Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data and experimental guidelines
Structural equation model linking ELS to multi-morbidity outcomes

Structural equation model linking ELS to multimorbidity outcomes

Analysis of the omics data generated by the in vitro models
"White paper ""Blueprint for new prevention and treatment strategies"""

White paper “Blueprint for new prevention and treatment strategies”

Technological impact evaluation report
Candidate genes and molecular pathways components altered by pre- and/or postnatal stress in different tissues
Contribution of ELS-induced microbiota deviations to multi-morbidity development
Dissemination, communication & outreach strategy
Identified sex differences in the in vitro experimental system
Top-hit mechanisms replicated in selected cellular models
Data management Plan version 2
Quantitative measures of ELS-induced metabolic alterations, endocrine response and cardiovascular parameters

Quantitative measures of ELSinduced metabolic alterations endocrine response and cardiovascular parameters

Report on ELS-related stress-induced insults in human cell lines derived from human brain, blood, heart, pancreas, liver, and blood immune cells
Modifiers linked to life conditions with beneficial effects on multi-morbidity
EarlyCause final workshop programme
Multi-omics signatures of ELS-induced multi-morbidity
Data harmonisation process for public use
Project website and communication materials
"White paper ""Potential clinical impact of new biomarkers and causative pathways"""

White paper “Potential clinical impact of new biomarkers and causative pathways”

Quantitative measures of ELS-induced behavioural symptoms

Quantitative measures of ELSinduced behavioural symptoms

Candidates functionally linked to comorbid symptoms
Socio-economic impact assessment framework

Socioeconomic impact assessment framework

Machine learning model of multi-morbidity trajectories

Data Coordination Centre
Final EarlyCause web-portal
System for dataset incorporation into DCC
Development and evaluation of the multimorbidity open-access tool

Deliverables D7.5 and D7.6 will be merged into D7.5.Description: this deliverable will include pilot software with all the information and also a report on accuracy and sensitivity of multi-morbidity predictions.

Data Management Plan version 1

Publications

DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication

Author(s): Fadila Serdarevic, Mannan Luo, Irma Karabegović, Anne-Claire Binter, Silvia Alemany, Ryan Mutzel, Monica Guxens, Mariona Bustamante, Aida Hajdarpasic, Tonya White, Janine F Felix, Charlotte A.M. Cecil, Henning Tiemeier
Published in: Epigenetics, Issue 18, 2023, ISSN 1559-2294
Publisher: Landes Bioscience
DOI: 10.1080/15592294.2023.2207253

Epigenetic Inheritance: Impact for Biology and Society

Author(s): Arzate-Mejia, R. G and Mansuy, I.M.
Published in: Environmental Epigenetics, 2022, ISSN 2470-0991
Publisher: Oxford University Press
DOI: 10.1093/eep/dvac021

Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study

Author(s): Kristina Salontaji, Kristine L. Haftorn, Faye Sanders, Christian M. Page, Esther Walton, Janine F. Felix, Mona Bekkhus, Jon Bohlin, Henning Tiemeier, Charlotte A. M. Cecil
Published in: Molecular Psychiatry, 2024, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-024-02544-2

Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age

Author(s): Romy Gonçalves, Romy Gaillard, Charlotte Cecil, Serena Defina, Eric. A. P. Steegers, Vincent W. V. Jaddoe
Published in: Journal of the American Heart Association, Issue 13, 2024, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.123.029771

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Author(s): Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa267

Exposure to prenatal infection and the development of internalizing and externalizing problems in children: a longitudinal population‐based study

Author(s): Anna Suleri, Anna‐Sophie Rommel, Alexander Neumann, Mannan Luo, Manon Hillegers, Lotje de Witte, Veerle Bergink, Charlotte A. M. Cecil
Published in: Journal of Child Psychology and Psychiatry, Issue 65, 2024, Page(s) 874-886, ISSN 0021-9630
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13923

The impact of early adversity and education on genetic and brain morphological predictors of cognitive ability

Author(s): Emma Corley, Laura Fahey, Joan Fitzgerald, Laurena Holleran, Esther Walton, Derek W. Morris, Gary Donohoe
Published in: Genes, Brain and Behavior, Issue 22, 2023, ISSN 1601-1848
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/gbb.12850

