Objective The aim of this project is to assess the facilitators and barriers to scale-up of two proven active TB case finding and comprehensive patient care models in Vietnam and Nepal as examples of these low and lower-middle income country settings. We will use these data to develop an evidence-based framework for scale-up of implementation by the respective National TB Programs in consultation with relevant stakeholders and governments. This will facilitate programmatic adoption of realistic and optimised active case finding strategies by national TB control programmes.We will compare two alternative implementation strategies in each country appropriate to the local level of current service delivery. For Vietnam, we will compare implementation using salaried employees with volunteer counsellors. For Nepal, we will compare two diagnostic testing strategies as a component of active case finding: traditional smear microscopy or the novel Xpert Omni molecular testing. We will determine the health economic impact of active case detection under the different models and model the long-term epidemiologic impact and cost-effectiveness.The research seeks to achieve the following objectives:1) Implementation of active case finding with comprehensive patient support in 6 districts of Ho Chi Minh City, Vietnam detecting 1,450 additional cases in 2 years.2) Implementation of active case finding with comprehensive patient support in 4 districts of the Central Development Region of Nepal, detecting 1,050 additional cases in 2 years.3) Health economic evaluation of alternative implementation models in low (Nepal) and middle income (Vietnam) scenarios to inform policy.4) Consultation with policy makers, stakeholders and end-users to evaluate facillatators and barriers to scale-up at health system and individual level and development of an evidence-based framework for scale-up for each country.5) Transmission modelling of epidemic impact and long-term cost-effectiveness. Fields of science social scienceseconomics and businesseconomicshealth economicseconomic impact of epidemics Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.6. - Health care provision and integrated care Topic(s) SC1-PM-21-2016 - Implementation research for scaling-up of evidence based innovations and good practice in Europe and low- and middle-income countries Call for proposal H2020-SC1-2016-2017 See other projects for this call Sub call H2020-SC1-2016-RTD Funding Scheme RIA - Research and Innovation action Coordinator LIVERPOOL SCHOOL OF TROPICAL MEDICINE Net EU contribution € 1 225 000,00 Address PEMBROKE PLACE L35QA LIVERPOOL 3 United Kingdom See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 225 000,00 Participants (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all FREUNDESKREIS FUR INTERNATIONALE TUBERKULOSEHILFE EV Germany Net EU contribution € 1 524 026,25 Address HUGELSTRASSE 4 82166 GRAFELFING See on map Region Bayern Oberbayern München, Landkreis Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 524 026,25 BIRAT NEPAL MEDICAL TRUST Nepal Net EU contribution € 1 022 995,00 Address LAZIMPAT KATHMANDU WARD N 2 20564 KATHMANDU See on map Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 022 995,00 KAROLINSKA INSTITUTET Sweden Net EU contribution € 646 563,75 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 646 563,75 KONINKLIJKE NEDERLANDSE CENTRALE VERENIGING TOT BESTRIJDING DER TUBERCULOSE (KNCV) Netherlands Net EU contribution € 493 838,75 Address MAANWEG 174 2516 AB 's-Gravenhage (Den Haag) See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 493 838,75