Deliverables Documents, reports (28) Initial draft of Data management plan (Open data pilot) A workflow and checklist for experimental design and informatics workflow for risk assessment for use in WP9 Training Needs Specification and Proposed Solutions Report on needs identification for new member states and Action plan proposed Report on 2nd series demonstration cases and analysis of remaining weaknesses Initial version of NanoCommons Sustainability Plan First Testing and Evaluation Results of NanoCommons Sustainability Plan Description of tools for automated data mining Dissemination strategy First TA Resource Access and Use Report Action Plan for Year 3 3rd Annual conference & nano-exploitation day, social web activities, stakeholder workshop with TA calls/ demonstrations 3rd Annual conference nanoexploitation day social web activities stakeholder workshop with TA calls demonstrations First Demonstration cases selected Second Testing and Evaluation Results of NanoCommons Sustainability Plan First Report on Training Activities, focussing on virtual tools Community suggestion box and 1st rolling call (and evaluation) –Action plan Year 2 Report on 1st series demonstration cases and 2nd series selected Workshops with different stakeholders Action Plan for Year 4 A workflow and checklist of key information needed from modelling tool owners to facilitate integration into KB Final version of NanoCommons Sustainability Plan 2nd Annual conference & nano-exploitation day, stakeholder workshop with TA calls and demonstrations Initial NanoCommons Ontology Final report on utilisation of Helpdesk, Tutorials and FAQ, stakeholder distribution (experimental, modellers, SME / enterprise, regulatory, other) and on TA provision overall Final report on utilisation of Helpdesk Tutorials and FAQ stakeholder distribution experimental modellers SME enterprise regulatory other and on TA provision overall Interactions Needs and Goals of Nano Safety Projects and Programs 1st set of stakeholder workshops and Report on Stakeholder feedback on usability of NanoCommons portal & tools Final Report on Training Activities and analysis of stakeholder groups reached Final Guidance on Emerging Data and Metadata Standards Demonstrators, pilots, prototypes (10) AOP-based grouping of ENMs First corona simulation tools integrated into NanoCommons KnowledgeBase Firstraw data processing and knowledge extraction tools integrated into KB and first theoretical descriptor calculation services available Firstraw data processing and knowledge extraction tools integrated into KB and first theoretical descriptor calculation services available First tools for MIE prediction integrated into NanoCommons KnowledgeBase First predictive nanoQSAR models integrated into NanoCommons KnowledgeBase Initial Knowledge Infrastructure Functionalities and Services Implemented First version of data warehouse & collaborative knowledge infrastructure Initial integration of decision support system for safe-by-design strategy Initial version of integrated web-based decision support system for regulators First big data (omics) analysis and mining tools integrated into KnowledgeBase Other (1) 1st Annual conference & nano-exploitation day, stakeholder workshop & User call Open Research Data Pilot (1) Final version of Open Data management plan (Open data pilot) Final version of Open Data management plan Open data pilot Publications Peer reviewed articles (59) Iron oxide nanoparticles in bioimaging – an immune perspective