Cooperative Intelligence in Swarms of Enzyme-Nanobots

Project Information

i-NANOSWARMS

Grant agreement ID: 866348

DOI

10.3030/866348

EC signature date 28 April 2020

Start date 1 October 2020

End date 30 September 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 819,00

EU contribution

€ 1 999 819,00

Coordinated by

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (26)

Urease-powered nanomotor containing STING agonist for bladder cancer immunotherapy

Author(s): Hyunsik Choi, Seung-hwan Jeong, Cristina Simó, Anna Bakenecker, Jordi Liop, Hye Sun Lee, Tae Yeon Kim, Cheol Kwak, Gou Young Koh, Samuel Sánchez, Sei Kwang Hahn
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-54293-z

Collective buoyancy-driven dynamics in swarming enzymatic nanomotors

Author(s): Shuqin Chen, Xander Peetroons, Anna C. Bakenecker, Florencia Lezcano, Igor S. Aranson, Samuel Sánchez
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53664-w

Multicolor Super-Resolution Microscopy of Protein Corona on Single Nanoparticles

Author(s): Yuyang Wang; Paul E. D. Soto Rodriguez; Laura Woythe; Samuel Sánchez; Josep Samitier; Peter Zijlstra; Lorenzo Albertazzi
Published in: Acs Applied Materials & Interfaces, 2022, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.2c06975

Enzyme-powered micro- and nano-motors: key parameters for an application-oriented design

Author(s): Xavier Arqué; Tania Patiño; Samuel Sánchez
Published in: Chemical Science, 2022, ISSN 1478-6524
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc90162e

Catalase-Powered Nanobots for Overcoming the Mucus Barrier

Author(s): Meritxell Serra-Casablancas, Valerio Di Carlo, David Esporrín-Ubieto, Carles Prado-Morales, Anna C. Bakenecker, Samuel Sánchez
Published in: ACS Nano, Issue 18, 2024, Page(s) 16701-16714, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c01760

Inferring non-equilibrium interactions from tracer response near confined active Janus particles

Author(s): Jaideep Katuri, William E Uspal, Mihail N. Popescu, Samuel Sánchez
Published in: Science Advances, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abd0719

Micro- and Nanomotors: Engineered Tools for Targeted and Efficient Biomedicine

Author(s): Noelia Ruiz-González, David Esporrín-Ubieto, Il-Doo Kim, Joseph Wang, Samuel Sánchez
Published in: ACS Nano, Issue 19, 2025, Page(s) 8411-8432, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c12726

Radionuclide therapy based on accumulated urease-powered nanobots in the bladder tumor of an orthotopic murine model

Author(s): Cristina Simó, Meritxell Serra-Casablancas, Ana Hortelao, Valerio Di Carlo, Sandra Guallar-Garrido, Sandra Plaza-Garcia, Pedro Ramos-Cabrer, Balbino Yagüe, Laura Aguado, Lídia Bardía, Sebastien Tosi, Vanessa Gómez-Vallejo, Abraham Martín, Tania Patiño, Esther Julián, Julien Colombelli, Jordi Llop, Samuel Sanchez
Published in: Nature nanotechnology, 2024, ISSN 1748-3395
Publisher: Springer nature
DOI: 10.21203/rs.3.rs-2704683/v1

Biohybrid soft robots with self-stimulating skeletons

Author(s): Maria Guix, Rafael Mestre, Tania Patiño, Marco de Corato, Judith Fuentes, Giulia Zarpellon, Samuel Sánchez
Published in: Science Robotics, 2021, ISSN 2470-9476
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scirobotics.abe7577

Swarming behavior and in vivo monitoring of enzymatic nanomotors within the bladder

Author(s): Ana C. Hortelão; Cristina Simó; Maria Guix; Sandra Guallar-Garrido; Esther Julián; Diana Vilela; Luka Rejc; Pedro Ramos-Cabrer; Unai Cossío; Vanessa Gómez-Vallejo; Tania Patiño; Jordi Llop; Samuel Sanchez
Published in: Science Robotics, 2021, ISSN 2470-9476
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scirobotics.abd2823

Autonomous Treatment of Bacterial Infections in Vivo Using Antimicrobial Micro- and Nanomotors

Author(s): Xavier Arqué, Marcelo D. T. Torres, Tania Patiño, Andreia Boaro, Samuel Sánchez*, Cesar de la Fuente-Nunez*
Published in: ACS Nano, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c11013

Swarms of Enzyme‐Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media

Author(s): Noelia Ruiz‐González, David Esporrín‐Ubieto, Ana C. Hortelao, Juan C. Fraire, Anna C. Bakenecker, Marta Guri‐Canals, Ramón Cugat, José María Carrillo, Montserrat Garcia‐Batlletbó, Patricia Laiz, Tania Patiño, Samuel Sánchez
Published in: Small, Issue 20, 2024, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202309387

Urease-powered nanobots for radionuclide bladder cancer therapy

Author(s): Cristina Simó, Meritxell Serra-Casablancas, Ana C. Hortelao, Valerio Di Carlo, Sandra Guallar-Garrido, Sandra Plaza-García, Rosa Maria Rabanal, Pedro Ramos-Cabrer, Balbino Yagüe, Laura Aguado, Lídia Bardia, Sébastien Tosi, Vanessa Gómez-Vallejo, Abraham Martín, Tania Patiño, Esther Julián, Julien Colombelli, Jordi Llop, Samuel Sánchez
Published in: Nature Nanotechnology, Issue 19, 2024, Page(s) 554-564, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-023-01577-y

Nanorods Based on Mesoporous Silica Containing Iron Oxide Nanoparticles as Catalytic Nanomotors: Study of Motion Dynamics

Author(s): Rafael Mestre; Núria Cadefau; Ana C. Hortelão; Jan Grzelak; Martí Gich; Anna Roig; Samuel Sanchez
Published in: ChemNanoMat, 2020, ISSN 2199-692X
Publisher: Wiley
DOI: 10.1002/cnma.202000557

Enzyme-Powered Porous Micromotors Built from a Hierarchical Micro- and Mesoporous UiO-Type Metal-Organic Framework.

