Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Lifespan-applicable versus age-specific risk and protective factors

Analysis to distinguish which risk and protective factors work when

Lifebrain conference in Oxford

Organization and completion of conference

Lifebrain gender equity report (R)

The management in coordination with the Safety Board (SB) team will ensure and monitor that the consortium’s policy regarding gender issues is correctly implemented, including the awareness and sensitisation programmes.

Communication management routines and infrastructure implemented

Establish routines for communication amongst consortium partners including the exchange of information and materials, while ensuring maintenance the EC Grant Agreement and Consortium Agreement. Provide assistance and advice to partners regarding administrative matters, and to ensure compliance with EC rules including the communication with and reporting to the EC on behalf of the consortium

Multi-modal MRI-data processing stream which allows for a state-of-the art central integration of data across sites

A standardized analysis stream will be developed that all data can be run through, with special focus put on neuroimaging.

Enrichment of existing cohorts by home collection of DBS to be analysed across WP4 tasks 2-6

Kits for home collection of DBS will be sent to participants in all samples, which will send them back to Vitas for analyses, with the aim of getting 2000 samples

Lifebrain conference in Berlin

Organization and completion of conference

Risk and protective factors for cognitive and mental health in broader epidemiological samples

Divided into two parts: A) Using multivariate regression analysis and multilevel/hierarchical models, existing European Research Infrastructure Consortia (ERICs, SHARE) will be leveraged to analyze i) how cognitive performance and risks of depression and anxiety differ by socioeconomic status (SES), gender and age, ii) how these patterns differ across regions/countries, and iii) the extent to which the cognitive outcomes are associated with differences in health and everyday functioning. B) Based on results from task A, population-covering administrative register data from Scandinavian countries will be used to corroborate the real-world relevance of these findings

Business plan/s for post-project exploitation opportunities

Will examine the results achieved in the project and how this can lead to the uptake of productsservices to the market place As a minimum a business plan will be delivered for the exploitation of the advanced VITAS DBS Home kits and how this will be launched into the market place postproject and for use in LCBC and other multidisciplinary research investigations

Online/mobile tools for stakeholder engagement conceptualized and developed

Prepare tools and platform for stakeholder engagement. Social media, like twitter, will be one area of interest. Also web-based questionnaires, tests and engagement tools will be considered, and possibly developed

Tool for post hoc harmonization of MRI data across sites, to allow integration of data from different scanners/sites

Implement and test a novel procedure to correct images for scanner-specific differences in tissue contrast and intensity non-uniformity.

Refining and validation of novel statistical tools

Tool refinement and optimizing the model selection ie to tackle the important problem of identifying and selecting those models that best summarize data across sites

Reviewing Stakeholders Engagement - Best Practice

Presentation of comprehensive review of the stakeholder engagement in the project and production of a Best Practice report

Enrichment of existing cohorts by administration of buccal swabs for epigenetic analyses across WP4 tasks 2-6

Coordination of the sample collection, laboratory experiments and bioinformatic processing of the data for analysis in WP4

Input to the Dissemination, Exploitation and Communication(DEC) plan (T5.1)

Prepare tools and platform for stakeholder engagement, ensure that WP1 is fully aligned with WP5s DEC plan

DBS assays for relevant biomarkers for data enrichment

Develop and validate new additional biomarkers on DBS tailored for the Lifebrain project

Input from Stakeholders – Feedback Incorporated

Innovative approaches to retrieve stakeholder’s input and feedback will be developed and implemented. Timeline will be drawn and meeting arenas will be identified for the various phases and stakeholders, including relevant existing conferences and workshops where a stakeholder symposium might be added

DEC Strategy, Operative Plan and SOPs for the Lifebrain project

Details the communication and dissemination strategy including stakeholder engagement practices for targeting different audiences and resulting in the definition of a detailed activity plan for phase one (M1-30). The operative part of the DEC Plan will be updated based on project activities and experiences. Standard operating procedures (SOPs) for publications, participation in conferences and exploitation will be annexed to this plan

Data storage and processing system to share data, manage data access and integrated analysis

Establish an international image sharing, storage and processing platform for management of neuroimaging and harmonized target variables

Online platform for collection of questionnaire and test data for data enrichment

The implementation will include three major steps: (a) identifying and operationalizing (e.g., selecting standard and custom questionnaires, or neuropsychological tests) the variables to be assessed; (b) translating the instructions, questionnaires/test items or identifying language-specific version for standard questionnaires/tests); (c) implementing a OS independent internet browser-based platform which allows for data collection and transfer of data using secure file transfer protocol.

Policy reviews to advance well-being across all age groups - II

Selected NationalEuropean policies will be reviewed and policymakers engaged to determine the appropriateness and relevance of project results and how these results can lead to promotion of policies on personalised health opportunities for European citizens

Exploitation and IP management strategy - I

An integrated IP and exploitation strategy will be defined and implemented along with innovative communication channels developed

List of relevant stakeholders for project engagement

Identify and invite research participant groups, patient groups, clinicians and policy makers that will have an interest in the project and that should be taken into consideration

Individual pathways and mediator variables in relation to risk for poor cognitive function and decline versus resilience

Analysis in the integrated project cohort to identify whether individual differences in relation to risk for poor cognitive function and decline versus resilience are mediated by variations in lifestyle body mass index blood pressure cholesterol and other blood markers vitamins fatty acids proteins genetics epigenetics and brain factors