Author(s): Geppert M. and Himly M. Published in: Front Immunol, Issue 16643224, 2021, ISSN 1664-3224 Publisher: Front Immunol DOI: 10.3389/fimmu.2021.688927 Improved characterisation of clinical text through ontology-based vocabulary expansion Author(s): Luke T. Slater, William Bradlow, Simon Ball, Robert Hoehndorf and Georgios V Gkoutos Published in: Journal of Biomedical Semantics, Issue 20411480, 2021, ISSN 2041-1480 Publisher: Springer-Nature DOI: 10.1186/s13326-021-00241-5 Mechanisms of Particles in Sensitization, Effector Function and Therapy of Allergic Disease Author(s): Anna I. Joubert, Mark Geppert, Litty Johnson, Robert Mills-Goodlet, Sara Michelini, Evgeniia Korotchenko, Albert Duschl, Richard Weiss, Jutta Horejs-Höck, Martin Himly Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2020.01334 Ten simple rules for creating reusable pathway models for computational analysis and visualization Author(s): K. Hanspers, M. Kutmon, S. L. Coort, D. Digles, L. J. Dupuis, F. Ehrhart, F. Hu, E. N. Lopes, M. Martens, N. Pham, W. Shin, D. N. Slenter, A. Waagmeester, E. L. Willighagen, L. A. Winckers, C. T. Evelo, A. R. Pico Published in: Plos Computational Biology, Issue 15537358, 2021, ISSN 1553-7358 Publisher: PLOS DOI: 10.1371/journal.pcbi.1009226 Toxicokinetics of pristine and aged silver nanoparticles in Physa acuta Author(s): Patrícia V. Silva, Cornelis A. M. van Gestel, Rudo A. Verweij, Anastasios G. Papadiamantis, Sandra F. Gonçalves, Iseult Lynch and Susana Loureiro Published in: Environmental Science: Nano, Issue 20518161, 2020, ISSN 2051-8161 Publisher: Royal Society of Chemistry DOI: 10.1039/d0en00946f Surface Functionalization of Graphene-Based Materials: Biological Behavior, Toxicology, and Safe-By-Design Aspects Author(s): Zhiling Guo, Swaroop Chakraborty, Fazel Abdolahpur Monikh, Dimitra-Danai Varsou, Andrew J Chetwynd, Antreas Afantitis, Iseult Lynch, Peng Zhang Published in: Advanced Biology, Issue 27010198, 2021, ISSN 2701-0198 Publisher: Wiley DOI: 10.1002/adbi.202100637 The earthworm microbiome is resilient to exposure to biocidal metal nanoparticles Author(s): Elmer Swart; Tim Goodall; Peter Kille; David J. Spurgeon; Claus Svendsen; Published in: Journal: Environmental Pollution, Issue 02697491, 2020, ISSN 0269-7491 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.envpol.2020.115633 Can Systems Biology Advance Clinical Precision Oncology? Author(s): Andrea Rocca Boris N. Kholodenko Published in: Cancers, Issue 20726694, 2021, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13246312 Daphnia magna and mixture toxicity with nanomaterials – Current status Author(s): Diego Stéfani T. Martinez, Laura-Jayne A. Ellis, Gabriela H. Da Silva, Romana Petry, Aline M.Z. Medeiros, Hossein Hayat Davoudi, Anastasios G. Papadiamantis, Adalberto Fazzio, Antreas Afantitis, Georgia Melagraki, Iseult Lynch Published in: NanoToday, Issue 17480132, 2022, ISSN 1748-0132 Publisher: Elsevier BV DOI: 10.1016/j.nantod.2022.101430 WikiPathways: connecting communities Author(s): Marvin Martens, Ammar Ammar, Anders Riutta, Andra Waagmeester, Denise N Slenter, Kristina Hanspers, Ryan A. Miller, Daniela Digles, Elisson N Lopes, Friederike Ehrhart, Lauren J Dupuis, Laurent A Winckers, Susan L Coort, Egon L Willighagen, Chris T Evelo, Alexander R Pico, Martina Kutmon Published in: Nucleic Acids Research, Issue 49/D1, 2020, Page(s) D613-D621, ISSN 0305-1048 Publisher: Oxford University Press DOI: 10.1093/nar/gkaa1024 Biological effects of allergen-nanoparticle