The epigenome under pressure: On regulatory adaptation to chronic stress in the brain

Author(s): Rodrigo G. Arzate-Mejia, Nancy V.N. Carullo, Isabelle M. Mansuy
Published in: Current Opinion in Neurobiology, Issue 84, 2024, Page(s) 102832, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2023.102832

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Author(s): Constantinides, C., Han, L. K., Alloza, C., Antonucci, L., Arango, C., Ayesa-Arriola, R., ... & Walton, E.
Published in: Molecular Psychiatry, 2023, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01897-w

10-Year trajectories of depressive symptoms and subsequent brain health in middle-aged adults

Author(s): Isabel K. Schuurmans, Sander Lamballais, Runyu Zou, Ryan L. Muetzel, Manon H.J. Hillegers, Charlotte A.M. Cecil, Annemarie I. Luik
Published in: Journal of Psychiatric Research, Issue 158, 2023, Page(s) 126-133, ISSN 0022-3956
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2022.12.018

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Author(s): Tobi EW, Juvinao-Quintero DL, Ronkainen J, Ott R, Alfano R, Canouil M, Geurtsen ML, Khamis A, Küpers LK, Lim IY, Perron P, Pesce G, Tuhkanen J, Starling AP, Andrew T, Binder E, Caiazzo R, Chan JKY, Gaillard R, Gluckman PD, Keikkala E, Karnani N, Mustaniemi S, Nawrot TS, Pattou F, Plusquin M, Raverdy V, Tan KH, Tzala E, Raikkonen K, Winkler C, Ziegler AG, Annesi-Maesano I, Bouchard L, Chong YS, Da
Published in: Diabetes Care, 2022, ISSN 1939-327X
Publisher: American Diabetes Association
DOI: 10.2337/dc21-1701

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Author(s): Priyanka Choudhary, Giulietta S. Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G. Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou, Jason I. Feinberg, Charles Mordaunt, Giancarlo Pesce, Nour Baïz, Rossella Alfano, Dries S. Martens, Congrong Wang, Elena Isaevska, Elina Keikkala, Sanna Mustaniemi, Chris H. L. Thio, Eliza Fraszczyk, Elmar W. Tobi, Anne P. Starling, Mar
Published in: Molecular Psychiatry, Issue 29, 2024, Page(s) 348-358, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02331-5

Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.

Author(s): Boscardin C., Manuella, F. and Mansuy, I.M.
Published in: Environmental Epigenetics, 2022, ISSN 2470-0991
Publisher: Oxford University Press
DOI: 10.1093/eep/dvac024

Epigenetics of childhood trauma: Long-term sequelae and potential for treatment.

Author(s): Thumfart, K., Jawaid, A., Bright, K., Flachsmann, M and Mansuy, I.M.
Published in: Neurosci Biobehav Rev, 2022, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2021.10.042

Childhood abuse <i>v.</i> neglect and risk for major psychiatric disorders

Author(s): Anne Alkema, Mattia Marchi, Jeroen A. J. van der Zaag, Daniëlle van der Sluis, Varun Warrier, null null, Roel A. Ophoff, René S. Kahn, Wiepke Cahn, Jacqueline G. F. M. Hovens, Harriëtte Riese, Floortje Scheepers, Brenda W. J. H. Penninx, Charlotte Cecil, Albertine J. Oldehinkel, Christiaan H. Vinkers, Marco P. M. Boks
Published in: Psychological Medicine, Issue 54, 2024, Page(s) 1598-1609, ISSN 0033-2917
Publisher: Cambridge University Press
DOI: 10.1017/s0033291723003471

Associations of prenatal maternal depressive symptoms with cord blood glucocorticoids and child hair cortisol levels in the project viva and the generation R cohorts: a prospective cohort study

Author(s): Nathan J. Cohen, Serena Defina, Sheryl L. Rifas-Shiman, Sabrina Faleschini, Russell S. Kirby, Henian Chen, Ronee Wilson, Kimberly Fryer, Hanan El Marroun, Charlotte A.M. Cecil, Marie-France Hivert, Emily Oken, Henning Tiemeier, Amy C. Alman
Published in: BMC Pediatrics, Issue 23, 2023, ISSN 1471-2431
Publisher: BioMed Central
DOI: 10.1186/s12887-023-04372-9

