How cellular suicide programmes control phase transitions in fatty liver disease and liver cancer

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Differential role of chronic liver diseases on the incidence of cancer: a longitudinal analysis among 248,224 outpatients in Germany

Author(s): Sven H Loosen, David Schöler, Mark Luedde, Johannes Eschrich, Tom Luedde, Karel Kostev, Christoph Roderburg
Published in: Journal of Cancer Research and Clinical Oncology, 2022, ISSN 0171-5216
Publisher: Springer Verlag
DOI: 10.1007/s00432-022-04198-5

Skeletal Muscle Composition Predicts Outcome in Critically Ill Patients

Author(s): Sven H. Loosen, Maximilian Schulze-Hagen, Tobias Püngel, Lukas Bündgens, Theresa Wirtz, Jakob N. Kather, Mihael Vucur, Pia Paffenholz, Münevver Demir, Philipp Bruners, Christiane Kuhl, Christian Trautwein, Frank Tacke, Tom Luedde, Alexander Koch, Christoph Roderburg
Published in: Critical Care Explorations, Issue 2/8, 2020, Page(s) e0171, ISSN 2639-8028
Publisher: Wolters Kluwer
DOI: 10.1097/cce.0000000000000171

The association between the body height and cardiovascular diseases: a retrospective analysis of 657,310 outpatients in Germany

Author(s): Sarah Krieg, Karel Kostev, Mark Luedde, Andreas Krieg, Tom Luedde, Christoph Roderburg, Sven H Loosen
Published in: European Journal of Medical Research, Issue 27/1, 2022, Page(s) 240, ISSN 0949-2321
Publisher: Holzapfel Verlag GmbH
DOI: 10.1186/s40001-022-00881-y

Overweight and Obesity Determine the Risk for Gastrointestinal Cancer in a Sex-Dependent Manner: A Retrospective Cohort Study of 287,357 Outpatients in Germany

Author(s): Sven H. Loosen, Christoph Roderburg, Markus S. Jördens, Georg Fluegen, Tom Luedde, Karel Kostev
Published in: Cancers, Issue 14/4, 2022, Page(s) 931, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040931

Deep learning in cancer pathology: a new generation of clinical biomarkers

Author(s): Amelie Echle, Niklas Timon Rindtorff, Titus Josef Brinker, Tom Luedde, Alexander Thomas Pearson, Jakob Nikolas Kather
Published in: British Journal of Cancer, Issue 124, 2023, Page(s) 686-696, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-020-01122-x

Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19

Author(s): Salim S Hayek, Christoph Roderburg, Pennelope Blakely, Christopher Launius, Jesper Eugen-Olsen, Frank Tacke, Sofia Ktena, Verena Keitel, Mark Luedde, Evangelos J Giamarellos-Bourboulis, Tom Luedde, Sven H Loosen
Published in: Journal of Clinical Medicine, Issue 10/17, 2021, Page(s) 3907, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10173907

An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration

Author(s): Koppe, Reisinger, Wehr, Vucur, Trautwein, Tacke, Heikenwalder, Luedde
Published in: Cancers, Issue 11/7, 2019, Page(s) 999, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11070999

Overlap between irritable bowel syndrome and common gastrointestinal diagnoses: a retrospective cohort study of 29,553 outpatients in Germany

Author(s): Loosen SH, Kostev K, Jördens MS, Luedde T, Roderburg C
Published in: BMC Gastroenterology, Issue 22/1, 2022, Page(s) 48, ISSN 1471-230X
Publisher: BioMed Central
DOI: 10.1186/s12876-022-02118-y

An Elevated FIB-4 Score Is Associated with an Increased Incidence of Depression among Outpatients in Germany

Author(s): David Schöler; Karel Kostev; Münevver Demir; Mark Luedde; Marcel Konrad; Tom Luedde; Christoph Roderburg; Sven H. Loosen
Published in: Journal of Clinical Medicine, Issue 11/8, 2022, Page(s) 2214, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11082214

Recent Trends and In-Hospital Mortality of Transarterial Chemoembolization (TACE) in Germany: A Systematic Analysis of Hospital Discharge Data between 2010 and 2019

Author(s): Sarah Krieg, Tobias Essing, Andreas Krieg, Christoph Roderburg, Tom Luedde, Sven H Loosen
Published in: Cancers, Issue 14/9, 2022, Page(s) 2088, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092088

Hospital Mortality and Current Trends in Liver Transplantation in Germany — a Systematic Analysis of Standardized Hospital Discharge Data, 2008–2017

