Exploring the bacterial cell cycle to re-sensitize antibiotic-resistant bacteria

Project Information

ChronosAntibiotics

Grant agreement ID: 771709

DOI

10.3030/771709

Project closed

EC signature date 18 February 2018

Start date 1 March 2018

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 533 500,00

EU contribution

€ 2 533 500,00

Coordinated by

UNIVERSIDADE NOVA DE LISBOA
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

DeepBacs for multi-task bacterial image analysis using open-source deep learning approaches

Author(s): Christoph Spahn, Estibaliz Gómez-de-Mariscal, Romain F. Laine, Pedro M. Pereira, Lucas von Chamier, Mia Conduit, Mariana G. Pinho, Guillaume Jacquemet, Séamus Holden, Mike Heilemann, Ricardo Henriques
Published in: Communications Biology, Issue 5, 2022, Page(s) 688, ISSN 2399-3642
Publisher: Nature Portfolio
DOI: 10.1038/s42003-022-03634-z

The role of GpsB in cell morphogenesis of Staphylococcus aureus

Author(s): Costa SF, Saraiva BM, Veiga H, Marques LB, Schäper S, Sporniak M, Vega DE, Jorge AM, Duarte AM, Brito AD, Tavares AC, Reed P, Pinho MG.
Published in: mBIO, 2024, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mbio.03235-23

BPEI-Induced Delocalization of PBP4 Potentiates β-lactams Against MRSA.

Author(s): Hill, Melissa A.; Lam, Anh K.; Reed, Patricia; Harney, Madeline C.; Wilson, Beatrice A.; Moen, Erika L.; Wright, Summer N.; Pinho, Mariana G.; Rice, Charles V.
Published in: Biochemistry, Issue 2, 2019, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.9b00523

Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan

Author(s): Truc Do, Kaitlin Schaefer, Ace George Santiago, Kathryn A. Coe, Pedro B. Fernandes, Daniel Kahne, Mariana G. Pinho, Suzanne Walker
Published in: Nature Microbiology, Issue 5/2, 2020, Page(s) 291-303, ISSN 2058-5276
Publisher: Springer Nature
DOI: 10.1038/s41564-019-0632-1

Cell division protein FtsK coordinates bacterial chromosome segregation and daughter cell separation in <i>Staphylococcus aureus</i>

Author(s): Helena Veiga; Ambre Jousselin; Simon Schäper; Bruno M Saraiva; Leonor B Marques; Patricia Reed; Joana Wilton; Pedro M Pereira; Sérgio R Filipe; Mariana G Pinho
Published in: The EMBO Journal, 2023, ISSN 1460-2075
Publisher: Springer Nature Limited
DOI: 10.15252/embj.2022112140

eHooke: A tool for automated image analysis of spherical bacteria based on cell cycle progression

Author(s): Bruno M. Saraiva; Ludwig Krippahl; Sergio R. Filipe; Ricardo Henriques; Mariana G. Pinho
Published in: Biological Imaging, Issue 1, 2021, ISSN 2633-903X
Publisher: Cambridge University Press
DOI: 10.1017/s2633903x21000027

Cell constriction requires processive septal peptidoglycan synthase movement independent of FtsZ treadmilling in Staphylococcus aureus

Author(s): Schaeper S, Brito AD, Saraiva BM, Squyres GR, Holmes MJ, Garner EC, Hensel Z, Henriques R, Pinho MG.
Published in: Nature Microbiology, 2024, ISSN 2058-5276
Publisher: Nature POrtfolio
DOI: 10.1038/s41564-024-01629-6

The pentaglycine bridges of Staphylococcus aureus peptidoglycan are essential for cell integrity

Author(s): João M. Monteiro, Gonçalo Covas, Daniela Rausch, Sérgio R. Filipe, Tanja Schneider, Hans-Georg Sahl, Mariana G. Pinho
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-41461-1

SEDS–bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus

Author(s): Nathalie T. Reichmann, Andreia C. Tavares, Bruno M. Saraiva, Ambre Jousselin, Patricia Reed, Ana R. Pereira, João M. Monteiro, Rita G. Sobral, Michael S. VanNieuwenhze, Fábio Fernandes, Mariana G. Pinho
Published in: Nature Microbiology, Issue 4/8, 2019, Page(s) 1368-1377, ISSN 2058-5276
Publisher: Nature Research
DOI: 10.1038/s41564-019-0437-2

Revisiting the Role of VraTSR in Staphylococcus aureus Response to Cell Wall-Targeting Antibiotics

Author(s): Pedro B. Fernandes, Patricia Reed, João M. Monteiro, Mariana G. Pinho
Published in: Journal of Bacteriology, Issue 204, 2022, Page(s) e0016222, ISSN 0021-9193
Publisher: American Society for Microbiology
DOI: 10.1128/jb.00162-22

Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria

Author(s): John R. Schultz; Stephen K. Costa; Gorakhnath R. Jachak; Pooja Hegde; Matthew Zimmerman; Yan Pan; Michaele Josten; Chinedu Ejeh; Travis Hammerstad; Hans Georg Sahl; Pedro M. Pereira; Mariana G. Pinho; Véronique Dartois; Ambrose Cheung; Courtney C. Aldrich
Published in: J Med Chem, Issue 2, 2022, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01151

Reassessment of the distinctive geometry of Staphylococcus aureus cell division

Author(s): Bruno M. Saraiva, Moritz Sorg, Ana R. Pereira, Mário J. Ferreira, Léo C. Caulat, Nathalie T. Reichmann, Mariana G. Pinho
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17940-9

A CRISPRi-based genetic resource to study essential Staphylococcus aureus genes

Author(s): Reed P, Sorg M, Alwardt D, Serra L, Veiga H, Schäper S, Pinho MG.
Published in: mBIO, 2023, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mbio.02773-23

Encapsulation of the septal cell wall protects Streptococcus pneumoniae from its major peptidoglycan hydrolase and host defenses

Author(s): Figueiredo J, Henriques MX, Catalão MJ, Pinheiro S, Narciso AR, Mesquita F, Saraiva BM, Carido M, Cabanes D, Pinho MG, Filipe SR.
Published in: PLoS Pathogens, Issue 18, 2022, Page(s) e1010516, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1010516