Understanding pathogen, livestock, environment interactions involving bluetongue virus

Informazioni relative al progetto

PALE-Blu

ID dell’accordo di sovvenzione: 727393

DOI

10.3030/727393

Progetto chiuso

Data della firma CE 12 Maggio 2017

Data di avvio 1 Giugno 2017

Data di completamento 30 Novembre 2021

Finanziato da

• SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy

Costo totale

€ 6 039 301,50

Contributo UE

€ 6 039 301,50

Coordinato da

THE UNIVERSITY OF NOTTINGHAM
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (43)

Evaluated serotype specific ELISA

D55 Magplex Luminex assay system for detection and typing of BTV RNA Partner 1 12 16 M48

Protocol for collection, shipment and onward processing of Culicoides eggs

D6.1: Protocol for collection, shipment and onward processing of Culicoides eggs (Partner 1,11,13,14,16,18). (M24)

Identify cell proteins involved in competence of cell lines

D73 Identification of cellular proteins partners involved in competencerefractory status of cells lines and therefore identification of the mechanisms underlying competence Partners 1 2 M48

Viral vectored and sub-unit vaccine efficacy, mice

D104 Report on protection and immune response of AdV CAV2 and rMVA vaccines against several serotypes in IFNAR mice Partners 1 2 8 9 15 19 M30

High impact scientific publications

D127 High impact scientific publications all Partners M48

Description of ecological factors in vector populations and dispersion

D45 Description of ecological factors driving population structure and of natural barriers to vector dispersion Partner 3 6 7 12 M48

Levels of protection by statins in IFNAR mouse model

Determination of levels of protection afforded by statins that have been deemed as most efficient in cell cultures using IFNAR mouse model Partner 2 M48

Improved epidemiological models

D75 Improved epidemiological models integrating vector competence data Partners 6 7 10 12 M48

DISA cocktail efficacy cattle

D107 Report on protection in cattle by vaccination with a cocktail of DISA vaccines Partners 9 M48

Serotype specific qRT-PCR for novel BTV serotypes

D5.1: Serotype specific qRT-PCR for novel BTV serotypes (Partner 1, 2, 4, 5, 12, 16). (M18)

Validation of RNA microarrays

D53 Validation of the RNA microarrays Partner 1 4 5 P16 M27

Magplex / Luminex assay for detection and typing of BTV

D54 Diagnostic ELISA which has been evaluated Partner 1 5 16 M30

Established friction surfaces and connectivity matrices

D3.4: Established friction surfaces and connectivity matrices (Partner 1, 3, 6, 7, 10, 12). (M24)

Identify BTV protein domains restricting infection of Culicoides cells

D72 Identification of protein domains involved in restricting infection of Culicoides cells Partners 1 2 16 M48

Model for wind-borne introduction of flying insects into Europe

D46 A model for windborne introduction of flying insects into Europe to estimate the risk under specific climatic conditions Partner 3 6 7 12 M48

Determine possibility / frequency of reassortment between conventional and novel BTVs

D85 Determine possibility frequency of natural reassortment between conventional and novel BTVs Partners 1 2 5 M48

Characterisation of IFN response of ruminant endothelial cells to BTV-8 and BTV-26 (+/-saliva)

D91 Characterisation of the IFN response of ruminant endothelial cells to BTV8 and BTV26 in the presence or absence of Culicoides saliva Partner 10 and 16 M48

The effect of statins/inhibitory molecules on vaccination regimes

D115 Determination of effect of statinsinhibitory molecules on vaccination regimes Partner 2 8 M48

Refined spatial epizone maps

D3.3: Refined spatial epizone maps (Partner 1, 3, 6, 7, 10, 12). (M18)

List of required environmental and landscape factors

D4.1: List of required environmental and landscape factors needed (Partner 3, 6, 7) (with WP3). (M3)

Array system for typing BTV

D5.2: Array based system for typing BTV (Partner 1, 4, 5). (M27)

Phylogeographic analysis linking BTV diffusion to epizones and vector populations

D35 Phylogeographic analysis linking BTV diffusion to epizones and vector populations Partner 1 3 6 7 10 12 M48

BTV vaccine efficacy sheep

D106 Report on protection and immune response of AdV CAV2 rMVA and Ppastoris vaccines against several serotypes in sheep Partners 1 2 8 15 19 M48

DISA single BTV serotype protection

D105 Report on early protection against one serotype in cattle by monoserotype DISA vaccination Partners 9 M24

Antiviral / control strategies based on viral proteins involved in permissive / refractory status

D114 Development of potential antiviralcontrol strategies based on identification of viral proteins involved in permissiverefractory status Partner 2 8 M48

Reassortant strains between conventional and novel / atypical strains

D82 Reassortant viruses between conventional eg BTV1 or BTV4 and novelatypical strains eg to explore the genetic basis for horizontal transmission Partners 1 2 4 5 M18

Assess pathogenesis / horizontal transmission of BTV strains

D81 An assessment of the the pathogenesis and horizontal transmission characteristics of BTV8 BTV26 and other novel BTV strains in goats and sheep Partners 2 4 5 M18

Virus purification and sequencing/modelling of VP2 cleavage sites of 10 BTV strains

D92 Virus purification and sequencing modelling of VP2 cleavage sites of 10 BTV strains Partners 16 10 and 1 M48