Author(s): Sven H Loosen, Hans H Bock, Martin Hellmich, Wolfram T. Knoefel, Christian Trautwein, Verena Keitel, Johannes G. Bode, Ulf P. Neumann, Tom Luedde
Published in: Deutsches Ärzteblatt International, Issue 118/29-30, 2021, Page(s) 497-502, ISSN 1866-0452
Publisher: Deutscher Arzte-Verlag
DOI: 10.3238/arztebl.m2021.0210

Golgi Protein 73 (GP73) Serum Levels Predict Outcome after Resection of Biliary Tract Cancer

Author(s): Sven H Loosen, Justus Halpaap, Simon Labuhn, Jan Bednarsch, Patrick H Alizai, Anjali A Roeth, Sven A Lang, Mihael Vucur, Jakob N Kather, Wolfram T Knoefel, Tom F Ulmer, Ulf P Neumann, Christoph Roderburg, Tom Luedde
Published in: Cancers, Issue 14/18, 2022, Page(s) 4428, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14184428

Prolonged Survival of a Patient with Advanced-Stage Combined Hepatocellular-Cholangiocarcinoma

Author(s): Sven H. Loosen, Nadine T. Gaisa, Maximilian Schmeding, Christoph Heining, Sebastian Uhrig, Theresa H. Wirtz, Sebastian Kalverkamp, Jan Spillner, Frank Tacke, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Christian Trautwein, Christoph Roderburg, Thomas Longerich, Ulf Peter Neumann, Tom Luedde
Published in: Case Reports in Gastroenterology, Issue 14/3, 2021, Page(s) 658-667, ISSN 1662-0631
Publisher: Karger AG
DOI: 10.1159/000511034

Perception of the 2020 SARS-CoV-2 pandemic among medical professionals in Germany: results from a nationwide online survey

Author(s): Pia Paffenholz, Arne Peine, Martin Hellmich, Stella V. Paffenholz, Lukas Martin, Mark Luedde, Miriam Haverkamp, Christoph Roderburg, Gernot Marx, Axel Heidenreich, Christian Trautwein, Tom Luedde, Sven H. Loosen
Published in: Emerging Microbes & Infections, Issue 9/1, 2020, Page(s) 1590-1599, ISSN 2222-1751
Publisher: Nature Publishing Group
DOI: 10.1080/22221751.2020.1785951

Telomere Shortening in Peripheral Leukocytes Is Associated With Poor Survival in Cancer Patients Treated With Immune Checkpoint Inhibitor Therapy

Author(s): Benjamin Rolles, Joao Gorgulho, Mareike Tometten, Christoph Roderburg, Margherita Vieri, Anne Abels, Mihael Vucur, Felix Heymann, Frank Tacke, Tim H Brümmendorf, Tom Luedde, Fabian Beier, Sven H Loosen
Published in: Frontiers in Oncology, Issue 11, 2021, Page(s) 729207, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.729207

Impact of the COVID-19 Pandemic on Cancer Diagnoses in General and Specialized Practices in Germany

Author(s): Louis Jacob, Sven H. Loosen, Matthias Kalder, Tom Luedde, Christoph Roderburg, Karel Kostev
Published in: Cancers, Issue 13/3, 2021, Page(s) 408, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030408

Factors Associated with Non-Severe Adverse Reactions after Vaccination against SARS-CoV-2: A Cohort Study of 908,869 Outpatient Vaccinations in Germany

Author(s): Sven H Loosen, Jens Bohlken, Kerstin Weber, Marcel Konrad, Tom Luedde, Christoph Roderburg, Karel Kostev
Published in: Vaccines, Issue 10/4, 2022, Page(s) 566, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10040566

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

Author(s): Anne T. Schneider, Christiane Koppe, Emilie Crouchet, Aristeidis Papargyriou, Michael T. Singer, Veronika Büttner, Leonie Keysberg, Marta Szydlowska, Frank Jühling, Julien Moehlin, Min-Chun Chen, Valentina Leone, Sebastian Mueller, Thorsten Neuß, Mirco Castoldi, Marina Lesina, Frank Bergmann, Thilo Hackert, Katja Steiger, Wolfram T. Knoefel, Alex Zaufel, Jakob N. Kather, Irene Esposito, Matthia
Published in: Nature Communications, Issue 16, 2025, Page(s) 1765, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-56493-7

Obesity and lipid metabolism disorders determine the risk for development of long COVID syndrome: a cross-sectional study from 50,402 COVID-19 patients

