Metabolic crosstalk in the regulation of inflammation

Información del proyecto

Metabinnate

Identificador del acuerdo de subvención: 834370

DOI

10.3030/834370

Proyecto cerrado

Fecha de la firma de la CE 10 Mayo 2019

Fecha de inicio 1 Junio 2019

Fecha de finalización 31 Mayo 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 484 858,00

Aportación de la UE

€ 2 484 858,00

Coordinado por

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (40)

Caspase-4: A Therapeutic Target for Peptic Ulcer Disease

Autores: Zbigniew Zaslona, Ewelina Flis, Ciara Nulty, Jay Kearney, Rebecca Fitzgerald, Atiyekeogbebe R. Douglas, Deirdre McNamara, Sinead Smith, Luke A. J. O’Neill, Emma M. Creagh
Publicado en: ImmunoHorizons, Edición 4/10, 2020, Página(s) 627-633, ISSN 2573-7732
Editor: AAI
DOI: 10.4049/immunohorizons.2000080

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.

Autores: Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ.
Publicado en: Cell Metabolism, 2022, Página(s) 487-501, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2022.02.002

Pseudomonas Persists by Feeding off Itaconate

Autores: Marah C. Runtsch, Luke A.J. O’Neill
Publicado en: Cell Metabolism, Edición 31/6, 2020, Página(s) 1045-1047, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.05.005

Modification of Proteins by Metabolites in Immunity

Autores: Ciana Diskin , Tristram Ryan , L A J O'Neill
Publicado en: Immunity, 2021, Página(s) 19-31, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2020.09.014

Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase

Autores: Shane M. O’Carroll, Christian G. Peace, Juliana E. Toller-Kawahisa, Yukun Min, Alexander Hooftman, Sara Charki, Louise Kehoe, Maureen J. O’Sullivan, Aline Zoller, Anne F. Mcgettrick, Alessia Zotta, Emily A. Day, Maria Simarro, Neali Armstrong, Justin P. Annes, Luke A. J. O’Neill
Publicado en: Nature Metabolism, Edición 6, 2024, Página(s) 2060-2069, ISSN 2522-5812
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-01145-1

The Immunomodulatory Potential of the Metabolite Itaconate

Autores: Alexander Hooftman, Luke A.J. O’Neill
Publicado en: Trends in Immunology, Edición 40/8, 2019, Página(s) 687-698, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2019.05.007

Can NLRP3 inhibitors improve on dexamethasone for the treatment of COVID-19?

Autores: Alexander Hooftman, Luke A.J. O'Neill
Publicado en: Current Research in Pharmacology and Drug Discovery, Edición 2, 2023, Página(s) 100048, ISSN 2590-2571
Editor: Elsevier BV
DOI: 10.1016/j.crphar.2021.100048

Fumarate hydratase as a metabolic regulator of immunity

Autores: Christian G Peace, Shane M O'Carroll and Luke A J O'Neill
Publicado en: Trends in Cell Biology, Edición S0962-8924(23)00209-X., 2023, Página(s) S0962-8924(23)00209-X., ISSN 1879-3088
Editor: Elsevier
DOI: 10.1016/j.tcb.2023.10.005

Daily variation in macrophage phagocytosis is clock‐independent and dispensable for cytokine production

Autores: Sarah S. Geiger, Annie M. Curtis, Luke A. J. O'Neill, Richard M. Siegel
Publicado en: Immunology, Edición 157/2, 2019, Página(s) 122-136, ISSN 0019-2805
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imm.13053

Caspase-11 promotes allergic airway inflammation

Autores: Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill
Publicado en: Nature Communications, Edición 11/1, 2020, Página(s) monthly, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-14945-2

Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion

Autores: Alessia Zotta, Juliana Toller-Kawahisa, Eva M. Palsson-McDermott, Shane M. O’Carroll, Órlaith C. Henry, Emily A. Day, Anne F. McGettrick, Ross W. Ward, Dylan G. Ryan, Mark A. Watson, Martin D. Brand, Marah C. Runtsch, Kathrin Maitz, Anna Lueger, Julia Kargl, Jan L. Miljkovic, Ed C. Lavelle, Luke A. J. O’Neill
Publicado en: Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adq7307

Protein targeting by the itaconate family in immunity and inflammation

Autores: Emily A Day and Luke A J O'Neill
Publicado en: Biochemical Journal, Edición 479(24), 2022, Página(s) 2499-2510, ISSN 1470-8728
Editor: Portland Press
DOI: 10.1042/bcj20220364

