CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Deliverables
Yearly update of the main project contacts and to external subscribers
Press releases (M24) (opens in new window)Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.
Visual identity kit (M36) (opens in new window)Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression.
Extended model, describing relationship between FeCaPs and deposition site when exposed to an external magnetic field (M30) (opens in new window)Definition of FeCaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc
Validation of therapeutic efficiency of drug-loaded dpCaP/FedpCaPs in HFrEF mouse model (opens in new window)Definition of Proof of Concept that administration of dpCaP (and FedpCaP) therapeutic formulations exert beneficial cardiac effects in small animal model of cardiac disease.
E-newsletter (M24) (opens in new window)Yearly update of the main project contacts and to external subscribers
Summary of annual workshops and networking events building communities (M36) (opens in new window)Generation of period report regarding CUPIDO major results and activites
Aptamer-mediated guidance of CaP (M12) (opens in new window)CaP functionalized with aptamers for improved myocardial-specific targeting
In vivo assessment of the studied nanopartilces using different imaging modalities (M30) (opens in new window)In vivo assessment of loaded and unloaded dpCaPs and FedpCaPs for a full spectrum of biocompatibility, toxicity, blood-interaction, air/blood flow-interaction at pulmonary barrier, inflammatory responses, and pharmacokinetics.
Summary of annual workshops and networking events building communities (M12) (opens in new window)Generation of period report regarding CUPIDO major results and activites
Demonstration of the therapeutic effect of formulation for the treatment of cardiovascular function in mini-pigs (opens in new window)Definition of Proof of Concept that administration of dpCaP (and FedpCaP) therapeutic formulations exert beneficial cardiac effects in large animal model of cardiac disease.
Project videos (M48) (opens in new window)Interviews on key project figures produced and posted on YouTube and other networks to provide a basis for communication to a large audience
Data on the efficiency of wearable device for continuous remote monitoring of cardiopulmonary activity of mini-pigs (opens in new window)Validation of the efficacy of wearable device on continuous remote monitoring of cardiopulmonary activity of diseased mini-pigs upon inhalation treatment
Extended model, describing relationship between FeCaPs and deposition site when exposed to an external magnetic field (M12) (opens in new window)Definition of FeCaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc
Extension of open-source flow simulation framework to also include porous media flow. Establish relationship between different nanoparticles and deposition sites in both small and large animal models (M36) (opens in new window)Definition of CaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc
Validation of nanoparticle biodistribution in large animals (opens in new window)Demonstration of efficacy of nanoparticle biodistribution in large animals (mini-pigs).
Extension of open-source flow simulation framework to also include porous media flow. Establish relationship between different nanoparticles and deposition sites in both small and large animal models (M18) (opens in new window)Definition of CaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc
EMD-mediated guidance of FeCaP (M24) (opens in new window)Optimized FeCaPs for electromagnetic-mediated guidance to the heart via an electromagnetic device.
Distribution of electromagnetic fields in the target area due to the drug targeting systems (opens in new window)Comparison of different system solutions able to generate the magnetic field gradient (or the magnetic field) needed to guide the FeCaPs at the level of the heart tissues
Press releases (M12) (opens in new window)Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.
In vitro assessment of nanoparticle behavior at/across the pulmonary barrier (M24) (opens in new window)In vitro assessment of loaded and unloaded dpCaPs for a full spectrum of biocompatibility, toxicity, and air/blood flow-interaction at pulmonary barrier.
Training satisfaction questionnaires (opens in new window)Generation of training satisfaction questionnaires in regard of training topics and contents organized during the project
EMD-mediated guidance of FeCaP (M12) (opens in new window)Optimized FeCaPs for electromagnetic-mediated guidance to the heart via an electromagnetic device.
E-newsletter (M12) (opens in new window)Yearly update of the main project contacts and to external subscribers
Aptamer-mediated guidance of CaP (M20) (opens in new window)CaP functionalized with aptamers for improved myocardial-specific targeting
Press releases (M48) (opens in new window)Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.
Visual identity kit (M12) (opens in new window)Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression.
In vitro assessment of nanoparticle behavior at/across the pulmonary barrier (M12) (opens in new window)In vitro assessment of loaded and unloaded dpCaPs for a full spectrum of biocompatibility, toxicity, and air/blood flow-interaction at pulmonary barrier.