conjugates: uptake and immune effects determined on hAELVi cells under submerged vs. air-liquid interface conditions Author(s): Mills-Goodlet R., Schenck M., Chary A., Geppert M., Serchi T., Hofer S., Hofstätter N., Feinle A., Hüsing N., Gutleb A.C., Himly M., and Duschl A. Published in: Environ. Sci. Nano., Issue 20518161, 2020, ISSN 2051-8161 Publisher: Royal Society of Chemistry DOI: 10.1039/C9EN01353A Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction. Author(s): Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde & Boris N. Kholodenko Published in: Scientific Reports, Issue 20452322, 2018, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-018-34353-3 Surface functionalization of silica nanoparticles: strategies to optimize the immune-activating profile of biopharmaceutical carrier platforms Author(s): Punz B., Johnson L., Geppert M., Dang H.-H., Horejs-Hoeck J., Duschl A., and Himly M. Published in: Pharmaceutics, Issue 19994923, 2022, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics14051103 Editorial for the Special Issue From Nanoinformatics to Nanomaterials Risk Assessment and Governance Author(s): Iseult Lynch, Antreas Afantitis, Dario Greco, Maria Dusinska, Miguel A. Banares, Georgia Melagraki Published in: Nanomaterials, Issue 11/1, 2021, Page(s) 121, ISSN 2079-4991 Publisher: MDPI DOI: 10.3390/nano11010121 A survey on the state of nanosafety research in the European Union and the United States. Author(s): Duschl, A., Windgasse, G. Published in: J Nanopart Res, Issue 13880764, 2018, ISSN 1388-0764 Publisher: Kluwer Academic Publishers DOI: 10.1007/s11051-018-4434-9 Can an InChI for Nano Address the Need for a Simplified Representation of Complex Nanomaterials across Experimental and Nanoinformatics Studies? Author(s): Iseult Lynch, Antreas Afantitis, Thomas Exner, Martin Himly, Vladimir Lobaskin, Philip Doganis, Dieter Maier, Natasha Sanabria, Anastasios G. Papadiamantis, Anna Rybinska-Fryca, Maciej Gromelski, Tomasz Puzyn, Egon Willighagen, Blair D. Johnston, Mary Gulumian, Marianne Matzke, Amaia Green Etxabe, Nathan Bossa, Angela Serra, Irene Liampa, Stacey Harper, Kaido Tämm, Alexander CØ Jensen, Pekka Koh Published in: Nanomaterials, Issue 10/12, 2020, Page(s) 2493, ISSN 2079-4991 Publisher: MDPI DOI: 10.3390/nano10122493 Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study Author(s): Ewan Carr, Rebecca Bendayan, Daniel Bean, Matt Stammers, Wenjuan Wang, Huayu Zhang, Thomas Searle, Zeljko Kraljevic, Anthony Shek, Hang T. T. Phan, Walter Muruet, Rishi K. Gupta, Anthony J. Shinton, Mike Wyatt, Ting Shi, Xin Zhang, Andrew Pickles, Daniel Stahl, Rosita Zakeri, Mahdad Noursadeghi, Kevin O’Gallagher, Matt Rogers, Amos Folarin, Andreas Karwath, Kristin E. Wickstrøm, Alvaro Köhn-Lu Published in: BMC Medicine, Issue 17417015, 2021, ISSN 1741-7015 Publisher: BioMed Central DOI: 10.1186/s12916-020-01893-3 Apellis: An online tool for read-across model development Author(s): Dimitra-Danai Varsou, Haralambos Sarimveis Published in: Computational Toxicology, Issue 17, 2021, Page(s) 100146, ISSN 2468-1113 Publisher: Science Direct DOI: 10.1016/j.comtox.2020.100146 The nanotopography of SiO2 particles impacts selectivity and 3D fold of bound allergens Author(s): Mills-Goodlet R., Johnson L., Hoppe I.J., Regl C., Geppert M., Schenck M., Huber S., Hauser M., Ferreira F., Hüsing N., Huber C.G., Brandstetter H., Duschl A., and Himly M. Published in: Nanoscale, Issue 20403372, 2021, ISSN 2040-3372 Publisher: Nanoscale DOI: 10.1039/d1nr05958k