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Autores: Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark M. Hughes, Alan D. Irvine, Roman Fischer, Luke A.J. O’Neill
Publicado en: Cell Metabolism, Edición 32/3, 2020, Página(s) 468-478.e7, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.07.016

Targetting mitochondria to beat HIV

Autores: Emily Day, Luke O'Neill
Publicado en: Nature Immunology, 2021, Página(s) 398-399, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-021-00881-w

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation

Autores: Eva M. Pålsson-McDermott, Luke A.J. O’Neill
Publicado en: Cell Metabolism, Edición 37, 2025, Página(s) 1049-1059, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2025.03.004

The itaconate family of immunomodulators grows

Autores: Anne F McGettrick and Luke A J O'Neill
Publicado en: Nature Metabolism, Edición 4(5), 2022, Página(s) 499-500, ISSN 2522-5812
Editor: Nature Portfolic
DOI: 10.1038/s42255-022-00578-w

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Autores: Hooftman A et al and including Emily Day, Juliana E Toller Kawahisa, Tristram Ryan and Luke O'Neill
Publicado en: Nature, Edición 615(7952), 2023, Página(s) 490-498, ISSN 1476-4687
Editor: Nature Portfolio
DOI: 10.1038/s41586-023-05720-6

Targeting immunometabolism as an anti-inflammatory strategy

Autores: Eva M. Pålsson-McDermott, Luke A. J. O’Neill
Publicado en: Cell Research, Edición 30/4, 2020, Página(s) 300-314, ISSN 1001-0602
Editor: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-020-0291-z

How should we talk about metabolism?

Autores: Michael P. Murphy, Luke A. J. O’Neill
Publicado en: Nature Immunology, Edición 21/7, 2020, Página(s) 713-715, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-020-0691-8

The next decade of metabolism

Autores: Fredrik Bäckhed, Elisabetta Bugianesi, Heather Christofk, Ivan Dikic, Rana Gupta, William B. Mair, Luke A. J. O’Neill, Markus Ralser, David M. Sabatini, Matthias Tschöp
Publicado en: Nature Metabolism, Edición 1/1, 2019, Página(s) 2-4, ISSN 2522-5812
Editor: npg
DOI: 10.1038/s42255-018-0022-7

Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants

Autores: Ryan TAJ, Preston RJS, O'Neill LAJ
Publicado en: Biochemical Journal, 2022, Página(s) 731-750, ISSN 0264-6021
Editor: Portland Press, Ltd.
DOI: 10.1042/bcj20210522

Krebs Cycle Reborn in Macrophage Immunometabolism

Autores: Dylan G. Ryan, Luke A.J. O'Neill
Publicado en: Annual Review of Immunology, Edición 38/1, 2020, Página(s) 289-313, ISSN 0732-0582
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-081619-104850

The Role of HIF in Immunity and Inflammation

Autores: Anne F. McGettrick, Luke A.J. O’Neill
Publicado en: Cell Metabolism, Edición 32/4, 2020, Página(s) 524-536, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.08.002

Targeting macrophage immunometabolism to prevent atherosclerosis

Autores: Luke A. J. O’Neill
Publicado en: Nature Metabolism, Edición 1/12, 2019, Página(s) 1173-1174, ISSN 2522-5812
Editor: Springer
DOI: 10.1038/s42255-019-0154-4

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1

Autores: Pau Ribó-Molina and including Hauke J Weiss and Luke A J O'Neill
Publicado en: Journal of Virology, Edición 97(10), 2023, Página(s) e0132523, ISSN 1098-5514
Editor: American Society for Microbiology
DOI: 10.1128/jvi.01325-23

From periphery to center stage: 50 years of advancements in innate immunity

Autores: Susan Carpenter, Luke A.J. O’Neill
Publicado en: Cell, Edición 187, 2024, Página(s) 6780-6782, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2024.10.013

Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages

Autores: Niamh C. Williams, Dylan G. Ryan, Ana S.H. Costa, Evanna L. Mills, Mark P. Jedrychowski, Suzanne M. Cloonan, Christian Frezza, Luke A. O'Neill
Publicado en: Journal of Biological Chemistry, Edición 298, 2025, Página(s) 101501, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101501