Individual pathways and mediator variables in relation to risk for mental health problems and resilience

Analyses in the integrated project cohort are to identify whether individual differences in mental health and resilience are mediated via variations in lifestyle smoking alcohol drugs body mass index blood pressure cholesterol and other blood markers vitamins fatty acid protein status metals genetic epigenetic factors and brain structure and function

Enrichment of existing cohorts by online data collection

Develop and apply a tool for online collection of data to enrich available database, allowing Lifebrain databases to attain data which not all sites have available and data on new variables, and by doing so optimize the utilization of the existing data

DEC strategy and Operative plan – Update

Update strategy report conducted under D5.1

Financial and legal management routines implemented

To establish a robust management structure to ensure that the objectives of the project are met within agreed budget and timeframe, granting that the administrative, legal and ethical aspects are fulfilled by each partner and ensuring that allocated finances are appropriately managed and reported, carrying out adequate quality control of the work performed and of the deliverables;

Data harmonization guidelines and standardized data management/processing protocol across sites

We will develop and implement harmonization protocols, i.e. develop technical and semantic data standards, and quality protocols to unify and bridge the different coding standards of target variables between sites

Exploitation and IP management strategy - Updated

An IP management strategy will be delivered considering the necessary and most appropriate consortium agreement to lead to effective exploitation opportunities postproject This will also examine the results achieved in the project and how this can lead to the uptake of productsservices to the market place

Report/policy brief on concepts and mechanisms for uptake of research output

Specific focus on engagement with policy makers and identification of the mechanisms that will enable uptake of research outputs.

GWAS data and harmonization of genetic data across samples for genetic analyses across WP4 tasks 2-6

This will include re-calling of genotypes, from existing genome-wide SNP genotype data, quality checking, imputation, determination of population substructure, and producing of analysis-ready genotypes maximally harmonized across the different Lifebrain centres.

Replication, validation and extension of findings in non-European samples

Part of the analyses from T4246 will be redone in US databases PING ADNI NACC VETSA RUSH to replicate and extend findings identify differences and crossvalidate statistical models

Novel longitudinal statistical tools, allowing to tackle challenges associated with multi-side mixed model lifespan data

Develop tools where goal is to identify models that optimally represent the consolidated findings of the consortium, and hence contribute to theory development and generalizability.

Gender-specific risk and protective factors

Analyses to identify sexspecific differences in developmental trajectories of brain and behavioral measures and how these are related to life style factors eg physical activity and substances use and bodily functions eg hormones and metabolic profiles Moderating effects of genetic epigenetic factors and biological markers will be investigated

Societal factors mitigating genetic/ epigenetic risk for neurodegenerative disease and their mediators

We will test whether the effects of SES differ across societies applying the Nordic model Denmark REGIONH Norway UiO Sweden UMU and the Netherlands VUMC the Continental model Germany MPIB the British model UK UOXF UCAM and the Mediterranean model Spain UB Simultaneously frequency of risk alleles for developing Alzheimers disease APOE 4 differs across Europe with higher risk allele frequency in Northern Europe

Dissemination tools and communication strategies - I

Tools include both printed material (flyers, flyer inlays, posters and factsheets etc.) as well as online / digital tools - website, social media accounts, newsletters and power point presentations. Project partners will be actively involved in determining appropriate tools, content generation and dissemination & communication opportunities associated with agreed DEC activities.

Kick-off meeting completed; advisory board, safety board, executive board instantiated

Organization of meeting and establishment of relevant boards

Dissemination tools and communication strategies II

Update strategy report conducted under D5.2

Data obtained from national registries; incl standardization, integration, quality control and pooling with existing data across sites

Coupling of existing data with national health, conscription and population registries. This will be done for the Nordic countries (Norway, Sweden, Denmark) as well as the Netherlands and Spain.

Policy reviews on cognitive & mental well-being across all age groups - I

Selected National/European policies will be reviewed and policy-makers engaged to determine the appropriateness and relevance of project results and how these results can lead to promotion of policies on ‘personalised health’ opportunities for European citizens

Pubblicazioni

How to promote citizens’ brain health? Insights from the Global Brain HealthSurvey on citizen’s perceptions of brain health interventions

Autori: Lifebrain consortium
Pubblicato in: 2022, ISBN 978-82-8406-223-5
Editore: Lifebrain consortium

Nettskjema R-package

Autori: Athanasia Monika Mowinckel, Waldir Leoncio
Pubblicato in: Open Access R-package at Zenodo, 2021
Editore: University of Oslo
DOI: 10.5281/zenodo.4745481

Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women

Autori: Schindler LS., Subramaniapillai S., Barth C., van der Meer D., Pedersen ML., Kaufmann T., Maximov II., Linge J., Leinhard OD., Beck D., Gurholt TP., Voldsbekk I., SURI S., EBMEIER KP., Draganski B., Andreassen OA., Westlye LT., de Lange A-MG. (2022)
Pubblicato in: OSF preprint, 2022
Editore: Center for Open Science
DOI: 10.31219/osf.io/vr9uz

What motivates people to look after their brain health? Insights from the Global Brain Health Survey.