Author(s): Sven H Loosen, Björn-Erik Ole Jensen, Christian Tanislav, Tom Luedde, Christoph Roderburg, Karel Kostev
Published in: Infection, 2022, Page(s) 1-6, ISSN 0300-8126
Publisher: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-022-01784-0

Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases

Author(s): Sven H Loosen, Christoph Roderburg, Patrick H Alizai, Anjali A Roeth, Sophia M Schmitz, Mihael Vucur, Mark Luedde, David Schöler, Pia Paffenholz, Frank Tacke, Christian Trautwein, Tom Luedde, Ulf P Neumann, Tom F Ulmer
Published in: Diagnostics, Issue 11/11, 2021, Page(s) 1999, ISSN 2075-4418
Publisher: MDPI
DOI: 10.3390/diagnostics11111999

Infectious mononucleosis is associated with an increased incidence of multiple sclerosis: Results from a cohort study of 32,116 outpatients in Germany

Author(s): Sven H Loosen, Corinna Doege, Sven G Meuth, Tom Luedde, Karel Kostev, Christoph Roderburg
Published in: Frontiers in Immunology, Issue 13, 2022, Page(s) 937583, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2022.937583

Pan-cancer image-based detection of clinically actionable genetic alterations

Author(s): Jakob Nikolas Kather, Lara R. Heij, Heike I. Grabsch, Chiara Loeffler, Amelie Echle, Hannah Sophie Muti, Jeremias Krause, Jan M. Niehues, Kai A. J. Sommer, Peter Bankhead, Loes F. S. Kooreman, Jefree J. Schulte, Nicole A. Cipriani, Roman D. Buelow, Peter Boor, Nadina Ortiz-Brüchle, Andrew M. Hanby, Valerie Speirs, Sara Kochanny, Akash Patnaik, Andrew Srisuwananukorn, Hermann Brenner, Michael Hoff
Published in: Nature Cancer, Issue 1/8, 2020, Page(s) 789-799, ISSN 2662-1347
Publisher: Springer Nature
DOI: 10.1038/s43018-020-0087-6

Infectious mononucleosis is associated with an increased incidence of NAFLD

Author(s): Sven H Loosen, Karel Kostev, Tom Luedde, Christoph Roderburg
Published in: European Journal of Clinical Investigation, Issue 53/3, 2023, Page(s) e13911, ISSN 0014-2972
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eci.13911

Soluble and EV-bound CD27 act as antagonistic biomarkers in patients with solid tumors undergoing immunotherapy

Author(s): Joao Gorgulho, Sven H. Loosen, Ramsha Masood, Franziska Giehren, Francesca Pagani, Gustav Buescher, Lorenz Kocheise, Vincent Joerg, Constantin Schmidt, Kornelius Schulze, Christoph Roderburg, Eva Kinkel, Britta Fritzsche, Simon Wehmeyer, Benjamin Schmidt, Paul Kachel, Christina Rolling, Julian Götze, Alina Busch, Marianne Sinn, Thais Pereira-Veiga, Harriet Wikman, Maria Geffken, Sven Peine, Urte
Published in: Journal of Experimental & Clinical Cancer Research, Issue 43, 2024, Page(s) 298, ISSN 1756-9966
Publisher: BMC
DOI: 10.1186/s13046-024-03215-4

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

Author(s): Jakob Nikolas Kather, Alexander T. Pearson, Niels Halama, Dirk Jäger, Jeremias Krause, Sven H. Loosen, Alexander Marx, Peter Boor, Frank Tacke, Ulf Peter Neumann, Heike I. Grabsch, Takaki Yoshikawa, Hermann Brenner, Jenny Chang-Claude, Michael Hoffmeister, Christian Trautwein, Tom Luedde
Published in: Nature Medicine, Issue 25/7, 2019, Page(s) 1054-1056, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0462-y

Perilipin 5 and Lipocalin 2 Expression in Hepatocellular Carcinoma

Author(s): Anastasia Asimakopoulou, Mihael Vucur, Tom Luedde, Silvia Schneiders, Stavroula Kalampoka, Thomas Weiss, Ralf Weiskirchen
Published in: Cancers, Issue 11/3, 2019, Page(s) 385, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11030385

Current epidemiological trends and in-hospital mortality of acute pancreatitis in Germany: a systematic analysis of standardized hospital discharge data between 2008 and 2017