List of spatial data required

D3.1: A list of spatial data requirements from WP1, (Partners 1, 3, 4, 10). (M3)

Histopathological changes in mice / sheep treated with statins and infected with BTV

D116 Determination of histopathological changes in mice andor sheep treated with selected statin molecules and infected with BTV Partner 2 M48

A mouse model for horizontal transmission of BTV

D83 A mouse model for horizontal transmission of atypical BTV strains between mammalian hosts Partners 2 M24

Standardisation of procedures for Culicoides infections

D74 Standardisation of procedures for the infection of adult Culicoides vectors and vectorderived cell lines to generate statistically robust data for vector competence Partners 1 2 16 M24

Virus-protein targets for novel anti-BTV strategies

D112 Identification of virusprotein targets for novel antiBTV strategies Partner 2 8 M24

Identification of BTV sequences influencing horizontal transmission in mammalian host

D86 Identification of BTV protein domains influencing horizontal transmission in a mammalian host Partners 1 2 5 M48

Attachment / uptake / replication characteristics for selected BTVs in different ruminant target cells

D95 Attachment uptake and replication characteristics for selected BTV strains in different ruminant target cells vascular endothelial cells monocytes Partner 16 and 10 M48

Identification of BTV genes that support horizontal transmission in mammalian host.

D84 Identification of genome segments of the novelatypical BTV strainsserotypes that support horizontal transmission in a mammalian host Partners 1 2 4 5 M24

Generation by reverse genetics and characterisation of cleavage resistant BTV strain(s)

D93 Generation by reverse genetics and characterisation of cleavage resistant BTV strains Partners 10 16 and 1 M48

Information/ advice for policy makers

D76 Information advice for policy makers concerning the biological characteristics of novel viral strains Partners 1 2 4 5 6 9 10 12 16 M1 to M48

Identification and characterisation of ruminant interferon stimulated genes that block BTV replication

D96 Identification and characterisation of ruminant ISGs that block BTV replication Partner 10 M48

Identification of statin doses that inhibit BTV in cell culture

D111 Identification of inhibitory doses of statin molecules on selected BTV strains in cell culture Partner 2 M24

Identify BTV genes restricting infection of Culicoides cells

D71 Identification of individual BTV genes involved in restricting infection of Culicoides cells Partners 1 2 16 M48

Infectivity assays in Culicoides (KC cells) and ruminant endothelial cells for select BTVs

D94 Infectivity assays in Culicoides KC cells and ruminant endothelial cells for selected BTV strains Partner 16 and 10 M48

Protocol for successful generation of primary cell cultures from different Culicoides spp.

D6.2: Protocol for successful generation of primary cell cultures from different Culicoides spp. (Partner 1). (M27)

Websites, patent fillings, videos etc. (4)

Adaptation and maintenance of spatial data website to include PALE-Blu data

D125 Adaptation and maintenance of spatial data website to include PALEBlu data all Partners M12

Updated website with environment / anthropogenic data

D3.2: Updated website with environmental and anthropogenic data archive and dissemination capabilities (Partner 1, 3, 6, 7, 10, 12). (M12)

Project website

Task 124 Establish and maintain project websites with regular updates over the project lifetime with all partners contributing new material with review of the site at every consortium meeting all Partners M1 to M36

Archive of standardised and processed spatial data

D3.6: Archive of standardised and processed spatial data for use by WP1, WP3, & WP4 (Partner 1, 3, 6, 7, 10, 12). (M24)

Other (11)

Continuous cell lines from a European BTV-vector and a non-vector Culicoides species

D6.3: Continuous cell lines from at least one European BTV-vector and one non-vector Culicoides species (Partner 1). (M48)

New non-EU virus isolates

D2.3: Virus isolates from clinical samples from outbreaks, whenever feasible (Partners 1, 2, 4, 5, 11, 14, 15, 16, 17, 18, 19). (M48).

Genome sequence for EU BTVs

D1.3: Genome sequences for novel BTV outbreak strains (from clinical samples /insects /isolates) (Partners 1, 2, 4, 5, 8, 10, 12, 16). (M48).

Culicoides host maps

D4.3: Culicoides host maps as determined by available data (Partners 3, 6, 7). (M30)

Generate new EU virus isolates

D1.5: Virus isolates from clinical samples from outbreaks, whenever feasible (Partners 1, 2, 4, 5, 10, 12, 16). (M48).

Spacial/temporal data for non-EU BT outbreaks

D2.2: Spatial / temporal data for the incidence and spread of BT outbreaks (Partners 1, 2, 4, 5, 11, 14, 15, 16, 17, 18, 19) (M48).

Genetic structure maps and Culicoides microbiome

D4.4: Genetic structure maps and Culicoides microbiome composition (Partner 3, 6, 7, 12). (M48)

Sequence data for non-EU BTVs

D2.1: Genome sequences for novel BTV outbreak strains (from clinical samples /insects /isolates) (Partners 1, 2, 4, 5, 10, 11, 17) (M48).

Spacial /temporal data for EU BT outbreaks

D1.4: Spatial / temporal data for the incidence and spread of BT outbreaks (Partners 1, 2, 4, 5, 10, 12, 16) (M48).

