Detecting, understanding and exploiting intracellular redox signaling relays

Project Information

Redox Relays

Grant agreement ID: 742039

DOI

10.3030/742039

Project closed

EC signature date 3 June 2017

Start date 1 October 2017

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 006 250,00

EU contribution

€ 2 006 250,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals

Author(s): Uladzimir Barayeu; Danny Schilling; Mohammad Eid; Thamara Nishida Xavier da Silva; Lisa Schlicker; Nikolina Mitreska; Christopher Zapp; Frauke Gräter; Aubry K. Miller; Reinhard Kappl; Almut Schulze; José Pedro Friedmann Angeli; Tobias P. Dick
Published in: Nature Chemical Biology, Issue 19, 2023, Page(s) 28–37, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-022-01145-w

DOPA residues endow collagen with radical scavenging capacity

Author(s): Markus Kurth; Uladzimir Barayeu; Hassan Gharibi; Andrei Kuzhelev; Kai Riedmiller; Jennifer Zilke; Kasimir Noack; Vasyl Denysenkov; Reinhard Kappl; Thomas F. Prisner; Roman A. Zubarev; Tobias P. Dick; Frauke Gräter
Published in: Angewandte Chemie International Edition, Issue 135, 2022, Page(s) e202216610, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202216610

Real-time monitoring of peroxiredoxin oligomerization dynamics in living cells

Author(s): Daniel Pastor-Flores, Deepti Talwar, Brandán Pedre, Tobias P. Dick
Published in: Proceedings of the National Academy of Sciences, Issue 117/28, 2020, Page(s) 16313-16323, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1915275117

The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells

Author(s): Talwar D, Miller CG, Grossmann J, Szyrwiel L, Schwecke T, Demichev V, Mikecin Drazic A-M, Mayakonda A, Lutsik P, Veith C, Milsom MD, Müller-Decker K, Mülleder M, Ralser M, Dick TP
Published in: Nature Metabolism, Issue 5, 2023, Page(s) 660–676, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-023-00781-3

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Author(s): Murphy, Michael P; Bayir, Hülya; Belousov, Vsevolod; Chang, Christopher J; Davies, Kelvin JA; Davies, Michael J; Dick, Tobias P; Finkel, Toren; Forman, Henry J; Janssen-Heininger, Yvonne; Gems, David; Kagan, Valerian E; Kalyanaraman, Balaraman; Larsson, Nils-Göran; Milne, Ginger L; Nyström, Thomas; Poulsen, Henrik E; Radi, Rafael; Van Remmen, Holly; Schumacker, Paul T; Thornalley, Paul J; Toyok
Published in: Nature Metabolism, Issue 4, 2022, Page(s) 651–662, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-022-00591-z

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

Author(s): Denolly S, Stukalov A, Barayeu U, Rosinski AN, Kritsiligkou P, Joecks S, Dick TP, Pichlmair A, Bartenschlager R
Published in: Nature Communications, Issue 14, 2023, Page(s) 8045, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43665-6

Ferroptosis in health and disease

Author(s): Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser-von Bieren, Maria Fedoro
Published in: Redox Biology, Issue 75, 2024, Page(s) 103211, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2024.103211

Proteome-wide tagging with an H2O2 biosensor reveals highly localized and dynamic redox microenvironments

Author(s): Kritsiligkou P, Bosch K, Shen TK, Meurer M, Knop M, Dick TP
Published in: Proceedings Of The National Academy Of Sciences, Issue 120, 2023, Page(s) e2314043120, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2314043120

Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death

Author(s): Zijun Wu; Uladzimir Barayeu; Danny Schilling; Tobias P. Dick; Derek A. Pratt
Published in: Current Opinion in Chemical Biology, Issue 76, 2023, Page(s) 102353, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2023.102353

A comparison of Prx- and OxyR-based H2O2 probes expressed in S. cerevisiae

Author(s): Paraskevi Kritsiligkou, Tzu Keng Shen and Tobias P. Dick
Published in: Journal of Biological Chemistry, Issue 297(1), 2021, Page(s) 100866, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100866

Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers

Author(s): Danny Schilling, Uladzimir Barayeu, Raphael R. Steimbach, Deepti Talwar, Aubry K. Miller, Tobias P. Dick
Published in: Angewandte Chemie International Edition, Issue e202203684, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202203684

A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex

Author(s): Deepti Talwar, Joris Messens, Tobias P. Dick
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18324-9

A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation

Author(s): Sarah Stöcker, Michael Maurer, Thomas Ruppert, Tobias P Dick
Published in: Nature Chemical Biology, Issue 14/2, 2018, Page(s) 148-155, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/nchembio.2536

N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production

Author(s): Daria Ezeriņa, Yoko Takano, Kenjiro Hanaoka, Yasuteru Urano, Tobias P. Dick
Published in: Cell Chemical Biology, Issue 25/4, 2018, Page(s) 447-459.e4, ISSN 2451-9456
Publisher: Elsevier
DOI: 10.1016/j.chembiol.2018.01.011

A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway

Author(s): Ana G. Barata, Tobias P. Dick
Published in: Redox Biology, Issue 28, 2020, Page(s) 101340, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2019.101340

The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides

Author(s): Schilling D, Ditrói T, Barayeu U, Jurányi EP, Nagy P, Dick TP
Published in: Current Opinion in Chemical Biology, Issue 76, 2023, Page(s) 102368, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2023.102368

Using the heme peroxidase APEX2 to probe intracellular H2O2 flux and diffusion

Author(s): Mohammad Eid; Uladzimir Barayeu; Kateřina Sulková; Carla Aranda-Vallejo; Tobias P. Dick
Published in: Nature Communications, Issue 15, 2024, Page(s) 1-15, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-45511-9

3-Mercaptopyruvate sulfur transferase is a protein persulfidase

Author(s): Brandán Pedre; Deepti Talwar; Uladzimir Barayeu; Danny Schilling; Marcin Luzarowski; Mikolaj Sokolowski; Sebastian Glatt; Tobias P. Dick
Published in: Nature Chemical Biology, Issue 19, 2023, Page(s) 507–517, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-022-01244-8