Autori: Lifebrain consortium
Pubblicato in: 2022, ISBN 978-82-8406-267-9
Editore: Lifebrain consortium

Global Brain Health Survey raw data

Autori: Budin-Ljøsne I, Friedman BB, Suri S, Solé-Padullés C, Düzel S, Drevon CA, Baaré WFC, Mowinckel AM, Zsoldos E, Madsen KS, Carver RB, Ghisletta P, Arnesen MR, Bartrés Faz D, Brandmaier AM, Fjell AM, Kvalbein A, Henson RN, Kievit RA, Nawijn L, Pochet R, Schnitzler A, Walhovd KB and Zasiekina L
Pubblicato in: 2022
Editore: Lifebrain consortium

Education and Income Show Heterogeneous Relationships to Lifespan Brain and Cognitive Differences Across European and US Cohorts

Autori: Kristine B Walhovd, Anders M Fjell, Yunpeng Wang, Inge K Amlien, Athanasia M Mowinckel, Ulman Lindenberger, Sandra Düzel, David Bartrés-Faz, Klaus P Ebmeier, Christian A Drevon, William F C Baaré, Paolo Ghisletta, Louise Baruël Johansen, Rogier A Kievit, Richard N Henson, Kathrine Skak Madsen, Lars Nyberg, Jennifer R Harris, Cristina Solé-Padullés, Sara Pudas, Øystein Sørensen, René Weste
Pubblicato in: Cerebral Cortex, 2021, ISSN 1047-3211
Editore: Oxford University Press
DOI: 10.1093/cercor/bhab248

TEMPORARY REMOVAL: Hippocampal maintenance after a 12-month physical activity intervention in older adults: The REACT MRI study

Autori: Naiara Demnitz, Afroditi Stathi, Janet Withall, Candida Stainer, Poppy Seager, Jolanthe De Koning, Patrick Esser, Thomas Wassenaar, Helen Dawes, Jonathan Brooks, Klaus P. Ebmeier, Heidi Johansen-Berg, Claire E. Sexton
Pubblicato in: NeuroImage: Clinical, 2021, Pagina/e 102762, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2021.102762

Associations of dietary markers with brain volume and connectivity: A systematic review of MRI studies

Autori: Daria E.A. Jensen, Virginia Leoni, Miriam C. Klein-Flügge, Klaus P. Ebmeier, Sana Suri
Pubblicato in: Ageing Research Reviews, Numero 70, 2021, Pagina/e 101360, ISSN 1568-1637
Editore: Elsevier BV
DOI: 10.1016/j.arr.2021.101360

Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging

Autori: Melis Anatürk, Tobias Kaufmann, James H. Cole, Sana Suri, Ludovica Griffanti, Enikő Zsoldos, Nicola Filippini, Archana Singh‐Manoux, Mika Kivimäki, Lars T. Westlye, Klaus P. Ebmeier, Ann‐Marie G. de Lange
Pubblicato in: Human Brain Mapping, 2020, ISSN 1065-9471
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hbm.25316

Associations between depression, lifestyle and brain structure: A longitudinal MRI study

Autori: Julia Binnewies, Laura Nawijn, Marie-José van Tol, Nic J.A. van der Wee, Dick J. Veltman, Brenda W.J.H. Penninx
Pubblicato in: NeuroImage, Numero 231, 2021, Pagina/e 117834, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2021.117834

Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change

Autori: Didac Vidal-Pineiro, Yunpeng Wang, Stine K Krogsrud, Inge K Amlien, William FC Baaré, David Bartres-Faz, Lars Bertram, Andreas M Brandmaier, Christian A Drevon, Sandra Düzel, Klaus Ebmeier, Richard N Henson, Carme Junqué, Rogier Andrew Kievit, Simone Kühn, Esten Leonardsen, Ulman Lindenberger, Kathrine S Madsen, Fredrik Magnussen, Athanasia Monika Mowinckel, Lars Nyberg, James M Roe, Barbara S
Pubblicato in: eLife, Numero 10, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.69995

Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study.

Autori: Sana Suri; Scott T Chiesa; Enikő Zsoldos; Clare E. Mackay; Nicola Filippini; Ludovica Griffanti; Abda Mahmood; Archana Singh-Manoux; Archana Singh-Manoux; Martin J. Shipley; Eric J. Brunner; Mika Kivimäki; John E. Deanfield; Klaus P. Ebmeier
Pubblicato in: PLoS Medicine, Vol 17, Iss 12, p e1003467 (2020), Numero 44, 2020, ISSN 1549-1676
Editore: PLOS
DOI: 10.1371/journal.pmed.1003467

Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline—Results From the Lifebrain Consortium

Autori: Anders M Fjell, Øystein Sørensen, Inge K Amlien, David Bartrés-Faz, Andreas M Brandmaier, Nikolaus Buchmann, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P Ebmeier, Paolo Ghisletta, Ane-Victoria Idland, Tim C Kietzmann, Rogier A Kievit, Simone Kühn, Ulman Lindenberger, Fredrik Magnussen, Didac Macià, Athanasia M Mowinckel, Lars Nyberg, Claire E Sexton, Cristina Solé-Padullés, Sara
Pubblicato in: Cerebral Cortex, Numero 31/4, 2020, Pagina/e 1953-1969, ISSN 1047-3211
Editore: Oxford University Press
DOI: 10.1093/cercor/bhaa332

tDCS-Induced Memory Reconsolidation Effects and Its Associations With Structural and Functional MRI Substrates in Subjective Cognitive Decline

