism

Autori: Zhigang Liu, Bing Xia, Jasmina Saric, Jürg Utzinger, Elaine Holmes, Jennifer Keiser, Jia V. Li
Pubblicato in: Journal of Proteome Research, Numero 17/10, 2018, Pagina/e 3565-3573, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00583

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota

Autori: Julie A.K. McDonald, Benjamin H. Mullish, Alexandros Pechlivanis, Zhigang Liu, Jerusa Brignardello, Dina Kao, Elaine Holmes, Jia V. Li, Thomas B. Clarke, Mark R. Thursz, Julian R. Marchesi
Pubblicato in: Gastroenterology, Numero 155/5, 2018, Pagina/e 1495-1507.e15, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.07.014

Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans

Autori: L. Katsidzira, S. Ocvirk, A. Wilson, J. Li, C. B. Mahachi, D. Soni, J. DeLany, J. K. Nicholson, E. G. Zoetendal, S. J. D. O’Keefe
Pubblicato in: Nutrition and Cancer, Numero 71/8, 2019, Pagina/e 1313-1324, ISSN 0163-5581
Editore: Lawrence Erlbaum Associates Inc.
DOI: 10.1080/01635581.2019.1602659

Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery

Autori: Kiana Ashley West, Chidimma Kanu, Tanya Maric, Julie Anne Kathryn McDonald, Jeremy K Nicholson, Jia V Li, Mark R Johnson, Elaine Holmes, Makrina D Savvidou
Pubblicato in: Gut, 2020, Pagina/e gutjnl-2019-319620, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319620

Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients

Autori: Yong Guo, Yingchuan Li, Yinan Zhang, Shudong Fang, Xiaotao Xu, Aihua Zhao, Junfeng Zhang, Jia V Li, Daqing Ma, Wei Jia, Wei Jiang
Pubblicato in: Age and Ageing, Numero 49/1, 2019, Pagina/e 88-95, ISSN 0002-0729
Editore: Oxford University Press
DOI: 10.1093/ageing/afz132

A biochemical comparison of the lung, colonic, brain, renal, and ovarian cancer cell lines using 1H-NMR spectroscopy

Autori: Cong Hu, Zhigang Liu, Hailin Zhao, Lingzhi Wu, Qingquan Lian, Daqing Ma, Jia V. Li
Pubblicato in: Bioscience Reports, Numero 40/4, 2020, ISSN 0144-8463
Editore: Kluwer Academic Publishers
DOI: 10.1042/bsr20194027

Microbiota- and Radiotherapy-Induced Gastrointestinal Side-Effects (MARS) Study: A Large Pilot Study of the Microbiome in Acute and Late-Radiation Enteropathy

Autori: Miguel Reis Ferreira, H. Jervoise N. Andreyev, Kabir Mohammed, Lesley Truelove, Sharon M. Gowan, Jia Li, Sarah L. Gulliford, Julian R. Marchesi, David P. Dearnaley
Pubblicato in: Clinical Cancer Research, Numero 25/21, 2019, Pagina/e 6487-6500, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-19-0960

In vitro metabolomic footprint of the Echinococcus multilocularis metacestode

Autori: Dominic Ritler, Reto Rufener, Jia V. Li, Urs Kämpfer, Joachim Müller, Claudia Bühr, Stefan Schürch, Britta Lundström-Stadelmann
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-56073-y

Evaluation of Direct from Sample Metabolomics of Human Feces Using Rapid Evaporative Ionization Mass Spectrometry

Autori: Simon J. S. Cameron, James L. Alexander, Frances Bolt, Adam Burke, Hutan Ashrafian, Julian Teare, Julian R. Marchesi, James Kinross, Jia V. Li, Zoltán Takáts
Pubblicato in: Analytical Chemistry, Numero 91/21, 2019, Pagina/e 13448-13457, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.9b02358

A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer

Autori: Soeren Ocvirk, Annette S Wilson, Joram M Posma, Jia V Li, Kathryn R Koller, Gretchen M Day, Christie A Flanagan, Jill Evon Otto, Pam E Sacco, Frank D Sacco, Flora R Sapp, Amy S Wilson, Keith Newton, Faye Brouard, James P DeLany, Marissa Behnning, Corynn N Appolonia, Devavrata Soni, Faheem Bhatti, Barbara Methé, Adam Fitch, Alison Morris, H Rex Gaskins, James Kinross, Jeremy K Nicholson, Timothy K
Pubblicato in: The American Journal of Clinical Nutrition, Numero 111/2, 2019, Pagina/e 406-419, ISSN 0002-9165
Editore: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqz301