Web portal, social media (opens in new window)Facilitate the communication of information to the media and through the media to become the key multiplier to reach the wider public.
Wearable devices for usage on mini-pigs (M24) (opens in new window)Delivery of wearable garments designed and validated or a continuous and non-invasive monitoring of pig heart and respiratory activity
In vivo assessment of the studied nanopartilces using different imaging modalities (M12) (opens in new window)In vivo assessment of loaded and unloaded dpCaPs and FedpCaPs for a full spectrum of biocompatibility, toxicity, blood-interaction, air/blood flow-interaction at pulmonary barrier, inflammatory responses, and pharmacokinetics.
Summary of annual workshops and networking events building communities (M18) (opens in new window)Generation of period report regarding CUPIDO major results and activites
Summary of annual workshops and networking events building communities (M48) (opens in new window)Generation of period report regarding CUPIDO major results and activites
Project videos (M24) (opens in new window)Interviews on key project figures produced and posted on YouTube and other networks to provide a basis for communication to a large audience
Press releases (M3) (opens in new window)Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.
Functional assessment (compatibility, physic-chemical and biological stability) of CaP restoration and drug release (opens in new window)The biological activity of the powders and the reconstitution of CaP population will be thoroughly evaluated in vitro in cardiomyocyte lines (HL-1), adult primary mouse cardiomyocytes and human induced pluripotent stem cells (hiPS)-derived cardiomyocytes.
Functional assessment (compatibility, physic-chemical and biological stability) of FeCaP restoration and drug release (opens in new window)The biological activity of the powders and the reconstitution of FeCaP population will be thoroughly evaluated in vitro in cardiomyocyte lines (HL-1), adult primary mouse cardiomyocytes and human induced pluripotent stem cells (hiPS)-derived cardiomyocytes.
Visual identity kit (M48) (opens in new window)Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression.
Wearable devices for usage on mini-pigs (M36) (opens in new window)Delivery of wearable garments designed and validated or a continuous and non-invasive monitoring of pig heart and respiratory activity
Publications
Author(s):
Lorenzo Degli Esposti, Alessandro Dotti, Alessio Adamiano, Claudia Fabbi, Eride Quarta, Paolo Colombo, Daniele Catalucci, Claudio De Luca, Michele Iafisco
Published in:
Crystals, Issue 10/10, 2020, Page(s) 953, ISSN 2073-4352
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cryst10100953
Author(s):
Dawud Abawi, Alessandro Faragli, Michael Schwarzl, Martin Manninger, David Zweiker, Karl-Patrik Kresoja, Jochen Verderber, Birgit Zirngast, Heinrich Maechler, Paul Steendijk, Burkert Pieske, Heiner Post, Alessio Alogna
Published in:
BMC Cardiovascular Disorders, Issue 19/1, 2019, ISSN 1471-2261
Publisher:
BioMed Central
DOI:
10.1186/s12872-019-1212-2
Author(s):
Michele Miragoli, Paola Ceriotti, Michele Iafisco, Marco Vacchiano, Nicolò Salvarani, Alessio Alogna, Pierluigi Carullo, Gloria Belén Ramirez-Rodríguez, Tatiana Patrício, Lorenzo Degli Esposti, Francesca Rossi, Francesca Ravanetti, Silvana Pinelli, Rossella Alinovi, Marco Erreni, Stefano Rossi, Gianluigi Condorelli, Heiner Post, Anna Tampieri, Daniele Catalucci
Published in:
Science Translational Medicine, Issue 10/424, 2018, Page(s) eaan6205, ISSN 1946-6234
Publisher:
American Association for the Advancement of Science
DOI:
10.1126/scitranslmed.aan6205
Author(s):
Vittoria Di Mauro, Maria Barandalla-Sobrados, Daniele Catalucci
Published in:
Non-coding RNA Research, 2018, ISSN 2468-0540
Publisher:
Elsevier
DOI:
10.1016/j.ncrna.2018.02.001
Author(s):
Lorenzo Fassina, Giacomo Rozzi, Stefano Rossi, Simone Scacchi, Maricla Galetti, Francesco Paolo Lo Muzio, Fabrizio Del Bianco, Piero Colli Franzone, Giuseppe Petrilli, Giuseppe Faggian, Michele Miragoli
Published in:
Scientific Reports, Issue 7, 2017, Page(s) 46143, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/srep46143
Author(s):
Alessandra Marrella, Michele Iafisco, Alessio Adamiano, Stefano Rossi, Maurizio Aiello, Maria Barandalla-Sobrados, Pierluigi Carullo, Michele Miragoli, Anna Tampieri, Silvia Scaglione, Daniele Catalucci
Published in:
Journal of The Royal Society Interface, Issue 15/144, 2018, Page(s) 20180236, ISSN 1742-5689
Publisher:
The Royal Society
DOI:
10.1098/rsif.2018.0236
Author(s):
Lorenzo Degli Esposti, Francesca Carella, Alessio Adamiano, Anna Tampieri, Michele Iafisco
Published in:
Drug Development and Industrial Pharmacy, Issue 44/8, 2018, Page(s) 1223-1238, ISSN 0363-9045
Publisher:
Marcel Dekker Inc.
