''One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals

Project Information

NOVIRUSES2BRAIN

Grant agreement ID: 828774

DOI

10.3030/828774

Project closed

EC signature date 17 December 2018

Start date 1 September 2019

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 3 933 965,63

EU contribution

€ 3 933 965,63

Coordinated by

FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

"A Data Management Plan (DMP) will be elaborated including what data the project will generate, whether and how it will be made accessible for verification and re-use, and how it will be curated and preserved. Through this DMP the Consortium can define certain datasets to remain closed according to the principle ""as open as possible, as closed as necessary""."

Documents, reports (3)

Communication and dissemination outputs

1. Outreach: >60 visitors, >5 journalists, and >2 decision–empowered politicians in outreaching activities; >5 international press releases on achievements2. Dissemination: >2 patents, >6 papers in Q1 journals, >3 seminars, >8 communications.

First technical/scientific review meeting report

The Report will include the draft agenda and the presentations to be delivered during the review meeting with the REAEC

Second technical/scientific review meeting report

The Report will include the draft agenda and the presentations to be delivered during the review meeting with the REAEC

Websites, patent fillings, videos etc. (1)

Website and project logo

Dedicated website will be launched and a project logo, as the first communication package of the project.

Publications

Peer reviewed articles (7)

A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms

Author(s): Dias, Susana Pinto, Sandra Silva-Herdade, Ana S. Cheneval, Olivier Craik, David J Coutinho, Ana Castanho, Miguel A. R. B. Henriques, Sónia T. Veiga, Ana Salomé
Published in: J Antimicrob Chemother., 2022, ISSN 0305-7453
Publisher: Oxford University Press
DOI: 10.1093/jac/dkac309

Penetrating the Blood-Brain Barrier with New Peptide-Porphyrin Conjugates Having anti-HIV Activity.

Author(s): Mendonça, Diogo A. Bakker, Mariët Cruz-Oliveira, Christine Neves, Vera Angeles Jiménez, Maria Defaus, Sira Cavaco, Marco Veiga, Ana Salomé Cadima Couto, Carla Iris Castanho, Miguel A. R. B. Andreu, David Todorovski, Toni
Published in: Bioconjugate Chem., 2021, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00123

Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide–Porphyrin Conjugates

Author(s): Toni Todorovski ,Diogo A. Mendonça ,Lorena O. Fernandes-Siqueira, Christine Cruz-Oliveira ,Giuseppina Guida 1,Javier Valle 1,Marco Cavaco 2ORCID,Fernanda I. V. Limas 3,Vera Neves 2ORCID,Íris Cadima-Couto 2,Sira Defaus 1,Ana Salomé Veiga 2,Andrea T. Da Poian 3,Miguel A. R. B. Castanho 2 and David Andreu
Published in: Pharmaceutics, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14040738

Design of Natterins-based peptides improves antimicrobial and antiviral activities

Author(s): Gabrielle L. de Cena, Dayane B. Tada, Danilo B.M. Lucchi, Tiago A.A. Santos, Montserrat Heras, Maria Juliano, Carla Torres Braconi, Miguel A.R.B. Castanho, Mônica Lopes-Ferreira, Katia Conceição
Published in: Biotechnology Reports, Issue 45, 2025, Page(s) e00867, ISSN 2215-017X
Publisher: Elsevier BV
DOI: 10.1016/j.btre.2024.e00867

Antiviral Peptide-Based Conjugates: State of the Art and Future Perspectives

Author(s): David Andreu; Daniela Kalafatovic; Toni Todorovski
Published in: Pharmaceutics, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020357

Unravelling the role of key amino acid residues of the parainfluenza fusion peptide in membrane fusion

Author(s): Mariana Valério, Carolina C. Buga, Diogo A. Mendonça, Miguel A. R. B. Castanho, Manuel N. Melo, Cláudio M. Soares, Diana Lousa, Ana Salomé Veiga
Published in: RSC Chemical Biology, Issue 6, 2025, Page(s) 1100-1114, ISSN 2633-0679
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d5cb00058k

Repurposing anti-cancer porphyrin derivative drugs to target SARS-CoV-2 envelope

Author(s): Diogo A. Mendonça, Iris Cadima-Couto, Carolina C. Buga, Zoe A. Arnaut, Fabio A. Schaberle, Luis G. Arnaut, Miguel A.R.B. Castanho, Christine Cruz-Oliveira
Published in: Biomedicine & Pharmacotherapy, Issue 176, 2024, Page(s) 116768, ISSN 0753-3322
Publisher: Elsevier Masson
DOI: 10.1016/j.biopha.2024.116768