Bacteria-mucin interactions – Shaping intestinal epithelial responses in health and disease

Informazioni relative al progetto

Bac2MUC

ID dell’accordo di sovvenzione: 852452

DOI

10.3030/852452

Progetto chiuso

Data della firma CE 29 Novembre 2019

Data di avvio 1 Marzo 2020

Data di completamento 28 Febbraio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 500 000,00

Contributo UE

€ 1 500 000,00

Coordinato da

UNIVERSITEIT UTRECHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (11)

Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface

Autori: Maitrayee Chatterjee, Liane Z.X. Huang, Anna Z. Mykytyn, Chunyan Wang, Mart M. Lamers, Bart Westendorp, Richard W. Wubbolts, Jos P.M. van Putten, Berend-Jan Bosch, Bart L. Haagmans, Karin Strijbis
Pubblicato in: PLOS Pathogens, Numero Monthly, 2024, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1101/2021.10.29.466408

Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2

Autori: Maitrayee Chatterjee, Jos P M van Putten, Karin Strijbis
Pubblicato in: mBio, Numero 21507511, 2020, ISSN 2150-7511
Editore: mBio
DOI: 10.1128/mbio.02374-20

Development of a Caco-2-based intestinal mucosal model to study intestinal barrier properties and bacteria–mucus interactions

Autori: Evelien Floor, Jinyi Su, Maitrayee Chatterjee, Elise S. Kuipers, Noortje IJssennagger, Faranak Heidari, Laura Giordano, Richard W. Wubbolts, Silvia M. Mihăilă, Daphne A. C. Stapels, Yvonne Vercoulen, Karin Strijbis
Pubblicato in: Gut Microbes, Numero 17, 2024, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2024.2434685

The Transmembrane Mucin MUC1 Facilitates β1-Integrin-Mediated Bacterial Invasion

Autori: Xinyue Li, Richard W Wubbolts, Nancy M C Bleumink-Pluym, Jos P M van Putten, Karin Strijbis
Pubblicato in: mBio, Numero Every two months, 2021, ISSN 2150-7511
Editore: mBio
DOI: 10.1128/mbio.03491-20

Bacteroides fragilis fucosidases facilitate growth and invasion of Campylobacter jejuni in the presence of mucins

Autori: Yvette M.C.A. Luijkx, Nancy M.C. Bleumink, Jianbing Jiang, Herman S. Overkleeft, Marc M.S.M. Wösten, Karin Strijbis, Tom Wennekes
Pubblicato in: Cellular Microbiology, Numero 22/12, 2020, ISSN 1462-5814
Editore: Blackwell Publishing Inc.
DOI: 10.1111/cmi.13252

O-Glycomic and Proteomic Signatures of Spontaneous and Butyrate-Stimulated Colorectal Cancer Cell Line Differentiation

Autori: K. Madunić, Y.M.C.A. Luijkx, O.A. Mayboroda, G.M.C. Janssen, P.A. van Veelen, K. Strijbis, T. Wennekes, G.S.M. Lageveen-Kammeijer, M. Wuhrer
Pubblicato in: Molecular & Cellular Proteomics, Numero 22, 2024, Pagina/e 100501, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100501

Detection of Bacterial α-l-Fucosidases with an Ortho-Quinone Methide-Based Probe and Mapping of the Probe-Protein Adducts.

Autori: Luijkx, Yvette M C A; Henselijn, Anniek J; Bosman, Gerlof P; Cramer, Dario A T; Giesbers, Koen C A P; van 't Veld, Esther M; Boons, Geert-Jan; Heck, Albert J R; Reiding, Karli R; Strijbis, Karin; Wennekes, Tom; Afd Chemical Biology and Drug Discovery; Afd Biomol.Mass Spect. and Proteomics; Infectiebiologie; Sub Chemical Biology and Drug Discovery; Sub Biomol.Mass Spectrometry & Proteom.; dI&I I&I-
Pubblicato in: Molecules (Basel, Switzerland), Numero 1, 2022, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051615

Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function

Autori: Celia Segui-Perez, Liane Z. X. Huang, Fernanda L. Paganelli, Elke Lievens, Karin Strijbis
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-92125-2

Development of a 1,2-difluorofucoside activity-based probe for profiling GH29 fucosidases.

Autori: Luijkx, Yvette M C A; Jongkees, Seino; Strijbis, Karin; Wennekes, Tom; Afd Chemical Biology and Drug Discovery; Infectiebiologie; dI&I I&I-2
Pubblicato in: Organic & Biomolecular Chemistry, Numero 14770520, 2022, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/d1ob00054c

MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via protein kinase C

Autori: Celia Segui-Perez, Daphne A. C. Stapels, Ziliang Ma, Jinyi Su, Elsemieke Passchier, Bart Westendorp, Richard W. Wubbolts, Wei Wu, Jos P. M. van Putten, Karin Strijbis
Pubblicato in: Journal of Cell Science, Numero 137, 2024, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.261468

Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing

Autori: Weiwei Peng, Koen CAP Giesbers, Marta Šiborová, J Wouter Beugelink, Matti F Pronker, Douwe Schulte, John Hilkens, Bert JC Janssen, Karin Strijbis, Joost Snijder
Pubblicato in: Life Science Alliance, Numero 7, 2024, Pagina/e e202302366, ISSN 2575-1077
Editore: Life Science Alliance, LLC
DOI: 10.26508/lsa.202302366