3D bioprinting of pancreatic tissue for biomedical research

Project Information

Pan3DP

Grant agreement ID: 800981

DOI

10.3030/800981

Project closed

EC signature date 3 May 2018

Start date 1 October 2018

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 3 000 000,00

EU contribution

€ 3 000 000,00

Coordinated by

KING'S COLLEGE LONDON
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (6)

Public dissemination
Dissemination WP2

Dissemination for WP2

Consortium website
Dissemination WP1

Dissemination for WP1

Consortium workshops I
Consortium workshop II

Other (2)

3D image-based mechanistic model
Generation of a digital embryonic pancreas atlas

Documents, reports (3)

Dissemination WP3

Dissemination for WP3

Definition of each cell population in the pancreas
Deposing RNAseq datasets in public repositories

Demonstrators, pilots, prototypes (5)

Protocol of printability conditions of pancreatic cells
Protocol of biomaterials for printing pancreatic cells
Generation of CAD files for 3D bio-printing
Protocol of vasculature integration
Optimized protocol of culture conditions post-printing

Publications

Non-peer reviewed articles (4)

Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions

Author(s): Laura Glorieux, Aleksandra Sapala, David Willnow, Manon Moulis, Shlomit Edri, Jean-Francois Darrigrand, Anat Schonblum, Lina Sakhneny, Laura Schaumann, Harold F Gomez, Christine Lang, Lisa Conrad, Fabien Guillemot, Shulamit Levenberg, Limor Landsman, Dagmar Iber, Christophe Pierreux, Francesca M Spagnoli
Published in: bioRxiv, 2021, ISSN 2692-8205
Publisher: Cold Spring Harbour Laboratories
DOI: 10.1101/2021.04.28.441857

Quantitative lineage analysis identifies a long-term progenitor niche for the hepato-pancreato-biliary organ system

Author(s): David Willnow, Uwe Benary, Anca Margineanu, Maria Lillina Vignola, Igor M. Pongrac, Zahra Karimaddini, Alessandra Vigilante, Jana Wolf,  Francesca M. Spagnoli
Published in: bioRxiv, 2020, ISSN 2692-8205
Publisher: Cold Spring Harbour Laboratories
DOI: 10.1101/2020.08.06.240176

Single cell transcriptomic comparison between mouse embryonic pancreas and pancreatic organoids generated from mouse embryonic stem cell-derived mesoderm and pancreatic progenitors

Author(s): Shlomit Edri, Vardit Rosenthal, Or Ginsburg, Abigail Newman Frisch, Christophe E. Pierreux, Nadav Sharon, Shulamit Levenberg
Published in: BioRxiv, Issue 26928205, 2022, ISSN 2692-8205
Publisher: CSHL
DOI: 10.1101/2022.10.11.511696

Cell-based simulations of Notch-dependent cell differentiation on growing domains

Author(s): Stopka Anna, Boareto do Amaral Marcelo, Iber Dagmar
Published in: bioRxiv, 2019, Page(s) 859363, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/859363

Peer reviewed articles (8)

Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect

Author(s): Joana Almaça, Alejandro Caicedo, Limor Landsman
Published in: Diabetologia, Issue 63/10, 2020, Page(s) 2076-2085, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05186-5

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche

Author(s): David Willnow, Uwe Benary , Anca Margineanu , Maria Lillina Vignola, Fabian Konrath, Igor M Pongrac, Zahra Karimaddini , Alessandra Vigilante, Jana Wolf, Francesca M Spagnoli
Published in: Nature, Issue 00280836, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03844-1

The Role of Vascular Cells in Pancreatic Beta-Cell Function

Author(s): Guzel Burganova, Claire Bridges, Peter Thorn, Limor Landsman
Published in: Frontiers in Endocrinology, Issue 12, 2021, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/fendo.2021.667170

Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions

Author(s): Laura Glorieux; Aleksandra Sapala; David Willnow; Manon Moulis; Anna Salowka; Jean-Francois Darrigrand; Shlomit Edri; Anat Schonblum; Lina Sakhneny; Laura Schaumann; Harold F. Gómez; Christine Lang; Lisa Conrad; Fabien Guillemot; Shulamit Levenberg; Limor Landsman; Dagmar Iber; Christophe E. Pierreux; Francesca M. Spagnoli
Published in: Development, Issue 09501991, 2022, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.199655

Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming.

Author(s): Abigail Isaacson; Francesca M. Spagnoli
Published in: Current Opinion in Genetics & Development, Issue 0959437X, 2021, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2021.05.003

Pancreatic pericytes originate from the embryonic pancreatic mesenchyme

Author(s): Neta Harari, Lina Sakhneny, Laura Khalifa-Malka, Anke Busch, Klemens J. Hertel, Matthias Hebrok, Limor Landsman
Published in: Developmental Biology, Issue 449/1, 2019, Page(s) 14-20, ISSN 0012-1606
Publisher: Academic Press
DOI: 10.1016/j.ydbio.2019.01.020

Identification and implication of tissue-enriched ligands in epithelial–endothelial crosstalk during pancreas development

Author(s): Manon Moulis; Steve Vincent Maurice Runser; Laura Glorieux; Nicolas Dauguet; Christophe Vanderaa; Laurent Gatto; Donatienne Tyteca; Patrick Henriet; Francesca M. Spagnoli; Dagmar Iber; Christophe E. Pierreux
Published in: Scientific Reports, Issue 20452322, 2022, Page(s) 12498, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-16072-y 

A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation

Author(s): Corinna Cozzitorto, Laura Mueller, Silvia Ruzittu, Nancy Mah, David Willnow, Jean-Francois Darrigrand, Heather Wilson, Daniel Khosravinia, Amir-Ala Mahmoud, Maurizio Risolino, Licia Selleri, Francesca M. Spagnoli
Published in: Developmental Cell, 2020, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.08.003