Monosodium Glutamate (MSG) Renders Alkalinizing Properties and Its Urinary Metabolic Markers of MSG Consumption in Rats

Autori: Nahok, Li, Phetcharaburanin, Abdul, Wongkham, Thanan, Silsirivanit, Anutrakulchai, Selmi, Cha’on
Pubblicato in: Biomolecules, Numero 9/10, 2019, Pagina/e 542, ISSN 2218-273X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom9100542

Bile salt metabolism is not the only factor contributing to Clostridioides ( Clostridium ) difficile disease severity in the murine model of disease

Autori: Caitlin A. Jukes, Umer Zeeshan Ijaz, Anthony Buckley, Janice Spencer, June Irvine, Denise Candlish, Jia V. Li, Julian R. Marchesi, Gillian Douce
Pubblicato in: Gut Microbes, Numero 11/3, 2020, Pagina/e 481-496, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2019.1678996

Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms

Autori: Cong Hu, Bincheng Wang, Zhigang Liu, Qiling Chen, Masashi Ishikawa, Han Lin, Qingquan Lian, Jun Li, Jia V. Li, Daqing Ma, null null
Pubblicato in: Cell Biology and Toxicology, Numero 39, 2023, Pagina/e 1395-1411, ISSN 0742-2091
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10565-022-09766-6

Improved Spatial Resolution of Metabolites in Tissue Biopsies Using High-Resolution Magic-Angle-Spinning Slice Localization NMR Spectroscopy

Autori: Elisabeth V. Vonhof, Martial Piotto, Elaine Holmes, John C. Lindon, Jeremy K. Nicholson, Jia V. Li
Pubblicato in: Analytical Chemistry, Numero 92, 2023, Pagina/e 11516-11519, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.0c02377

Tumour necrosis factor-α (TNF-α) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway

Autori: Aminah G. Alotaibi, Jia V. Li, Nigel J. Gooderham
Pubblicato in: Toxicology, Numero 457, 2022, Pagina/e 152806, ISSN 0300-483X
Editore: Elsevier BV
DOI: 10.1016/j.tox.2021.152806

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype

Autori: Jia V. Li, Hutan Ashrafian, Magali Sarafian, Daniel Homola, Laura Rushton, Grace Barker, Paula Momo Cabrera, Matthew R. Lewis, Ara Darzi, Edward Lin, Nana Adwoa Gletsu-Miller, Stephen L. Atkin, Thozhukat Sathyapalan, Nigel J. Gooderham, Jeremy K. Nicholson, Julian R. Marchesi, Thanos Athanasiou, Elaine Holmes
Pubblicato in: Microbiome, Numero 9, 2021, ISSN 2049-2618
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s40168-021-01086-x

Book chapters (1)

Metabolic Profiling in IBD

Autori: Maria Glymenaki, Jia V. Li, Julian R. Marchesi
Pubblicato in: Biomarkers in Inflammatory Bowel Diseases, 2019, Pagina/e 303-312, ISBN 978-3-030-11445-9
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-11446-6_25

Non-peer reviewed articles (1)

Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer

Autori: M. C. Ramaboli, S. Ocvirk, M. Khan Mirzaei, B. L. Eberhart, M. Valdivia-Garcia, A. Metwaly, K. Neuhaus, G. Barker, J. Ru, L. T. Nesengani, D. Mahdi-Joest, A. S. Wilson, S. K. Joni, D. C. Layman, J. Zheng, R. Mandal, Q. Chen, M. R. Perez, S. Fortuin, B. Gaunt, D. Wishart, B. Methé, D. Haller, J. V. Li, L. Deng, R. Swart, S. J. D. O’Keefe
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-46265-0

Thesis and dissertations (1)

Investigating the metabolic function of the gut microbiota in colorectal carcinogenesis via choline metabolism

Autori: Yang Bi
Pubblicato in: 2024
Editore: Imperial College London