Objectif The aim of this project is to assess the facilitators and barriers to scale-up of two proven active TB case finding and comprehensive patient care models in Vietnam and Nepal as examples of these low and lower-middle income country settings. We will use these data to develop an evidence-based framework for scale-up of implementation by the respective National TB Programs in consultation with relevant stakeholders and governments. This will facilitate programmatic adoption of realistic and optimised active case finding strategies by national TB control programmes.We will compare two alternative implementation strategies in each country appropriate to the local level of current service delivery. For Vietnam, we will compare implementation using salaried employees with volunteer counsellors. For Nepal, we will compare two diagnostic testing strategies as a component of active case finding: traditional smear microscopy or the novel Xpert Omni molecular testing. We will determine the health economic impact of active case detection under the different models and model the long-term epidemiologic impact and cost-effectiveness.The research seeks to achieve the following objectives:1) Implementation of active case finding with comprehensive patient support in 6 districts of Ho Chi Minh City, Vietnam detecting 1,450 additional cases in 2 years.2) Implementation of active case finding with comprehensive patient support in 4 districts of the Central Development Region of Nepal, detecting 1,050 additional cases in 2 years.3) Health economic evaluation of alternative implementation models in low (Nepal) and middle income (Vietnam) scenarios to inform policy.4) Consultation with policy makers, stakeholders and end-users to evaluate facillatators and barriers to scale-up at health system and individual level and development of an evidence-based framework for scale-up for each country.5) Transmission modelling of epidemic impact and long-term cost-effectiveness. Champ scientifique social scienceseconomics and businesseconomicshealth economicseconomic impact of epidemics Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.6. - Health care provision and integrated care Thème(s) SC1-PM-21-2016 - Implementation research for scaling-up of evidence based innovations and good practice in Europe and low- and middle-income countries Appel à propositions H2020-SC1-2016-2017 Voir d’autres projets de cet appel Sous appel H2020-SC1-2016-RTD Régime de financement RIA - Research and Innovation action Coordinateur LIVERPOOL SCHOOL OF TROPICAL MEDICINE Contribution nette de l'UE € 1 225 000,00 Adresse PEMBROKE PLACE L35QA LIVERPOOL 3 Royaume-Uni Voir sur la carte Région North West (England) Merseyside Liverpool Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 225 000,00 Participants (4) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire FREUNDESKREIS FUR INTERNATIONALE TUBERKULOSEHILFE EV Allemagne Contribution nette de l'UE € 1 524 026,25 Adresse HUGELSTRASSE 4 82166 GRAFELFING Voir sur la carte Région Bayern Oberbayern München, Landkreis Type d’activité Other Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 524 026,25 BIRAT NEPAL MEDICAL TRUST Népal Contribution nette de l'UE € 1 022 995,00 Adresse LAZIMPAT KATHMANDU WARD N 2 20564 KATHMANDU Voir sur la carte Type d’activité Other Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 022 995,00 KAROLINSKA INSTITUTET Suède Contribution nette de l'UE € 646 563,75 Adresse Nobels Vag 5 17177 Stockholm Voir sur la carte Région Östra Sverige Stockholm Stockholms län Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 646 563,75 KONINKLIJKE NEDERLANDSE CENTRALE VERENIGING TOT BESTRIJDING DER TUBERCULOSE (KNCV) Pays-Bas Contribution nette de l'UE € 493 838,75 Adresse MAANWEG 174 2516 AB 's-Gravenhage (Den Haag) Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Type d’activité Other Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 493 838,75
