MEFISTO - Meniscal functionalised scaffold to prevent knee Osteoarthritis onset after meniscectomy

Project Information

MEFISTO

Grant agreement ID: 814444

DOI

10.3030/814444

Project closed

EC signature date 5 March 2019

Start date 1 April 2019

End date 30 November 2024

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials

Total cost

€ 5 996 590,00

EU contribution

€ 5 996 590,00

Coordinated by

GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (5)

MEFISTO doctoral schools

MEFISTO doctoral schools. Summary description of the two doctoral schools to be organised in M24 and M48.

Website

Website. Public project website serving as a dissemination gateway. A first version will be published at the latest in M03, a comprehensive version in M06.

Video

Video. Conceived as a dissemination tool to interest researchers, stakeholders and the public in the project, also addressing an audience, which cannot easily be reached via other means.

Stakeholder forum meetings and demo sessions

Stakeholder forum meetings and demo sessions. Conceived to update the stakeholders on the project achievements and receive their feedback these meetings will take place on an annual basis, coinciding with the consortium meetings. D9.5 will summarise all four meetings of this forum.

Flyer and press kit

Flyer and press kit. Summary description of the MEFISTO flyer and ready-made press kits.

Publications

Peer reviewed articles (29)

One‐Step Photoactivation of a Dual‐Functionalized Bioink as Cell Carrier and Cartilage‐Binding Glue for Chondral Regeneration

Author(s): Khoon S. Lim, Florencia Abinzano, Paulina Nuñez Bernal, Ane Albillos Sanchez, Pau Atienza‐Roca, Iris A. Otto, Quentin C. Peiffer, Michiya Matsusaki, Tim B. F. Woodfield, Jos Malda, Riccardo Levato
Published in: Advanced Healthcare Materials, Issue 9/15, 2020, Page(s) 1901792, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201901792

Selection of Highly Proliferative and Multipotent Meniscus Progenitors through Differential Adhesion to Fibronectin: A Novel Approach in Meniscus Tissue Engineering

Author(s): Jasmijn V. Korpershoek, Margot Rikkers, Tommy S. de Windt, Marianna A. Tryfonidou, Daniel B. F. Saris, Lucienne A. Vonk
Published in: International Journal of Molecular Sciences, Issue 22/16, 2021, Page(s) 8614, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22168614

Single Cell Bioprinting with Ultrashort Laser Pulses

Author(s): Jun Zhang,Patrick Byers,Amelie Erben,Christine Frank,Levin Schulte-Spechtel,Michael Heymann,Denitsa Docheva,Heinz P. Huber,Stefanie Sudhop,Hauke Clausen-Schaumann
Published in: Advanced Functional Materials, 2021, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202100066

Biosynthetic scaffolds for partial meniscal loss: A systematic review from animal models to clinical practice

Author(s): F. Veronesi, B. Di Matteo, N.D. Vitale, G. Filardo, A. Visani, E. Kon, M. Fini
Published in: Bioactive Materials, Issue 6/11, 2021, Page(s) 3782-3800, ISSN 2452-199X
Publisher: KeAi
DOI: 10.1016/j.bioactmat.2021.03.033

Fibronectin Adherent Cell Populations Derived From Avascular and Vascular Regions of the Meniscus Have Enhanced Clonogenicity and Differentiation Potential Under Physioxia

Author(s): Girish Pattappa, Franziska Reischl, Judith Jahns, Ruth Schewior, Siegmund Lang, Johannes Zellner, Brian Johnstone, Denitsa Docheva, Peter Angele
Published in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2021.789621

Hydrogel-Based Bioinks for Cell Electrowriting of Well-Organized Living Structures with Micrometer-Scale Resolution

Author(s): Miguel Castilho, Riccardo Levato, Paulina Nunez Bernal, Mylène de Ruijter, Christina Y. Sheng, Joost van Duijn, Susanna Piluso, Keita Ito, Jos Malda
Published in: Biomacromolecules, 2021, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.0c01577

Extending Single Cell Bioprinting from Femtosecond to Picosecond Laser Pulse Durations

Author(s): Jun Zhang, Yasemin Geiger, Florian Sotier, Sasa Djordjevic, Denitsa Docheva, Stefanie Sudhop, Hauke Clausen-Schaumann, Heinz P. Huber
Published in: Micromachines, 2022, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi12101172

Progenitor Cells in Healthy and Osteoarthritic Human Cartilage Have Extensive Culture Expansion Capacity while Retaining Chondrogenic Properties

Author(s): M. Rikkers, J.V. Korpershoek, R. Levato, J. Malda, and L.A. Vonk
Published in: Cartilage, 2021, ISSN 1947-6035
Publisher: SAGE Publications Inc.
DOI: 10.1177/19476035211059600

