Enhancers Decoding the Mechanisms Underlying CAD Risk

Project Information

EnDeCAD

Grant agreement ID: 802825

DOI

10.3030/802825

Project closed

EC signature date 15 November 2018

Start date 1 January 2019

End date 30 June 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 647,00

EU contribution

€ 1 498 647,00

Coordinated by

ITA-SUOMEN YLIOPISTO
Finland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (30)

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells

Author(s): Redouane Aherrahrou, Liang Guo, V. Peter Nagraj, Aaron Aguhob, Jameson Hinkle, Lisa Chen, Joon Yuhl Soh, Dillon Lue, Gabriel F. Alencar, Arjan Boltjes, Sander W. van der Laan, Emily Farber, Daniela Fuller, Rita Anane-Wae, Ngozi Akingbesote, Ani W. Manichaikul, Lijiang Ma, Minna U. Kaikkonen, Johan L.M. Björkegren, Suna Önengüt-Gümüşcü, Gerard Pasterkamp, Clint L. Miller, Gary K. Owens, Alok
Published in: Circulation Research, Issue 127/12, 2020, Page(s) 1552-1565, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.317415

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Author(s): Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26536-w

Technological advancements in functional interpretation of genome‐wide association studies (<scp>GWAS</scp>) findings: bridging the gap to clinical translation

Author(s): Redouane Aherrahrou, Minna U Kaikkonen
Published in: FEBS Letters, Issue Apr 29, 2024, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.14884

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Author(s): Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali
Published in: Nature Communications, Issue 12, 2022, Page(s) 6486, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26536-w

Meta-Analysis of Smooth Muscle Lineage Transcriptomes in Atherosclerosis and Their Relationships to In Vitro Models

Author(s): Austin C. Conklin, Hitoo Nishi, Florencia Schlamp, Tiit Örd, Kadri Õunap, Minna U. Kaikkonen, Edward A. Fisher, Casey E. Romanoski
Published in: Immunometabolism, 2021, ISSN 2633-0407
Publisher: Hapres Limited
DOI: 10.20900/immunometab20210022

Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Author(s): Tiit Örd, Kadri Õunap, Lindsey K. Stolze, Redouane Aherrahrou, Valtteri Nurminen, Anu Toropainen, Ilakya Selvarajan, Tapio Lönnberg, Einari Aavik, Seppo Ylä-Herttuala, Mete Civelek, Casey E. Romanoski, Minna U. Kaikkonen
Published in: Circulation Research, Issue 129/2, 2021, Page(s) 240-258, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.318971

ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component

Author(s): Suvi Jauhiainen, Henna Ilmonen, Pia Vuola, Heta Rasinkangas, Heidi H Pulkkinen, Sara Keränen, Miika Kiema, Jade J Liikkanen, Nihay Laham-Karam, Svetlana Laidinen, Mustafa Beter, Einari Aavik, Kimmo Lappalainen, Jouko Lohi, Johanna Aronniemi, Tiit Örd, Minna U Kaikkonen, Päivi Salminen, Erkki Tukiainen, Seppo Ylä-Herttuala, Johanna P Laakkonen
Published in: eLife, Issue 12, 2023, Page(s) e82543, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.82543

Genetic variation drives differences in obesity-related gene regulation

Author(s): Minna U. Kaikkonen
Published in: Trends in Genetics, Issue 40, 2024, Page(s) 296-298, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2024.02.009

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Author(s): Marie A.C. Depuydt, Koen H.M. Prange, Lotte Slenders, Tiit Örd, Danny Elbersen, Arjan Boltjes, Saskia C.A. de Jager, Folkert W. Asselbergs, Gert J. de Borst, Einari Aavik, Tapio Lönnberg, Esther Lutgens, Christopher K. Glass, Hester M. den Ruijter, Minna U. Kaikkonen, Ilze Bot, Bram Slütter, Sander W. van der Laan, Seppo Yla-Herttuala, Michal Mokry, Johan Kuiper, Menno P.J. de Winther, Gerard P
Published in: Circulation Research, Issue 127/11, 2020, Page(s) 1437-1455, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316770

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Author(s): Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D Nguyen, Sinem Karaman, Emilia A Korhonen, Ralf H Adams, Hellmut G Augustin, Katariina Öörni, Oliver Soehnlein, Minna U Kaikkonen, Kari Alitalo
Published in: Nature Cardiovascular Research, Issue Mar 13;2(3), 2022, Page(s) 307-321, ISSN 2731-0590
Publisher: Nature Portfolio
DOI: 10.1038/s44161-023-00224-y

Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease

Author(s): Seung Hyuk T. Lee, Kristina M. Garske, Uma Thanigai Arasu, Asha Kar, Zong Miao, Marcus Alvarez, Amogha Koka, Nicholas Darci-Maher, Jihane N. Benhammou, David Z. Pan, Tiit Örd, Dorota Kaminska, Ville Männistö, Sini Heinonen, Martin Wabitsch, Markku Laakso, Vatche G. Agopian, Joseph R. Pisegna, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Minna U. Kaikkonen, Päivi Pajukanta
Published in: eBioMedicine, Issue 106, 2024, Page(s) 105232, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105232

Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes

Author(s): Rédouane Aherrahrou, Dillon Lue, R Noah Perry, Yonathan Tamrat Aberra, Mohammad Daud Khan, Joon Yuhl Soh, Tiit Örd, Prosanta Singha, Qianyi Yang, Huda Gilani, Ernest Diez Benavente 4 , Doris Wong, Jameson Hinkle, Lijiang Ma, Gloria M Sheynkman, Hester M den Ruijter, Clint L Miller, Johan L M Björkegren, Minna U Kaikkonen, Mete Civelek
Published in: Circulation Research, Issue Feb 3;132(3), 2023, Page(s) 323-338, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.321586

The Power of Single-Cell RNA Sequencing in eQTL Discovery

Author(s): Maleeha Maria, Negar Pouyanfar, Tiit Örd, Minna U Kaikkonen
Published in: Genes, Issue Mar 12;13(3), 2022, Page(s) 502, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13030502

The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages

Author(s): Huang, Zhiqiang; Liang, Ning; Goñi, Saioa; Damdimopoulos, Anastasios; Wang, Cheng; Ballaire, Raphaelle; Jager, Jennifer; Niskanen, Henri; Han, HongYa; Jakobsson, Tomas; Bracken, Adrian,; Aouadi, Myriam; Venteclef, Nicolas; Kaikkonen, Minna,; Fan, Rongrong; Treuter, Eckardt
Published in: Molecular Cell, Issue 81/5, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.12.040

Functional non-coding SNPs in human endothelial cells fine-map vascular trait associations

Author(s): Anu Toropainen; Lindsey K. Stolze; Tiit Örd; Michael B. Whalen; Paula Martí Torrell; Verena M. Link; Minna U. Kaikkonen; Casey E. Romanoski
Published in: Crossref, Issue Mar;32(3), 2022, Page(s) 409-424, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/2021.08.03.454513

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures

Author(s): Tiit Örd, Tapio Lönnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen, Miika Kiema, Kadri Õunap, Maleeha Maria, Pierre R Moreau, Pashupati P Mishra, Senthil Palani, Jenni Virta, Heidi Liljenbäck, Einari Aavik, Anne Roivainen, Seppo Ylä-Herttuala, Johanna P Laakkonen, Terho Lehtimäki, Minna U Kaikkonen
Published in: American Journal of Human Genetics, Issue May 4;110(5), 2023, Page(s) 722-740, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2023.03.013

Profiling of Primary and Mature miRNA Expression in Atherosclerosis-Associated Cell Types

Author(s): Pierre R. Moreau, Vanesa Tomas Bosch, Maria Bouvy-Liivrand, Kadri Õunap, Tiit Örd, Heidi H. Pulkkinen, Petri Pölönen, Merja Heinäniemi, Seppo Ylä-Herttuala, Johanna P. Laakkonen, Suvi Linna-Kuosmanen, Minna U. Kaikkonen
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 41/7, 2021, Page(s) 2149-2167, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.121.315579

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Author(s): Ilakya Selvarajan, Anu Toropainen, Kristina M. Garske, Maykel López Rodríguez, Arthur Ko, Zong Miao, Dorota Kaminska, Kadri Õunap, Tiit Örd, Aarthi Ravindran, Oscar H. Liu, Pierre R. Moreau, Ashik Jawahar Deen, Ville Männistö, Calvin Pan, Anna-Liisa Levonen, Aldons J. Lusis, Sami Heikkinen, Casey E. Romanoski, Jussi Pihlajamäki, Päivi Pajukanta, Minna U. Kaikkonen
Published in: The American Journal of Human Genetics, Issue 108/3, 2021, Page(s) 411-430, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2021.02.006

Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis

Author(s): Isidore Mushimiyimana, Henri Niskanen, Mustafa Beter, Johanna P Laakkonen, Minna U Kaikkonen, Seppo Ylä-Herttuala, Nihay Laham-Karam
Published in: Nucleic Acids Research, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab633

NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli

Author(s): Suvi Linna-Kuosmanen, Vanesa Tomas Bosch, Pierre R Moreau, Maria Bouvy-Liivrand, Henri Niskanen, Emilia Kansanen, Annukka Kivelä, Juha Hartikainen, Mikko Hippeläinen, Hannu Kokki, Pasi Tavi, Anna-Liisa Levonen, Minna U Kaikkonen
Published in: Cardiovascular Research, Issue Jul 19, 2020, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvaa219

Novel Lipid Long Intervening Noncoding RNA, Oligodendrocyte Maturation‐Associated Long Intergenic Noncoding RNA, Regulates the Liver Steatosis Gene Stearoyl‐Coenzyme A Desaturase As an Enhancer RNA

