PREvention of STroke in Intracerebral haemorrhaGE survivors with Atrial Fibrillation

Project Information

PRESTIGE-AF

Grant agreement ID: 754517

DOI

10.3030/754517

Project closed

EC signature date 5 December 2017

Start date 1 December 2017

End date 30 November 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 958 896,00

EU contribution

€ 6 958 896,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (2)

"PRESTIGE-AF ""Dissemination Package"""

PRESTIGE-AF “Dissemination Package”

Physician education materials for antithrombotic consultations with ICH survivors

Documents, reports (4)

Final Meeting & Conference Report

This specific report will be prepared and issued following the project’s final meeting and conference, as a final outline of the project’s main outcomes and results, against the original proposal idea

Dissemination & Communication Plan
First study subject approvals package

First study subject approvals package submitted

Annual Meeting Reports

Reports prepared following on from each consortium meeting, focusing on progress on major deliverables and milestones.Updated after every annual meeting. (M25, M37, M49)

Websites, patent fillings, videos etc. (3)

"Educational video on""Sample Collection Methods for Biomarker Studies"""

Educational video on“Sample Collection Methods for Biomarker Studies at PRESTIGE-AFtrial”

Development of a campaign to increase participation of female patients in trials

Development of a campaign model to increase participation of female patients in trials

Launch of website and social media accounts

Publications

Peer reviewed articles (24)

Stroke genetics informs drug discovery and risk prediction across ancestries

Author(s): Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel C. Posner, Frederick K. Kamanu, Masaru Koido, Quentin Le Grand, Mingyang Shi, Yunye He, Marios K. Georgakis, Ilana Caro, Kristi Krebs, Yi-Ching Liaw, Felix C. Vaura, Kuang Lin, Bendik Slagsvold Winsvold, Vinodh Srinivasasainagendra, Livia Parodi, Hee-Joon Bae, Ganesh Chauhan, Michael R. Chong, Liisa Tomppo, Ruf
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05165-3

ESO Guideline on covert cerebral small vessel disease

Author(s): Joanna M Wardlaw, Stephanie Debette, Hanna Jokinen, Frank-Erik De Leeuw, Leonardo Pantoni, Hugues Chabriat, Julie Staals, Fergus Doubal, Salvatore Rudilosso, Sebastian Eppinger, Sabrina Schilling, Raffaele Ornello, Christian Enzinger, Charlotte Cordonnier, Martin Taylor-Rowan, Arne G Lindgren
Published in: European Stroke Journal, 2021, ISSN 2396-9881
Publisher: SAGE Publications
DOI: 10.1177/23969873211012132

Extent of routine diagnostic cardiac work-up at certified German stroke units participating in the prospective MonDAFIS study

Author(s): Manuel C. Olma, Serdar Tütüncü, Ulrike Grittner, Claudia Kunze, Muhammad Jawad-Ul-Qamar, Paulus Kirchhof, Joachim Röther, Götz Thomalla, Roland Veltkamp, Ulrich Laufs, Darius G. Nabavi, Peter U. Heuschmann, Matthias Endres & Karl Georg Haeusler
Published in: Neurological Research and Practice, 2023, ISSN 2524-3489
Publisher: BioMed Central Ltd
DOI: 10.1186/s42466-023-00246-8

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

Author(s): Aniket Mishra, Cécile Duplaà, Dina Vojinovic, Hideaki Suzuki, Muralidharan Sargurupremraj, Nuno R Zilhão, Shuo Li, Traci M Bartz, Xueqiu Jian, Wei Zhao, Edith Hofer, Katharina Wittfeld, Sarah E Harris, Sandra van der Auwera-Palitschka, Michelle Luciano, Joshua C Bis, Hieab H H Adams, Claudia L Satizabal, Rebecca F Gottesman, Piyush G Gampawar, Robin Bülow, Stefan Weiss, Miao Yu, Mark E Bastin,
Published in: Brain, 2022, ISSN 1460-2156
Publisher: Oxford University Press
DOI: 10.1093/brain/awab432

Natalizumab in acute ischemic stroke (ACTION II)

Author(s): Mitchell S.V. Elkind, Roland Veltkamp, Joan Montaner, S. Claiborne Johnston, Aneesh B. Singhal, Kyra Becker, Maarten G. Lansberg, Weihua Tang, Rachna Kasliwal, Jacob Elkins
Published in: Neurology, Issue 95/8, 2020, Page(s) e1091-e1104, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000010038

Cerebral small vessel disease genomics and its implications across the lifespan

Author(s): Muralidharan Sargurupremraj, Hideaki Suzuki, Xueqiu Jian, Chloé Sarnowski, Tavia E. Evans, Joshua C. Bis, Gudny Eiriksdottir, Saori Sakaue, Natalie Terzikhan, Mohamad Habes, Wei Zhao, Nicola J. Armstrong, Edith Hofer, Lisa R. Yanek, Saskia P. Hagenaars, Rajan B. Kumar, Erik B. van den Akker, Rebekah E. McWhirter, Stella Trompet, Aniket Mishra, Yasaman Saba, Claudia L. Satizabal, Gregory Beaudet,
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19111-2

Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials

Author(s): Prof Rustam Al-Shahi Salman PhD, Jacqueline Stephen PhD, Prof Jayne F Tierney PhD, Prof Steff C Lewis PhD , Prof David E Newby MD, Adrian R Parry-Jones PhD, Prof Philip M White MD, Prof Stuart J Connolly MD, Prof Oscar R Benavente MD, Dar Dowlatshahi PhD, Prof Charlotte Cordonnier PhD, Catherine M Viscoli MD, Prof Kevin N Sheth MD, Prof Hooman Kamel MD, Prof Roland Veltkamp MD, Kristin T Larsen MD
Published in: The Lancet Neurology, 2023, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(23)00315-0

Effectiveness and Safety of Antithrombotic Medication in Patients With Atrial Fibrillation and Intracranial Hemorrhage: Systematic Review and Meta-Analysis

Author(s): Elena Ivany, Leona A. Ritchie, Gregory Y.H. Lip, Robyn R. Lotto, David J. Werring and Deirdre A. Lane
Published in: Stroke, 2022, ISSN 1524-4628
Publisher: AHA Journals
DOI: 10.1161/strokeaha.122.038752

Time course of neuroinflammation after human stroke – a pilot study using co-registered PET and MRI

Author(s): Lucio D’Anna, Graham Searle, Kirsten Harvey, Paul M. Matthews & Roland Veltkamp
Published in: BMC Neurology, 2023, ISSN 1471-2377
Publisher: BioMed Central
DOI: 10.1186/s12883-023-03178-7

Burden of Stroke in Europe

Author(s): Hatem A. Wafa, Charles D.A. Wolfe, Eva Emmett, Gregory A. Roth, Catherine O. Johnson, Yanzhong Wang
Published in: Stroke, Issue 51/8, 2020, Page(s) 2418-2427, ISSN 0039-2499
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.029606

In‐Hospital ECG Findings, Changes in Medical Management, and Cardiovascular Outcomes in Patients With Acute Stroke or Transient Ischemic Attack

Author(s): Manuel C. Olma, Serdar Tütüncü, Cornelia Fiessler, Claudia Kunze, Michael Krämer, Lena Steindorf‐Sabath, Muhammad Jawad‐Ul‐Qamar, Paulus Kirchhof, Ulrich Laufs, Johannes Schurig, Peter Kraft, Joachim Röther, Albrecht Günther, Götz Thomalla, Boris Dimitrijeski, Darius G. Nabavi, Roland Veltkamp, Peter U. Heuschmann, Karl Georg Haeusler and Matthias Endres
Published in: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.122.027149

Heart failure, recurrent vascular events and death in patients with ischemic stroke—results of the MonDAFIS study

Author(s): Serdar Tütüncü, Manuel C. Olma, Claudia Kunze, Joanna Dietzel, Johannes Schurig, Michael Rosenkranz, Robert Stingele, Matthias Maschke, Peter U. Heuschmann, Paulus Kirchhof, Ulrich Laufs, Darius G. Nabavi, Joachim Röther, Götz Thomalla, Roland Veltkamp, Matthias Endres, Karl Georg Haeusler, null null
Published in: Internal and Emergency Medicine, Issue 19, 2024, Page(s) 1247-1254, ISSN 1828-0447
Publisher: CEPI-AIM Group
DOI: 10.1007/s11739-024-03594-8

Managing Uncertainty: Physicians' Decision Making for Stroke Prevention for Patients with Atrial Fibrillation and Intracerebral Hemorrhage

Author(s): Elena Ivany, Robyn R Lotto, Gregory Y H Lip, Deirdre A Lane
Published in: Thrombosis and Haemostasis, 2022, ISSN 0340-6245
Publisher: Schattauer
DOI: 10.1055/a-1789-4824

Association of stroke lesion shape with newly detected atrial fibrillation – Results from the MonDAFIS study

Author(s): Bernardo Crespo Pimentel, Thies Ingwersen, Karl Georg Haeusler, Eckhard Schlemm, Nils D Forkert, Deepthi Rajashekar, Pauline Mouches, Alina Königsberg, Paulus Kirchhof, Claudia Kunze, Serdar Tütüncü, Manuel C Olma, Michael Krämer, Dominik Michalski, Andrea Kraft, Timolaos Rizos, Torsten Helberg, Sven Ehrlich, Darius G Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U Heuschmann,
Published in: European Stroke Journal, 2022, ISSN 2396-9873
Publisher: European Stroke Organisation
DOI: 10.1177/23969873221100895

Drug–Drug Interactions with Direct Oral Anticoagulants

Author(s): Kathrin I. Foerster, Simon Hermann, Gerd Mikus, Walter E. Haefeli
Published in: Clinical Pharmacokinetics, Issue 59/8, 2020, Page(s) 967-980, ISSN 0312-5963
Publisher: Adis International Ltd.
DOI: 10.1007/s40262-020-00879-x

