Mechanical Biomarkers for Prediction of Cancer Immunotherapy

Project Information

Immuno-Predictor

Grant agreement ID: 863955

DOI

10.3030/863955

Project closed

EC signature date 16 March 2020

Start date 1 April 2020

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITY OF CYPRUS
Cyprus

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (30)

The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

Author(s): Christiana M. Neophytou, Myrofora Panagi, Triantafyllos Stylianopoulos, Panagiotis Papageorgis
Published in: Cancers, Issue 13/9, 2021, Page(s) 2053, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092053

Dynamic heterogeneity in COVID-19: Insights from a mathematical model

Author(s): Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Lance L. Munn, Rakesh K. Jain, Triantafyllos Stylianopoulos
Published in: PLOS ONE, Issue 19, 2024, Page(s) e0301780, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0301780

Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes

Author(s): Constantinos Harkos, Triantafyllos Stylianopoulos, Rakesh K. Jain
Published in: PLOS Computational Biology, Issue 19, 2024, Page(s) e1011740, ISSN 1553-7358
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1011740

Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy

Author(s): Chrysovalantis Voutouri, Fotios Mpekris, Myrofora Panagi, Connor Krolak, Christina Michael, John D. Martin, Michalakis A. Averkiou, Triantafyllos Stylianopoulos
Published in: Acta Biomaterialia, Issue 167, 2024, Page(s) 121-134, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2023.06.007

Pirfenidone-Loaded Polymeric Micelles as an Effective Mechanotherapeutic to Potentiate Immunotherapy in Mouse Tumor Models

Author(s): Fotios Mpekris, Petri Ch. Papaphilippou, Myrofora Panagi, Chrysovalantis Voutouri, Christina Michael, Antonia Charalambous, Mariyan Marinov Dinev, Anna Katsioloudi, Marianna Prokopi-Demetriades, Andreas Anayiotos, Horacio Cabral, Theodora Krasia-Christoforou, Triantafyllos Stylianopoulos
Published in: ACS Nano, Issue 17, 2023, Page(s) 24654-24667, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c03305

Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition

Author(s): Maria Kalli, Fotios Mpekris, Antonia Charalambous, Christina Michael, Chrystalla Stylianou, Chrysovalantis Voutouri, Andreas G. Hadjigeorgiou, Antonia Papoui, John D. Martin, Triantafyllos Stylianopoulos
Published in: Communications Biology, Issue 7, 2024, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07268-1

Nanomechanical properties of solid tumors as treatment monitoring biomarkers

Author(s): Andreas Stylianou, Fotios Mpekris, Chrysovalantis Voutouri, Antonia Papoui, Anastasia Constantinidou, Evros Kitiris, Michalis Kailides, Triantafyllos Stylianopoulos
Published in: Acta Biomaterialia, Issue 17427061, 2022, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.021

Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy

Author(s): Fotios Mpekris, Myrofora Panagi, Antonia Charalambous, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
Published in: Cell Reports Medicine, Issue 5, 2024, Page(s) 101626, ISSN 2666-3791
Publisher: Cell
DOI: 10.1016/j.xcrm.2024.101626

Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy

Author(s): Mpekris F., C. Voutouri, M. Panagi, J.W Baish, R.K Jain, T. Stylianopoulos
Published in: Journal of Controlled Release, Issue 01683659, 2022, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.03.008

Endothelin Inhibition Potentiates Cancer Immunotherapy Revealing Mechanical Biomarkers Predictive of Response

Author(s): Chrysovalantis Voutouri, Myrofora Panagi, Fotios Mpekris, Andreas Stylianou, Christina Michael, Michalakis A. Averkiou, John D. Martin, Triantafyllos Stylianopoulos
Published in: Advanced Therapeutics, Issue 2000289, 2021, Page(s) 2000289, ISSN 2366-3987
Publisher: Wiley-VCH
DOI: 10.1002/adtp.202000289

Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano‐immunotherapy in Breast Cancer Lung Metastasis

Author(s): Fotios Mpekris, Myrofora Panagi, Chrysovalantis Voutouri, John D. Martin, Rekha Samuel, Shinichiro Takahashi, Naoto Gotohda, Toshiyuki Suzuki, Panagiotis Papageorgis, Philippos Demetriou, Chryso Pierides, Laura Koumas, Paul Costeas, Motohiro Kojima, Genichiro Ishii, Anastasia Constantinidou, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Published in: Advanced Science, Issue 8/3, 2021, Page(s) 2001917, ISSN 2198-3844
Publisher: Wiley-VCH
DOI: 10.1002/advs.202001917

Convection-Enhanced Delivery in silico study for personalized brain cancer treatment

Author(s): Chryso Lambride, Vasileios Vavourakis, Triantafyllos Stylianopoulos
Published in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.21203/rs.3.rs-998895/v1

Machine learning analysis reveals tumor stiffness and hypoperfusion as biomarkers predictive of cancer treatment efficacy

Author(s): Demetris Englezos, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
Published in: Translational Oncology, Issue 44, 2024, Page(s) 101944, ISSN 1936-5233
Publisher: Neoplasia Press
DOI: 10.1016/j.tranon.2024.101944

Hybrid model of tumor growth, angiogenesis and immune response yields strategies to improve antiangiogenic therapy

Author(s): Andreas G. Hadjigeorgiou, Triantafyllos Stylianopoulos
Published in: npj Biological Physics and Mechanics, Issue 1, 2024, ISSN 3004-863X
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44341-024-00002-2

Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models

Author(s): Myrofora Panagi, Fotios Mpekris, Pengwen Chen, Chrysovalantis Voutouri, Yasuhiro Nakagawa, John D. Martin, Tetsuro Hiroi, Hiroko Hashimoto, Philippos Demetriou, Chryso Pierides, Rekha Samuel, Andreas Stylianou, Christina Michael, Shigeto Fukushima, Paraskevi Georgiou, Panagiotis Papageorgis, Petri Ch. Papaphilippou, Laura Koumas, Paul Costeas, Genichiro Ishii, Motohiro Kojima, Kazunori Kataoka, Ho
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34744-1

Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition

Author(s): Myrofora Panagi, Fotios Mpekris, Chrysovalantis Voutouri, Andreas G. Hadjigeorgiou, Chloe Symeonidou, Eleni Porfyriou, Christina Michael, Andreas Stylianou, John D. Martin, Horacio Cabral, Anastasia Constantinidou, Triantafyllos Stylianopoulos
Published in: Clinical Cancer Research, Issue 30, 2024, Page(s) 2582-2597, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-24-0246

Investigating the synergistic effects of immunotherapy and normalization treatment in modulating tumor microenvironment and enhancing treatment efficacy

Author(s): Constantinos Harkos, Triantafyllos Stylianopoulos
Published in: Journal of Theoretical Biology, Issue 583, 2024, Page(s) 111768, ISSN 0022-5193
Publisher: Academic Press
DOI: 10.1016/j.jtbi.2024.111768

Exploring the landscape of immunotherapy approaches in sarcomas

Author(s): Pampina Pilavaki, Myrofora Panagi, Samia Arifi, Robin L. Jones, Triantafyllos Stylianopoulos, Anastasia Constantinidou
Published in: Frontiers in Oncology, 2023, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.1069963

Mechanical stress signaling in pancreatic cancer cells triggers p38 MAPK- and JNK-dependent cytoskeleton remodeling and promotes cell migration via Rac1/Cdc42/Myosin II

Author(s): Kalli M., R. Li, G.B. Mills, T. Stylianopoulos, I.K. Zervantonakis
Published in: Molecular Cancer Research, Issue 15417786, 2022, ISSN 1541-7786
Publisher: American Association for Cancer Research
DOI: 10.1158/1541-7786.mcr-21-0266

Inducing Biomechanical Heterogeneity in Brain Tumor Modeling by MR Elastography: Effects on Tumor Growth, Vascular Density and Delivery of Therapeutics

Author(s): Harkos, C.; Svensson, S.F., Emblem, K.E., and Stylianopoulos, T.
Published in: Cancers, Issue 20726694, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040884

In silico clinical studies for optimal COVID-19 vaccination schedules in patients with cancer

Author(s): Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Published in: Cell Reports Medicine, Issue 5, 2024, Page(s) 101436, ISSN 2666-3791
Publisher: Elsevier BV
DOI: 10.1016/j.xcrm.2024.101436

Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer

Author(s): Lance L. Munn, Triantafyllos Stylianopoulos, Natalie K. Jain, C. Corey Hardin, Melin J. Khandekar, Rakesh K. Jain
Published in: Clinical Cancer Research, Issue 27, 2022, Page(s) 2706-2711, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-4750

Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2

Author(s): Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Published in: Proceedings of the National Academy of Sciences, Issue 120, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2211132120

Immunotherapy in soft tissue and bone sarcoma: unraveling the barriers to effectiveness

Author(s): Panagi M., P. Pilavaki, A. Constantinidou, T. Stylianopoulos
Published in: Theranostics, Issue 18387640, 2022, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.72800

A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas

Author(s): Fotios Mpekris, Myrofora Panagi, Antonia Charalambous, Chrysovalantis Voutouri, Christina Michael, Antonia Papoui, Triantafyllos Stylianopoulos
Published in: Neoplasia, Issue 51, 2024, Page(s) 100990, ISSN 1476-5586
Publisher: Elsevier
DOI: 10.1016/j.neo.2024.100990

In silico dynamics of COVID-19 phenotypes for optimizing clinical management

Author(s): Chrysovalantis Voutouri, Mohammad Reza Nikmaneshi, C. Corey Hardin, Ankit B. Patel, Ashish Verma, Melin J. Khandekar, Sayon Dutta, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Published in: Proceedings of the National Academy of Sciences, Issue 118, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2021642118

Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment

Author(s): Maria Kalli, Triantafyllos Stylianopoulos
Published in: APL Bioengineering, Issue 8, 2025, ISSN 2473-2877
Publisher: AIP Publishing
DOI: 10.1063/5.0183302

Pancreatic Cancer Presents Distinct Nanomechanical Properties During Progression

Author(s): Andreas Stylianou; Chrysovalantis Voutouri; Fotios Mpekris; Triantafyllos Stylianopoulos
Published in: Annals of Biomedical Engineering, Issue 1, 2023, ISSN 1573-9686
Publisher: Springer
DOI: 10.1007/s10439-023-03168-3

Beyond matrix stiffness: targeting force-induced cancer drug resistance

Author(s): Maria Kalli, Matthew D. Poskus, Triantafyllos Stylianopoulos, Ioannis K. Zervantonakis
Published in: Trends in Cancer, Issue 9, 2024, Page(s) 937-954, ISSN 2405-8033
Publisher: Elsevier BV
DOI: 10.1016/j.trecan.2023.07.006

Evaluation of growth-induced, mechanical stress in solid tumors and spatial association with extracellular matrix content

Author(s): Andreas G. Hadjigeorgiou, Triantafyllos Stylianopoulos
Published in: Biomechanics and Modeling in Mechanobiology, Issue 22, 2023, Page(s) 1625-1643, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-023-01716-3

Other (1)

Dissecting the Impact of the Gut Microbiome on Cancer Immunotherapy

Author(s): Rakesh Jain, Andreas Hadjigeorgiou, Constantinos Harkos, Aditya Mishra, Golnaz Morad, Sarah Johnson, Nadim Ajami, Jennifer Wargo, Lance Munn, Triantafyllos Stylianopoulos
Published in: 2024
Publisher: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-3647386/v1