From Shape to Function: The Next Step in Bioprinting

Author(s): Riccardo Levato, Tomasz Jungst, Ruben G. Scheuring, Torsten Blunk, Juergen Groll, Jos Malda
Published in: Advanced Materials, Issue 32/12, 2020, Page(s) 1906423, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201906423

Therapeutic Manipulation of Macrophages Using Nanotechnological Approaches for the Treatment of Osteoarthritis

Author(s): Aldo Ummarino, Francesco Manlio Gambaro, Elizaveta Kon, Fernando Torres Andón
Published in: Nanomaterials, Issue 10/8, 2020, Page(s) 1562, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10081562

Volumetric Bioprinting of Complex Living‐Tissue Constructs within Seconds

Author(s): Paulina Nuñez Bernal, Paul Delrot, Damien Loterie, Yang Li, Jos Malda, Christophe Moser, Riccardo Levato
Published in: Advanced Materials, Issue 31/42, 2019, Page(s) 1904209, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201904209

An in vitro model for osteoarthritis using long‐cultured inflammatory human macrophages repeatedly stimulated with TLR agonists

Author(s): A. Ummarino, A. Pensado-López, R. Migliore, L. A. Ruggiero, N. Calà, M. Caputo, F. M. Gambaro, C. Anfray, F. L. 5 Ronzoni, E. Kon, P. Allavena, F. T. Andón.
Published in: European Journal of Immunology, 2023, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350507

Automated Landmark Annotation for Morphometric Analysis of Distal Femur and Proximal Tibia

Author(s): Grammens, Jonas; Van Haver, Annemieke; Lumban-Gaol, Imelda; Danckaers, Femke; Verdonk, Peter; Sijbers, Jan
Published in: J. Imaging, 2024, ISSN 2313-433X
Publisher: Journal of Imaging
DOI: 10.3390/jimaging10040090

Cell-based treatment options facilitate regeneration of cartilage, ligaments and meniscus in demanding conditions of the knee by a whole joint approach

Author(s): Peter Angele, Denitsa Docheva, Girish Pattappa, Johannes Zellner
Published in: Knee Surgery, Sports Traumatology, Arthroscopy, 2021, ISSN 0942-2056
Publisher: Springer Verlag
DOI: 10.1007/s00167-021-06497-9

Conservative vs. surgical approach for degenerative meniscal injuries: a systematic review of clinical evidence

Author(s): A. GIUFFRIDA, A. DI BARI, E. FALZONE, F. IACONO, E. KON1,M. MARCACCI, R. GATTI, B. DI MATTEO
Published in: European Review for Medical and Pharmacological Sciences, Issue 24, 2020, Page(s) 2874-2885, ISSN 1128-3602
Publisher: Verduci Editore srl
DOI: 10.26355/eurrev_202003_20651

Stem cells application in meniscal tears: a systematic review of pre-clinical and clinical evidence

Author(s): G. Rinonapoli, P. Gregori, B. Di Matteo, L. Impieri, P. Ceccarini, F. Manfreda, G. Campofreda, A. Caraffa
Published in: European Review for Medical and Pharmacological Sciences, 2021, ISSN 1128-3602
Publisher: Verduci Editore srl
DOI: 10.26355/eurrev_202112_27622

Physioxia Expanded Bone Marrow Derived Mesenchymal Stem Cells Have Improved Cartilage Repair in an Early Osteoarthritic Focal Defect Model

Author(s): Girish Pattappa, Jonas Krueckel, Ruth Schewior, Dustin Franke, Alexander Mench, Matthias Koch, Johannes Weber, Siegmund Lang, Christian G. Pfeifer, Brian Johnstone, Denitsa Docheva, Volker Alt, Peter Angele, Johannes Zellner
Published in: Biology, Issue 9/8, 2020, Page(s) 230, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology9080230

Biofunctionalization of 3D printed collagen with bevacizumab-loaded microparticles targeting pathological angiogenesis

Author(s): Anna Abbadessa, Paulina N. Bernal, Giorgio Buttitta, Alfredo Ronca, Ugo D’Amora, Carla Zihlmann, Niklaus Stiefel, Luigi Ambrosio, Jos Malda, Riccardo Levato, José Crecente-Campo, María José Alonso
Published in: Journal of Controlled Release, 2023, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2023.07.017

Drug Delivery Systems for the Treatment of Knee Osteoarthritis: A Systematic Review of In Vivo Studies

Author(s): F. Gambaro, A. Ummarino, F. Torres Andon, F. Ronzoni, B. Di Matteo, E. Kon
Published in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179137