Extent of white matter lesion is associated with early hemorrhagic transformation in acute ischemic stroke related to atrial fibrillation

Author(s): Lucio D'Anna, Filippos T. Filippidis, Kirsten Harvey, Marilena Marinescu, Paul Bentley, Eleni Korompoki, Roland Veltkamp
Published in: Brain and Behaviour, 2021, ISSN 2162-3279
Publisher: Wiley Open Access
DOI: 10.1002/brb3.2250

Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives

Author(s): Stéphanie Debette and Hugh S. Markus
Published in: Circulation Research, 2022, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.319950

Burden of intracerebral haemorrhage in Europe: forecasting incidence and mortality between 2019 and 2050

Author(s): Hatem A. Wafa, Iain Marshall, Charles D.A. Wolfe, Wanqing Xie, Catherine O. Johnson, Roland Veltkamp, Yanzhong Wang, Roland Veltkamp, Kirsten H. Harvey, Eleni Korompoki, Lucio D’Anna, Omid Halse, Emily R. Harvey, Klemens Hügen, Uwe Malzahn, Sabine Ullmann, Carolin Schuhmann, Gabriele Putz Todd, Hannes Brinz, Cornelia Fiessler, Peter U. Heuschmann, Kirsten Haas, Viktoria Rücker, Christian Enzin
Published in: The Lancet Regional Health - Europe, Issue 38, 2024, Page(s) 100842, ISSN 2666-7762
Publisher: The Lancet Regional Health - Europe
DOI: 10.1016/j.lanepe.2024.100842

Early initiation of direct anticoagulation after stroke in patients with atrial fibrillation

Author(s): L. D'Anna, F. T. Filippidis, S. Antony, Z. Brown, H. Wyatt, A. Malik, P. Sivakumaran, K. Harvey, M. Marinescu, P. Bentley, E. Korompoki, R. Veltkamp
Published in: European Journal of Neurology, Issue 27/11, 2020, Page(s) 2168-2175, ISSN 1351-5101
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ene.14396

Risk of Cerebrovascular Events in Intracerebral Hemorrhage Survivors With Atrial Fibrillation: A Nationwide Cohort Study

Author(s): Peter Brønnum Nielsen, Line Melgaard, Thure Filskov Overvad, Martin Jensen, Torben Bjerregaard Larsen, Gregory Y.H. Lip
Published in: Stroke, 2022, ISSN 1524-4628
Publisher: American Heart Association
DOI: 10.1161/strokeaha.121.038331

Independent external validation of a stroke recurrence score in patients with embolic stroke of undetermined source

Author(s): Thies Ingwersen, Manuel C. Olma, Eckhard Schlemm, Carola Mayer, Bastian Cheng, Serdar Tütüncü, Paulus Kirchhof, Roland Veltkamp, Joachim Röther, Ulrich Laufs, Darius G. Nabavi, George Ntaios, Matthias Endres, Karl Georg Haeusler & Götz Thomalla
Published in: Neurological Research and Practice, 2023, ISSN 2524-3489
Publisher: BioMed Central Limited
DOI: 10.1186/s42466-023-00279-z

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Author(s): Marie-Gabrielle Duperron, Maria J. Knol, Quentin Le Grand, Tavia E. Evans, Aniket Mishra, Ami Tsuchida, Gennady Roshchupkin, Takahiro Konuma, David-Alexandre Trégouët, Jose Rafael Romero, Stefan Frenzel, Michelle Luciano, Edith Hofer, Mathieu Bourgey, Nicole D. Dueker, Pilar Delgado, Saima Hilal, Rick M. Tankard, Florian Dubost, Jean Shin, Yasaman Saba, Nicola J. Armstrong, Constance Bordes, Mar
Published in: Nature Medicine, 2023, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-023-02268-w

Genetics of common cerebral small vessel disease

Author(s): Constance Bordes, Muralidharan Sargurupremraj, Aniket Mishra, Stéphanie Debette
Published in: Nature reviews neurology, 2022, ISSN 1759-4766
Publisher: Springer Nature
DOI: 10.1038/s41582-021-00592-8

Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes

Author(s): Quentin Le Grand, Claudia L. Satizabal, Muralidharan Sargurupremraj, Aniket Mishra, Aicha Soumaré, Alexandre Laurent, Fabrice Crivello, Ami Tsuchida, Jean Shin, Mélissa Macalli, Baljeet Singh, Alexa S. Beiser, Charles DeCarli, Evan Fletcher, Tomas Paus, Mark Lathrop, Hieab H.H. Adams, Joshua C. Bis, Sudha Seshadri, Christophe Tzourio, Bernard Mazoyer, Stéphanie Debette
Published in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021, ISSN 2451-9022
Publisher: Elsevier Ltd
DOI: 10.1016/j.bpsc.2021.10.011