Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients

Informazioni relative al progetto

TOPCAPI

ID dell’accordo di sovvenzione: 720793

DOI

10.3030/720793

Progetto chiuso

Data della firma CE 9 Novembre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 30 Settembre 2021

Finanziato da

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology

Costo totale

€ 5 063 361,25

Contributo UE

€ 5 063 361,25

Coordinato da

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Dissemination of the project through outputs with the highest possible academic impact

Diseemination of research publications

Other (3)

Annual physical TOPCAPI consortium, SC, EAB, and IMB meetings

Annual physical TOPCAPI consortium SC EAB and IMB meetings

Full open release of generic project resources/tools

Full open release of generic project resourcestools

Project manager appointed

Websites, patent fillings, videos etc. (3)

Communicate/outreach with the public

Publicly accessible TOPCAPI website newsletter publications press releases social media accounts outreach activities and each academic Partner will have Institutional open days

International conference to coincide with the last annual meeting
TOPCAPI Website

Pubblicazioni

Peer reviewed articles (16)

Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling

Autori: Areti Tsigkinopoulou, Eriko Takano, Rainer Breitling
Pubblicato in: PLOS Computational Biology, Numero 16/7, 2020, Pagina/e e1008039, ISSN 1553-7358
Editore: PLOS
DOI: 10.1371/journal.pcbi.1008039

Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A

Autori: Francesco Del Carratore, Marianna Iorio, Mercedes Pérez-Bonilla, Kamila Schmidt, Rosario Pérez-Redondo, Margherita Sosio, Sandy J. Macdonald, Ivan S. Gyulev, Areti Tsigkinopoulou, Gavin H. Thomas, Olga Genilloud, Antonio Rodríguez-García, Stefano Donadio, Rainer Breitling, Eriko Takano
Pubblicato in: mSystems, Numero 6/3, 2021, ISSN 2379-5077
Editore: ASM Journals
DOI: 10.1128/msystems.00341-21

Structure and Function of an Elongation Factor P Subfamily in Actinobacteria

Autori: Bruno Pinheiro, Christopher M. Scheidler, Pavel Kielkowski, Marina Schmid, Ignasi Forné, Suhui Ye, Norbert Reiling, Eriko Takano, Axel Imhof, Stephan A. Sieber, Sabine Schneider, Kirsten Jung
Pubblicato in: Cell Reports, Numero 30/13, 2020, Pagina/e 4332-4342.e5, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.03.009

Synthetic biology approaches to actinomycete strain improvement

Autori: Rainer Breitling, Martina Avbelj, Oksana Bilyk, Francesco Del Carratore, Alessandro Filisetti, Erik K R Hanko, Marianna Iorio, Rosario Pérez Redondo, Fernando Reyes, Michelle Rudden, Emmanuele Severi, Lucija Slemc, Kamila Schmidt, Dominic R Whittall, Stefano Donadio, Antonio Rodríguez García, Olga Genilloud, Gregor Kosec, Davide De Lucrezia, Hrvoje Petković, Gavin Thomas, Eriko Takano
Pubblicato in: FEMS Microbiology Letters, Numero 368/10, 2021, ISSN 1574-6968
Editore: Oxford University Press
DOI: 10.1093/femsle/fnab060

Fine-tuning the regulation of Cas9 expression levels for efficient CRISPR-Cas9 mediated recombination in Streptomyces

Autori: Suhui Ye, Behnam Enghiad, Huimin Zhao, Eriko Takano
Pubblicato in: Journal of Industrial Microbiology and Biotechnology, Numero 47/4-5, 2020, Pagina/e 413-423, ISSN 1367-5435
Editore: Springer Verlag
DOI: 10.1007/s10295-020-02277-5

Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries

Autori: Andrew Currin, Neil Swainston, Mark S Dunstan, Adrian J Jervis, Paul Mulherin, Christopher J Robinson, Sandra Taylor, Pablo Carbonell, Katherine A Hollywood, Cunyu Yan, Eriko Takano, Nigel S Scrutton, Rainer Breitling
Pubblicato in: Synthetic Biology, Numero 4/1, 2019, ISSN 2397-7000
Editore: Oxford University Press
DOI: 10.1093/synbio/ysz025

