VIral and BacteRial Adhesin Network Training

Información del proyecto

ViBrANT

Identificador del acuerdo de subvención: 765042

DOI

10.3030/765042

Proyecto cerrado

Fecha de la firma de la CE 31 Agosto 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 30 Junio 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 925 220,40

Aportación de la UE

€ 3 925 220,40

Coordinado por

UNIVERSITY OF LEEDS
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

Release of the modelling protocol for adhesin structure determination as software
Report with updated exploitation strategy
Report on exploitation strategy
Outreach plan

Plan for communications and outreach

White paper on best practices in the ETN
Data management plan

Websites, patent fillings, videos etc. (4)

>10 review articles published/in press
Developed materials and methods for capture/enrichment of multiple pathogens based on adhesin-ligand binding

Developed materials and methods for captureenrichment of multiple pathogens based on adhesinligand binding

Initial website

Initial public website goes live

30 publications in high-quality open-access journals

30 publications in highquality openaccess journals

Other (2)

Recruitment of all ESRs
Supervisory Board of network

Compulsory Deliverable

Demonstrators, pilots, prototypes (1)

Mapping of Interfaces between viral adhesins and receptors

Publicaciones

Peer reviewed articles (31)

Novel Biorecognition Elements against Pathogens in the Design of State-of-the Art Diagnostics

Autores: Sande M.G, Rodrigues J.L, Ferreira D, Silva C.J, Rodrigues L. R.
Publicado en: Biosensors, 2021, ISSN 2079-6374
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios11110418

Complete Genome Sequence of Bartonella alsatica Strain IBS 382 (CIP 105477)

Autores: Arno Thibau, Tilman G. Schultze, Wibke Ballhorn, Volkhard A. J. Kempf
Publicado en: Microbiology Resource Announcements, Edición Volume 9 Edición 34, 2020, ISSN 2576-098X
Editor: American Society for Microbiology
DOI: 10.1128/mra.00769-20

Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens

Autores: Alex van Belkum, Carina Almeida, Benjamin Bardiaux, Sarah V. Barrass, Sarah J. Butcher, Tuğçe Çaykara, Sounak Chowdhury, Rucha Datar, Ian Eastwood, Adrian Goldman, Manisha Goyal, Lotta Happonen, Nadia Izadi-Pruneyre, Theis Jacobsen, Pirjo H. Johnson, Volkhard A. J. Kempf, Andreas Kiessling, Juan Leva Bueno, Anchal Malik, Johan Malmström, Ina Meuskens, Paul A. Milner, Michael Nilges, Nicole Pam
Publicado en: Diagnostics, Edición 11/7, 2021, Página(s) 1259, ISSN 2075-4418
Editor: MDPI
DOI: 10.3390/diagnostics11071259

Secondary structure and 1H, 15N & 13C resonance assignments of the periplasmic domain of OutG, Major pseudodopilin from Dickeya dadantii type II secretion system

Autores: Jacobsen T, Dazzoni R, Renault M.G, Bardiaux B, Nilges M, Shevchik V, Izadi-Pruneyre N.
Publicado en: Biomol NMR Assign, 2022, ISSN 1874-2718
Editor: Springer Verlag
DOI: 10.1007/s12104-022-10085-4

Type V Secretion Systems: An Overview of Passenger Domain Functions

Autores: Ina Meuskens, Athanasios Saragliadis, Jack C. Leo, Dirk Linke
Publicado en: Frontiers in Microbiology, Edición 10, 2019, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2019.01163

Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels

Autores: Pablo Rodriguez-Mateos, Bongkot Ngamsom, Charlotte E. Dyer, Alexander Iles, Nicole Pamme
Publicado en: Electrophoresis, Edición 42, 2021, Página(s) 2246-2255, ISSN 0173-0835
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/elps.202100083

Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH

Autores: Stephan Wimmi, Alexander Balinovic, Hannah Jeckel, Lisa Selinger, Dimitrios Lampaki, Emma Eisemann, Ina Meuskens, Dirk Linke, Knut Drescher, Ulrike Endesfelder, Andreas Diepold
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-21863-4