The clinical potential of articular cartilage-derived progenitor cells: a systematic review

Author(s): Rikkers, Margot; Korpershoek, Jasmijn V.; Levato, Riccardo; Malda, Jos; Vonk, Lucienne A.
Published in: npj Regenerative Medicine, Issue 7(1), 2022, ISSN 2057-3995
Publisher: Springer Nature
DOI: 10.1038/s41536-021-00203-6

Potential of Melt Electrowritten Scaffolds Seeded with Meniscus Cells and Mesenchymal Stromal Cells

Author(s): Jasmijn V. Korpershoek, Mylène de Ruijter, Bastiaan F. Terhaard 1, Michella H. Hagmeijer, Daniël B.F. Saris, Miguel Castilho, Jos Malda, and Lucienne A. Vonk
Published in: International Journal of Molecular Sciences, Issue 22, 2021, Page(s) 11200, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222011200

Orthobiologic injections for treating degenerative meniscus lesions: a matter of facts? Ten years of clinical experience in a systematic review.

Author(s): Conte, P., Anzillotti, G., Di Matteo, B., Gallese, A., Vitale, U., Marcacci, M. & Kon, E.
Published in: Journal of Cartilage & Joint Preservation, 2023, ISSN 2667-2545
Publisher: Elsevier
DOI: 10.1016/j.jcjp.2023.100104

Bioink with cartilage-derived extracellular matrix microfibers enables spatial control of vascular capillary formation in bioprinted constructs

Author(s): Margo Luchiena Terpstra; Jinyu Li; Anneloes Mensinga; Mylène de Ruijter; Mattie H P van Rijen; Charalampos Androulidakis; Costas Galiotis; Ioannis Papantoniou; Michiya Matsusaki; Jos Malda; Riccardo Levato
Published in: Biofabrication, Issue 2, 2022, Page(s) 034104, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.1088/1758-5090/ac6282

Synthetic peptides of IL-1Ra and HSP70 have anti-inflammatory activity on human primary monocytes and macrophages: Potential treatments for inflammatory diseases

Author(s): Alba Pensado-López, Aldo Ummarino, Sophia Khan, Anna Guildford, Iain U Allan, Matteo Santin, Nathalie Chevallier, Elina Varaillon, Elizaveta Kon, Paola Allavena, Fernando Torres Andón
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, 2024, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2023.102719

Development of a highly concentrated collagen ink for the creation of a 3D printed meniscus

Author(s): Alfredo Ronca, Ugo D’Amora, Elisa Capuana, Carla Zihlmann, Niklaus Stiefel, Girish Pattappa, Ruth Schewior, Denitsa Docheva, Peter Angele, Luigi Ambrosio
Published in: Heliyon, 2023, ISSN 2405-8440
Publisher: Heliyon
DOI: 10.1016/j.heliyon.2023.e23107

Engineering Anisotropic Meniscus: Zonal Functionality and Spatiotemporal Drug Delivery

Author(s): Anna Abbadessa, José Crecente-Campo, María José Alonso
Published in: Tissue Engineering Part B: Reviews, 2020, ISSN 1937-3368
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.teb.2020.0096

Three‐dimensional bone morphology is a risk factor for medial postmeniscectomy syndrome: A retrospective cohort study

Author(s): Jonas Grammens, Annemieke Van Haver, Femke Danckaers, Kristien Vuylsteke, Jan Sijbers, Lotem Mahluf, Peter Angele, Elizaveta Kon, Peter Verdonk, null null
Published in: Journal of Experimental Orthopaedics, Issue 11, 2024, ISSN 2197-1153
Publisher: Wiley
DOI: 10.1002/jeo2.12090

Bioprinting Neural Systems to Model Central Nervous System Diseases

Author(s): Boning Qiu, Nils Bessler, Kianti Figler, Maj‐Britt Buchholz, Anne C. Rios, Jos Malda, Riccardo Levato, Massimiliano Caiazzo
Published in: Advanced Functional Materials, Issue 30/44, 2020, Page(s) 1910250, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201910250

Small medial femoral condyle morphotype is associated with medial compartment degeneration and distinct morphological characteristics: a comparative pilot study

Author(s): Jonas Grammens, Annemieke Van Haver, Femke Danckaers, Brian Booth, Jan Sijbers, Peter Verdonk
Published in: Knee Surgery, Sports Traumatology, Arthroscopy, 2020, ISSN 0942-2056
Publisher: Springer Verlag
DOI: 10.1007/s00167-020-06218-8

Thesis and dissertations (1)

Crafting Tissue Complexity

Author(s): null null, Paulina Núñez Bernal
Published in: 2024
Publisher: Utrecht University Library
DOI: 10.33540/2116