Author(s): Yunhui Yang; Xavier Arqué; Tania Patiño; Vincent Guillerm; Pascal-Raphael Blersch; Javier Pérez-Carvajal; Inhar Imaz; Daniel Maspoch; Samuel Sanchez
Published in: Journal of the American Chemical Society, 2020, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c11061

Enzyme Purification Improves the Enzyme Loading, Self-Propulsion, and Endurance Performance of Micromotors

Author(s): Morgane Valles; Sílvia Pujals; Lorenzo Albertazzi; Samuel Sánchez
Published in: ACS Nano, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c10520

Improved Performance of Biohybrid Muscle-Based Bio-Bots Doped with Piezoelectric Boron Nitride Nanotubes

Author(s): Mestre, R; Fuentes, J; Lefaix, L; Wang, JJ; Guix, M; Murillo, G; Bashir, R; Sanchez, S
Published in: Advanced Materials Technologies., 2023, ISSN 2365-709X
Publisher: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/admt.202200505

Biohybrid robotics: From the nanoscale to the macroscale

Author(s): Rafael Mestre; Tania Patiño; Samuel Sanchez; Samuel Sanchez
Published in: WIREs Nanomedicine and Nanobiotechnology, 2021, ISSN 1939-0041
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/wnan.1703

Natural Hydrogels Support Kidney Organoid Generation and Promote In Vitro Angiogenesis

Author(s): Elena Garreta, Daniel Moya‐Rull, Andrés Marco, Gaia Amato, Asier Ullate‐Agote, Carolina Tarantino, Maria Gallo, David Esporrín‐Ubieto, Alberto Centeno, Amaia Vilas‐Zornoza, Rafael Mestre, María Kalil, Izar Gorroñogoitia, Ane Miren Zaldua, Samuel Sanchez, Laura Izquierdo Reyes, María Eugenia Fernández‐Santos, Felipe Prosper, Nuria Montserrat
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202400306

Convective Dynamics of Swarming Enzymatic Nanomotors

Author(s): Samuel Sánchez, Shuqin Chen, Xander Peetroons, Anna Bakenecker, Florencia Lezcano, Igor Aronson
Published in: Nature communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-3999734/v1

Guided accumulation of active particles by topological design of a second-order skin effect

Author(s): Lucas S. Palacios; Serguei Tchoumakov; Maria Guix; Ignacio Pagonabarraga; Ignacio Pagonabarraga; Samuel Sanchez; Adolfo G. Grushin
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24948-2

Drug-Free Enzyme-Based Bactericidal Nanomotors against Pathogenic Bacteria.

Author(s): Diana Vilela; Núria Blanco-Cabra; Ander Eguskiza; Ana C. Hortelão; Eduard Torrents; Samuel Sanchez
Published in: ACS Applied Materials & Interfaces, 2021, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c00986

Light-Triggered Mechanical Disruption of Extracellular Barriers by Swarms of Enzyme-Powered Nanomotors for Enhanced Delivery

Author(s): Juan C. Fraire, Maria Guix, Ana C. Hortelao, Noelia Ruiz-González, Anna C. Bakenecker, Pouria Ramezani, Charlotte Hinnekens, Félix Sauvage, Stefaan C. De Smedt, Kevin Braeckmans, Samuel Sánchez
Published in: ACS nano, 2023, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c09380

Swarms of Enzymatic Nanobots for Efficient Gene Delivery

Author(s): Juan C. Fraire, Carles Prado-Morales, Ana Aldaz Sagredo, Ainhoa G. Caelles, Florencia Lezcano, Xander Peetroons, Anna C. Bakenecker, Valerio Di Carlo, Samuel Sánchez
Published in: ACS Applied Materials & Interfaces, Issue 16, 2024, Page(s) 47192-47205, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c08770

Boosting the Efficiency of Photoactive Rod-Shaped Nanomotors via Magnetic Field-Induced Charge Separation

Author(s): Rebeca Ferrer Campos, Anna C. Bakenecker, Yufen Chen, Maria Chiara Spadaro, Juan Fraire, Jordi Arbiol, Samuel Sánchez, Katherine Villa
Published in: ACS Applied Materials & Interfaces, Issue 16, 2024, Page(s) 30077-30087, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c03905

Real-Time Optical Tracking of Protein Corona Formation on Single Nanoparticles in Serum

Author(s): Mathias Dolci, Yuyang Wang, Sjoerd W. Nooteboom, Paul Eduardo David Soto Rodriguez, Samuel Sánchez, Lorenzo Albertazzi, Peter Zijlstra
Published in: ACS Nano, Issue 17, 2023, Page(s) 20167-20178, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c05872

Other (1)

Protein corona formation around biocatalytic nanomotors unveiled by STORM

Author(s): Tania Patino, Joaquin Llacer-Wintle, Silvia Pujals, Lorenzo Albertazzi, Samuel Sánchez
Published in: 2023
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2021-rhtps