Multiscale Mechanics of Bone Fragility in Type-2 Diabetes

Project Information

MULT2D

Grant agreement ID: 804108

DOI

10.3030/804108

Project closed

EC signature date 30 October 2018

Start date 1 February 2019

End date 31 January 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 659,00

EU contribution

€ 1 499 659,00

Coordinated by

UNIVERSITY OF GALWAY
Ireland

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Longitudinal alterations in bone morphometry, mechanical integrity and composition in Type-2 diabetes in a Zucker diabetic fatty (ZDF) rat

Author(s): Genna E Monahan, Jessica Schiavi-Tritz, Marissa Britton, Ted J Vaughan
Published in: Bone, Issue 170, 2023, Page(s) 116678, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2023.116672

An investigation of composition, morphology, mechanical properties, and microdamage accumulation of human type 2 diabetic bone

Author(s): Marissa Britton, Genna E. Monahan, Colin G. Murphy, Stephen R. Kearns, Aiden T. Devitt, Anaïs Okwieka, Stéphane Jaisson, Laurence Van Gulick, Abdelilah Beljebbar, Halima Kerdjoudj, Jessica Schiavi, Ted J. Vaughan
Published in: Bone, Issue 187, 2024, Page(s) 117190, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2024.117190

A multiscale finite element investigation on the role of intra- and extra-fibrillar mineralisation on the elastic properties of bone tissue

Author(s): Hamid Alijani, Ted J.Vaughan
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 129, 2022, Page(s) 105139, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105139

Exploring the hierarchical structure of lamellar bone and its impact on fracture behaviour: A computational study using a phase field damage model

Author(s): Hamid Alijani, Ted J. Vaughan
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 153, 2024, Page(s) 106471, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2024.106471

Bone Mineral Is More Heterogeneously Distributed in the Femoral Heads of Osteoporotic and Diabetic Patients: A Pilot Study

Author(s): Eoin Parle, Sherdya Tio, Annie Behre, John J Carey, Colin G Murphy, Timothy F O'Brien, William A Curtin, Stephen R Kearns, John P McCabe, Cynthia M Coleman, Ted J Vaughan, Laoise M McNamara
Published in: JBMR Plus, Issue 4/2, 2020, ISSN 2473-4039
Publisher: Wiley
DOI: 10.1002/jbm4.10253

An investigation on the effects of in vitro induced advanced glycation end-products on cortical bone fracture mechanics at fall-related loading rates

Author(s): Marissa Britton, Eoin Parle, Ted Vaughan
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 138, 2023, Page(s) 105619, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105619

Elucidating the role of diverse mineralisation paradigms on bone biomechanics – a coarse-grained molecular dynamics investigation

Author(s): Mahdi Tavakol, Ted J. Vaughan
Published in: Nanoscale, Issue 16, 2024, Page(s) 3173-3184, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3nr04660e

The structural role of osteocalcin in bone biomechanics and its alteration in Type-2 Diabetes

Author(s): Mahdi Tavakol, Ted J. Vaughan
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-73141-w

Designing Hydrogel-Based Bone-On-Chips for Personalized Medicine

Author(s): Gabriele Nasello, Mar Cóndor, Ted Vaughan, Jessica Schiavi
Published in: Applied Sciences, Issue 11/10, 2021, Page(s) 4495, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app11104495

A coarse-grained molecular dynamics investigation of the role of mineral arrangement on the mechanical properties of mineralized collagen fibrils

Author(s): Mahdi Tavakol, Ted Vaughan
Published in: Journal of the Royal Society Interface, Issue 20, 2023, ISSN 1742-5689
Publisher: The Royal Society
DOI: 10.1098/rsif.2022.0803

Experimental and Computational Analysis of Energy Absorption Characteristics of Three Biomimetic Lattice Structures Under Compression

Author(s): Mahtab Vafaeefar, Kevin M. Moerman, Ted Vaughan
Published in: Journal of Mechanical Behaviour of Biomedical Materials, 2023, ISSN 1878-0180
Publisher: Elsevier
DOI: 10.2139/ssrn.4555182

Energy dissipation of osteopontin at a HAp mineral interface: Implications for bone biomechanics

Author(s): Mahdi Tavakol, Ted Vaughan
Published in: Biophysical Journal, Issue 121, 2022, Page(s) 228-236, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2021.12.023

LatticeWorks: An open-source MATLAB toolbox for nonuniform, gradient and multi-morphology lattice generation, and analysis

Author(s): Mahtab Vafaeefar, Kevin M. Moerman, Ted J. Vaughan
Published in: Materials & Design, Issue 250, 2025, Page(s) 113564, ISSN 0264-1275
Publisher: Elsevier BV
DOI: 10.1016/j.matdes.2024.113564

Micromechanical modelling of transverse fracture behaviour of lamellar bone using a phase-field damage model: The role of non-collagenous proteins and mineralised collagen fibrils

Author(s): Hamid Alijani, Ted J. Vaughan
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 153, 2024, Page(s) 106472, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2024.106472

Non-peer reviewed articles (1)

A morphological, topological and mechanical investigation of gyroid, spinodoid and dual-lattice algorithms as structural models of trabecular bone

Author(s): Mahtab Vafaeefar, Kevin M Moerman, Majid Kavousi, Ted J Vaughan
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 138, 2023, Page(s) 105584, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105584

Conference proceedings (1)

The role of the osteocalcin-osteopontin protein complex in bone biomechanics: a key contributor to energy dissipation at mineral-mineral interfaces

Author(s): Mahdi Tavakol, Ted Vaughan
Published in: Biophysical Journal, Issue 121, 2022, Page(s) 332A, ISSN 0006-3495
Publisher: Elsevier
DOI: 10.1016/j.bpj.2021.11.1113