Author(s): Sven H Loosen, Tobias Essing, Markus Jördens, Alexander Koch, Frank Tacke, Wolfram T Knoefel, Johannes Bode, Christoph Roderburg, Tom Luedde
Published in: Zeitschrift für Gastroenterologie, Issue 60/3, 2022, Page(s) 310-31, ISSN 1439-7803
Publisher: Karl Demeter Verlag
DOI: 10.1055/a-1682-7621

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

Author(s): Ahmed Ghallab, Reham Hassan, Ute Hofmann, Adrian Friebel, Zaynab Hobloss, Lisa Brackhagen, Brigitte Begher-Tibbe, Maiju Myllys, Joerg Reinders, Nina Overbeck, Selahaddin Sezgin, Sebastian Zühlke, Abdel-Latif Seddek, Walaa Murad, Tim Brecklinghaus, Franziska Kappenberg, Jörg Rahnenführer, Daniela González, Christopher Goldring, Ian M Copple, Rosemarie Marchan, Thomas Longerich, Mihael Vucur, To
Published in: Journal of Hepatology, Issue 77/1, 2022, Page(s) 71-83, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2022.01.020

Antibiotic therapy is associated with an increased incidence of cancer

Author(s): Christoph Roderburg, Sven H Loosen, Markus S Joerdens, Münevver Demir, Tom Luedde, Karel Kostev
Published in: Journal of Cancer Research and Clinical Oncology, Issue 149/3, 2023, Page(s) 1285-1293, ISSN 0171-5216
Publisher: Springer Verlag
DOI: 10.1007/s00432-022-03998-z

Decreased Bone Mineral Density Is a Predictor of Poor Survival in Critically Ill Patients.

Author(s): Maximilian Schulze-Hagen; Christoph Roderburg; Theresa H. Wirtz; Markus S. Jördens; Lukas Bündgens; Samira Abu Jhaisha; Philipp Hohlstein; Jonathan F. Brozat; Philipp Bruners; Christina Loberg; Christiane K. Kuhl; Christian Trautwein; Frank Tacke; Tom Luedde; Sven H. Loosen; Alexander Koch
Published in: Journal of Clinical Medicine, Issue 10/16, 2021, Page(s) 3741, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10163741

Diverticular disease is associated with an increased incidence rate of depression and anxiety disorders

Author(s): Sven H. Loosen, Pia Paffenholz, Tom Luedde, Karel Kostev, Christoph Roderburg
Published in: International Journal of Colorectal Disease, 2021, ISSN 0179-1958
Publisher: Springer Verlag
DOI: 10.1007/s00384-021-03937-3

JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging

Author(s): Katrin Müller, Hanna Honcharova-Biletska, Christiane Koppe, Michèle Egger, Lap Kwan Chan, Anne T. Schneider, Lena Küsgens, Friederike Böhm, Yannick Boege, Marc E. Healy, Johannes Schmitt, Sarah Comtesse, Mirco Castoldi, Christian Preisinger, Marta Szydlowska, Enrico Focaccia, Nadine T. Gaisa, Sven H. Loosen, Simone Jörs, Frank Tacke, Christoph Roderburg, Verena Keitel, Johannes G. Bode, Peter
Published in: Proceedings of the National Academy of Sciences, Issue 118/12, 2021, Page(s) e2007194118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2007194118

Life is fragile: FMRP controls cell death in liver disease

Author(s): Mihael Vucur, Tom Luedde
Published in: Gut, Issue 69/1, 2019, Page(s) 2-3, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319534

Soluble lymphocyte activation gene-3 (sLAG3) and CD4/CD8 ratio dynamics as predictive biomarkers in patients undergoing immune checkpoint blockade for solid malignancies

Author(s): Joao Gorgulho, Christoph Roderburg, Fabian Beier, Carsten Bokemeyer, Tim H. Brümmendorf, Sven H. Loosen, Tom Luedde
Published in: British Journal of Cancer, Issue 130, 2024, Page(s) 1013-1022, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-023-02558-7

Non-Alcoholic Fatty Liver Disease (NAFLD) and risk of new-onset heart failure: a retrospective analysis of 173,966 patients

Author(s): Christoph Roderburg, Sarah Krieg, Andreas Krieg, Sascha Vaghiri, Raphael Mohr, Marcel Konrad, Mark Luedde, Tom Luedde, Karel Kostev, Sven H. Loosen
Published in: Clinical Research in Cardiology, Issue 112, 2023, Page(s) 1446-1453, ISSN 1861-0684
Publisher: Steinkopff
DOI: 10.1007/s00392-023-02250-z