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Author(s): Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg,
Published in: Clinical Epigenetics, Issue 15, 2023, Page(s) 148, ISSN 1868-7083
Publisher: BMC
DOI: 10.1186/s13148-023-01542-5

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Author(s): Solomon O, Huen K, Yousefi P, Küpers LK, González JR, Suderman M, Reese SE, Page CM, Gruzieva O, Rzehak P, Gao L, Bakulski KM, Novoloaca A, Allard C, Pappa I, Llambrich M, Vives M, Jima DD, Kvist T, Baccarelli A, White C, Rezwan FI, Sharp GC, Tindula G, Bergström A, Grote V, Dou JF, Isaevska E, Magnus MC, Corpeleijn E, Perron P, Jaddoe VWV, Nohr EA, Maitre L, Foraster M, Hoyo C, Håberg SE, Lah
Published in: Mutat Res Rev Mutat Res, 2022, ISSN 1383-5742
Publisher: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

Long-term effects of early postnatal stress on Sertoli cells functions.

Author(s): Thumfart, K, Lazzeri, S. Manuella F. and Mansuy, I.M.
Published in: Frontiers in Genetics, 2022, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2022.1024805

An epigenome-wide association study of child appetitive traits and DNA methylation

Author(s): Holly A. Harris, Chloe Friedman, Anne P. Starling, Dana Dabelea, Susan L. Johnson, Bernard F. Fuemmeler, Dereje Jima, Susan K. Murphy, Cathrine Hoyo, Pauline W. Jansen, Janine F. Felix, Rosa H. Mulder
Published in: Appetite, Issue 191, 2023, Page(s) 107086, ISSN 0195-6663
Publisher: Elsevier BV
DOI: 10.1016/j.appet.2023.107086

The Association of Life Stress with Subsequent Brain and Cognitive Reserve in Middle-Aged Women

Author(s): Isabel K. Schuurmans, Sanne J.W. Hoepel, Charlotte A.M. Cecil, Manon H.J. Hillegers, M. Arfan Ikram, Annemarie I. Luik
Published in: Journal of Alzheimer's Disease, Issue 93, 2023, Page(s) 97-106, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-220923

Maternal Psychological Problems During Pregnancy and Child Externalizing Problems: Moderated Mediation Model with Child Self-regulated Compliance and Polygenic Risk Scores for Aggression

Author(s): Mannan Luo, Irene Pappa, Charlotte A. M. Cecil, Philip Jansen, Marinus H. van IJzendoorn, Rianne Kok
Published in: Child Psychiatry & Human Development, 2021, ISSN 0009-398X
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10578-021-01154-1

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Author(s): Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Henning Tiemeier, Graeme Fairchild, Janine F. Felix, Charlotte A.M. Cecil, Esther Walton
Published in: Preventive Medicine, Issue 182, 2024, Page(s) 107926, ISSN 0091-7435
Publisher: Academic Press
DOI: 10.1016/j.ypmed.2024.107926

The association of early life stress with IQ-achievement discrepancy in children: A population-based study

Author(s): Schuurmans IK, Luik AI, de Maat DA, Hillegers MHJ, Ikram MA & Cecil CAM
Published in: Child Development, 2022, ISSN 0009-3920
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13825

Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood

Author(s): Christin S. Kaupper, Sophia M. Blaauwendraad, Charlotte A. M. Cecil, Rosa H. Mulder, Romy Gaillard, Romy Goncalves, Ingo Borggraefe, Berthold Koletzko, Vincent W. V. Jaddoe
Published in: Metabolites, Issue 13, 2023, Page(s) 1140, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo13111140

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Author(s): Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Published in: Clinical Epigenetics, 2022, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-022-01298-4

Plasma neurofilament light chain in association to late‐life depression in the general population

Author(s): Isabel K. Schuurmans, Mohsen Ghanbari, Charlotte A. M. Cecil, M. Arfan Ikram, Annemarie I. Luik
Published in: Psychiatry and Clinical Neurosciences, Issue 78, 2024, Page(s) 97-103, ISSN 1323-1316
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/pcn.13608