Author(s): Jihane N. Benhammou, Arthur Ko, Marcus Alvarez, Minna U. Kaikkonen, Carl Rankin, Kristina M. Garske, David Padua, Yash Bhagat, Dorota Kaminska, Vesa Kärjä, Jussi Pihlajamäki, Joseph R. Pisegna, Päivi Pajukanta
Published in: Hepatology Communications, Issue 3/10, 2019, Page(s) 1356-1372, ISSN 2471-254X
Publisher: American Association for the Study of Liver Diseases
DOI: 10.1002/hep4.1413

Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits

Author(s): Lindsey K. Stolze, Austin C. Conklin, Michael B. Whalen, Maykel López Rodríguez, Kadri Õunap, Ilakya Selvarajan, Anu Toropainen, Tiit Örd, Jin Li, Anna Eshghi, Alice E. Solomon, Yun Fang, Minna U. Kaikkonen, Casey E. Romanoski
Published in: The American Journal of Human Genetics, Issue 106/6, 2020, Page(s) 748-763, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2020.04.008

Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation

Author(s): Leena E. Viiri, Tommi Rantapero, Mostafa Kiamehr, Anna Alexanova, Mikko Oittinen, Keijo Viiri, Henri Niskanen, Matti Nykter, Minna U. Kaikkonen, Katriina Aalto-Setälä
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-39215-0

Genomic Landscapes of Noncoding RNAs Regulating VEGFA and VEGFC Expression in Endothelial Cells

Author(s): Isidore Mushimiyimana, Vanesa Tomas Bosch, Henri Niskanen, Nicholas L. Downes, Pierre R. Moreau, Kiley Hartigan, Seppo Ylä-Herttuala, Nihay Laham-Karam, Minna U. Kaikkonen
Published in: Molecular and Cellular Biology, Issue 41/7, 2021, ISSN 0270-7306
Publisher: American Society for Microbiology
DOI: 10.1128/mcb.00594-20

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Author(s): Sanna Kettunen, Anna-Kaisa Ruotsalainen, Tiit Örd, Tuisku Suoranta, Janne Heikkilä, Minna U. Kaikkonen, Nihay Laham-Karam, Seppo Ylä-Herttuala
Published in: Frontiers in Cardiovascular Medicine, Issue 10, 2023, Page(s) Mar 6:10:1113890, ISSN 2297-055X
Publisher: Frontiers in Cardiovascular Medicine
DOI: 10.3389/fcvm.2023.1113890

Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease

Author(s): Suvi Linna-Kuosmanen, Eloi Schmauch, Kyriakitsa Galani, Johannes Ojanen, Carles A. Boix, Tiit Örd, Anu Toropainen, Prosanta K. Singha, Pierre R. Moreau, Kristiina Harju, Adriana Blazeski, Åsa Segerstolpe, Veikko Lahtinen, Lei Hou, Kai Kang, Elamaran Meibalan, Leandro Z. Agudelo, Hannu Kokki, Jari Halonen, Juho Jalkanen, Jarmo Gunn, Calum A. MacRae, Maija Hollmén, Juha E.K. Hartikainen, Minna U.
Published in: Cell Reports Medicine, Issue 5, 2024, Page(s) 101556, ISSN 2666-3791
Publisher: Cell Press
DOI: 10.1016/j.xcrm.2024.101556

Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection

Author(s): Z. Alireza, M. Maleeha, M. Kaikkonen, V. Fortino
Published in: Journal of Translational Medicine, Issue 22, 2024, Page(s) 356, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-024-05090-1

Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro

Author(s): Ilakya Selvarajan, Miika Kiema, Ru-Ting Huang, Jin Li, Jiayu Zhu, Petri Pölönen, Tiit Örd, Kadri Õunap, Mehvash Godiwala, Anna Kathryn Golebiewski, Aarthi Ravindran, Kiira Mäklin, Anu Toropainen, Lindsey K. Stolze, Maximiliano Arce, Peetra U. Magnusson, Stephen White, Casey E. Romanoski, Merja Heinäniemi, Johanna P. Laakkonen, Yun Fang, Minna U. Kaikkonen
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 44, 2024, Page(s) 1330-1345, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.123.318964

Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease

Author(s): Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T Lee, David Z Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N Benhammou, Martin Wabitsch, Joseph R Pisegna, Ville Männistö, Kirsi H Pietiläinen, Markku Laakso, Janet S Sinsheimer, Minna U Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta
Published in: EBioMedicine, Issue Jun;92, 2023, Page(s) 104620, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104620

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Author(s): Giuseppe Mocci, Katyayani Sukhavasi, Tiit Örd, Sean Bankier, Prosanta Singha, Uma Thanigai Arasu, Olayinka Oluwasegun Agbabiaje, Petri Mäkinen, Lijiang Ma, Chani J. Hodonsky, Redouane Aherrahrou, Lars Muhl, Jianping Liu, Sonja Gustafsson, Byambajav Byandelger, Ying Wang, Simon Koplev, Urban Lendahl, Gary K. Owens, Nicholas J. Leeper, Gerard Pasterkamp, Michael Vanlandewijck, Tom Michoel, Arno Ru
Published in: Circulation Research, Issue 134, 2024, Page(s) 1405-1423, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.123.323184