Current Trends in Inpatient Care and In-Hospital Mortality of Cholangiocarcinoma in Germany: A Systematic Analysis between 2010 and 2019

Author(s): Christoph Roderburg, Tobias Essing, Linde Kehmann, Sarah Krieg, Simon Labuhn, Jennis Kandler, Tom Luedde, Sven H Loosen
Published in: Cancers, Issue 14/16, 2022, Page(s) 4038, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14164038

Non-alcoholic fatty liver disease (NAFLD) is associated with an increased incidence of osteoporosis and bone fractures

Author(s): Sven H Loosen, Christoph Roderburg, Münevver Demir, Natalia Qvartskhava, Verena Keitel, Karel Kostev, Tom Luedde
Published in: Zeitschrift für Gastroenterologie, 2021, ISSN 1439-7803
Publisher: Karl Demeter Verlag
DOI: 10.1055/a-1482-9236

Sarcopenia Predicts Cancer Mortality in Male but Not in Female Patients Undergoing Surgery for Cholangiocellular Carcinoma

Author(s): Markus Sebastian Jördens, Lisa Heinrichs, Sven H Loosen, Linda Wittig, Verena Keitel, David Schöler, Maximilian Schulze-Hagen, Christina Loberg, Gerald Antoch, Wolfram Trudo Knoefel, Tom Luedde, Georg Fluegen, Christoph Roderburg
Published in: Cancers, Issue 13/21, 2021, Page(s) 5359, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13215359

Circulating levels of microRNA193a-5p predict outcome in early stage hepatocellular carcinoma

Author(s): Sven H. Loosen, Theresa H. Wirtz, Sanchari Roy, Mihael Vucur, Mirco Castoldi, Anne T. Schneider, Christiane Koppe, Tom F. Ulmer, Anjali A. Roeth, Jan Bednarsch, Patrick H. Alizai, Pia Paffenholz, Münevver Demir, Christian Trautwein, Frank Tacke, Ulf P. Neumann, Christoph Roderburg, Tom Luedde
Published in: PLOS ONE, Issue 15/9, 2020, Page(s) e0239386, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0239386

Serum levels of soluble B and T lymphocyte attenuator predict overall survival in patients undergoing immune checkpoint inhibitor therapy for solid malignancies

Author(s): Joao Gorgulho, Christoph Roderburg, Felix Heymann, Maximilian Schulze‐Hagen, Fabian Beier, Mihael Vucur, Jakob N. Kather, Narmin Ghaffari Laleh, Frank Tacke, Tim H. Brümmendorf, Tom Luedde, Sven H. Loosen
Published in: International Journal of Cancer, Issue 149/5, 2021, Page(s) 1189-1198, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33610

Serum Levels of Kisspeptin Are Elevated in Patients with Pancreatic Cancer

Author(s): Sven H. Loosen, Mark Luedde, Georg Lurje, Martina Spehlmann, Pia Paffenholz, Tom Florian Ulmer, Frank Tacke, Mihael Vucur, Christian Trautwein, Ulf P. Neumann, Tom Luedde, Christoph Roderburg
Published in: Disease Markers, Issue 2019, 2019, Page(s) 1-8, ISSN 0278-0240
Publisher: IOS Press
DOI: 10.1155/2019/5603474

The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis

Author(s): Sven H. Loosen, Alexander Koch, Frank Tacke, Christoph Roderburg, Tom Luedde
Published in: International Journal of Molecular Sciences, Issue 20/19, 2019, Page(s) 4820, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20194820

Bone mineral density is a predictor of mortality in female patients with cholangiocellular carcinoma undergoing palliative treatment

Author(s): Markus S. Jördens; Linda Wittig; Christina Loberg; Lisa Heinrichs; Verena Keitel; Maximilian Schulze-Hagen; Gerald Antoch; Wolfram T. Knoefel; Georg Fluegen; Sven H. Loosen; Christoph Roderburg; Tom Luedde
Published in: Biomedicines, Issue 10/7, 2022, Page(s) 1660, ISSN 2227-9059
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines10071660

Sublethal necroptosis signaling promotes inflammation and liver cancer

Author(s): Mihael Vucur, Ahmed Ghallab, Anne T Schneider, Arlind Adili, Mingbo Cheng, Mirco Castoldi, Michael T Singer, Veronika Büttner, Leonie S Keysberg, Lena Küsgens, Marlene Kohlhepp, Boris Görg, Suchira Gallage, Jose Efren Barragan Avila, Kristian Unger, Claus Kordes, Anne-Laure Leblond, Wiebke Albrecht, Sven H Loosen, Carolin Lohr, Markus S Jördens, Anne Babler, Sikander Hayat, David Schumacher, M
Published in: Immunity, Issue 56/7, 2023, Page(s) 1578-1595, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2023.05.017

