Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients

Información del proyecto

TOPCAPI

Identificador del acuerdo de subvención: 720793

DOI

10.3030/720793

Proyecto cerrado

Fecha de la firma de la CE 9 Noviembre 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 30 Septiembre 2021

Financiado con arreglo a

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology

Coste total

€ 5 063 361,25

Aportación de la UE

€ 5 063 361,25

Coordinado por

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (1)

Dissemination of the project through outputs with the highest possible academic impact

Diseemination of research publications

Other (3)

Annual physical TOPCAPI consortium, SC, EAB, and IMB meetings

Annual physical TOPCAPI consortium SC EAB and IMB meetings

Full open release of generic project resources/tools

Full open release of generic project resourcestools

Project manager appointed

Websites, patent fillings, videos etc. (3)

Communicate/outreach with the public

Publicly accessible TOPCAPI website newsletter publications press releases social media accounts outreach activities and each academic Partner will have Institutional open days

International conference to coincide with the last annual meeting
TOPCAPI Website

Publicaciones

Peer reviewed articles (16)

Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling

Autores: Areti Tsigkinopoulou, Eriko Takano, Rainer Breitling
Publicado en: PLOS Computational Biology, Edición 16/7, 2020, Página(s) e1008039, ISSN 1553-7358
Editor: PLOS
DOI: 10.1371/journal.pcbi.1008039

Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A

Autores: Francesco Del Carratore, Marianna Iorio, Mercedes Pérez-Bonilla, Kamila Schmidt, Rosario Pérez-Redondo, Margherita Sosio, Sandy J. Macdonald, Ivan S. Gyulev, Areti Tsigkinopoulou, Gavin H. Thomas, Olga Genilloud, Antonio Rodríguez-García, Stefano Donadio, Rainer Breitling, Eriko Takano
Publicado en: mSystems, Edición 6/3, 2021, ISSN 2379-5077
Editor: ASM Journals
DOI: 10.1128/msystems.00341-21

Structure and Function of an Elongation Factor P Subfamily in Actinobacteria

Autores: Bruno Pinheiro, Christopher M. Scheidler, Pavel Kielkowski, Marina Schmid, Ignasi Forné, Suhui Ye, Norbert Reiling, Eriko Takano, Axel Imhof, Stephan A. Sieber, Sabine Schneider, Kirsten Jung
Publicado en: Cell Reports, Edición 30/13, 2020, Página(s) 4332-4342.e5, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.03.009

Synthetic biology approaches to actinomycete strain improvement

Autores: Rainer Breitling, Martina Avbelj, Oksana Bilyk, Francesco Del Carratore, Alessandro Filisetti, Erik K R Hanko, Marianna Iorio, Rosario Pérez Redondo, Fernando Reyes, Michelle Rudden, Emmanuele Severi, Lucija Slemc, Kamila Schmidt, Dominic R Whittall, Stefano Donadio, Antonio Rodríguez García, Olga Genilloud, Gregor Kosec, Davide De Lucrezia, Hrvoje Petković, Gavin Thomas, Eriko Takano
Publicado en: FEMS Microbiology Letters, Edición 368/10, 2021, ISSN 1574-6968
Editor: Oxford University Press
DOI: 10.1093/femsle/fnab060

Fine-tuning the regulation of Cas9 expression levels for efficient CRISPR-Cas9 mediated recombination in Streptomyces

Autores: Suhui Ye, Behnam Enghiad, Huimin Zhao, Eriko Takano
Publicado en: Journal of Industrial Microbiology and Biotechnology, Edición 47/4-5, 2020, Página(s) 413-423, ISSN 1367-5435
Editor: Springer Verlag
DOI: 10.1007/s10295-020-02277-5

Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries

Autores: Andrew Currin, Neil Swainston, Mark S Dunstan, Adrian J Jervis, Paul Mulherin, Christopher J Robinson, Sandra Taylor, Pablo Carbonell, Katherine A Hollywood, Cunyu Yan, Eriko Takano, Nigel S Scrutton, Rainer Breitling
Publicado en: Synthetic Biology, Edición 4/1, 2019, ISSN 2397-7000
Editor: Oxford University Press
DOI: 10.1093/synbio/ysz025