Spatial data base of vector distributions

D4.2: Spatial data base of vector distributions (Partner 3, 4, 6, 7, 12). (M12)

Continuous cell lines from a Middle Eastern and an African BTV-vector Culicoides species

D6.4: Continuous cell lines from at least one Middle Eastern and one African BTV-vector Culicoides species (Partner 1). (M48)

Pubblicazioni

Peer reviewed articles (69)

Evaluation of an IGM ‐specific ELISA for early detection of bluetongue virus infections in domestic ruminants sera

Autori: Emmanuel Bréard, Axel Gorlier, Cyril Viarouge, Fabien Donnet, Corinne Sailleau, Claudia Schulz, Bernd Hoffmann, Loic Comtet, Martin Beer, Stéphan Zientara, Damien Vitour
Pubblicato in: Transboundary and Emerging Diseases, Numero 66/1, 2018, Pagina/e 537-545, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.13060

Clinical cases of Bluetongue serotype 8 in calves in France in the 2018-2019 winter.

Autori: Vinomack C, Rivière J, Bréard E, Viarouge C, Postic L, Zientara S, Vitour D, Belbis G, Spony V, Pagneux C, Sailleau C, Zanella G.
Pubblicato in: Transbound Emerg Dis., 2018, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1016/j.jviromet.2019.04.002

Emerging vectorial diseases: West Nile fever, Bluetongue and Schmallenberg

Autori: S Zientara 1, C Beck 1, S Lecollinet 1
Pubblicato in: Bulletin de l'Académie nationale de médecine, 2020, ISSN 0001-4079
Editore: Elsevier BV
DOI: 10.1016/j.banm.2020.09.041

Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot

Autori: Maude Jacquot, Pavuluri P Rao, Sarita Yadav, Kyriaki Nomikou, Sushila Maan, Y Krishna Jyothi, Narasimha Reddy, Kalyani Putty, Divakar Hemadri, Karam P Singh, Narender Singh Maan, Nagendra R Hegde, Peter Mertens, Roman Biek
Pubblicato in: Virus Evolution, Numero 5/2, 2019, ISSN 2057-1577
Editore: Oxford University Press
DOI: 10.1093/ve/vez027

Global emergence and evolutionary dynamics of bluetongue virus

Autori: Moh A. Alkhamis, Cecilia Aguilar-Vega, Nicholas M. Fountain-Jones, Kai Lin, Andres M. Perez & José M. Sánchez-Vizcaíno
Pubblicato in: Scientific Reports, Numero 10, 21677 (2020), 2020, Pagina/e 10:21677, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-78673-9

Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model. Viruses

Autori: Houssam Attoui 1, Baptiste Monsion 1, Bernard Klonjkowski 1, Stéphan Zientara 1, Peter P C Mertens 2, Fauziah Mohd Jaafar 1
Pubblicato in: Viruses, 2021, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13112208

"""Frozen evolution"" of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence."

Autori: Pascall DJ, Nomikou K, Bréard E, Zientara S, Filipe ADS, Hoffmann B, Jacquot M, Singer JB, De Clercq K, Bøtner A, Sailleau C, Viarouge C, Batten C, Puggioni G, Ligios C, Savini G, van Rijn PA, Mertens PPC, Biek R, Palmarini M.
Pubblicato in: Plos Biology, 2020, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3000673

Western Bluetongue virus serotype 3 in Sardinia, diagnosis and characterization.

Autori: Cappai S, Rolesu S, Loi F, Liciardi M, Leone A, Marcacci M, Teodori L, Mangone I, Sghaier S, Portanti O, Savini G, Lorusso A.
Pubblicato in: Transboundary and Emerging Diseases, Numero 2019 May;66(3):1426-1431., 2019, Pagina/e 1426-1431., ISSN 1865-1682
Editore: Wiley
DOI: 10.1111/tbed.13156.

Presence of bluetongue and epizootic hemorrhagic disease viruses in Egypt in 2016 and 2017

Autori: Sahar Ahmed, Mohamed Abd El-Fatah Mahmoud, Cyril Viarouge, Corinne Sailleau, Stephan Zientara, Emmanuel Breard
Pubblicato in: Infection, Genetics and Evolution, Numero 73, 2019, Pagina/e 221-226, ISSN 1567-1348
Editore: Elsevier BV
DOI: 10.1016/j.meegid.2019.04.033

Recombinant Newcastle disease viruses with targets for PCR diagnostics for rinderpest and peste des petits ruminants

Autori: van Rijn PA, Boonstra J, van Gennip HGP.
Pubblicato in: J Virol Methods ., 2018, ISSN 0166-0934
Editore: Elsevier BV
DOI: 10.1016/j.jviromet.2018.06.007

Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved.

Autori: Mohd Jaafar, F.; Monsion, B.; Belhouchet, M.; Mertens, P.P.C.; Attoui, H.
Pubblicato in: Viruses, 2021, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13081437

The genome segments of bluetongue virus differ in copy number in a host-specific manner.