Metadata Stewardship in Nanosafety Research: Community-Driven Organisation of Metadata Schemas to Support FAIR Nanoscience Data Author(s): Anastasios G. Papadiamantis, Frederick C. Klaessig, Thomas E. Exner, Sabine Hofer, Norbert Hofstaetter, Martin Himly, Marc A. Williams, Philip Doganis, Mark D. Hoover, Antreas Afantitis, Georgia Melagraki, Tracy S. Nolan, John Rumble, Dieter Maier, Iseult Lynch Published in: Nanomaterials, Issue 10/10, 2020, Page(s) 2033, ISSN 2079-4991 Publisher: MDPI DOI: 10.3390/nano10102033 Mechanistic insights into toxicity pathways induced by nanomaterials in Daphnia magna from analysis of the composition of the acquired protein corona Author(s): Laura-Jayne A. Ellis and Iseult Lynch Published in: Environmental Science Nano, Issue 20518161, 2020, ISSN 2051-8161 Publisher: Royal Society of Chemistry DOI: 10.1039/d0en00625d Children’s privilege in COVID-19: The protective role of the juvenile lung morphometry and ventilatory pattern on airborne SARS-CoV-2 transmission and severe pulmonary disease Author(s): Hofstätter N., Hofer S., Duschl A., and Himly M. Published in: MDPI, Issue 22279059, 2021, ISSN 2227-9059 Publisher: MDPI DOI: 10.3390/biomedicines9101414 Toxicokinetics of silver nanoparticles in the mealworm Tenebrio molitor exposed via soil or food Author(s): Zahra Khodaparast, Cornelis A.M.van Gestel, Anastasios G.Papadiamantis, Sandra F.Gonçalves, Iseult Lynch, Susana Loureiro Published in: Science Direct, Issue 00489697, 2021, ISSN 0048-9697 Publisher: Elsevier BV DOI: 10.1016/j.scitotenv.2021.146071 A Semi-Automated Workflow for FAIR Maturity Indicators in the Life Sciences Author(s): Ammar Ammar, Serena Bonaretti, Laurent Winckers, Joris Quik, Martine Bakker, Dieter Maier, Iseult Lynch, Jeaphianne van Rijn, Egon Willighagen Published in: Nanomaterials, Issue 10/10, 2020, Page(s) 2068, ISSN 2079-4991 Publisher: nanomaterials DOI: 10.3390/nano10102068 Systems biology approaches to macromolecules: the role of dynamic protein assemblies in information processing Author(s): Oleksii Rukhlenko, Boris N Kholodenko, Walter Kolch Published in: Current Opinion in Structural Biology, Issue 0959440X, 2021, ISSN 0959-440X Publisher: Elsevier BV DOI: 10.1016/j.sbi.2020.09.007 Towards semantic interoperability: finding and repairing hidden contradictions in biomedical ontologies Author(s): Luke T. Slater, Georgios V. Gkoutos & Robert Hoehndorf Published in: BMC Med Inform Decis Mak, Issue 14726947, 2020, ISSN 1472-6947 Publisher: BioMed Central DOI: 10.1186/s12911-020-01336-2 Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts Author(s): L. A. Winckers, C. T. Evelo, E. L. Willighagen, M. Kutmon Published in: International Journal of Molecular Sciences, Issue 14220067, 2021, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22179432 Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model Author(s): Zhiling Guo, Peng Zhang, Swaroop Chakraborty, Andrew J Chetwynd, Fazel Abdolahpur Monikh, Christopher Stark, Hanene Ali-Boucetta, Sandra Wilson, Iseult Lynch, Eugenia Valsami-Jones Published in: Proceedings of the National Academy of Sciences, Issue 118/28, 2021, Page(s) e2105245118, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.2105245118 Nanocharacterization, Materials Modeling, and Research Integrity as Enablers of Sound Risk Assessment: Designing Responsible Nanotechnology Author(s): Ioannis Xiarchos, Athanasios K. Morozinis, Panagiotis Kavouras, Costas A. Charitidis Published in: Small, Issue 16/36, 2020, Page(s) 2001590, ISSN 