Autori: Lídia Vaqué-Alcázar, Lídia Mulet-Pons, Kilian Abellaneda-Pérez, Cristina Solé-Padullés, María Cabello-Toscano, Dídac Macià, Roser Sala-Llonch, Nuria Bargalló, Javier Solana, Gabriele Cattaneo, José M. Tormos, Alvaro Pascual-Leone, David Bartrés-Faz
Pubblicato in: Frontiers in Aging Neuroscience, Numero 13, 2021, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2021.695232

Integrating large-scale neuroimaging research datasets: Harmonisation of white matter hyperintensity measurements across Whitehall and UK Biobank datasets

Autori: Valentina Bordin, Ilaria Bertani, Irene Mattioli, Vaanathi Sundaresan, Paul McCarthy, Sana Suri, Enikő Zsoldos, Nicola Filippini, Abda Mahmood, Luca Melazzini, Maria Marcella Laganà, Giovanna Zamboni, Archana Singh-Manoux, Mika Kivimäki, Klaus P Ebmeier, Giuseppe Baselli, Mark Jenkinson, Clare E Mackay, Eugene P Duff, Ludovica Griffanti
Pubblicato in: NeuroImage, Numero 237, 2021, Pagina/e 118189, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2021.118189

Alcohol consumption and MRI markers of brain structure and function: Cohort study of 25,378 UK Biobank participants

Autori: Anya Topiwala; Klaus P. Ebmeier; Thomas Maullin-Sapey; Thomas E. Nichols
Pubblicato in: NeuroImage: Clinical, Numero 22131582, 2022, Pagina/e 103066, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2022.103066

No Association Between Loneliness, Episodic Memory and Hippocampal Volume Change in Young and Healthy Older Adults: A Longitudinal European Multicenter Study

Autori: Solé-Padullés Cristina, Macià Dídac, Andersson Micael, Stiernstedt Mikael, Pudas Sara, Düzel Sandra, Zsoldos Enikő, Ebmeier Klaus P., Binnewies Julia, Drevon Christian A., Brandmaier Andreas M., Mowinckel Athanasia M., Fjell Anders M., Madsen Kathrine Skak, Baaré William F. C., Lindenberger Ulman, Nyberg Lars, Walhovd Kristine B., Bartrés-Faz David
Pubblicato in: Neurocognitive Ageing and Behaviour, 2022, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.795764

Brain aging differs with cognitive ability regardless of education

Autori: Walhovd, K.B., Nyberg, L., Lindenberger, U. et al.
Pubblicato in: Scientific Reports, Numero 20452322, 2022, Pagina/e 13886, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-17727-6

Greater lifestyle engagement is associated with better age-adjusted cognitive abilities

Autori: G. Sophia Borgeest, Richard N. Henson, Meredith Shafto, David Samu, Rogier A. Kievit
Pubblicato in: PLOS ONE, Numero 15/5, 2020, Pagina/e e0230077, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0230077

Separating vascular and neuronal effects of age on fMRI BOLD signals

Autori: Kamen A. Tsvetanov, Richard N. A. Henson, James B. Rowe
Pubblicato in: Philosophical Transactions of the Royal Society B: Biological Sciences, Numero 376/1815, 2021, Pagina/e 20190631, ISSN 0962-8436
Editore: Royal Society of London
DOI: 10.1098/rstb.2019.0631

Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study

Autori: Ann-Marie G. de Lange, Melis Anatürk, Sana Suri, Tobias Kaufmann, James H. Cole, Ludovica Griffanti, Enikő Zsoldos, Daria E.A. Jensen, Nicola Filippini, Archana Singh-Manoux, Mika Kivimäki, Lars T. Westlye, Klaus P. Ebmeier
Pubblicato in: NeuroImage, Numero 222, 2020, Pagina/e 117292, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2020.117292

Longitudinal association between hippocampus atrophy and episodic‐memory decline in non‐demented APOE ε4 carriers

Autori: Tetiana Gorbach Sara Pudas David Bartrés‐Faz Andreas M. Brandmaier Sandra Düzel Richard N. Henson Ane‐Victoria Idland Ulman Lindenberger Didac Macià Bros Athanasia M. Mowinckel Cristina Solé‐Padullés Øystein Sørensen Kristine B. Walhovd Leiv Otto Watne René Westerhausen Anders M. Fjell Lars Nyberg
Pubblicato in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Numero Volume12, Numero1, 2020, ISSN 2352-8729
Editore: Alzheimer’s Association
DOI: 10.1002/dad2.12110

Meta-analysis of generalized additive models in neuroimaging studies

Autori: Øystein Sørensen, Andreas M. Brandmaier, Dídac Macià, Klaus Ebmeier, Paolo Ghisletta, Rogier A. Kievit, Athanasia M. Mowinckel, Kristine B. Walhovd, Rene Westerhausen, Anders Fjell
Pubblicato in: NeuroImage, Numero 224, 2021, Pagina/e 117416, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2020.117416

Functional brain changes associated with cognitive trajectories determine specific tDCS‐induced effects among older adults

Autori: Lídia Vaqué‐Alcázar, Kilian Abellaneda‐Pérez, Cristina Solé‐Padullés, Núria Bargalló, Cinta Valls‐Pedret, Emilio Ros, Roser Sala‐Llonch, David Bartrés‐Faz
Pubblicato in: Journal of Neuroscience Research, Numero 99/9, 2021, Pagina/e 2188-2200, ISSN 0360-4012
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jnr.24849