Molecular Organisation of Tick-Borne Encephalitis Virus

Autores: Pulkkinen L.I.A, Barrass S. V, Domanska A, Överby A.K, Anastasina M, Butcher S. J.
Publicado en: Viruses, 2022, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14040792

Long-Read Sequencing Reveals Genetic Adaptation of Bartonella Adhesin A Among Different Bartonella henselae Isolates

Autores: Arno Thibau, Katharina Hipp, Diana J. Vaca, Sounak Chowdhury, Johan Malmström, Athanasios Saragliadis, Wibke Ballhorn, Dirk Linke, Volkhard A. J. Kempf
Publicado en: Frontiers in Microbiology, Edición Volume 13, Article 838267, 2022, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2022.838267

The C-terminal head domain of Burkholderia pseudomallei BpaC has a striking hydrophilic core with an extensive solvente network

Autores: Kiessling A. R, Harris S. A, Weimer K. M, Wells G, Goldman A.
Publicado en: Mol Microbiology, 2022, ISSN 1365-2958
Editor: Wiley
DOI: 10.1111/mmi.14953

Different SARS-CoV-2 haplotypes associate with geographic origin and case fatality rates of COVID-19 patients

Autores: Goyal M, De Bruyne K, van Belkum A, West B
Publicado en: Infection Genetics and Evolution, Edición 90, 2021, ISSN 1567-1348
Editor: Elsevier BV
DOI: 10.1016/j.meegid.2021.104730

Automated antimicrobial susceptibility testing of slow-growing Pseudomonas aeruginosa strains in the presence of tetrazolium salt WST-1

Autores: Datar R, Perrin G, Chalansonnet V, Perry A, Perry JD, van Belkum A, Orenga S
Publicado en: Journal of Microbiological Methods, Edición 186, 2021, ISSN 0167-7012
Editor: Elsevier BV
DOI: 10.1016/j.mimet.2021.106252

The Trimeric Autotransporter Adhesin YadA of Yersina enterocolitica Serotype O:9 Binds Glycan Moieties

Autores: Meuskens I, Leva-Bueno J, Millner P, Schutz M, Peyman SA, Linke D.
Publicado en: Front Microbiology, Edición Volume 22, 2022, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2021.738818

Interaction of Bartonella henselae with fibronectin represents the molecular basis for adhesion to host cells

Autores: Diana J. Vaca, Arno Thibau, Matthias S. Leisegang, Johan Malmström, Dirk Linke, Johannes A. Eble, Wibke Ballhorn, Martin Schaller, Lotta Happonen, Volkhard A. J. Kempf
Publicado en: Microbiology Spectrum, 2022, ISSN 2165-0497
Editor: American Society for Microbiology
DOI: 10.1128/spectrum.00598-22

A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings

Autores: Pablo Rodriguez-Mateos, Bongkot Ngamsom, Cheryl Walter, Charlotte E.Dyer, Jesse Gitaka Alexander Iles, Nicole Pamme
Publicado en: Analytica Chimica Acta, Edición Volume 1177, 8 September 2021, 2021, Página(s) 338758, ISSN 0003-2670
Editor: Elsevier BV
DOI: 10.1016/j.aca.2021.338758

Distinct serotypes of streptococcal M proteins mediate fibrinogen-dependent platelet activation and pro-inflammatory effects

Autores: Palm F, Chowdhury S, Wettemark S, Malmström J, Happonen L, Shannon O
Publicado en: Infect Immunology, 2022, ISSN 2379-5077
Editor: ASM Journals
DOI: 10.1128/iai.00462-21

Contemporary diagnostics for medically relevant fastidious microorganisms belonging to the genera Anaplasma, Bartonella, Coxiella, Orientia and Rickettsia

Autores: Diana J. Vaca, Gerhard Dobler, Silke F. Fischer, Christian Keller, Maik Konrad, Friederike D. von Loewenich, Sylvain Orenga, Siddhesh U. Sapre, Alex van Belkum, Volkhard A. J. Kempf
Publicado en: FEMS Microbiology Reviews, Edición fuac013, 2022, ISSN 0168-6445
Editor: Blackwell
DOI: 10.1093/femsre/fuac013