Autori: 14. Moreau Y, Gil P, Exbrayat A, Rakotoarivony I, Bréard E, Sailleau C, Viarouge C, Zientara S, Savini G, Goffredo M, Mancini G, Loire E, Gutierrez S.
Pubblicato in: J.Virol, 2021, ISSN 1098-5514
Editore: American Society for Microbiology
DOI: 10.1128/jvi.01834-20

Inhibition of Orbivirus Replication by Aurintricarboxylic Acid

Autori: Alonso C, Utrilla-Trigo S, Calvo-Pinilla E, Jiménez-Cabello L, Ortego J, Nogales A.
Pubblicato in: Int J Mol Sci., 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197294

Identifying Spanish Areas at More Risk of Monthly BTV Transmission with a Basic Reproduction Number Approach

Autori: Cecilia Aguilar-Vega, Jaime Bosch, Eduardo Fernández-Carrión, Javier Lucientes, José Manuel Sánchez-Vizcaíno
Pubblicato in: Viruses, Numero 12/10, 2020, Pagina/e 1158, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12101158

Mapping livestock movements in Sahelian Africa

Autori: Camille Jahel, Maxime Lenormand, Ismaila Seck, Andrea Apolloni, Ibra Toure, Coumba Faye, Baba Sall, Mbargou Lo, Cecile Squarzoni Diaw, Renaud Lancelot, Caroline Coste
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-65132-8

Bluetongue Disabled Infectious Single Animal (DISA) vaccine: Studies on the optimal route and dose in sheep.

Autori: van Rijn PA, Daus FJ, Maris-Veldhuis MA, Feenstra F, van Gennip RGP.
Pubblicato in: Vaccine, 2017, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2016.11.081

Bluetongue Virus in France: An Illustration of the European and Mediterranean Context since the 2000s

Autori: Cindy Kundlacz, Grégory Caignard, Corinne Sailleau, Cyril Viarouge, Lydie Postic, Damien Vitour, Stéphan Zientara, Emmanuel Breard
Pubblicato in: Viruses, Numero 11/7, 2019, Pagina/e 672, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11070672

Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor

Autori: Alejandro Marín-Lopez, Eva Calvo-Pinilla, Sandra Moreno, Sergio Utrilla-Trigo, Aitor Nogales, Alejandro Brun, Erol Fikrig, Javier Ortego
Pubblicato in: Viruses, Numero 11/1, 2019, Pagina/e 35, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11010035

A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host

Autori: Lisa M. Stevens, Katy Moffat, Lyndsay Cooke, Kyriaki Nomikou, Peter P. C. Mertens, Terry Jackson, Karin E. Darpel
Pubblicato in: Journal of General Virology, Numero 100/4, 2019, Pagina/e 568-582, ISSN 0022-1317
Editore: Society for General Microbiology
DOI: 10.1099/jgv.0.001240

“Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence

Autori: David J. Pascall, Kyriaki Nomikou, Emmanuel Bréard, Stephan Zientara, Ana da Silva Filipe, Bernd Hoffmann, Maude Jacquot, Joshua B. Singer, Kris De Clercq, Anette Bøtner, Corinne Sailleau, Cyril Viarouge, Carrie Batten, Giantonella Puggioni, Ciriaco Ligios, Giovanni Savini, Piet A. van Rijn, Peter P. C. Mertens, Roman Biek, Massimo Palmarini
Pubblicato in: PLOS Biology, Numero 18/4, 2020, Pagina/e e3000673, ISSN 1545-7885
Editore: Plos
DOI: 10.1371/journal.pbio.3000673

Environment, vector, or host? Using machine learning to untangle the mechanisms driving arbovirus outbreaks

Autori: Moh A. Alkhamis,Nicholas M. Fountain-Jones,Cecilia Aguilar-Vega,José M. Sánchez-Vizcaíno
Pubblicato in: Ecological Applications, Numero Vol.31,Numero 7, 2021, Pagina/e 31(7):e02407. 10.1002/eap.2407, ISSN 1939-5582
Editore: Ecological Society of America
DOI: 10.1002/eap.2407

Virological, immunological and pathological findings of transplacentally transmitted bluetongue virus serotype 1 in IFNAR1-blocked mice during early and mid gestation

Autori: Saminathan M, Singh KP, Vineetha S, Maity M, Biswas SK, Manjunathareddy GB, Chauhan HC, Milton AAP, Ramakrishnan MA, Maan S, Maan NS, Hemadri D, Chandel BS, Gupta VK, Mertens PPC.
Pubblicato in: Sci Rep., 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-58268-0

Evidence of reduced viremia, pathogenicity and vector competence in a re-emerging European strain of bluetongue virus serotype 8 in sheep.

Autori: Flannery J, Sanz-Bernardo B, Ashby M, Brown H, Carpenter S, Cooke L, Corla A, Frost L, Gubbins S, Hicks H, Qureshi M, Rajko-Nenow P, Sanders C, Tully M, Bréard E, Sailleau C, Zientara S, Darpel K, Batten C.
Pubblicato in: Transboundary and Emerging Diseases, 2019, ISSN 1865-1682
Editore: Wiley
DOI: 10.1111/tbed.13131.

African horse sickness in Thailand: Challenges of controlling an outbreak by vaccination,

Autori: Castillo-Olivares, J.,
Pubblicato in: Equine Vet Journal, 2021, ISSN 2042-3306
Editore: Wiley BEVA
DOI: 10.1111/evj.13353

A protective bivalent vaccine against Rift Valley fever and bluetongue. NPJ Vaccines.