1613-6810 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/smll.202001590 Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration Author(s): Alfonso Bolado-Carrancio, Oleksii S Rukhlenko, Elena Nikonova, Mikhail A Tsyganov, Anne Wheeler, Amaya Garcia-Munoz, Walter Kolch, Alex von Kriegsheim Is a corresponding author, Boris N Kholodenko Published in: eLife Science, Issue 2050084X, 2020, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/elife.58165 Structural alterations of antigens at the material interface: an early decision toolbox facilitating Safe-by-Design nanovaccine development Author(s): Johnson L., Aglas L., Soh W.T., Geppert M., Hofer S., Hofstätter N., Briza P., Ferreira F., Weiss R., Brandstetter H., Duschl A., and Himly M. Published in: Int. J. Mol. Sci., Issue 14220067, 2021, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms221910895 Nanomaterials exposure, extracellular vesicles biogenesis and adverse cellular outcomes: a scoping review Author(s): Lima T.S.M., de Souza W., Geaquinto L.R.O., Sanches P.L., Stepień E.L., Meneses J., Fernández de Gortari E., Meisner-Kober N., Himly M., Granjeiro J.M., and Ribeiro A.R.L.P. Published in: Nanomaterials, Issue 20794991, 2022, ISSN 2079-4991 Publisher: MDPI DOI: 10.3390/nano12071231 Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials Author(s): James D. Ede, Vladimir Lobaskin, Ulla Vogel, Iseult Lynch, Sabina Halappanavar, Shareen H. Doak, Megan G. Roberts, Jo Anne Shatkin Published in: Nanomaterials, Issue 10/6, 2020, Page(s) 1229, ISSN 2079-4991 Publisher: MDPI DOI: 10.3390/nano10061229 A safe-by-design tool for functionalised nanomaterials through the Enalos Nanoinformatics Cloud platform Author(s): Dimitra-Danai Varsou, Antreas Afantitis, Andreas Tsoumanis, Georgia Melagraki, Haralambos Sarimveis, Eugenia Valsami-Jones, Iseult Lynch Published in: Nanoscale Advances, Issue Nanoscale Advances, 2019, ISSN 2516-0230 Publisher: RSC DOI: 10.1039/C8NA00142A Read-across predictions of nanoparticle hazard endpoints: a mathematical optimization approach Author(s): Dimitra-Danai Varsou, Antreas Afantitis, Georgia Melagraki, Haralambos Sarimveis Published in: Nanoscale Advances, 2019, ISSN 2516-0230 Publisher: Royal Society of Chemistry DOI: 10.1039/c9na00242a Zeta‐Potential Read‐Across Model Utilizing Nanodescriptors Extracted via the NanoXtract Image Analysis Tool Available on the Enalos Nanoinformatics Cloud Platform Author(s): Dimitra‐Danai Varsou, Antreas Afantitis, Andreas Tsoumanis, Anastasios Papadiamantis, Eugenia Valsami‐Jones, Iseult Lynch, Georgia Melagraki Published in: Small, 2020, Page(s) 1906588, ISSN 1613-6810 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/smll.201906588 When Would Immunologists Consider a Nanomaterial to be Safe? Recommendations for Planning Studies on Nanosafety Author(s): Martin Himly, Mark Geppert, Sabine Hofer, Norbert Hofstätter, Jutta Horejs-Höck, Albert Duschl Published in: Small, 2020, Page(s) 1907483, ISSN 1613-6810 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/smll.201907483 Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor Author(s): Keesha E. Erickson, Oleksii S. Rukhlenko, Md Shahinuzzaman, Kalina P. Slavkova, Yen Ting Lin, Ryan Suderman, Edward C. Stites, Marian Anghel, Richard G. Posner, Dipak Barua, Boris N. Kholodenko, William S. Hlavacek Published in: PLOS Computational Biology, Issue 15/1, 2019, Page(s) e1006706, ISSN 1553-7358 Publisher: journal plos org DOI: 10.1371/journal.pcbi.1006706 The rise of the