Development and validation of deep learning classifiers to detect Epstein-Barr virus and microsatellite instability status in gastric cancer: a retrospective multicentre cohort study

Author(s): Hannah Sophie Muti, Lara Rosaline Heij, Gisela Keller, Meike Kohlruss, Rupert Langer, Bastian Dislich, Jae-Ho Cheong, Young-Woo Kim, Hyunki Kim, Myeong-Cherl Kook, David Cunningham, William H Allum, Ruth E Langley, Matthew G Nankivell, Philip Quirke, Jeremy D Hayden, Nicholas P West, Andrew J Irvine, Takaki Yoshikawa, Takashi Oshima, Ralf Huss, Bianca Grosser, Franco Roviello, Alessia d'Ignazio, A
Published in: Lancet Digital Health, Issue 3/10, 2021, Page(s) e654-e664, ISSN 2589-7500
Publisher: Elsevier
DOI: 10.1016/s2589-7500(21)00133-3

Incidences of hypothyroidism and autoimmune thyroiditis are increased in patients with nonalcoholic fatty liver disease.

Author(s): Sven H. Loosen; Münevver Demir; Karel Kostev; Tom Luedde; Christoph Roderburg
Published in: European Journal of Gastroenterology and Hepatology, Issue 1, 2021, Page(s) e1008-e1012, ISSN 1473-5687
Publisher: Wolters Kluwer
DOI: 10.1097/meg.0000000000002136

Serum Levels of CXCL13 Are an Independent Predictor of Survival Following Resection of Biliary Tract Cancer

Author(s): Sven H Loosen, Tom F Ulmer, Simon Labuhn, Jan Bednarsch, Sven A Lang, Patrick H Alizai, Anne T Schneider, Mihael Vucur, Ulf P Neumann, Tom Luedde, Christoph Roderburg
Published in: Cancers, Issue 14/14, 2022, Page(s) 4073, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14174073

Antihypertensive Therapy and Incidence of Cancer.

Author(s): Sven H. Loosen; David Schöler; Mark Luedde; Johannes Eschrich; Tom Luedde; Niklas Gremke; Matthias Kalder; Karel Kostev; Christoph Roderburg
Published in: J Clin Med, Issue 11/22, 2022, Page(s) 6624, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11226624

Adult Body Height Is Associated with the Risk of Type 2 but Not Type 1 Diabetes Mellitus: A Retrospective Cohort Study of 783,029 Individuals in Germany

Author(s): Sven H Loosen, Sarah Krieg, Andreas Krieg, Tom Luedde, Karel Kostev, Christoph Roderburg
Published in: Journal of Clinical Medicine, Issue 12/6, 2023, Page(s) 2199, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12062199

Digital single-operator cholangioscopy with EHL as salvage therapy of an internalized and stone-impacted biliary stent 13 years after implantation

Author(s): Sven H. Loosen, Anselm Kunstein, Stephan vom Dahl, Johannes G. Bode, Tom Luedde, Jennis Kandler
Published in: Endoscopy International Open, Issue 10/3, 2022, Page(s) E269-E272, ISSN 2196-9736
Publisher: Thieme Open
DOI: 10.1055/a-1728-9526

Serum Levels of Soluble Urokinase Plasminogen Activator Receptor Predict Tumor Response and Outcome to Immune Checkpoint Inhibitor Therapy

Author(s): Sven H. Loosen, Joao Gorgulho, Markus S. Jördens, Maximilian Schulze-Hagen, Fabian Beier, Mihael Vucur, Anne T. Schneider, Christiane Koppe, Alexander Mertens, Jakob N. Kather, Frank Tacke, Verena Keitel, Tim H. Brümmendorf, Christoph Roderburg, Tom Luedde
Published in: Frontiers in Oncology, Issue 11, 2021, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.646883

Infectious mononucleosis is associated with an increased incidence of Crohn's disease: results from a cohort study of 31 862 outpatients in Germany