Autori: Calvo-Pinilla E, Marín-López A, Moreno S, Lorenzo G, Utrilla-Trigo S, Jiménez-Cabello L, Benavides J, Nogales A, Blasco R, Brun A, Ortego J.
Pubblicato in: NPJ Vaccines, 2020, ISSN 2059-0105
Editore: Springer Nature
DOI: 10.1038/s41541-020-00218-y

Experimental infection of sheep, goats and cattle with a bluetongue virus serotype 4 field strain from Bulgaria, 2014

Autori: Schulz C, Sailleau C, Bréard E, Flannery J, Viarouge C, Zientara S, Beer M, Batten C, Hoffmann B.
Pubblicato in: Transbound Emerg Dis ., 2018, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.12746

Pentavalent Disabled Infectious Single Animal (DISA)/DIVA Vaccine Provides Protection in Sheep and Cattle against Different Serotypes of Bluetongue Virus.

Autori: van Rijn, P.A.; Maris-Veldhuis, M.A.; Spedicato, M.; Savini, G.; van Gennip, R.G.P.
Pubblicato in: Vaccines, 2021, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9101150

High dispersal capacity of Culicoides obsoletus (Diptera: Ceratopogonidae), vector of bluetongue and Schmallenberg viruses, revealed by landscape genetic analyses.

Autori: 10. Mignotte, A., Garros, C., Dellicour, S., Jacquot M., Gilbert M., Gardès L., Balenghien T., Duhayon M., Rakotoarivony I., de Wavrechin M., Huber K.
Pubblicato in: Parasit Vectors, 2021, ISSN 1756-3305
Editore: BioMed Central
DOI: 10.1186/s13071-020-04522-3

The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells.

Autori: Stokes S, Almire F, Tatham MH, McFarlane S, Mertens P, Pondeville E, Boutell C.
Pubblicato in: Plos Pathogens, 2020, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1009134

An advection-deposition-survival model to assess the risk of introduction of vector-borne diseases through the wind: Application to bluetongue outbreaks in Spain

Autori: Fernández-Carrión E, Ivorra B, Ramos ÁM, Martínez-López B, Aguilar-Vega C, Sánchez-Vizcaíno JM.
Pubblicato in: Plos One, 2018, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0194573

Continuous Cell Lines from the European Biting Midge Culicoides nubeculosus (Meigen, 1830)

Autori: Lesley Bell-Sakyi, Fauziah Mohd Jaafar, Baptiste Monsion, Lisa Luu, Eric Denison, Simon Carpenter, Houssam Attoui, Peter P. C. Mertens
Pubblicato in: Microorganisms, Numero 8/6, 2020, Pagina/e 825, ISSN 2076-2607
Editore: MDPI.AG
DOI: 10.3390/microorganisms8060825

CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR −/− Mice

Autori: Alejandro Marín-López, Eva Calvo-Pinilla, Diego Barriales, Gema Lorenzo, Alejandro Brun, Juan Anguita, Javier Ortego
Pubblicato in: Journal of Virology, Numero 92/16, 2018, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/jvi.00938-18

Bluetongue Serotype 3 in Israel 2013–2018: Clinical Manifestations of the Disease and Molecular Characterization of Israeli Strains

Autori: Natalia Golender, Velizar Bumbarov, Avi Eldar, Alessio Lorusso, Gabriel Kenigswald, Joseph Seffi Varsano, Dan David, Shani Schainin, Ilan Dagoni, Iosef Gur, Alon Kaplan, Anna Gorohov, Ori Koren, Eldad Oron, Yevgeny Khinich, Ily Sclamovich, Abraham Meir, Giovanni Savini
Pubblicato in: Frontiers in Veterinary Science, Numero 7, 2020, ISSN 2297-1769
Editore: Frontiers Media S.A.
DOI: 10.3389/fvets.2020.00112

Diagnostic DIVA tests accompanying the Disabled Infectious Single Animal (DISA) vaccine platform for African horse sickness

Autori: van Rijn PA, Maris-Veldhuis MA, Boonstra J, van Gennip RGP.
Pubblicato in: Vaccine, 2018, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2018.05.044

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue.

Autori: EFSA Panel on Animal Health and Welfare (AHAW); More S, Bicout D, Bøtner A, Butterworth A, Depner K, Edwards S, Garin-Bastuji B, Good M, Gortázar Schmidt C, Michel V, Miranda MA, Nielsen SS, Raj M, Sihvonen L, Spoolder H, Stegeman JA, Thulke HH, Velarde A, Willeberg P, Winckler C, Mertens P, Savini G, Zientara S, Broglia A, Baldinelli F, Gogin A, Kohnle L, Calistri P.
Pubblicato in: EFSA Journal, 2017, ISSN 1831-4732
Editore: Wiley
DOI: 10.2903/j.efsa.2017.4957

Prospects of Next-Generation Vaccines for Bluetongue

Autori: Piet A. van Rijn
Pubblicato in: Frontiers in Veterinary Science, Numero 6, 2019, Pagina/e 407-422, ISSN 2297-1769
Editore: Frontiers Media S.A.
DOI: 10.3389/fvets.2019.00407

BTV antibody longevity in cattle five to eight years post BTV-8 vaccination

Autori: Christina Ries 1, Martin Beer 1, Bernd Hoffmann 2
Pubblicato in: Vaccine, 2019, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2019.03.082.