nanomaterial metabolite corona, and emergence of the complete corona Author(s): Andrew J. Chetwynd, Iseult Lynch Published in: Environmental Science: Nano, Issue 7/4, 2020, Page(s) 1041-1060, ISSN 2051-8153 Publisher: Royal Society of Chemistry DOI: 10.1039/c9en00938h An Integrative Computational Approach for a Prioritization of Key Transcription Regulators Associated With Nanomaterial-Induced Toxicity Author(s): Vadim Zhernovkov, Tapesh Santra, Hilary Cassidy, Oleksii Rukhlenko, David Matallanas, Aleksandar Krstic, Walter Kolch, Vladimir Lobaskin, Boris N Kholodenko Published in: Toxicological Sciences, Issue 171/2, 2019, Page(s) 303-314, ISSN 1096-6080 Publisher: Oxford University Press DOI: 10.1093/toxsci/kfz151 Mapping connections in signaling networks with ambiguous modularity Author(s): Daniel Lill, Oleksii S. Rukhlenko, Anthony James Mc Elwee, Eugene Kashdan, Jens Timmer, Boris N. Kholodenko Published in: npj Systems Biology and Applications, Issue 5/1, 2019, ISSN 2056-7189 Publisher: npj Systems Biology and Applications DOI: 10.1038/s41540-019-0096-1 Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D Author(s): Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-019-14224-9 Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling Author(s): Oleksii S. Rukhlenko, Fahimeh Khorsand, Aleksandar Krstic, Jan Rozanc, Leonidas G. Alexopoulos, Nora Rauch, Keesha E. Erickson, William S. Hlavacek, Richard G. Posner, Silvia Gómez-Coca, Edina Rosta, Cheree Fitzgibbon, David Matallanas, Jens Rauch, Walter Kolch, Boris N. Kholodenko Published in: Cell Systems, Issue 7/2, 2018, Page(s) 161-179.e14, ISSN 2405-4712 Publisher: Science Direct DOI: 10.1016/j.cels.2018.06.002 Semantic Interoperability and Characterization of Data Provenance in Computational Molecular Engineering Author(s): Martin Thomas Horsch, Christoph Niethammer, Gianluca Boccardo, Paola Carbone, Silvia Chiacchiera, Mara Chiricotto, Joshua D. Elliott, Vladimir Lobaskin, Philipp Neumann, Peter Schiffels, Michael A. Seaton, Ilian T. Todorov, Jadran Vrabec, Welchy Leite Cavalcanti Published in: Journal of Chemical & Engineering Data, Issue 65/3, 2020, Page(s) 1313-1329, ISSN 0021-9568 Publisher: American Chemical Society DOI: 10.1021/acs.jced.9b00739 Automated Grouping of Nanomaterials and Read-Across Prediction of Their Adverse Effects Based on Mathematical Optimization Author(s): Dimitra-Danai Varsou, Nikoletta-Maria Koutroumpa, and Haralambos Sarimveis Published in: J. Chem. Inf. Model., Issue 15499596, 2021, Page(s) 2766–2779, ISSN 1549-9596 Publisher: American Chemical Society DOI: 10.1021/acs.jcim.1c00199 Multi-walled carbon nanotubes improve nitrogen use efficiency and nutritional quality in Brassica campestris† Author(s): Shixin Cai, Peng Zhang, Zhiling Guo, Feng Jin, Jingyuan Wang, Zijie Song, Tcyganova Nadezhda, Iseult Lynch and Xiuli Dang Published in: Environ. Sci.: Nano, Issue 20518161, 2022, Page(s) 1315-1329, ISSN 2051-8161 Publisher: Royal Society of Chemistry DOI: 10.1039/d1en01211h European Registry of Materials: global, unique identifiers for (undisclosed) nanomaterials Author(s): J. van Rijn, A. Afantitis, M. Culha, M. Dusinska, T. Exner, N. Jeliazkova, E.M. Longhin, I. Lynch, G. Melagraki, P. Nymark, A.G. Papadiamantis, D.A. Winkler, H. Yilmaz, E.L. Willighagen Published in: Journal of Cheminformatics, Issue 17582946, 2021, ISSN 1758-2946 Publisher: Chemistry Central DOI: 10.1186/s13321-022-00614-7 Nanotechnology-Based Vaccines for Allergen-Specific Immunotherapy: Potentials