DOI:
10.1080/03639045.2018.1451879
Author(s):
Alexandra K. Diem, Kristian Valen-Sendstad
Published in:
Biophysical Journal, Issue 117/12, 2019, Page(s) 2316-2323, ISSN 0006-3495
Publisher:
Biophysical Society
DOI:
10.1016/j.bpj.2019.09.029
Author(s):
Syver Agdestein, Kristian Valen-Sendstad, Alexandra Diem
Published in:
Journal of Open Source Software, Issue 3/32, 2018, Page(s) 1107, ISSN 2475-9066
Publisher:
Journal of Open Source Software
DOI:
10.21105/joss.01107
Author(s):
Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri
Published in:
Acta Biomaterialia, Issue 73, 2018, Page(s) 458-469, ISSN 1742-7061
Publisher:
Elsevier BV
DOI:
10.1016/j.actbio.2018.04.040
Author(s):
Michele Iafisco, Alessio Alogna, Michele Miragoli, Daniele Catalucci
Published in:
Nanomedicine, Issue 14/18, 2019, Page(s) 2391-2394, ISSN 1743-5889
Publisher:
Future Medicine Ltd.
DOI:
10.2217/nnm-2019-0228
Author(s):
Alessio Adamiano, Victoria M Wu, Francesca Carella, Gianrico Lamura, Fabio Canepa, Anna Tampieri, Michele Iafisco, Vuk Uskoković
Published in:
Nanomedicine, Issue 14/10, 2019, Page(s) 1267-1289, ISSN 1743-5889
Publisher:
Future Medicine Ltd.
DOI:
10.2217/nnm-2018-0372
Author(s):
Karl-Patrik Kresoja, Alessandro Faragli, Dawud Abawi, Oliver Paul, Burkert Pieske, Heiner Post, Alessio Alogna
Published in:
PLOS ONE, Issue 14/12, 2019, Page(s) e0226561, ISSN 1932-6203
Publisher:
Public Library of Science
DOI:
10.1371/journal.pone.0226561
Author(s):
Pietro Ameri, Gabriele Giacomo Schiattarella, Lia Crotti, Margherita Torchio, Edoardo Bertero, Daniele Rodolico, Maurizio Forte, Vittoria Di Mauro, Roberta Paolillo, Cristina Chimenti, Daniele Torella, Daniele Catalucci, Sebastiano Sciarretta, Cristina Basso, Ciro Indolfi, Cinzia Perrino
Published in:
International Journal of Molecular Sciences, Issue 21/4, 2020, Page(s) 1192, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21041192
Author(s):
Alexandra Diem, Kristian Valen-Sendstad
Published in:
2019 Computing in Cardiology Conference (CinC), 2019, ISBN 978-1-7281-6936-1
Publisher:
Computing in Cardiology
DOI:
10.22489/cinc.2019.291
Author(s):
S. Fiocchi, E. Chiaramello, M. Bonato, G. Tognola, D. Catalucci, M. Parazzini, P. Ravazzani
Published in:
2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 5674-5677, ISBN 978-1-5386-1311-5
Publisher:
IEEE
DOI:
10.1109/embc.2019.8857364
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