Emergence of a Novel Reassortant Strain of Bluetongue Serotype 6 in Israel, 2017: Clinical Manifestations of the Disease and Molecular Characterization

Autori: Natalia Golender 1, Avi Eldar 2, Marcelo Ehrlich 3, Yevgeny Khinich 2, Gabriel Kenigswald 4, Joseph Seffi Varsano 5, Shachar Ertracht 6, Itzik Abramovitz 4, Itay Assis 4, Ily Shlamovitz 4, Eitan Tiomkin 4, Erez Yonay 7, Benny Sharir 4, Velizar Y Bumbarov 2
Pubblicato in: Viruses, 2019, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11070633.

Current and next-generation bluetongue vaccines: Requirements, strategies, and prospects for different field situations

Autori: Feenstra F, van Rijn PA
Pubblicato in: Crit Rev Microbiol ., 2017, ISSN 1040-841X
Editore: Taylor & Francis
DOI: 10.1080/1040841x.2016.1186005

Assessing the Risk of Occurrence of Bluetongue in Senegal.

Autori: 20. Gahn, M.C.B.; Niakh, F.; Ciss, M.; Seck, I.; Lo, M.M.; Fall, A.G.; Biteye, B.; Fall, M.; Ndiaye, M.; Ba, A.; Seck, M.T.; Sall, B.; Lo, M.; Faye, C.; Squarzoni-Diaw, C.; Ka, A.; Amevoin, Y.; Apolloni, A.
Pubblicato in: Microorganisms, 2020, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms8111766

Emergence of bluetongue virus serotype 4 in mainland France in November 2017.

Autori: Sailleau C, Breard E, Viarouge C, Gorlier A, Leroux A, Hirchaud E, Lucas P, Blanchard Y, Vitour D, Grandcollot-Chabot M, Zientara S.
Pubblicato in: Transbound Emerg Dis ., 2018, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.12919

Recombinant Rift Valley fever viruses encoding bluetongue virus (BTV) antigens: Immunity and efficacy studies upon a BTV-4 challenge

Autori: Moreno S, Calvo-Pinilla E, Devignot S, Weber F, Ortego J, Brun A.
Pubblicato in: PLoS Negl Trop Dis ., 2020, ISSN 1935-2735
Editore: Plos
DOI: 10.1371/journal.pntd.0008942

Concurrent infection of Bluetongue and Peste-des-petits-ruminants virus in small ruminants in Haryana State of India.

Autori: Maan S, Kumar A, Gupta AK, Dalal A, Chaudhary D, Gupta TK, Bansal N, Kumar V, Batra K, Sindhu N, Kumar A, Mahajan NK, Maan NS, Mertens PPC.
Pubblicato in: Transbound Emerg Dis ., 2018, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.12610

Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus

Autori: Sushila Maan, Manjunatha N. Belaganahalli, Narender Singh Maan, Abraham C. Potgieter, Peter P. C. Mertens
Pubblicato in: Brazilian Journal of Microbiology, Numero 50/1, 2019, Pagina/e 287-296, ISSN 1517-8382
Editore: Sociedade Braslleira de Microbiologia/Brazilian Society for Microbiology
DOI: 10.1007/s42770-018-0034-1

A study of the composition of the Obsoletus complex and genetic diversity of Culicoides obsoletus populations in Spain.

Autori: Cecilia Aguilar-Vega; Belén Rivera; Javier Lucientes; Isabel Gutiérrez-Boada; José Manuel Sánchez-Vizcaíno
Pubblicato in: Parasites & Vectors14, Numero 6, 2021, Pagina/e 351, ISSN 1756-3305
Editore: BioMed Central
DOI: 10.1186/s13071-021-04841-z

Bluetongue virus serotype 27: Experimental infection of goats, sheep and cattle with three BTV-27 variants reveal atypical characteristics and likely direct contact transmission BTV-27 between goats.

Autori: Bréard E, Schulz C, Sailleau C, Bernelin-Cottet C, Viarouge C, Vitour D, Guillaume B, Caignard G, Gorlier A, Attoui H, Gallois M, Hoffmann B, Zientara S, Beer M.
Pubblicato in: Transbound Emerg Dis ., 2018, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.12780

Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference

Autori: Maude Jacquot, Kyriaki Nomikou, Massimo Palmarini, Peter Mertens, Roman Biek
Pubblicato in: Proceedings of the Royal Society B: Biological Sciences, Numero 284/1864, 2017, Pagina/e 20170919, ISSN 0962-8452
Editore: Royal Society of London
DOI: 10.1098/rspb.2017.0919

Development of a Novel Reverse Transcription Loop-Mediated Isothermal Amplification Assay for the Rapid Detection of African Horse Sickness Virus

Autori: V. L. Fowler, E. L. A. Howson, J. Flannery, M. Romito, A. Lubisi, M. Agüero, P. Mertens, C. A. Batten, H. R. Warren, J. Castillo-Olivares
Pubblicato in: Transboundary and Emerging Diseases, Numero 64/5, 2017, Pagina/e 1579-1588, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.12549

Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines

Autori: Cristina C. Celma, Meredith Stewart, Kerstin Wernike, Michael Eschbaumer, Lorenzo Gonzalez-Molleda, Emmanuel Breard, Claudia Schulz, Bernd Hoffmann, Andy Haegeman, Kris De Clercq, Stephan Zientara, Piet A. van Rijn, Martin Beer, Polly Roy
Pubblicato in: Journal of Virology, Numero 91/1, 2016, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.01892-16

Viral Vector Vaccines against Bluetongue Virus

Autori: Jiménez-Cabello L, Utrilla-Trigo S, Calvo-Pinilla E, Moreno S, Nogales A, Ortego J, Marín-López A.
Pubblicato in: Microorganisms, 2020, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms9010042

PPR Control in a Sahelian Setting: What Vaccination Strategy for Mauritania?

