Integrating the tissue-specificity and chronology of hereditary renal cancer predisposition

Project Information

ONCOFUM

Grant agreement ID: 819920

DOI

10.3030/819920

Project closed

EC signature date 20 February 2019

Start date 1 March 2019

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 998 698,00

EU contribution

€ 1 998 698,00

Coordinated by

KLINIKUM DER UNIVERSITAET ZU KOELN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

TCA cycle signalling and the evolution of eukaryotes

Author(s): Dylan G Ryan, Christian Frezza, Luke AJ O’Neill
Published in: Current Opinion in Biotechnology, Issue 68, 2021, Page(s) 72-88, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2020.09.014

Fumarate induces vesicular release of mtDNA to drive innate immunity

Author(s): Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M. N. Wortel, Jordan L. Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S. H. Costa, Gonçalo C. Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith Samarajiwa, Maxine Tran, Thomas
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05770-w

Hypoxia promotes osteogenesis by facilitating acetyl-CoA-mediated mitochondrial–nuclear communication

Author(s): Andromachi Pouikli Monika Maleszewska Swati Parekh Ming Yang Chrysa Nikopoulou Juan Jose Bonfiglio Constantine Mylonas Tonantzi Sandoval Anna-Lena Schumacher Yvonne Hinze Ivan Matic Christian Frezza Peter Tessarz
Published in: The EMBO Journal, 2022, ISSN 1460-2075
Publisher: EMBOpress
DOI: 10.15252/embj.2022111239

Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism

Author(s): Lorea Valcarcel-Jimenez & Christian Frezza
Published in: British Journal of Cancer (BJC), 2023, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-023-02412-w

HIRA loss transforms FH-deficient cells

Author(s): Lorea Valcarcel-Jimenez, Connor Rogerson, Cissy Yong, Christina Schmidt, Ming Yang, Monica Cremades-Rodelgo, Victoria Harle, Victoria Offord, Kim Wong, Ariane Mora, Alyson Speed, Veronica Caraffini, Maxine Gia Binh Tran, Eamonn R. Maher, Grant D. Stewart, Sakari Vanharanta, David J. Adams, Christian Frezza
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abq8297

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

Author(s): Sarah-Maria Fendt, Christian Frezza, Ayelet Erez
Published in: Cancer Discovery, Issue 10/12, 2020, Page(s) 1797-1807, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0844

The context-specific roles of urea cycle enzymes in tumorigenesis

Author(s): Emma Hajaj, Marco Sciacovelli, Christian Frezza, Ayelet Erez
Published in: Molecular Cell, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.08.005

Metabolic symbiosis in pancreatic cancer.

Author(s): Ryan DG, Frezza C.
Published in: Nature Cancer, 2022, ISSN 2662-1347
Publisher: Springer nAture Limited
DOI: 10.1038/s43018-022-00454-2

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Author(s): Marco Sciacovelli , Aurelien Dugourd , Lorea Valcarcel Jimenez , Ming Yang , Efterpi Nikitopoulou , Ana S. H. Costa , Laura Tronci , Veronica Caraffini , Paulo Rodrigues , Christina Schmidt , Dylan Gerard Ryan , Timothy Young , Vincent R. Zecchini , Sabrina H. Rossi , Charlie Massie , Caroline Lohoff , Maria Masid , Vassily Hatzimanikatis , Christoph Kuppe , Alex Von Kriegsheim , Rafael Kr
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35036-4

FOXA2 controls the anti-oxidant response in FH-deficient cells

Author(s): Connor Rogerson , Marco Sciacovelli , Lucas A Maddalena , Andromachi Pouikli , Marc Segarra-Mondejar , Lorea Valcarcel-Jimenez , Christina Schmidt , Ming Yang , Elena Ivanova , Joshua Kent , Ariane Mora , Danya Cheeseman , Jason S Carroll , Gavin Kelsey , Christian Frezza
Published in: Cell Reports, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112751