The effects of age on resting‐state BOLD signal variability is explained by cardiovascular and cerebrovascular factors

Autori: Kamen A. Tsvetanov, Richard N. A. Henson, P. Simon Jones, Henk Mutsaerts, Delia Fuhrmann, Lorraine K. Tyler, James B. Rowe
Pubblicato in: Psychophysiology, Numero 58/7, 2021, ISSN 0048-5772
Editore: Blackwell Publishing Inc.
DOI: 10.1111/psyp.13714

Contributing factors to advanced brain aging in depression and anxiety disorders

Autori: Laura K. M. Han, Hugo G. Schnack, Rachel M. Brouwer, Dick J. Veltman, Nic J. A. van der Wee, Marie-José van Tol, Moji Aghajani, Brenda W. J. H. Penninx
Pubblicato in: Translational Psychiatry, Numero 11/1, 2021, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-021-01524-2

Educational attainment does not influence brain aging

Autori: Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baaré, David Bartrés-Faz, Lars Bertram, C. J. Boraxbekk, Andreas M. Brandmaier, Christian A. Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N. Henson, Carme Junqué, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kühn, Ulman Lindenberger, Brenda W. J. H. Penninx, Sara Pudas, Øystein Sørensen, Lídia Vaqué-Alcázar, Kristine B.
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 118/18, 2021, Pagina/e e2101644118, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2101644118

Study Protocol: The Heart and Brain Study

Autori: Sana Suri, Daniel Bulte, Scott T. Chiesa, Klaus P. Ebmeier, Peter Jezzard, Sebastian W. Rieger, Jemma E. Pitt, Ludovica Griffanti, Thomas W. Okell, Martin Craig, Michael A. Chappell, Nicholas P. Blockley, Mika Kivimäki, Archana Singh-Manoux, Ashraf W. Khir, Alun D. Hughes, John E. Deanfield, Daria E. A. Jensen, Sebastian F. Green, Veronika Sigutova, Michelle G. Jansen, Enikő Zsoldos, Clare E. Ma
Pubblicato in: Frontiers in Physiology, Numero 12, 2021, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.643725

The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan

Autori: Anders M. Fjell; Anders M. Fjell; Håkon Grydeland; Yunpeng Wang; Inge K Amlien; David Bartrés-Faz; Andreas M. Brandmaier; Sandra Düzel; Jeremy A. Elman; Carol E. Franz; Asta Håberg; Tim C. Kietzmann; Rogier A. Kievit; William S. Kremen; William S. Kremen; Stine K. Krogsrud; Simone Kühn; Ulman Lindenberger; Dídac Macià; Athanasia M. Mowinckel; Lars Nyberg; Lars Nyberg; Matthew S. Panizzon; C
Pubblicato in: eLife, Numero 52, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.66466

an international, online cross-sectional survey

Autori: Isabelle Budin-Ljøsne; Athanasia Monika Mowinckel; Barbara Bodorkos Friedman; Klaus P Ebmeier; Christian A Drevon; Rebecca Bruu Carver; Enikő Zsoldos; Nanna Alida Grit Fredheim; Øystein Sørensen; William Frans Christiaan Baaré; Kathrine Skak Madsen; Anders M Fjell; Rogier A Kievit; Paolo Ghisletta; David Bartrés-Faz; Laura Nawijn; Cristina Solé-Padullés; Kristine B Walhovd; Sandra Düzel;
Pubblicato in: VOLUME=12;ISSN=2044-6055;TITLE=BMJ Open, Numero 36, 2022, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-057999

Supplementary materials [Code] to: A tutorial for joint modeling of longitudinal and time to-event data in R.

Autori: Cekic, Sezen Aichele, Stephen Brandmaier, Andreas M. Köhncke, Ylva Ghisletta, Paolo
Pubblicato in: Quantitative and Computational Methods in Behavioral Sciences, Numero 1(1), e2979, 2021, ISSN 2699-8432
Editore: PsychOpen
DOI: 10.23668/psycharchives.4621

Hippocampal and Parahippocampal Gray Matter Structural Integrity Assessed by Multimodal Imaging Is Associated with Episodic Memory in Old Age

Autori: Ylva Köhncke, Sandra Düzel, Myriam C Sander, Ulman Lindenberger, Simone Kühn, Andreas M Brandmaier
Pubblicato in: Cerebral Cortex, Numero 31/3, 2020, Pagina/e 1464-1477, ISSN 1047-3211
Editore: Oxford University Press
DOI: 10.1093/cercor/bhaa287

Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort

Autori: Richard N. Henson, Sana Suri, Ethan Knights, James B. Rowe, Rogier A. Kievit, Donald M. Lyall, Dennis Chan, Else Eising, Simon E. Fisher
Pubblicato in: Brain and Neuroscience Advances, Numero 4, 2020, Pagina/e 239821282096170, ISSN 2398-2128
Editore: Sage Journals
DOI: 10.1177/2398212820961704

Association of trajectories of depressive symptoms with vascular risk, cognitive function and adverse brain outcomes: The Whitehall II MRI sub-study

Autori: NaiaraDemnitz, MelisAnatürk, Charlotte L.Allanc, Nicola Filippini, Ludovica Griffant, Clare E. Mackay , Abda Mahmood, Claire E. Sexton, Sana Suri, Anya G.Topiwala, Enikő Zsoldo, Mika Kivimäk, Archana Singh-Manoux, Klaus P. Ebmeier
Pubblicato in: Journal of Psychiatric Research, Numero Volume 131, December 2020, 2020, Pagina/e 85-93, ISSN 0022-3956
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2020.09.005