Author(s): Sven H Loosen, Karel Kostev, David Schöler, Hans-Martin Orth, Noemi F Freise, Björn-Erik Ole Jensen, Petra May, Johannes G Bode, Christoph Roderburg, Tom Luedde
Published in: European Journal of Gastroenterology & Hepatology, Issue 35/3, 2023, Page(s) 255-260, ISSN 0954-691X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/meg.0000000000002505

Progressive Sarcopenia Correlates with Poor Response and Outcome to Immune Checkpoint Inhibitor Therapy

Author(s): Sven H. Loosen, Vincent van den Bosch, Joao Gorgulho, Maximilian Schulze-Hagen, Jennis Kandler, Markus S. Jördens, Frank Tacke, Christina Loberg, Gerald Antoch, Tim Brümmendorf, Ulf P. Neumann, Christiane Kuhl, Tom Luedde, Christoph Roderburg
Published in: Journal of Clinical Medicine, Issue 10/7, 2021, Page(s) 1361, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10071361

Sarcopenia Is a Negative Prognostic Factor in Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatic Malignancies

Author(s): Loosen, Schulze-Hagen, Bruners, Tacke, Trautwein, Kuhl, Luedde, Roderburg
Published in: Cancers, Issue 11/10, 2019, Page(s) 1503, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11101503

TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation

Author(s): Ibone Labiano, Aloña Agirre-Lizaso, Paula Olaizola, Anne Echebarria, Maider Huici-Izagirre, Irene Olaizola, Aitor Esparza-Baquer, Omar Sharif, Elizabeth Hijona, Piotr Milkiewicz, Malgorzata Milkiewicz, Francisco González-Romero, Patricia Aspichueta , Maria J Monte, Jose J G Marin, Mihael Vucur, Tom Luedde, Marco Marzioni, Derek A Mann , Luis Bujanda , Pedro M Rodrigues, Jesus M Banales, Maria J
Published in: Journal of Hepatology, Issue 77/4, 2022, Page(s) 991-1004, ISSN 1600-0641
Publisher: Elsevier
DOI: 10.1016/j.jhep.2022.05.044

Prediction of heart transplant rejection from routine pathology slides with self-supervised deep learning

Author(s): Tobias Paul Seraphin; Mark Luedde; Christoph Roderburg; Marko van Treeck; Pascal Scheider; Roman D Buelow; Peter Boor; Sven H Loosen; Zdenek Provaznik; Daniel Mendelsohn; Filip Berisha; Christina Magnussen; Dirk Westermann; Tom Luedde; Christoph Brochhausen; Samuel Sossalla; Jakob Nikolas Kather
Published in: European Heart Journal – Digital Health, Issue 4/3, 2023, Page(s) 265-274, ISSN 2634-3916
Publisher: Oxford University Press
DOI: 10.1093/ehjdh/ztad016

Cancer Patients Have an Increased Incidence of Dementia: A Retrospective Cohort Study of 185,736 Outpatients in Germany

Author(s): Christoph Roderburg, Sven H. Loosen, Anselm Kunstein, Raphael Mohr, Markus S. Jördens, Mark Luedde, Karel Kostev, Tom Luedde
Published in: Cancers, Issue 13/9, 2021, Page(s) 2027, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092027

Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning

Author(s): Amelie Echle, Heike Irmgard Grabsch, Philip Quirke, Piet A. van den Brandt, Nicholas P. West, Gordon G.A. Hutchins, Lara R. Heij, Xiuxiang Tan, Susan D. Richman, Jeremias Krause, Elizabeth Alwers, Josien Jenniskens, Kelly Offermans, Richard Gray, Hermann Brenner, Jenny Chang-Claude, Christian Trautwein, Alexander T. Pearson, Peter Boor, Tom Luedde, Nadine Therese Gaisa, Michael Hoffmeister, Jakob
Published in: Gastroenterology, Issue 159/4, 2020, Page(s) 1406-1416.e11, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2020.06.021

Levels of Circulating PD-L1 Are Decreased in Patients with Resectable Cholangiocarcinoma

Author(s): Christoph Roderburg, Sven H Loosen, Jan Bednarsch, Patrick H Alizai, Anjali A Roeth, Sophia M Schmitz, Mihael Vucur, Mark Luedde, Pia Paffenholz, Frank Tacke, Christian Trautwein, Tom F Ulmer, Ulf Peter Neumann, Tom Luedde
Published in: International Journal of Molecular Sciences, Issue 22/12, 2021, Page(s) 6569, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22126569