and Challenges of Conventional and Novel Adjuvants under Research Author(s): Johnson L., Duschl A., and Himly M. Published in: MDPI, Issue 2076393X, 2020, ISSN 2076-393X Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/vaccines8020237 The impact of nanoparticles on innate immune activation by live bacteria. Author(s): Swartzwelter B.J., Fux A.C., Johnson L., Swart E., Hofer S., Hofstätter N., Geppert M., Italiani P., Boraschi D., Duschl A., and Himly M. Published in: Int. J. Mol. Sci., Issue 14220067, 2020, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21249695 First principles characterisation of bio–nano interface Author(s): Ian Rouse, David Power, Erik G. Brandt, Matthew Schneemilch, Konstantinos Kotsis, Nick Quirke, Alexander P. Lyubartsev and Vladimir Lobaskin Published in: Physical Chemistry Chemical Physics, Issue 14639084, 2021, ISSN 1463-9084 Publisher: Royal Society of Chemistry DOI: 10.1039/d1cp01116b Ecotoxicological read-across models for predicting acute toxicity of freshly dispersed versus medium-aged NMs to Daphnia magna Author(s): Dimitra-Danai Varsou, Laura-Jayne A. Ellis, Antreas Afantitis, Georgia Melagraki, Iseult Lynch Published in: Chemosphere, Issue 285, 2021, Page(s) 131452, ISSN 0045-6535 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.chemosphere.2021.131452 Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade Author(s): Olesja Bondarenko, Monika Mortimer, Anne Kahru, Neus Feliu, Ibrahim Javed, Aleksandr Kakinen, Sijie Lin, Tian Xia, Yang Song, Thomas P. Davis, Iseult Lynch, Wolfgang J. Parak, David Tai Leong, Pu Chun Ke,Chunying Chen, Yuliang Zhao Published in: NanoToday, Issue 17480132, 2021, Page(s) 101, ISSN 1748-0132 Publisher: Elsevier BV DOI: 10.1016/j.nantod.2021.101184 Computational prediction and experimental analysis of the nanoparticle-protein corona: showcasing an in vitro-in silico workflow providing FAIR data Author(s): Hasenkopf I., Mills-Goodlet R., Johnson L., Rouse I., Geppert M,. Duschl A., Maier D., Lobaskin V., Lynch I., and Himly M. Published in: NanoToday, Issue 17480132, 2022, ISSN 1748-0132 Publisher: Elsevier BV DOI: 10.1016/j.nantod.2022.101561 Ensemble learning for poor prognosis predictions: A case study on SARS-CoV-2 Author(s): Honghan Wu, Huayu Zhang, Andreas Karwath, Zina Ibrahim, Ting Shi, Xin Zhang, Kun Wang, Jiaxing Sun, Kevin Dhaliwal, Daniel Bean, Victor Roth Cardoso, Kezhi Li, James T Teo, Amitava Banerjee, Fang Gao-Smith, Tony Whitehouse, Tonny Veenith, Georgios V Gkoutos, Xiaodong Wu, Richard Dobson, Bruce Guthrie Published in: J Am Med Inform Assoc, Issue 1527974X, 2021, ISSN 1527-974X Publisher: Oxfrod Univeristy Press DOI: 10.1093/jamia/ocaa295 SARS-CoV-2-laden respiratory aerosol deposition in the lung alveolar-interstitial region is a potential risk factor for severe disease: a modeling study Author(s): Hofer S., Hofstätter N., Duschl A., and Himly M. Published in: J. Personalized Med., Issue 14220067, 2021, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/jpm11050431 Development of a novel cellulose foam augmented with candle-soot derived carbon nanoparticles for solar-powered desalination of brackish water Author(s): Amrit Kumar Thakur; Ravishankar Sathyamurthy; R. Velraj; Iseult Lynch; Published in: Environmental Science: Nano, Issue 20518161, 2022, ISSN 2051-8161 Publisher: Royal Society of Chemistry DOI: 10.1039/d1en01112j Control of cell state transitions Author(s): Rukhlenko, O.S., Halasz, M., Rauch, N. Vadim Zhernovkov, Thomas Prince, Kieran Wynne, Stephanie