Defining informative priors for ensemble modeling in systems biology

Autori: Areti Tsigkinopoulou, Aliah Hawari, Megan Uttley, Rainer Breitling
Pubblicato in: Nature Protocols, Numero 13/11, 2018, Pagina/e 2643-2663, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-018-0056-z

Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor

Autori: Katsuaki Nitta, Francesco Del Carratore, Rainer Breitling, Eriko Takano, Sastia P. Putri, Eiichiro Fukusaki
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, Pagina/e 595552, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2020.595552

Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism

Autori: Adam Amara, Eriko Takano, Rainer Breitling
Pubblicato in: BMC Genomics, Numero 19/1, 2018, ISSN 1471-2164
Editore: BioMed Central
DOI: 10.1186/s12864-018-4905-5

Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters

Autori: Francesco Del Carratore, Konrad Zych, Matthew Cummings, Eriko Takano, Marnix H. Medema, Rainer Breitling
Pubblicato in: Communications Biology, Numero 2/1, 2019, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-019-0333-6

Integrated Probabilistic Annotation: A Bayesian-Based Annotation Method for Metabolomic Profiles Integrating Biochemical Connections, Isotope Patterns, and Adduct Relationships

Autori: Francesco Del Carratore, Kamila Schmidt, Maria Vinaixa, Katherine A. Hollywood, Caitlin Greenland-Bews, Eriko Takano, Simon Rogers, Rainer Breitling
Pubblicato in: Analytical Chemistry, Numero 91/20, 2019, Pagina/e 12799-12807, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.9b02354

Antibiotic export: transporters involved in the final step of natural product production

Autori: Emmanuele Severi, Gavin H. Thomas
Pubblicato in: Microbiology, Numero 165/8, 2019, Pagina/e 805-818, ISSN 1350-0872
Editore: Society for General Microbiology
DOI: 10.1099/mic.0.000794

The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters

Autori: Kai Blin, Victòria Pascal Andreu, Emmanuel L C de los Santos, Francesco Del Carratore, Sang Yup Lee, Marnix H Medema, Tilmann Weber
Pubblicato in: Nucleic Acids Research, Numero 47/D1, 2018, Pagina/e D625-D630, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gky1060

A plasmid toolset for CRISPR‐mediated genome editing and CRISPRi gene regulation in Escherichia coli.

Autori: Adrian J. Jervis, Erik K.R. Hanko, Mark S. Dunstan, Christopher J. Robinson, Eriko Takano, Nigel S. Scrutton
Pubblicato in: Microbial Biotechnology, Numero 14/3, 2021, Pagina/e 1120-1129, ISSN 1751-7915
Editore: John Wiley and Sons Ltd
DOI: 10.1111/1751-7915.13780

Metabolomics tools for the synthetic biology of natural products

Autori: Katherine A Hollywood, Kamila Schmidt, Eriko Takano, Rainer Breitling
Pubblicato in: Current Opinion in Biotechnology, Numero 54, 2018, Pagina/e 114-120, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2018.02.015

Switchable foldamer ion channels with antibacterial activity

Autori: Anna D. Peters, Stefan Borsley, Flavio della Sala, Dominic F. Cairns-Gibson, Marios Leonidou, Jonathan Clayden, George F. S. Whitehead, Iñigo J. Vitórica-Yrezábal, Eriko Takano, John Burthem, Scott L. Cockroft, Simon J. Webb
Pubblicato in: Chemical Science, Numero 11/27, 2020, Pagina/e 7023-7030, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc02393k

Book chapters (2)

Molecular Biology Methods in Streptomyces rimosus, a Producer of Oxytetracycline

Autori: Lucija Slemc, Špela Pikl, Hrvoje Petković, Martina Avbelj
Pubblicato in: Antimicrobial Therapies - Methods and Protocols, Numero 2296, 2021, Pagina/e 303-330, ISBN 978-1-0716-1357-3
Editore: Springer US
DOI: 10.1007/978-1-0716-1358-0_18

Coupled Transcriptomics for Differential Expression Analysis and Determination of Transcription Start Sites: Design and Bioinformatics

Autori: Antonio Rodríguez-García, Alberto Sola-Landa, Rosario Pérez-Redondo
Pubblicato in: Antimicrobial Therapies - Methods and Protocols, Numero 2296, 2021, Pagina/e 263-278, ISBN 978-1-0716-1357-3
Editore: Springer US
DOI: 10.1007/978-1-0716-1358-0_16