Bacteria-mucin interactions – Shaping intestinal epithelial responses in health and disease

Project Information

Bac2MUC

Grant agreement ID: 852452

DOI

10.3030/852452

Project closed

EC signature date 29 November 2019

Start date 1 March 2020

End date 28 February 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

UNIVERSITEIT UTRECHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface

Author(s): Maitrayee Chatterjee, Liane Z.X. Huang, Anna Z. Mykytyn, Chunyan Wang, Mart M. Lamers, Bart Westendorp, Richard W. Wubbolts, Jos P.M. van Putten, Berend-Jan Bosch, Bart L. Haagmans, Karin Strijbis
Published in: PLOS Pathogens, Issue Monthly, 2024, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1101/2021.10.29.466408

Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2

Author(s): Maitrayee Chatterjee, Jos P M van Putten, Karin Strijbis
Published in: mBio, Issue 21507511, 2020, ISSN 2150-7511
Publisher: mBio
DOI: 10.1128/mbio.02374-20

Development of a Caco-2-based intestinal mucosal model to study intestinal barrier properties and bacteria–mucus interactions

Author(s): Evelien Floor, Jinyi Su, Maitrayee Chatterjee, Elise S. Kuipers, Noortje IJssennagger, Faranak Heidari, Laura Giordano, Richard W. Wubbolts, Silvia M. Mihăilă, Daphne A. C. Stapels, Yvonne Vercoulen, Karin Strijbis
Published in: Gut Microbes, Issue 17, 2024, ISSN 1949-0976
Publisher: Landes Bioscience
DOI: 10.1080/19490976.2024.2434685

The Transmembrane Mucin MUC1 Facilitates β1-Integrin-Mediated Bacterial Invasion

Author(s): Xinyue Li, Richard W Wubbolts, Nancy M C Bleumink-Pluym, Jos P M van Putten, Karin Strijbis
Published in: mBio, Issue 21507511, 2021, ISSN 2150-7511
Publisher: mBio
DOI: 10.1128/mbio.03491-20

Bacteroides fragilis fucosidases facilitate growth and invasion of Campylobacter jejuni in the presence of mucins

Author(s): Yvette M.C.A. Luijkx, Nancy M.C. Bleumink, Jianbing Jiang, Herman S. Overkleeft, Marc M.S.M. Wösten, Karin Strijbis, Tom Wennekes
Published in: Cellular Microbiology, Issue 22/12, 2020, ISSN 1462-5814
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cmi.13252

O-Glycomic and Proteomic Signatures of Spontaneous and Butyrate-Stimulated Colorectal Cancer Cell Line Differentiation

Author(s): K. Madunić, Y.M.C.A. Luijkx, O.A. Mayboroda, G.M.C. Janssen, P.A. van Veelen, K. Strijbis, T. Wennekes, G.S.M. Lageveen-Kammeijer, M. Wuhrer
Published in: Molecular & Cellular Proteomics, Issue 22, 2024, Page(s) 100501, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100501

Detection of Bacterial α-l-Fucosidases with an Ortho-Quinone Methide-Based Probe and Mapping of the Probe-Protein Adducts.

Author(s): Luijkx, Yvette M C A; Henselijn, Anniek J; Bosman, Gerlof P; Cramer, Dario A T; Giesbers, Koen C A P; van 't Veld, Esther M; Boons, Geert-Jan; Heck, Albert J R; Reiding, Karli R; Strijbis, Karin; Wennekes, Tom; Afd Chemical Biology and Drug Discovery; Afd Biomol.Mass Spect. and Proteomics; Infectiebiologie; Sub Chemical Biology and Drug Discovery; Sub Biomol.Mass Spectrometry & Proteom.; dI&I I&I-
Published in: Molecules (Basel, Switzerland), Issue 14203049, 2022, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051615

Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function

Author(s): Celia Segui-Perez, Liane Z. X. Huang, Fernanda L. Paganelli, Elke Lievens, Karin Strijbis
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-92125-2

Development of a 1,2-difluorofucoside activity-based probe for profiling GH29 fucosidases.

Author(s): Luijkx, Yvette M C A; Jongkees, Seino; Strijbis, Karin; Wennekes, Tom; Afd Chemical Biology and Drug Discovery; Infectiebiologie; dI&I I&I-2
Published in: Organic & Biomolecular Chemistry, Issue 14770520, 2022, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ob00054c

MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via protein kinase C

Author(s): Celia Segui-Perez, Daphne A. C. Stapels, Ziliang Ma, Jinyi Su, Elsemieke Passchier, Bart Westendorp, Richard W. Wubbolts, Wei Wu, Jos P. M. van Putten, Karin Strijbis
Published in: Journal of Cell Science, Issue 137, 2024, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.261468

Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing

Author(s): Weiwei Peng, Koen CAP Giesbers, Marta Šiborová, J Wouter Beugelink, Matti F Pronker, Douwe Schulte, John Hilkens, Bert JC Janssen, Karin Strijbis, Joost Snijder
Published in: Life Science Alliance, Issue 7, 2024, Page(s) e202302366, ISSN 2575-1077
Publisher: Life Science Alliance, LLC
DOI: 10.26508/lsa.202302366