Effects of Pre- and Postnatal Early-Life Stress on Internalizing, Adiposity, and Their Comorbidity

Author(s): Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Carmine M. Pariante, Karim Lekadir, Vincent W.V. Jaddoe, Fadila Serdarevic, Henning Tiemeier, Esther Walton, Janine F. Felix, Charlotte A.M. Cecil
Published in: Journal of the American Academy of Child & Adolescent Psychiatry, Issue 63, 2024, Page(s) 255-265, ISSN 0890-8567
Publisher: Elsevier BV
DOI: 10.1016/j.jaac.2023.05.034

Fairness and bias correction in machine learning for depression prediction across four study populations

Author(s): Vien Ngoc Dang, Anna Cascarano, Rosa H. Mulder, Charlotte Cecil, Maria A. Zuluaga, Jerónimo Hernández-González, Karim Lekadir
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-58427-7

Emotion Processing Differences Mediate the Link between Sex and Autistic Traits in Young Adulthood

Author(s): Lucy A. Livingston, Lucy H. Waldren, Esther Walton, Punit Shah
Published in: JCPP Advances, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1002/jcv2.12096

Epigenomics of being bullied: changes in DNA methylation following bullying exposure

Author(s): Rosa H. Mulder, Esther Walton, Alexander Neumann, Lotte C. Houtepen, Janine F. Felix, Marian J. Bakermans-Kranenburg, Matthew Suderman, Henning Tiemeier, Marinus H. van IJzendoorn, Caroline L. Relton, Charlotte A. M. Cecil
Published in: Epigenetics, Issue 15/6-7, 2020, Page(s) 750-764, ISSN 1559-2294
Publisher: Landes Bioscience
DOI: 10.1080/15592294.2020.1719303

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Author(s): Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortés Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Håberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Hüls, Nastassja Koen, Stephanie J. Londo
Published in: Molecular Psychiatry, Issue 28, 2024, Page(s) 5090-5100, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02010-5

Experiences of acquired brain injury survivors participating in online and hybrid performance arts programmes: an ethnographic study

Author(s): Elizabeth Rose Taylor, Carolina Estevao, Lucinda Jarrett, Anthony Woods, Nikki Crane, Daisy Fancourt, Carmine Pariante, Fiona Jones
Published in: Arts & Health, Issue 16, 2024, Page(s) 189-205, ISSN 1753-3015
Publisher: Taylor and Francis Inc.
DOI: 10.1080/17533015.2023.2226697

The Gut Microbiome in Early Life Stress: A Systematic Review

Author(s): Ana Agusti, Femke Lamers, Maria Tamayo, Carlos Benito-Amat, Gara V. Molina-Mendoza, Brenda W. J. H. Penninx, Yolanda Sanz
Published in: Nutrients, Issue 15, 2023, Page(s) 2566, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15112566

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Author(s): Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hiver
Published in: Molecular psychiatry, 2022, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01441-w

Childhood maltreatment and DNA methylation: A systematic review

Author(s): Charlotte A.M. Cecil, Yuning Zhang, Tobias Nolte
Published in: Neuroscience & Biobehavioral Reviews, Issue 112, 2020, Page(s) 392-409, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.02.019

Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children

Author(s): Lorenza Dall’ Aglio, Jolien Rijlaarsdam, Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Rianne Kok, Marian J. Bakermans-Kranenburg, Marinus H. van Ijzendoorn, Henning Tiemeier, Charlotte A.M. Cecil
Published in: Psychological Medicine, 2020, Page(s) 1-11, ISSN 0033-2917
Publisher: Cambridge University Press
DOI: 10.1017/s0033291720004353

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Author(s): Sara Sammallahti, Andrea P. Cortes Hidalgo, Samuli Tuominen, Anni Malmberg, Rosa H. Mulder, Kelly J. Brunst, Silvia Alemany, Nancy S. McBride, Paul Yousefi, Jonathan A. Heiss, Nia McRae, Christian M. Page, Jianping Jin, Giancarlo Pesce, Doretta Caramaschi, Sheryl L. Rifas-Shiman, Nastassja Koen, Charleen D. Adams, Maria C. Magnus, Nour Baïz, Andrew Ratanatharathorn, Darina Czamara, Siri E. Håber
Published in: Molecular Psychiatry, 2020, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-020-00976-0

Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Author(s): Nicole Mariani, Alessandra Borsini, Charlotte A. M. Cecil, Janine F. Felix, Sylvain Sebert, Annamaria Cattaneo, Esther Walton, Yuri Milaneschi, Guy Cochrane, Clara Amid, Jeena Rajan, Juliette Giacobbe, Yolanda Sanz, Ana Agustí, Tania Sorg, Yann Herault, Jouko Miettunen, Priyanka Parmar, Nadia Cattane, Vincent Jaddoe, Jyrki Lötjönen, Carme Buisan, Miguel A. González Ballester, Gemma Piella, Jos
Published in: PLOS ONE, Issue 16/1, 2021, Page(s) e0245475, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0245475

Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits

Author(s): Ellen Verhoef, Andrea G. Allegrini, Philip R. Jansen, Katherine Lange, Carol A. Wang, Angela T. Morgan, Tarunveer S. Ahluwalia, Christos Symeonides, Ole A. Andreassen, Meike Bartels, Dorret Boomsma, Philip S. Dale, Erik Ehli, Dietmar Fernandez-Orth, Mònica Guxens, Christian Hakulinen, Kathleen Mullan Harris, Simon Haworth, Lucía de Hoyos, Vincent Jaddoe, Liisa Keltikangas-Järvinen, Terho Lehtim
Published in: Biological Psychiatry, Issue 95, 2024, Page(s) 859-869, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2023.11.025

Life stress and adiposity in mothers: A 14‐year follow‐up in the general population

Author(s): Sanne J. W. Hoepel, Isabel K. Schuurmans, Charlotte A. M. Cecil, Vincent W. V. Jaddoe, Annemarie I. Luik
Published in: Stress and Health, Issue 40, 2024, ISSN 1532-2998
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/smi.3290

Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development

Author(s): Dylan E. Hughes, Keiko Kunitoki, Safia Elyounssi, Mannan Luo, Oren M. Bazer, Casey E. Hopkinson, Kevin F. Dowling, Alysa E. Doyle, Erin C. Dunn, Hamdi Eryilmaz, Jodi M. Gilman, Daphne J. Holt, Eve M. Valera, Jordan W. Smoller, Charlotte A. M. Cecil, Henning Tiemeier, Phil H. Lee, Joshua L. Roffman
Published in: Nature Neuroscience, Issue 26, 2023, Page(s) 959-969, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-023-01321-8

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Author(s): Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen, Maarit Niinimäki, Saranya Palaniswamy, Sylvain Sebert, Marja Ojaniemi
Published in: European Journal of Nutrition, 2021, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

Keeping It in the Family: Consanguinity Reveals <i>P4HTM</i> as a Novel Syndromic Obesity Gene

Author(s): Janine F. Felix, Struan F.A. Grant
Published in: Diabetes, Issue 72, 2023, Page(s) 1184-1186, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi23-0010

Associations between T cells and attention problems in the general pediatric population: the Generation R Study.

Author(s): Looman KIM, Cecil CAM, Grosserichter-Wagener C, Kiefte de Jong JC, van Zelm MC & Moll HA
Published in: JCPP Advances, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1002/jcv2.12038

Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

Author(s): Walton, E., Bernardoni, F., Batury, V. L., Bahnsen, K., Larivière, S., Abbate-Daga, G., ... & Ehrlich, S. (2022).
Published in: Biological Psychiatry, 2022, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2022.04.022

Associations of Arterial Thickness, Stiffness, and Blood Pressure With Brain Morphology in Early Adolescence: A Prospective Population-Based Study

Author(s): Serena Defina, Carolina C.V. Silva, Charlotte A.M. Cecil, Henning Tiemeier, Janine F. Felix, Ryan L. Mutzel, Vincent W.V. Jaddoe
Published in: Hypertension, Issue 81, 2024, Page(s) 162-171, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.21672

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Author(s): Cecil C, Neumann A, Walton E
Published in: JCPP Advances, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1002/jcv2.12133

Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation

Author(s): Koen Bolhuis, Lisa R. Steenkamp, Laura M. E. Blanken, Alexander Neumann, Philip R. Jansen, Manon H. J. Hillegers, Charlotte A. M. Cecil, Henning Tiemeier, Steven A. Kushner
Published in: European Child & Adolescent Psychiatry, 2021, ISSN 1018-8827
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-021-01727-4

What are Sertoli cells? Historical, methodological, and functional aspects

Author(s): Kristina M. Thumfart, Isabelle M. Mansuy
Published in: Andrology, Issue 11, 2023, Page(s) 849-859, ISSN 2047-2919
Publisher: Wiley Periodicals LLC
DOI: 10.1111/andr.13386

Metabolic syndrome after childhood trauma: a 9-year longitudinal analysis

Author(s): Camille Souama, Yuri Milaneschi, Femke Lamers, Christiaan H. Vinkers, Erik J. Giltay, Edith J. Liemburg, Brenda W. J. H. Penninx
Published in: Psychological Medicine, Issue 54, 2024, Page(s) 1373-1381, ISSN 0033-2917
Publisher: Cambridge University Press
DOI: 10.1017/s0033291723003264

Genome-wide DNA methylation patterns associated with general psychopathology in children

Author(s): Jolien Rijlaarsdam, Edward D. Barker, Chiara Caserini, M. Elisabeth Koopman-Verhoeff, Rosa H. Mulder, Janine F. Felix, Charlotte A.M. Cecil
Published in: Journal of Psychiatric Research, Issue 140, 2021, Page(s) 214-220, ISSN 0022-3956
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.jpsychires.2021.05.029

Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential

Author(s): Cecil CAM & Nigg JT
Published in: Molecular Diagnosis & Therapy, 2022, ISSN 1177-1062
Publisher: Adis International Ltd.
DOI: 10.1007/s40291-022-00609-y

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity

Author(s): Vilte Baltramonaityte, Jean-Baptiste Pingault, Charlotte A. M. Cecil, Priyanka Choudhary, Marjo-Riitta Järvelin, Brenda W. J. H. Penninx, Janine Felix, Sylvain Sebert, Yuri Milaneschi, Esther Walton, null null
Published in: PLOS Genetics, Issue 19, 2023, Page(s) e1010508, ISSN 1553-7404
Publisher: PLOS Genetics
DOI: 10.1371/journal.pgen.1010508

Single-cell multiomics techniques: from conception to applications.

Author(s): Dimitriu, M, Lazar-Contes, I., Roszkowski, M. and Mansuy, I.M.
Published in: Front. Cell. Dev. Biol., 2022, ISSN 2296-634X
Publisher: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2022.854317

Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

Author(s): Irina Lazar-Contes, Deepak K. Tanwar, Rodrigo G. Arzate-Mejia, Leonard C. Steg, Olivier Ulrich Feudjio, Marion Crespo, Pierre-Luc Germain, Isabelle M. Mansuy
Published in: Genetics and Genomics, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.91528.1

Association of Maternal Tobacco Use During Pregnancy With Preadolescent Brain Morphology Among Offspring

Author(s): Zou R, Boer OD, Felix JF, Muetzel R, Franken IHA, Cecil CAM & El Marroun H .
Published in: JAMA Network Open., 2022, ISSN 2574-3805
Publisher: JAMA network open
DOI: 10.1001/jamanetworkopen.2022.24701

The European Nucleotide Archive in 2020

Author(s): Peter W Harrison, Alisha Ahamed, Raheela Aslam, Blaise T F Alako, Josephine Burgin, Nicola Buso, Mélanie Courtot, Jun Fan, Dipayan Gupta, Muhammad Haseeb, Sam Holt, Talal Ibrahim, Eugene Ivanov, Suran Jayathilaka, Vishnukumar Balavenkataraman Kadhirvelu, Manish Kumar, Rodrigo Lopez, Simon Kay, Rasko Leinonen, Xin Liu, Colman O’Cathail, Amir Pakseresht, Youngmi Park, Stephane Pesant, Nadim Rahm
Published in: Nucleic Acids Research, Issue 49/D1, 2020, Page(s) D82-D85, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa1028

