Objective
Background: Recent large-scale genomic studies have provided evidence that a number of genetic variants implicate an inverse relationship between increased adiposity and an unfavorable cardiometabolic profile. So far, it is not known whether the loci showing “favorable adiposity”-like associations exert their influence already in childhood.
Objectives: The aims of the project proposed are 1.The identification of gene variants associated with increased adiposity yet a favorable cardiometabolic profile in children and adolescents and 2. Identification of the childhood genetic and environmental predictors of adult metabolically healthy obesity (MHO) and metabolically unhealthy normal weight (MUNW).
The approach: To study, whether such “favorable adiposity” genetic effects are found already in childhood, I will perform a meta-analysis of six child populations from Finland, Denmark and England including a total sample size of 10,038 children and adolescents aged 3-18 years. To examine associations of childhood genetic and environmental factors with MHO and MUNW in adulthood, I will utilize follow-up data from the Cardiovascular Risk in Young Finns study.
The impact: Identification of MHO and MUNW related genetic variants in children and the childhood predictors of adult MHO and MUNW will help to assess the risk of type 2 diabetes and cardiovascular disease as well as to target interventions in the high-risk groups. The ability to improve advice and intervention measures would help alleviate the burden of obesity-related comorbidities on health care systems worldwide. Moreover, this project will allow me to learn highly valuable research skills in the area of genetics and meta-analyses related to cardiometabolic risk factors and support my professional and research advancement.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.