Cytokine-like Roles for Metabolites in Immunity

Autores: Zbigniew Zasłona, Luke A.J. O’Neill
Publicado en: Molecular Cell, Edición 78/5, 2020, Página(s) 814-823, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2020.04.002

Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice

Autores: Stella Liong, Osezua Oseghale, Eunice E. To, Kurt Brassington, Jonathan R. Erlich, Raymond Luong, Felicia Liong, Robert Brooks, Cara Martin, Sharon O’Toole, Antony Vinh, Luke A. J. O’Neill, Steven Bozinovski, Ross Vlahos, Paris C. Papagianis, John J. O’Leary, Doug A. Brooks, Stavros Selemidis
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/40, 2020, Página(s) 24964-24973, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2006905117

4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2

Autores: Ciana Diskin, Emily A Day, Órlaith C Henry, Juliana E Toller-Kawahisa , Luke A J O'Neill
Publicado en: J Immunol, Edición 211(6), 2023, Página(s) 10321041, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.2200848

BCG-induced trained immunity: can it offer protection against COVID-19?

Autores: Luke A. J. O’Neill, Mihai G. Netea
Publicado en: Nature Reviews Immunology, Edición 20/6, 2020, Página(s) 335-337, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-020-0337-y

Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite

Autores: Anne F McGettrick Luke AJ O'Neill
Publicado en: Current Opinion in Immunology, Edición 80, 2023, Página(s) 102268, ISSN 0952-7915
Editor: Elsevier BV
DOI: 10.1016/j.coi.2022.102268

A break in mitochondrial endosymbiosis as a basis for inflammatory diseases

Autores: Michael P. Murphy, Luke A. J. O’Neill
Publicado en: Nature, Edición 626, 2024, Página(s) 271-279, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-023-06866-z

Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses

Autores: Eunice E. To, John J. O'Leary, Luke A.J. O'Neill, Ross Vlahos, Steven Bozinovski, Christopher J.H. Porter, Robert D. Brooks, Doug A. Brooks, Stavros Selemidis
Publicado en: Antioxidants & Redox Signaling, Edición 32/13, 2020, Página(s) 982-992, ISSN 1523-0864
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2020.8027

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

Autores: Stefano Angiari, Marah C. Runtsch, Caroline E. Sutton, Eva M. Palsson-McDermott, Beth Kelly, Nisha Rana, Harry Kane, Gina Papadopoulou, Erika L. Pearce, Kingston H.G. Mills, Luke A.J. O'Neill
Publicado en: Cell Metabolism, Edición 31/2, 2020, Página(s) 391-405.e8, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2019.10.015

How neutrophil metabolism affects bacterial killing

Autores: Juliana E Toller-Kawahisa and Luke A J O'Neill
Publicado en: Open Biology, Edición 12(11), 2022, Página(s) 220248, ISSN 2046-2441
Editor: Royal Society Publishing
DOI: 10.1098/rsob.220248

The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils

Autores: Juliana E Toller-Kawahisa and including Tristram Ryan and Luke O'Neill
Publicado en: Nature Communications, Edición 14(1), 2023, Página(s) 4280, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-40021-6

The role of itaconate in host defense and inflammation.

Autores: Peace C, O'Neill LA
Publicado en: J Clin Invest, 2022, Página(s) 132(2):e148548, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci148548

Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine

Autores: Juliana Escher Toller-Kawahisa, Paula Ramos Viacava, Eva Margareta Palsson-McDermott, Daniele Carvalho Nascimento, Mariana Patricia Cervantes-Silva, Shane Myles O'Carroll, Alessia Zotta, Luis Eduardo Alves Damasceno, Gabriel Azevedo Públio, Pedro Forti, João Paulo Mesquita Luiz, Bruno Marcel Silva de Melo, Timna Varela Martins, Vitor Marcel Faça, Annie Curtis, Thiago Mattar Cunha, Fernando de Q
Publicado en: Cell Reports, Edición 44, 2025, Página(s) 115172, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2024.115172

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

Autores: Tristram Ryan and including Juliana E Toller Emily Day Hauke Weiss and Luke O'Neill
Publicado en: Nature Communications, Edición 4(1), 2023, Página(s) 3513, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-39174-1

Non-peer reviewed articles (1)

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

Autores: Mark M. Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Palsson-McDermott, Sinead C. Corr, Kingston H.G. Mills, Roger J.S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board,
Publicado en: Cell Reports, Edición 29/1, 2019, Página(s) 151-161.e5, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.08.072