Developmental origins of psycho-cardiometabolic multimorbidity in adolescence and their underlying pathways through methylation markers: a two-cohort study

Author(s): Priyanka Choudhary, Justiina Ronkainen, Jennie Carson, Ville Karhunen, Ashleigh Lin, Phillip E. Melton, Marjo-Riitta Jarvelin, Jouko Miettunen, Rae-Chi Huang, Sylvain Sebert
Published in: European Child & Adolescent Psychiatry, 2024, ISSN 1018-8827
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-024-02390-1

Complete Genome Sequence of Phascolarctobacterium faecium G 104, Isolated from the Stools of a Healthy Lean Donor

Author(s): Sadjia Rachek, Naghmeh Nikpoor, Eva M. Gómez del Pulgar, Aitor Gonzaga, Yolanda Sanz, Thomas A. Tompkins
Published in: Microbiology Resource Announcements, Issue 10/4, 2021, ISSN 2576-098X
Publisher: ASM Journals (American Society for Microbiology)
DOI: 10.1128/mra.01054-20

Family Aggression Screening Tool (FAST): factor structure and psychometric properties of subscales.

Author(s): Vieira R, Pires PP, Cecil CAM, Barker E, Reis D, Couto I, Cypriano C & de Oliveira IR.
Published in: Child Abuse & Neglect, 2022, ISSN 0145-2134
Publisher: Elsevier BV
DOI: 10.1016/j.chiabu.2022.105548

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study.

Author(s): Bolhuis K*, Mulder RH*, de Mol CL, Defina S, Warrier V, White T, Tiemeier H, Muetzel RL & Cecil CAM†
Published in: JCPP Advances, 2022, ISSN 0021-9630
Publisher: Blackwell Publishing Inc.
DOI: 10.1002/jcv2.12113

Remembering through the genome: the role of chromatin states in brain functions and diseases

Author(s): Rodrigo G. Arzate-Mejia, Isabelle M. Mansuy
Published in: Translational Psychiatry, Issue 13, 2023, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-023-02415-4

<scp>DNA</scp> methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study

Author(s): Mannan Luo, Esther Walton, Alexander Neumann, Chris H. L. Thio, Janine F. Felix, Marinus H. van IJzendoorn, Irene Pappa, Charlotte A. M. Cecil
Published in: Journal of Child Psychology and Psychiatry, Issue 65, 2023, Page(s) 77-90, ISSN 0021-9630
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13866

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach

Author(s): Zhu, Y., Lussier, A. A., Smith, A. D., Simpkin, A. J., Suderman, M. J., Walton, E., ... & Dunn, E. C. (2022). Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach. Psychoneuroendocrinology, 144, 105854.
Published in: Psychoneuroendocrinology, 2022, ISSN 0306-4530
Publisher: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105854

Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals

Author(s): McWhinney, S.R., Brosch, K., Calhoun, V.D. et al.
Published in: Molecular Psychiatry, 2022, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01616-5

Child mental health problems as a risk factor for academic underachievement: a multi-informant, population-based study.

Author(s): Schuurmans IK, Tamayo Martinez N, Blok E, Hillegers MHJ, Ikram MA, Luik AI & Cecil CAM
Published in: Acta Psychiatrica Scandinavica, 2022, ISSN 0001-690X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acps.13426

On Navigating Analytical Choices in Research on Early Life Adversity: A Commentary on Sisitsky et al. (2023)

Author(s): Charlotte A. M. Cecil, Isabel K. Schuurmans
Published in: Research on Child and Adolescent Psychopathology, Issue 51, 2023, Page(s) 1805-1808, ISSN 2730-7166
Publisher: Springer
DOI: 10.1007/s10802-023-01103-7

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Author(s): Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Published in: Human Molecular Genetics, Issue 30/1, 2021, Page(s) 119-134, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddaa280

The gut microbiome and child mental health: a population-based study.

