Objective
Fungi have a devastating impact on human nutrition and health. Each year, fungal pathogens provoke enormous agricultural losses in crop plants and contaminating food with harmful mycotoxins. The soil-borne fungal pathogen Fusarium oxysporum infects plant root and vascular tissue, causing wilt disease in over a hundred different crops, including both dicots and monocots. A particular aggressive strain of this pathogen, tropical race 4, is threatening banana plantations worldwide. Currently, there is little information on the crucial biotrophic infection stage of vascular pathogens, from penetration of root to colonization of xylem vessels. Fusarium provides an excellent model to investigate the cell-specific sensing and adaptation and suppression of plant immunity related to early infection stages. The host group has recently reported the chemotrophic sensing mechanism used by this pathogen, and identified host plant signals perceived by Fusarium in the soil. Moreover, their work revealed a combined action of enzymes involved in fungal cell wall remodelling and plant cell wall degradation which contributes in virulence of this pathogen. In this project, we aim to identify the cell-specific virulence genes that F. oxysporum uses to colonize a dicot host (Arabidopsis) versus monocot (Banana) that has a fundamentally distinct vascular tissue architecture. We will use dual RNA-Seq coupled with Laser capture microdissection (LCM) to identify core compatibility components in both the pathogen and the plant, that are essential for establishing wilt disease. This will lead to identification and characterization of potential targets in this interaction that could be used to develop novel resistance strategies in ongoing banana breeding efforts. This project will thus advance fundamental knowledge of how a fungus senses and colonizes such a broad host range, while creating new opportunities for crop protection by dissecting the interaction at a cell-type specific resolution.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology mycology
- medical and health sciences health sciences nutrition
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences physical sciences optics laser physics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
14005 CORDOBA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.