Forecasting memory function in aging: pattern-completion ability and hippocampal activity relate to visuospatial functioning over 25 years

Autori: Lars Nyberg, Xenia Grande, Micael Andersson, David Berron, Anders Lundquist, Mikael Stiernstedt, Anders Fjell, Kristine Walhovd, Greger Orädd
Pubblicato in: Neurobiology of Aging, Numero 94, 2020, Pagina/e 217-226, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.06.005

The Global Brain Health Survey: Development of a Multi-Language Survey of Public Views on Brain Health

Autori: Isabelle Budin-Ljøsne, Barbara Bodorkos Friedman, Sana Suri, Cristina Solé-Padullés, Sandra Düzel, Christian A. Drevon, William F. C. Baaré, Athanasia Monika Mowinckel, Enikő Zsoldos, Kathrine Skak Madsen, Rebecca Bruu Carver, Paolo Ghisletta, Mari R. Arnesen, David Bartrés Faz, Andreas M. Brandmaier, Anders Martin Fjell, Aud Kvalbein, Richard N. Henson, Rogier A. Kievit, Laura Nawijn, Rola
Pubblicato in: Frontiers in Public Health, Numero 8, 2020, ISSN 2296-2565
Editore: Frontiers in Public Health
DOI: 10.3389/fpubh.2020.00387

A common polymorphism in the dopamine transporter gene predicts working memory performance and in vivo dopamine integrity in aging

Autori: Nina Karalija, Ylva Köhncke, Sandra Düzel, Lars Bertram, Goran Papenberg, Ilja Demuth, Christina M. Lill, Jarkko Johansson, Katrine Riklund, Martin Lövdén, Lars Bäckman, Lars Nyberg, Ulman Lindenberger, Andreas M. Brandmaier
Pubblicato in: NeuroImage, Numero 245, 2021, Pagina/e 118707, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2021.118707

White matter hyperintensities classified according to intensity and spatial location reveal specific associations with cognitive performance

Autori: Luca Melazzini, Clare E Mackay, Valentina Bordin, Sana Suri, Eniko Zsoldos, Nicola Filippini, Abda Mahmood, Vaanathi Sundaresan, Marina Codari, Eugene Duff, Archana Singh-Manoux, Mika Kivimäki, Klaus P Ebmeier, Mark Jenkinson, Francesco Sardanelli, Ludovica Griffanti
Pubblicato in: NeuroImage: Clinical, 2021, Pagina/e 102616, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2021.102616

Healthy minds 0–100 years: Optimising the use of European brain imaging cohorts (“Lifebrain”)

Autori: Kristine B. Walhovd, Anders M. Fjell, René Westerhausen, Lars Nyberg, Klaus P. Ebmeier, Ulman Lindenberger, David Bartrés-Faz, William F.C. Baaré, Hartwig R. Siebner, Richard Henson, Christian A. Drevon, Gun Peggy Strømstad Knudsen, Isabelle Budin Ljøsne, Brenda W.J.H. Penninx, Paolo Ghisletta, Ole Rogeberg, Lorraine Tyler, Lars Bertram
Pubblicato in: European Psychiatry, Numero 50, 2018, Pagina/e 47-56, ISSN 0924-9338
Editore: Elsevier Masson
DOI: 10.1016/j.eurpsy.2017.12.006

Assessing reliability in neuroimaging research through intra-class effect decomposition (ICED)

Autori: Andreas M Brandmaier , Elisabeth Wenger, Nils C Bodammer, Simone Kühn, Naftali Raz, Ulman Lindenberger
Pubblicato in: eLife, Numero eLife 2018;7:e35718, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.35718.001

A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults

Autori: M. Anatürk, N. Demnitz, K.P. Ebmeier, C.E. Sexton
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero 93, 2018, Pagina/e 71-84, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2018.06.012

Developmental cognitive neuroscience using latent change score models: A tutorial and applications

Autori: Rogier A. Kievit, Andreas M. Brandmaier, Gabriel Ziegler, Anne-Laura van Harmelen, Susanne M.M. de Mooij, Michael Moutoussis, Ian M. Goodyer, Ed Bullmore, Peter B. Jones, Peter Fonagy, Ulman Lindenberger, Raymond J. Dolan
Pubblicato in: Developmental Cognitive Neuroscience, 2017, ISSN 1878-9293
Editore: Elsevier BV
DOI: 10.1016/j.dcn.2017.11.007

Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities

Autori: Dennis Chan, Meredith Shafto, Rogier Kievit, Fiona Matthews, Molly Spink, Michael Valenzuela, Rik N. Henson
Pubblicato in: Neurobiology of Aging, Numero 70, 2018, Pagina/e 180-183, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.06.012

Age Differentiation within Gray Matter, White Matter, and between Memory and White Matter in an Adult Life Span Cohort

Autori: Susanne M.M. de Mooij, Richard N.A. Henson, Lourens J. Waldorp, Rogier A. Kievit
Pubblicato in: The Journal of Neuroscience, Numero 38/25, 2018, Pagina/e 5826-5836, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.1627-17.2018

Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging

Autori: Delia Fuhrmann, David Nesbitt, Meredith Shafto, James B. Rowe, Darren Price, Andrew Gadie, Rogier A. Kievit, Lorraine K. Tyler, Carol Brayne, Edward T. Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Richard N. Henson, Fiona E. Matthews, William D. Marslen-Wilson, James B. Rowe, Meredith A. Shafto, Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, An
Pubblicato in: Neurobiology of Aging, Numero 74, 2019, Pagina/e 46-55, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.10.005

Increased Prefrontal Activity with Aging Reflects Nonspecific Neural Responses Rather than Compensation

Autori: Alexa M. Morcom, Richard N.A. Henson
Pubblicato in: The Journal of Neuroscience, Numero 38/33, 2018, Pagina/e 7303-7313, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.1701-17.2018

In vivo visualization of age-related differences in the locus coeruleus

Autori: Kathy Y. Liu, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Clare Loane, Alex J. Berry, Matthew J. Betts, Rogier A. Kievit, Richard N. Henson, Emrah Düzel, Robert Howard, Dorothea Hämmerer
Pubblicato in: Neurobiology of Aging, Numero 74, 2019, Pagina/e 101-111, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.10.014

Self-reported sleep relates to hippocampal atrophy across the adult lifespan – results from the Lifebrain consortium

Autori: Anders M Fjell, Øystein Sørensen, Inge K Amlien, David Bartrés-Faz, Didac Maciá Bros, Nikolaus Buchmann, Ilja Demuth, Christian A Drevon, Sandra Düzel, Klaus P Ebmeier, Ane-Victoria Idland, Tim C Kietzmann, Rogier Kievit, Simone Kühn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Darren Price, Claire E Sexton, Cristina Solé-Padullés, Sara Pudas, Donatas Sederevicius, Sana Suri, G
Pubblicato in: Sleep, 2019, ISSN 0161-8105
Editore: The American Academy of Sleep Medicine
DOI: 10.1093/sleep/zsz280

Association of Midlife Cardiovascular Risk Profiles With Cerebral Perfusion at Older Ages

Autori: Sana Suri, Anya Topiwala, Michael A. Chappell, Thomas W. Okell, Eniko Zsoldos, Archana Singh-Manoux, Mika Kivimäki, Clare E. Mackay, Klaus P. Ebmeier
Pubblicato in: JAMA Network Open, Numero 2/6, 2019, Pagina/e e195776, ISSN 2574-3805
Editore: Jama Network Open
DOI: 10.1001/jamanetworkopen.2019.5776

A Practical Guide to Variable Selection in Structural Equation Modeling by Using Regularized Multiple-Indicators, Multiple-Causes Models

Autori: Ross Jacobucci, Andreas M. Brandmaier, Rogier A. Kievit
Pubblicato in: Advances in Methods and Practices in Psychological Science, Numero 2/1, 2019, Pagina/e 55-76, ISSN 2515-2459
Editore: Sage journals
DOI: 10.1177/2515245919826527

Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium

Autori: Barbara Bodorkos Friedman, Sana Suri, Cristina Solé-Padullés, Sandra Düzel, Christian A Drevon, William F C Baaré, David Bartrés-Faz, Anders M Fjell, Heidi Johansen-Berg, Kathrine S Madsen, Lars Nyberg, Brenda W J H Penninx, Claire Sexton, Kristine B Walhovd, Enikő Zsoldos, Isabelle Budin-Ljøsne
Pubblicato in: The Gerontologist, 2019, ISSN 0016-9013
Editore: Gerontological Society of America
DOI: 10.1093/geront/gnz155

On the use of growth models to study normal cognitive aging

Autori: Paolo Ghisletta, Fabio Mason, Timo von Oertzen, Christopher Hertzog, Lars-Göran Nilsson, Ulman Lindenberger
Pubblicato in: International Journal of Behavioral Development, Numero 44/1, 2020, Pagina/e 88-96, ISSN 0165-0254
Editore: SAGE Publications
DOI: 10.1177/0165025419851576

Optimal planned missing data design for linear latent growth curve models

Autori: Andreas M. Brandmaier, Paolo Ghisletta, Timo von Oertzen
Pubblicato in: Behavior Research Methods, 2020, ISSN 1554-3528
Editore: Springer Publishing
DOI: 10.3758/s13428-019-01325-y

Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study

Autori: Enikő Zsoldos, Abda Mahmood, Nicola Filippini, Sana Suri, Verena Heise, Ludovica Griffanti, Clare E Mackay, Archana Singh-Manoux, Mika Kivimäki, Klaus P Ebmeier
Pubblicato in: Brain Communications, Numero 2/1, 2020, ISSN 2632-1297
Editore: Oxford University Press
DOI: 10.1093/braincomms/fcaa026

Time, frequency, and time-varying Granger-causality measures in neuroscience

Autori: Sezen Cekic, Didier Grandjean, Olivier Renaud
Pubblicato in: Statistics in Medicine, Numero 37/11, 2018, Pagina/e 1910-1931, ISSN 0277-6715
Editore: John Wiley & Sons Inc.
DOI: 10.1002/sim.7621

Multiscale Bayesian state-space model for Granger causality analysis of brain signal

Autori: Sezen Cekic, Didier Grandjean, Olivier Renaud
Pubblicato in: Journal of Applied Statistics, Numero 46/1, 2018, Pagina/e 66-84, ISSN 0266-4763
Editore: Routledge
DOI: 10.1080/02664763.2018.1455814

Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents.