Author(s): Kraaij R, Schuurmans IK, Radjabzadeh D, Tiemeier H, Dinan TG, Uitterlinden AG, Hillegers M, Jaddoe VWV, Duijts L, Moll H, Rivadeneira F, Medina-Gomez C, Jansen PW, Cecil CAM†
Published in: Brain, Behavior and Immunity, 2023, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2022.12.006

Neonatal DNA methylation and childhood low prosocial behavior: An epigenome‐wide association meta‐analysis

Author(s): Mannan Luo, Alan J. Meehan, Esther Walton, Stefan Röder, Gunda Herberth, Ana C. Zenclussen, Marta Cosín‐Tomás, Jordi Sunyer, Rosa H. Mulder, Andrea P. Cortes Hidalgo, Marian J. Bakermans‐Kranenburg, Janine F. Felix, Caroline Relton, Matthew Suderman, Irene Pappa, Rianne Kok, Henning Tiemeier, Marinus H. IJzendoorn, Edward D. Barker, Charlotte A. M. Cecil
Published in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Issue 186/4, 2021, Page(s) 228-241, ISSN 1552-4841
Publisher: Wiley-Liss Inc
DOI: 10.1002/ajmg.b.32862

Long-Term Impact of Social Isolation and Molecular Underpinnings

Author(s): Rodrigo G. Arzate-Mejía, Zuzanna Lottenbach, Vincent Schindler, Ali Jawaid, Isabelle M. Mansuy
Published in: Frontiers in Genetics, Issue 11, 2020, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2020.589621

Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants

Author(s): Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke, Charlotte A. M. Cecil, Janine F. Felix, Hans J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton, Brenda W. J. H. Pen
Published in: BMC Medicine, Issue 21, 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-02769-y

Effectiveness of psychological and/or educational interventions in reducing anxiety and depression in people with type 2 diabetes: A systematic review and meta-analysis

Author(s): Kristina M.Thumfarta, Ali Jawaidab, Kristina Bright, Marc Flachsmann, Isabelle M.Mansuy
Published in: Diabetes Research and Clinical Practice, 2021, ISSN 0168-8227
Publisher: Elsevier BV
DOI: 10.1016/j.diabres.2021.108922

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Author(s): Rosa H. Mulder, Robert Kraaij, Isabel K. Schuurmans, Carlos Frances-Cuesta, Yolanda Sanz, Carolina Medina-Gomez, Liesbeth Duijts, Fernando Rivadeneira, Henning Tiemeier, Vincent W.V. Jaddoe, Janine F. Felix, Charlotte A.M. Cecil
Published in: Brain, Behavior, and Immunity, Issue 118, 2024, Page(s) 117-127, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2024.02.024

EXPLORE: a novel deep learning-based analysis method for exploration behaviour in object recognition tests

Author(s): Victor Ibañez, Laurens Bohlen, Francesca Manuella, Isabelle Mansuy, Fritjof Helmchen, Anna-Sophia Wahl
Published in: Scientific Reports, Issue 13, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-31094-w

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Author(s): Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Published in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Gene–environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach

Author(s): Varun Warrier, Alex S F Kwong, Mannan Luo, Shareefa Dalvie, Jazz Croft, Hannah M Sallis, Jessie Baldwin, Marcus R Munafò, Caroline M Nievergelt, Andrew J Grant, Stephen Burgess, Tyler M Moore, Ran Barzilay, Andrew McIntosh, Marinus H van IJzendoorn, Charlotte A M Cecil
Published in: The Lancet Psychiatry, Issue 8/5, 2021, Page(s) 373-386, ISSN 2215-0366
Publisher: Elsevier Limited
DOI: 10.1016/s2215-0366(20)30569-1

A systematic review of neuroimaging epigenetic research: calling for an increased focus on development

Author(s): Esther Walton, Vilte Baltramonaityte, Vince Calhoun, Bastiaan T. Heijmans, Paul M. Thompson, Charlotte A. M. Cecil
Published in: Molecular Psychiatry, Issue 28, 2023, Page(s) 2839-2847, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02067-2

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Author(s): Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G. F. de Kovel, Gary Donohoe, Lisa T. Eyler, Stephen V. Faraone, Pauline Favre, Courtney A. Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J. Gra
Published in: Translational Psychiatry, Issue 10/1, 2020, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-020-0705-1

Wir können unsere Gene steuern!

Author(s): Mansuy, I.M., Gurret, J.M. Lelief, A.
Published in: 2020
Publisher: Berlin Verlag

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