Defining informative priors for ensemble modeling in systems biology

Autores: Areti Tsigkinopoulou, Aliah Hawari, Megan Uttley, Rainer Breitling
Publicado en: Nature Protocols, Edición 13/11, 2018, Página(s) 2643-2663, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/s41596-018-0056-z

Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor

Autores: Katsuaki Nitta, Francesco Del Carratore, Rainer Breitling, Eriko Takano, Sastia P. Putri, Eiichiro Fukusaki
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 8, 2020, Página(s) 595552, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2020.595552

Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism

Autores: Adam Amara, Eriko Takano, Rainer Breitling
Publicado en: BMC Genomics, Edición 19/1, 2018, ISSN 1471-2164
Editor: BioMed Central
DOI: 10.1186/s12864-018-4905-5

Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters

Autores: Francesco Del Carratore, Konrad Zych, Matthew Cummings, Eriko Takano, Marnix H. Medema, Rainer Breitling
Publicado en: Communications Biology, Edición 2/1, 2019, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-019-0333-6

Integrated Probabilistic Annotation: A Bayesian-Based Annotation Method for Metabolomic Profiles Integrating Biochemical Connections, Isotope Patterns, and Adduct Relationships

Autores: Francesco Del Carratore, Kamila Schmidt, Maria Vinaixa, Katherine A. Hollywood, Caitlin Greenland-Bews, Eriko Takano, Simon Rogers, Rainer Breitling
Publicado en: Analytical Chemistry, Edición 91/20, 2019, Página(s) 12799-12807, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.9b02354

Antibiotic export: transporters involved in the final step of natural product production

Autores: Emmanuele Severi, Gavin H. Thomas
Publicado en: Microbiology, Edición 165/8, 2019, Página(s) 805-818, ISSN 1350-0872
Editor: Society for General Microbiology
DOI: 10.1099/mic.0.000794

The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters

Autores: Kai Blin, Victòria Pascal Andreu, Emmanuel L C de los Santos, Francesco Del Carratore, Sang Yup Lee, Marnix H Medema, Tilmann Weber
Publicado en: Nucleic Acids Research, Edición 47/D1, 2018, Página(s) D625-D630, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gky1060

A plasmid toolset for CRISPR‐mediated genome editing and CRISPRi gene regulation in Escherichia coli.

Autores: Adrian J. Jervis, Erik K.R. Hanko, Mark S. Dunstan, Christopher J. Robinson, Eriko Takano, Nigel S. Scrutton
Publicado en: Microbial Biotechnology, Edición 14/3, 2021, Página(s) 1120-1129, ISSN 1751-7915
Editor: John Wiley and Sons Ltd
DOI: 10.1111/1751-7915.13780

Metabolomics tools for the synthetic biology of natural products

Autores: Katherine A Hollywood, Kamila Schmidt, Eriko Takano, Rainer Breitling
Publicado en: Current Opinion in Biotechnology, Edición 54, 2018, Página(s) 114-120, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2018.02.015

Switchable foldamer ion channels with antibacterial activity

Autores: Anna D. Peters, Stefan Borsley, Flavio della Sala, Dominic F. Cairns-Gibson, Marios Leonidou, Jonathan Clayden, George F. S. Whitehead, Iñigo J. Vitórica-Yrezábal, Eriko Takano, John Burthem, Scott L. Cockroft, Simon J. Webb
Publicado en: Chemical Science, Edición 11/27, 2020, Página(s) 7023-7030, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sc02393k

Book chapters (2)

Molecular Biology Methods in Streptomyces rimosus, a Producer of Oxytetracycline

Autores: Lucija Slemc, Špela Pikl, Hrvoje Petković, Martina Avbelj
Publicado en: Antimicrobial Therapies - Methods and Protocols, Edición 2296, 2021, Página(s) 303-330, ISBN 978-1-0716-1357-3
Editor: Springer US
DOI: 10.1007/978-1-0716-1358-0_18

Coupled Transcriptomics for Differential Expression Analysis and Determination of Transcription Start Sites: Design and Bioinformatics

Autores: Antonio Rodríguez-García, Alberto Sola-Landa, Rosario Pérez-Redondo
Publicado en: Antimicrobial Therapies - Methods and Protocols, Edición 2296, 2021, Página(s) 263-278, ISBN 978-1-0716-1357-3
Editor: Springer US
DOI: 10.1007/978-1-0716-1358-0_16