Autori: Kathrine Skak Madsen; Kathrine Skak Madsen; Louise Baruël Johansen; Wesley K. Thompson; Hartwig R. Siebner; Hartwig R. Siebner; Terry L. Jernigan; William F. C. Baaré
Pubblicato in: Neuroimage, Numero Volume 220, 2020, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2020.117105

Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer’s disease in healthy samples across the lifespan

Autori: Yunpeng Wang, Håkon Grydeland, James M. Roe, Mengyu Pan, Fredrik Magnussen, Inge K. Amlien, Leiv Otto Watne, Ane-Victoria Idland, Lars Bertram, Thomas E. Gundersen, Alvaro Pascual-Leone, Maria Cabello-Toscano, Jose M. Tormos, David Bartres-Faz, Christian A. Drevon, Anders M. Fjell, Kristine W. Walhovd
Pubblicato in: Brain, Behavior, and Immunity, Numero Volume 100, 2022, Pagina/e 243-253, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2021.12.008

Cognition-Mortality Associations Are More Pronounced When Estimated Jointly in Longitudinal and Time-to-Event Models

Autori: Aichele, S., Cekic, S., Rabbitt, P., & Ghisletta, P.
Pubblicato in: Frontiers in Psychology, 2021, ISSN 1664-1078
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2021.708361

Associations of depression and regional brain structure across the adult lifespan: Pooled analyses of six population-based and two clinical cohort studies in the European Lifebrain consortium

Autori: Julia Binnewies, Laura Nawijn, Andreas M. Brandmaier, William F.C. Baaré, David Bartrés-Faz, Christian A. Drevon, Sandra Düzel, Anders M. Fjell, Laura K.M. Han, Ethan Knights, Ulman Lindenberger, Yuri Milaneschi, Athanasia M. Mowinckel, Lars Nyberg, Anna Plachti, Kathrine Skak Madsen, Cristina Solé-Padullés, Sana Suri, Kristine B. Walhovd, Enikő Zsoldos, Klaus P. Ebmeier, Brenda W.J.H. Penni
Pubblicato in: NeuroImage: Clinical, Numero Volume 36, 2022, Pagina/e 103180, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2022.103180

Transcriptome-wide Association Study in Frontotemporal Dementia Identifies New Disease Loci by In Silico Analysis.

Autori: Christina M. Lill
Pubblicato in: Biological Psychiatry, Numero 00063223, 2020, Pagina/e Pages e37-e39, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2021.02.010

People’s interest in brain health testing: Findings from an international, online cross-sectional survey.

Autori: Carver RB, Fredheim NAG, Mowinckel AM, Ebmeier KP, Friedman BB, Rosness TA, Drevon CA, Suri S, Baaré WFC, Zsoldos E, Solé-Padullés C, Bartrés-Faz D, Ghisletta P, Nawijn L, Düzel S, Madsen KS, Fjell AM, Lindenberger U, Walhovd KB and Budin-Ljøsne I
Pubblicato in: Frontiers in Public Health, Numero 10:998302, 2022, ISSN 2296-2565
Editore: Frontiers Media
DOI: 10.3389/fpubh.2022.998302

Autori: Noham Wolpe, James N. Ingram, Kamen A. Tsvetanov, Richard N. Henson, Daniel M. Wolpert, James B. Rowe, Lorraine K. Tyler, Carol Brayne, Edward T. Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Fiona E. Matthews, William D. Marslen-Wilson, Meredith A. Shafto, Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, Anna McCarrey, Abdur Mustafa, Darren Price
Pubblicato in: Neurobiology of Aging, Numero 90, 2020, Pagina/e 13-23, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.02.016

The Use of a Hidden Mixture Transition Distribution Model in Clustering Few but Long Continuous Sequences: An Illustration with Cognitive Skills Data

Autori: Zhivko Taushanov, Paolo Ghisletta
Pubblicato in: Symmetry, Numero 12/10, 2020, Pagina/e 1618, ISSN 2073-8994
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/sym12101618

Exploratory factor analysis with structured residuals for brain network data

Autori: Erik-Jan van Kesteren, Rogier A. Kievit
Pubblicato in: Network Neuroscience, Numero 5/1, 2021, Pagina/e 1-27, ISSN 2472-1751
Editore: Massachusetts Institute of Technology
DOI: 10.1162/netn_a_00162

Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses

Autori: Anya Topiwala; Chaoyue Wang; Klaus P. Ebmeier; Stephen Burgess; Steven Bell; Daniel F. Levey; Hang Zhou; Celeste McCracken; Adriana Roca-Fernández; Steffen E. Petersen; Betty Raman; Masud Husain; Joel Gelernter; Karla L. Miller; Stephen M. Smith; Thomas E. Nichols
Pubblicato in: PLOS medicine, Numero 19(7): e1004039, 2022, ISSN 1549-1676
Editore: PLOS
DOI: 10.17863/cam.85375

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease

Autori: James M. Roe, Didac Vidal-Piñeiro, Øystein Sørensen, Andreas M. Brandmaier, Sandra Düzel, Hector A. Gonzalez, Rogier A. Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Athanasia M. Mowinckel, Lars Nyberg, Denise C. Park, Sara Pudas, Melissa M. Rundle, Kristine B. Walhovd, Anders M. Fjell, René Westerhausen & The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
Pubblicato in: Nature Communications, Numero 12, Article number: 721, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21057-y

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