Autori: Ahmed Salem ElArbi, Yaghouba Kane, Raphaelle Metras, Pachka Hammami, Mamadou Ciss, Assane Beye, Renaud Lancelot, Adama Diallo, Andrea Apolloni
Pubblicato in: Frontiers in Veterinary Science, Numero 6, 2019, ISSN 2297-1769
Editore: Frontiers Media S.A
DOI: 10.3389/fvets.2019.00242

Red deer (Cervus elaphus) Did Not Play the Role of Maintenance Host for Bluetongue Virus in France: The Burden of Proof by Long-Term Wildlife Monitoring and Culicoides Snapshots

Autori: Sophie Rossi, Thomas Balenghien, Cyril Viarouge, Eva Faure, Gina Zanella, Corinne Sailleau, Bruno Mathieu, Jean-Claude Delécolle, Camille Ninio, Claire Garros, Laëtitia Gardès, Christophe Tholoniat, Agnès Ariston, Dominique Gauthier, Stevan Mondoloni, Aurélie Barboiron, Maryline Pellerin, Philippe Gibert, Corinne Novella, Stéphane Barbier, Etienne Guillaumat, Stéphan Zientara, Damien Vitour
Pubblicato in: Viruses, Numero 11/10, 2019, Pagina/e 903, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11100903

The tree that hides the forest: cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus Complex (Diptera: Ceratopogonidae) at the European level

Autori: Antoine Mignotte, Claire Garros, Laetitia Gardès, Thomas Balenghien, Maxime Duhayon, Ignace Rakotoarivony, Laura Tabourin, Léa Poujol, Bruno Mathieu, Adolfo Ibañez-Justicia, Ahmet Deniz, Aleksandar Cvetkovikj, Bethan V. Purse, David W. Ramilo, Despoina Stougiou, Doreen Werner, Dubravka Pudar, Dušan Petrić, Eva Veronesi, Frans Jacobs, Helge Kampen, Isabel Pereira da Fonseca, Javier Lucientes,
Pubblicato in: Parasites & Vectors, Numero 13/1, 2020, ISSN 1756-3305
Editore: BioMed Central
DOI: 10.1186/s13071-020-04114-1

One after the other: A novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North-western Italy), extends the panel of novel atypical BTV strains

Autori: Marcacci M, Sant S, Mangone I, Goria M, Dondo A, Zoppi S, van Gennip RGP, Radaelli MC, Cammà C, van Rijn PA, Savini G, Lorusso A.
Pubblicato in: Transbound Emerg Dis ., 2018, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.12822

The possible route of introduction of bluetongue virus serotype 3 into Sicily by windborne transportation of infected Culicoides spp.

Autori: Cecilia Aguilar‐Vega, Eduardo Fernández‐Carrión, José M. Sánchez‐Vizcaíno
Pubblicato in: Transboundary and Emerging Diseases, 2019, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.13201

A model for the assessment of bluetongue virus serotype 1 persistence in Spain

Autori: Cecilia Aguilar-Vega, Eduardo Fernández-Carrión, Javier Lucientes, José Manuel Sánchez-Vizcaíno
Pubblicato in: PLOS ONE, Numero 15/4, 2020, Pagina/e e0232534, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0232534

African horse sickness virus (AHSV) with a deletion of 77 amino acids in NS3/NS3a protein is not virulent and a safe promising AHS Disabled Infectious Single Animal (DISA) vaccine platform

Autori: van Rijn PA, Maris-Veldhuis MA, Potgieter CA, van Gennip RGP.
Pubblicato in: Vaccine, 2018, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2018.03.003

Molecular typing of Bluetongue virus using the nCounter® analysis system platform.

Autori: Curini V, Marcacci M, Tonelli A, Di Teodoro G, Di Domenico M, D'Alterio N, Portanti O, Ancora M, Savini G, Panfili M, Camma' C, Lorusso A.
Pubblicato in: Journal of Virological Methods., 2019, ISSN 0166-0934
Editore: Elsevier BV
DOI: 10.1016/j.jviromet.2019.04.002.

Diversity of Transmission Outcomes Following Co-Infection of Sheep with Strains of Bluetongue Virus Serotype 1 and 8

Autori: Eva Veronesi, Karin Darpel, Simon Gubbins, Carrie Batten, Kyriaki Nomikou, Peter Mertens, Simon Carpenter
Pubblicato in: Microorganisms, Numero 8/6, 2020, Pagina/e 851, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms8060851

Ecological niche modelling to estimate the distribution of Culicoides, potential vectors of bluetongue virus in Senegal

Autori: Mamadou Ciss, Biram Biteye, Assane Gueye Fall, Moussa Fall, Marie Cicille Ba Gahn, Louise Leroux & Andrea Apolloni
Pubblicato in: BMC Ecology, 2019, ISSN 1472-6785
Editore: BioMed Central
DOI: 10.1186/s12898-019-0261-9

Re-parameterisation of a mathematical model of African horse horse sickness virus using data from a systematic literature search.