Maher, Eugene Kashdan, Kenneth MacLeod, Neil O. Carragher, Walter Kolch, Boris N. Kholodenko Published in: Nature, Issue 14764687, 2022, ISSN 1476-4687 Publisher: Nature DOI: 10.1038/s41586-022-05194-y A survey on the state of nanosafety research in the European Union and the United States Author(s): Albert Duschl, Gabriele Windgasse Published in: Journal of Nanoparticle Research, Issue 13880764, 2018, ISSN 1388-0764 Publisher: Kluwer Academic Publishers DOI: 10.1007/s11051-018-4434-9 A Novel Exposure System Termed NAVETTA for In Vitro Laminar Flow Electrodeposition of Nanoaerosol and Evaluation of Immune Effects in Human Lung Reporter Cells Author(s): Evelien Frijns, Sandra Verstraelen, Linda Corinna Stoehr, Jo Van Laer, An Jacobs, Jan Peters, Kristof Tirez, Matthew Samuel Powys Boyles, Mark Geppert, Pierre Madl, Inge Nelissen, Albert Duschl, Martin Himly Published in: Environmental Science & Technology, Issue 51/9, 2017, Page(s) 5259-5269, ISSN 0013-936X Publisher: American Chemical Society DOI: 10.1021/acs.est.7b00493 Other (8) Computational enrichment of physicochemical data for the development of a ζ-potential read-across predictive model with Isalos Analytics Platform Author(s): Papadiamantis, A.G., Afantitis, A., Tsoumanis, A., Valsami-Jones, E., Lynch, I., Melagraki, Published in: Nature Nanotechnology, 2021 Publisher: Nature Nanotechnology DOI: 10.1016/j.impact.2021.100308 Driving the nanoinformatics wave Author(s): Afantitis, Antreas; Lynch, Iseult; Published in: Scitech Europa Quarterly, Issue 2516435X, 2019, ISSN 2516-435X Publisher: Pan European Networks DOI: 10.5281/zenodo.3765525 Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D Author(s): Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Published in: nature.com, 2020 Publisher: Nature Communications DOI: 10.1038/s41467-019-14224-9 INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies) (Version_02) Author(s): Falk, Andreas; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; … Wilkens, Terence A. Published in: Zenodo, 2022 Publisher: Zenodo DOI: 10.5281/zenodo.6818049 Environmental dimensions of the protein corona Author(s): Korin E. Wheeler, Andrew J. Chetwynd, Kira M. Fahy, Brian S. Hong, Jose A. Tochihuitl, Lilah A. Foster & Iseult Lynch Published in: Nature Nanotecnology, 2021 Publisher: Nature Nanotecnology DOI: 10.1038/s41565-021-00924-1 D10.1 Initial draft of data management plan (Open data pilot) Author(s): Papadiamantis, Anastasios; Farcal, Lucian; Willighagen, Egon; Lynch, Iseult; Exner, Thomas Published in: Deliverable Report, Issue 1, 2018 Publisher: European Commission DOI: 10.5281/zenodo.1479556 Nanotechnology and artificial intelligence to enable sustainable and precision agriculture Author(s): Peng Zhang, Zhiling Guo, Sami Ullah, Georgia Melagraki, Antreas Published in: Nature Plants, 2021 Publisher: Nature Plants DOI: 10.1038/s41477-021-00946-6 INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies) (Version_01) Author(s): Falk, Andreas; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; … Wilkens, Terence A. Published in: Zenodo, 2021 Publisher: Zenodo DOI: 10.5281/zenodo.5004929 Book chapters (1) Enalos Suite of Tools: Enhancing Cheminformatics and Nanoinfor - matics through KNIME Author(s): Antreas Afantitis, Andreas Tsoumanis, Georgia Melagraki Published in: National Library of Medicine, Issue 1875533X, 2020, ISSN 1875-533X Publisher: Bentham Science DOI: 10.2174/0929867327666200727114410 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