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes

Author(s): Maria Feoktistova, Roman Makarov, Sihem Brenji, Anne T. Schneider, Guido J. Hooiveld, Tom Luedde, Martin Leverkus, Amir S. Yazdi, Diana Panayotova-Dimitrova
Published in: Cells, Issue 9/2, 2020, Page(s) 351, ISSN 2073-4409
Publisher: MDPI (Multidisciplinary Digital Publishing Institute)
DOI: 10.3390/cells9020351

The Association between Infectious Mononucleosis and Cancer: A Cohort Study of 24,190 Outpatients in Germany

Author(s): Christoph Roderburg, Sarah Krieg, Andreas Krieg, Tom Luedde, Karel Kostev, Sven H Loosen
Published in: Cancers, Issue 14/23, 2022, Page(s) 5837, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14235837

Clinical determinants of hospital mortality in liver failure: a comprehensive analysis of 62,717 patients

Author(s): Tom Luedde; Sven H. Loosen; Tobias Essing; Hans Bock; Björn Wieland; Georg Fluegen; Jan Bednarsch; Johannes G. Bode; Ulf P. Neumann; Christoph Roderburg
Published in: Zeitschrift für Gastroenterologie, 2023, ISSN 1439-7803
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-2016-9061

The association between body height and cancer: a retrospective analysis of 784,192 outpatients in Germany

Author(s): Sarah Krieg, Christoph Roderburg, Andreas Krieg, Tom Luedde, Sven H Loosen, Karel Kostev
Published in: Journal of Cancer Research and Clinical Oncology, 2022, ISSN 0171-5216
Publisher: Springer Verlag
DOI: 10.1007/s00432-022-04335-0

Circulating levels of soluble urokinase plasminogen activator receptor predict outcome after resection of biliary tract cancer

Author(s): Sven H. Loosen, Annemarie Breuer, Frank Tacke, Jakob N. Kather, Joao Gorgulho, Patrick H. Alizai, Jan Bednarsch, Anjali A. Roeth, Georg Lurje, Sophia M. Schmitz, Jonathan F. Brozat, Pia Paffenholz, Mihael Vucur, Thomas Ritz, Alexander Koch, Christian Trautwein, Tom F. Ulmer, Christoph Roderburg, Thomas Longerich, Ulf P. Neumann, Tom Luedde
Published in: JHEP Reports, Issue 2/2, 2020, Page(s) 100080, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2020.100080

Serum levels of circulating microRNA-107 are elevated in patients with early-stage HCC

Author(s): Sven H. Loosen, Mirco Castoldi, Markus S. Jördens, Sanchary Roy, Mihael Vucur, Jennis Kandler, Linda Hammerich, Raphael Mohr, Frank Tacke, Tom F. Ulmer, Ulf P. Neumann, Tom Luedde, Christoph Roderburg
Published in: PLOS ONE, Issue 16/3, 2021, Page(s) e0247917, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0247917

Elevated Serum Levels of CCL23 Are Associated with Poor Outcome after Resection of Biliary Tract Cancer

Author(s): Christoph Roderburg, Simon Labuhn, Jan Bednarsch, Sven A Lang, Anne T Schneider, Linda Hammerich, Mihael Vucur, Tom F Ulmer, Ulf P Neumann, Tom Luedde, Sven H Loosen
Published in: Mediators of Inflammation, 2022, Page(s) 6195004, ISSN 0962-9351
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2022/6195004

High baseline soluble urokinase plasminogen activator receptor (suPAR) serum levels indicate adverse outcome after resection of pancreatic adenocarcinoma

Author(s): Sven H Loosen, Frank Tacke, Niklas Püthe, Marcel Binneboesel, Georg Wiltberger, Patrick H Alizai, Jakob N Kather, Pia Paffenholz, Thomas Ritz, Alexander Koch, Frank Bergmann, Christian Trautwein, Thomas Longerich, Christoph Roderburg, Ulf P Neumann, Tom Luedde
Published in: Carcinogenesis, Issue 40/8, 2019, Page(s) 947-955, ISSN 0143-3334
Publisher: Oxford University Press
DOI: 10.1093/carcin/bgz033

Diagnostic and prognostic biomarkers in cholangiocarcinoma

Author(s): Rocio I. R. Macias, Miroslaw Kornek, Pedro M. Rodrigues, Nuno A. Paiva, Rui E. Castro, Sabine Urban, Stephen P. Pereira, Massimiliano Cadamuro, Christian Rupp, Sven H. Loosen, Tom Luedde, Jesus M. Banales
Published in: Liver International, Issue 39/S1, 2019, Page(s) 108-122, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.14090

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