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Autores: Arno Thibau, Alexander A. Dichter, Diana J. Vaca, Dirk Linke, Adrian Goldman, Volkhard A. J. Kempf
Publicado en: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-019-00649-y

Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria

Autores: Diana J. Vaca, Arno Thibau, Monika Schütz, Peter Kraiczy, Lotta Happonen, Johan Malmström, Volkhard A. J. Kempf
Publicado en: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-019-00644-3

Recent advances in the understanding of trimeric autotransporter adhesions

Autores: Andreas R. Kiessling, Anchal Malik, Adrian Goldman
Publicado en: Medical Microbiology and Immunology (2019), 2019, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-019-00652-3

Brexit in the channel: Europe cut off: a young German scientist's perspective

Autores: Andreas R. Kiessling
Publicado en: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-019-00646-1

Human adenovirus binding to host cell receptors: a structural view

Autores: Aleksandra Cecylia Stasiak, Thilo Stehle
Publicado en: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-019-00645-2

FISH and chips: a review of microfluidic platforms for FISH analysis

Autores: Pablo Rodriguez-Mateos, Nuno Filipe Azevedo, Carina Almeida, Nicole Pamme
Publicado en: Medical Microbiology and Immunology, 2020, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-019-00654-1

Advances in high-throughput methods for the identification of virus receptors

Autores: Sarah V. Barrass, Sarah J. Butcher
Publicado en: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-019-00653-2

Innovative training networks: a new way of collaboration-propped PhD training

Autores: Ina Meuskens, Seamus Higson, Dirk Linke
Publicado en: Medical Microbiology and Immunology, 2019, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-019-00647-0

New solutions to capture and enrich bacteria from complex samples

Autores: Maria G. Sande, Tugçe Çaykara, Carla Joana Silva, Ligia R. Rodrigues
Publicado en: Medical Microbiology and Immunology, 2020, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-020-00659-1

Structural proteomics, electron cryo-microscopy and structural modeling approaches in bacteria–human protein interactions

Autores: Sounak Chowdhury, Lotta Happonen, Hamed Khakzad, Lars Malmström, Johan Malmström
Publicado en: Medical Microbiology and Immunology, 2020, ISSN 0300-8584
Editor: Springer Verlag
DOI: 10.1007/s00430-020-00663-5

Phenotypic and Genomic Variability of Serial Peri-Lung Transplantation Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients

Autores: Datar R, Coello Pelegrin A, Orenga S, Chalansonnet V, Mirande C, Dombrecht J, Perry JD, Perry A, Goossens H, van Belkum A
Publicado en: Frontiers in Microbiology, Edición Volume 12, 2021, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2021.604555

Recent Advances in Rapid Antimicrobial Susceptibility Testing

Autores: Datar R, Orenge S, Pogorelcnik R, Rochas O, Simner PJ, van Belkum A
Publicado en: Clinical Chemistry, Edición Volume 68, Edición 1, 2021, ISSN 0009-9147
Editor: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvab207

Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein Complexes

Autores: Chowdhury S, Khakzad H, Bergdahl GE, Lood R, Ekström S, Linke D, Malmström L, Happonen L, Malmström J.
Publicado en: mSystems, 2021, ISSN 2379-5077
Editor: ASM Journals
DOI: 10.1128/msystems.00271-21

Retrospective Definition of Clostridioides difficile PCR Ribotypes on the Basis of Whole Genome Polymorphisms: A Proof of Principle Study

Autores: Goyal M, Hauben L, Pouseele H, Jaillard M, De Bruyne K, van Belkum A, Goering R
Publicado en: Diagnostics, Edición 10(12), 2020, ISSN 2075-4418
Editor: MDPI
DOI: 10.3390/diagnostics10121078

Non-peer reviewed articles (1)

Proteome-wide cross-linking mass spectrometry to identify specific virus capsid-host interactions between tick-borne encephalitis virus and neuroblastoma cells

Autores: Barrass S. V, Pulkkinen L.I.A, Vapalahti O, Kuivanen S. H, Anastasina M, Happonen L, Butcher S. J.
Publicado en: bioRxiv, 2021, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.10.29.464531