Autori: Fairbanks EL, Brennan ML, Mertens PPC, Tildesley MJ, Daly JM.
Pubblicato in: ransbound Emerg Dis ., 2022, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.14420

An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins.

Autori: 8. Guimerà Busquets, M.; Pullinger, G.D.; Darpel, K.E.; Cooke, L.; Armstrong, S.; Simpson, J.; Palmarini, M.; Fragkoudis, R.; Mertens, P.P.C.
Pubblicato in: Viruses, 2021, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13050919

Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes.

Autori: Fay, P.C.; Mohd Jaafar, F.; Batten, C.; Attoui, H.; Saunders, K.; Lomonossoff, G.P.; Reid, E.; Horton, D.; Maan, S.; Haig, D.; Daly, J.M.; Mertens, P.P.C.
Pubblicato in: Viruses, 2021, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13081455.

Complete Coding Sequence of a Novel Bluetongue Virus Isolated from a Commercial Sheeppox Vaccine

Autori: Paulina Rajko-Nenow, Natalia Golender, Velizar Bumbarov, Hannah Brown, Lorraine Frost, Karin Darpel, Chandana Tennakoon, John Flannery, Carrie Batten
Pubblicato in: Microbiology Resource Announcements, Numero 9/10, 2020, ISSN 2576-098X
Editore: American Society for Microbiology
DOI: 10.1128/mra.01539-19

Identification of a BTV-Strain-Specific Single Gene That Increases Culicoides Vector Infection Rate

Autori: 13. Ropiak HM, King S, Busquets MG, Newbrook K, Pullinger GD, Brown H, Flannery J, Gubbins S, Batten C, Rajko-Nenow P, Darpel KE.
Pubblicato in: Viruses, 2021, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13091781

Heterologous combination of ChAdOx1 and MVA vectors expressing protein NS1 as vaccination strategy to induce durable and cross-protective CD8+ T cell immunity to bluetongue virus.

Autori: Utrilla-Trigo S, Jiménez-Cabello L, Alonso-Ravelo R, Calvo-Pinilla E, Marín-López A, Moreno S, Lorenzo G, Benavides J, Gilbert S, Nogales A, Ortego J.
Pubblicato in: Vaccines (Basel) ., 2020, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8030346

Isolation and evolutionary analysis of Australasian topotype of bluetongue virus serotype 4 from India

Autori: Reddy YV, Susmitha B, Patil S, Krishnajyothi Y, Putty K, Ramakrishna KV, Sunitha G, Devi BV, Kavitha K, Deepthi B, Krovvidi S, Reddy YN, Reddy GH, Singh KP, Maan NS, Hemadri D, Maan S, Mertens PP, Hegde NR, Rao PP.
Pubblicato in: Transbound Emerg Dis ., 2017, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.12738

Serological status for BTV-8 in French cattle prior to the 2015 re-emergence

Autori: Courtejoie N, Durand B, Bréard E, Sailleau C, Vitour D, Zientara S, Gorlier A, Baurier F, Gourmelen C, Benoit F, Achour H, Milard C, Poliak S, Pagneux C, Viarouge C, Zanella G.
Pubblicato in: Transbound Emerg Dis ., 2018, ISSN 1865-1674
Editore: Blackwell-Wiss.-Verl
DOI: 10.1111/tbed.12718

Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR −/− mice

Autori: Petra C. Fay, Houssam Attoui, Carrie Batten, Fauziah Mohd Jaafar, George P. Lomonossoff, Janet M. Daly, Peter P.C. Mertens
Pubblicato in: Vaccine: X, Numero 2, 2019, Pagina/e 100026, ISSN 2590-1362
Editore: Elsevier
DOI: 10.1016/j.jvacx.2019.100026

Other (1)

Evolutionary stasis of an RNA virus indicates arbovirus re-emergence triggered by accidental release

Autori: David J Pascall, View ORCID ProfileKyriaki Nomikou, Emmanuel Bréard, Stephan Zientara, Ana da Silva Filipe, View ORCID ProfileBernd Hoffmann, View ORCID ProfileMaude Jacquot, View ORCID ProfileJoshua B. Singer, View ORCID ProfileKris De Clercq, Anette Bøtner, Corinne Sailleau, Cyrille Viarouge, Carrie Batten, Giantonella Puggioni, Ciriaco Ligios, Giovanni Savini, Piet A. van Rijn, Peter PC
Pubblicato in: 2019
Editore: BioRxiv
DOI: 10.1101/2019.12.11.872705

Monographic books (1)

Bluetongue Virus: From BTV-1 to BTV-27

Autori: Belbis G, Zientara S, Bréard E, Sailleau C, Caignard G, Vitour D, Attoui H.
Pubblicato in: Adv Virus Res ., 2017
Editore: Elsevier
DOI: 10.1016/bs.aivir.2017.08.003