Signal transduction and allosteric modulation of nicotinic acetylcholine receptors: from ion channel electrophysiology to atomic 3D structures

Project Information

DYNACOTINE

Grant agreement ID: 788974

DOI

10.3030/788974

Project closed

EC signature date 18 July 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 282 105,00

EU contribution

€ 2 282 105,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

The Nicotinic Acetylcholine Receptor and Its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level

Author(s): Marco Cecchini, Pierre-Jean Corringer, Jean-Pierre Changeux
Published in: Annual Review of Biochemistry, Issue 93, 2024, Page(s) 339-366, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-030122-033116

An original potentiating mechanism revealed by the cryoEM structures of the human α7 nicotinic receptor in complex with nanobodies

Author(s): Marie S. Prevost, Nathalie Barilone, Gabrielle Dejean De La Batie, Stéphanie Pons, Gabriel Ayme, Patrick England, Marc Gielen, François Bontems, Gérard Pehau-Arnaudet, Uwe Maskos, Pierre Lafaye, Pierre-Jean Corringer
Published in: Nature Communication, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2023.01.03.522595

Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors

Author(s): Marie S. Prevost, Hichem Bouchenaki, Nathalie Barilone, Marc Gielen, Pierre-Jean Corringer
Published in: Cellular and Molecular Life Sciences, 2020, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-020-03558-z

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

Author(s): Solène N Lefebvre; Antoine Taly; Anaïs Menny; Karima Medjebeur; Pierre-Jean Corringer
Published in: eLife, Issue 3, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60682

Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

Author(s): Laurie Peverini, Sophie Shi, Karima Medjebeur, Pierre-Jean Corringer
Published in: eLife, Issue 12, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.93174.3

The desensitization pathway of GABAA receptors, one subunit at a time

Author(s): Marc Gielen, Nathalie Barilone, Pierre-Jean Corringer
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19218-6

Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.

Author(s): Cerdan, Adrien H.; Peverini, Laurie; Changeux, Jean-Pierre; Corringer, Pierre-Jean; Cecchini, Marco
Published in: Science Advances, Issue 2, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adc9340

Neutralizing Nanobodies against Venoms from Naja haje Species Captured in North Africa

Author(s): Hiba Mejri, Rym Mokrani, Ayoub Ksouri, Mabrouk Seddik, Nour Awad, Gabriel Ayme, Thouraya Chagour, Ahlem Mokrani, Charraf eddine Louchene, Imed Salhi, Rahma Ben Abderrazek, Rym Ben Khalifa, Zakaria Benlasfar, Pierre-Jean Corringer, Mohamed Hammadi, Selma Djilani, Pierre Lafaye, Balkiss Bouhaouala-Zahar
Published in: Toxins, Issue 16, 2025, Page(s) 393, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins16090393

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Author(s): Sophie Shi; Solène N. Lefebvre; Laurie Peverini; Adrien H. Cerdan; Paula Milán Rodríguez; Marc Gielen; Jean-Pierre Changeux; Marco Cecchini; Pierre-Jean Corringer
Published in: Nature Communications, Issue 1, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-36471-7

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

Author(s): Li Q, Nemecz A, Aymé G, Dejean de la Bâtie G, Prevost MS, Pons S, Barilone N, Baachaoui R, Maskos U, Lafaye P, Corringer PJ
Published in: cellular and molecular life science, Issue 3, 2023, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-023-04779-8

A millisecond coarse-grained simulation approach to decipher allosteric cannabinoid binding at the glycine receptor<i>α</i>1

Author(s): Alessio Bartocci, Andrea Grazzi, Nour Awad, Pierre-Jean Corringer, Paulo C.T. Souza, Marco Cecchini
Published in: Nature Communication, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2023.04.19.537578

Intellectual Property Rights

Patent (1)

GENERATION OF ANTIBODIES ACTING AS SILENT AND POSITIVE ALLOSTERIC MODULATORS OF THE ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR

Application/Publication number: 20 23000654
Date: 2023-11-10
Applicant(s): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS