INnovative Training in Myeloid Regulatory Cell Therapy

Informazioni relative al progetto

INsTRuCT

ID dell’accordo di sovvenzione: 860003

DOI

10.3030/860003

Progetto chiuso

Data della firma CE 19 Agosto 2019

Data di avvio 1 Gennaio 2020

Data di completamento 30 Giugno 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 004 719,36

Contributo UE

€ 4 004 719,36

Coordinato da

KLINIKUM DER UNIVERSITAET REGENSBURG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (4)

Training schools proceedings: Proceedings of the three events

Proceedings of the three training schools at months 10 20 32 First submission month 10 additional due dates 20 32

Call for ESR applications

Call publication for the ESR on selected websites and through personal contacts

Recruitment of ESR

Recruitment of ESR Recruitment of the selected ESR with full employment contracts

Plan for using and disseminating knowledge

Yearly updated plan for using and disseminating knowledge First submission month 12 additional due dates 24 36 and 48

Documents, reports (6)

Submission and Defense of PhD theses

PhD theses submission

Local Training reports

Local Training Annual reports on local training of all ESR will be submitted at months 18 30 and 42 First submission month 18 additional due dates 30 42

Reports on public engagement activities

Reports on public engagement activities submitted at months 18 30 and 42 First submission month 18 additional due dates 30 42

Training School reports

Training Schools Reports on the organisation of training Schools will be submitted at months 10 20 and 32 First submission month 10 additional due dates 20 32

Reproducible Science Policy
Practical Courses

Practical Courses: Reports on the organisation of Workshops/Practical Courses will be submitted at months 14, 26 and 38. (First submission month 14 additional due dates 26, 38)

Websites, patent fillings, videos etc. (1)

Creation of Consortium Website

Website the website public page will be developed to disseminate project results

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan DMP

Pubblicazioni

Peer reviewed articles (25)

Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

Autori: Niels JM Verstegen,Ruth R Hagen,Jet van den Dijssel,Lisan H Kuijper,Christine Kreher,Thomas Ashhurst,Laura YL Kummer,Maurice Steenhuis,Mariel Duurland,Rivka de Jongh,Nina de Jong,C Ellen van der Schoot,Amélie V Bos,Erik Mul,Katherine Kedzierska,Koos PJ van Dam,Eileen W Stalman,Laura Boekel,Gertjan Wolbink,Sander W Tas,Joep Killestein,Zoé LE van Kempen,Luuk Wieske,Taco W Kuijpers,Filip Eftimov\,T
Pubblicato in: eLife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.77969

Regulatory Cell Therapy in Organ Transplantation: Achievements and Open Questions

Autori: Marta Fortunato, Konstantina Morali, Laura Passeri and Silvia Gregori
Pubblicato in: Frontiers in Immunonology, Numero 641596, 2021, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.641596

The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils

Autori: Escher Toller-Kawahisa J, […] Zotta A, […]
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-40021-6

4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages

Autori: Ciana Diskin, Alessia Zotta, Sarah E Corcoran, Victoria J Tyrrell, Zbigniew Zaslona, Valerie B O'Donnell, Luke A J O'Neill
Pubblicato in: J. Immunol, 2021, Pagina/e 2561-2569, ISSN 1550-6606
Editore: NCBI
DOI: 10.4049/jimmunol.2100488

Regulatory Macrophages and Tolerogenic Dendritic Cells in Myeloid Regulatory Cell-Based Therapies

Autori: Maaike Suuring and Aurélie Moreau
Pubblicato in: International journal of molecular science, Numero 22:7970, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22157970

CombiVacS study Group. Immunogenic dynamics and SARS-CoV-2 variant neutralisation of the heterologous ChAdOx1-S/BNT162b2 vaccination: Secondary analysis of the randomised CombiVacS study.

Autori: García-Pérez J1, Gonzalez-Perez M1, Castillo de la Osa M, Borobia AM, Castaño L, Bertrán MJ, Campins M, Portolés A, Lora D, Bermejo M, Conde P, Hernández-Gutierrez L, Carcas A, Arana-Arri E, Tortajada M, Fuentes I, Ascaso A, García-Morales MT, Erick de la Torre-Tarazona H, Arrib
Pubblicato in: EclinicalMedicine, 2022, ISSN 2589-5370
Editore: The Lancet
DOI: 10.1016/j.eclinm.2022.101529

Transfection of Vitamin D3-Induced Tolerogenic Dendritic Cells for the Silencing of Potential Tolerogenic Genes. Identification of CSF1R-CSF1 Signaling as a Glycolytic Regulator

Autori: María José Mansilla, Iñigo González-Larreategui, Neus Figa-Martín, Jaume Barallat, Federico Fondelli, Ares Sellés-Rius, Bibiana Quirant-Sánchez, Aina Teniente-Serra, Eva Martínez-Cáceres
Pubblicato in: International Journal of Molecular Sciences, Numero 22:7363, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22147363

The BCG Vaccine for COVID-19: First Verdict and Future Directions

Autori: Gonzalez-Perez M., Tarjuelo-Sanchez R., Shor Boris, Nistal-Villan E, Ochando J.
Pubblicato in: Frontiers in Immunology, Numero 632478, 2021, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2021.632478

Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals

Autori: Daniel Lozano-Ojalvo, Carmen Camara, Eduardo Lopez-Granados, Pilar Nozal, Lucıa del Pino-Molina, Luz Yadira Bravo-Gallego, Estela Paz-Artal, Marjorie Pion, Rafael Correa-Rocha, Alberto Ortiz, Marcos Lopez-Hoyos, Marta Erro Iribarren, Jose Portoles, Maria Pilar Rojo-Portoles, Gloria Ojeda, Isabel Cervera, Maria Gonzalez-Perez, Irene Bodega-Mayor, Maria Montes-Casado, Pilar Portoles, Mayte Perez-Ol
Pubblicato in: Cell Reports, Numero 109570, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109570

Combined Therapy of Vitamin D3-Tolerogenic Dendritic Cells and Interferon-β in a Preclinical Model of Multiple Sclerosis

Autori: Bibiana Quirant-Sánchez,María José Mansilla, Juan Navarro-Barriuso, Silvia Presas-Rodríguez, Aina Teniente-Serra, Federico Fondelli, Cristina Ramo-Tello, Eva Martínez-Cáceres
Pubblicato in: Biomedicines, Numero 12:1758, 2021, ISSN 2227-9059
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/biomedicines9121758

Fluorine labelling of therapeutic human tolerogenic dendritic cells for 19F-magnetic resonance imaging

Autori: Cooke Fiona, Neal Mary, Wood Matthew J., de Vries I. Jolanda M., Anderson Amy E., Diboll Julie, Pratt Arthur G., Stanway James, Nicorescu Ioana, Moyse Nicholas, Hiles Dawn, Caulfield David, Dickinson Anne M., Blamire Andrew M., Thelwall Pete, Isaacs John D., Hilkens Catharien M. U.
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media

Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy

Autori: M. J. Mansilla, S. Presas-Rodríguez, A. Teniente-Serra, I. González-Larreategui, B. Quirant-Sánchez, F. Fondelli, N. Djedovic, D. Iwaszkiewicz-Grześ, K. Chwojnicki, Đ. Miljković, P. Trzonkowski, C. Ramo-Tello & E. M. Martínez-Cáceres
Pubblicato in: Cellular & Molecular Immunology, 2021, Pagina/e 1353–1374, ISSN 1672-7681
Editore: Nature Publishing Group
DOI: 10.1038/s41423-020-00618-z

Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

Autori: Alberto M Borobia, Antonio J Carcas, Mayte Pérez-Olmeda, Luis Castaño, María Jesús Bertran, Javier García-Pérez, Magdalena Campins, Antonio Portolés, María González-Pérez, María Teresa García Morales, Eunate Arana-Arri, Marta Aldea, Francisco Díez-Fuertes, Inmaculada Fuentes, Ana Ascaso, David Lora, Natale Imaz-Ayo, Lourdes E Barón-Mira, Antonia Agustí, Carla Pérez-Ingidua, Agustí
Pubblicato in: The Lancet, 2021, Pagina/e 121-130, ISSN 0140-6736
Editore: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(21)01420-3

Dimethyl Fumarate and 4-Octyl itaconate are anticoagulants that suppress tissue factor in macrophages via inhibition of type I interferon

Autori: Tristram A. J. Ryan, […] Zotta A, […]
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-39174-1

Development of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients After 1273-mRNA SARS-CoV-2 Vaccination.

Autori: Gonzalez-Perez M, Montes-Casado M, Conde P, Cervera I, Baranda J, Berges-Buxeda MJ, Perez-Olmeda M, Sanchez-Tarjuelo R, Utrero-Rico A, Lozano-Ojalvo D, Torre D, Schwarz M, Guccione E, Camara C, Llópez-Carratalá MR, Gonzalez-Parra E, Portoles P, Ortiz A, Portoles J, Ochando J.
Pubblicato in: Frontiers of Immunology, 2022, ISSN 1664-3224
Editore: x
DOI: 10.3389/fimmu.2022.845882

External validation of biomarkers for immune-related adverse events after immune checkpoint inhibition

Autori: Gunther Glehr, Paloma Riquelme, Jordi Yang Zhou, Laura Cordero, Hannah-Lou Schilling, Michael Kapinsky, Hans J. Schlitt, Edward K. Geissler, Ralph Burkhardt, Barbara Schmidt, Sebastian Haferkamp, James A. Hutchinson, and  Katharina Kronenberg
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.1011040

Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR

Autori: Megan Schwarz, Denis Torre, Daniel Lozano-Ojalvo, Anthony T. Tan, Tommaso Tabaglio, Slim Mzoughi, Rodrigo Sanchez-Tarjuelo, Nina Le Bert, Joey Ming Er Lim, Sandra Hatem, Kevin Tuballes, Carmen Camara, Eduardo Lopez-Granados, Estela
Pubblicato in: Nature Biotechnology, 2022, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-022-01347-6

Is Citrate A Critical Signal in Immunity and Inflammation?

Autori: lessia Zotta*, Zbigniew Zaslona, Luke A. O’Neill*
Pubblicato in: Journal of Cellular Signaling, Numero Volume 1, Numero 3, 2020, Pagina/e 87-96, ISSN 2692-0638
Editore: Scientific Archives
DOI: 10.33696/signaling.1.017

CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity

Autori: Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G. Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H. O. Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V. L. Oates, Linden. J. Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutze
Pubblicato in: Nature Immunology, 2023, ISSN 1529-2916
Editore: Springer
DOI: 10.1038/s41590-023-01517-x

Tolerogenic dendritic cell reporting: Has a minimum information model made a difference?

Autori: Ayesha Sahar1, Ioana Nicorescu2, Gabrielle Barran2, Megan Paterson2, Catharien M.U. Hilkens​2, Phillip Lord​1
Pubblicato in: Peerj, 2023, ISSN 2167-8359
Editore: PeerJ

Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis

Autori: James A. Hutchinson, Katharina Kronenberg, Paloma Riquelme, Jürgen J. Wenzel, Gunther Glehr, Hannah-Lou Schilling, Florian Zeman, Katja Evert, Martin Schmiedel, Marion Mickler, Konstantin Drexler, Florian Bitterer, Laura Cordero, Lukas Beyer, Christian Bach, Josef Koestler, Ralph Burkhardt, Hans J. Schlitt, Dirk Hellwig, Jens M. Werner, Rainer Spang, Barbara Schmidt, Edward K. Geissler & Sebastia
Pubblicato in: Nature Communications, Numero 1439, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21572-y

Development of a Flow Cytometry Assay to Predict Immune Checkpoint Blockade-Related Complications

Autori: Hannah-Lou Schilling, Gunther Glehr, Michael Kapinsky, Norbert Ahrens, Paloma Riquelme, Laura Cordero, Florian Bitterer, Hans J. Schlitt, Edward K. Geissler, Sebastian Haferkamp, James A. Hutchinson, Katharina Kronenberg
Pubblicato in: Frontiers in Immunology, Numero 765644, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.765644

OPTIMAL: An OPTimised Imaging Mass cytometry AnaLysis framework for benchmarking segmentation and data exploration

Autori: Bethany Hunter, Ioana Nicorescu, Emma Foster, David McDonald, Gillian Hulme, Andrew Fuller, Amanda Thomson, Thibaut Goldsborough, Catharien M.U. Hilkens, Joaquim Majo, Luke Milross, Andrew Fisher, Peter Bankhead, John Wills, Paul Rees, Andrew Filby, George Merces
Pubblicato in: Cytometry:Part A, 2023, ISSN 1552-4930
Editore: wiley
DOI: 10.1002/cyto.a.24803

Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination

Autori: Gonzalez-Perez M, Baranda J, Berges-Buxeda MJ, Conde P, Pérez-Olmeda M, Lozano-Ojalvo D, Cámara C, Del Rosario Llópez-Carratalá M, Gonzalez-Parra E, Portolés P, Ortiz A, Portoles J, Ochando J.
Pubblicato in: MPDI, 2023, ISSN 1996-1944
Editore: MDPI Open Access Publishing
DOI: 10.3390/ph16040574

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Autori: Philipp Georg, Rosario Astaburuaga-Garcıa, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J. Lippert, Tomislav Kostevc, Christiane Gabel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemund Matthias Barone, Pinkus Tober-Lau, Elisa T. Helbig, David Hillus, Lev Petrov, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Christina Iwert, Michael Mulleder, Simran Kaur Aulakh, Sonja
Pubblicato in: Cell, 2021, Pagina/e 493-512.E25, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2021.12.040

Monographic books (1)

Inflammasome Biology

Autori: Hooftman A., Zotta A., O'Neill L.A.J.
Pubblicato in: Inflammasome Biology, 2022, ISBN 978-0-323-91802-2
Editore: Elsevier
DOI: 10.1016/c2021-0-01161-5