New Generation Cell Therapy: Bioartificial Pancreas to Cure Type 1 Diabetes

Informazioni relative al progetto

VANGUARD

ID dell’accordo di sovvenzione: 874700

DOI

10.3030/874700

Progetto chiuso

Data della firma CE 6 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 30 Giugno 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 844 625,00

Contributo UE

€ 6 844 625,00

Coordinato da

UNIVERSITE DE GENEVE
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (4)

VANGUARD Communication Portfolio

ACCEL will create a communication portfolio of updated VANGUARD print visual and media information and documentation including factsheets brochures and posters and visual content will be developed to offer information about the project in a condensed form that can be handed out during various events and downloaded from the project website

VANGUARD Stakeholder Engagement and Dissemination Assessment Reports

To asses the implementation and impact of the stakeholder engagement and dissemination activities, ACCEL will monitor and document (D9.4, M48) the implemented measures to assess the individual activities and adapt any activities where required to facilitate outreach and impact M24 and 48)

ELSA Training Manual

Training of VANGUARD researchers in M6, in particular newly recruited staff, on the ethical implications and safety requirements involved in regenerative medicine in general and the therapy developed during the VANGUARD project. The existing literature will be reviewed, experts in bioethics consulted, and together with partners we will develop a training manual.

Project website

To support aforementioned dissemination and communication activities throughout the duration of the project, ACCEL will set up and maintain the project website, which will notably function as the main source of information and resources related to the project, partners, latest developments, publications and public deliverables for all stakeholders.

Pubblicazioni

Conference proceedings (4)

Vascularized endocrine pancreas for type 1 diabetes

Autori: Bellofatto, Kevin; Lebreton, Fanny; Fonseca, Laura Mar; Hanna, Reine; Bignard, Juliette; Galvan, Victor; Peloso, Andrea; Berney, Thierry; Compagnon, Philippe; VANGUARD Consortium; Berishvili, Ekaterine
Pubblicato in: Transplantation, Numero 107, 2023, Pagina/e 58
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/01.tp.0000994052.77218.10

Ethics of Early Clinical Trials of Bio-Artificial Organs

Autori: Bunnik, E.M., de Jongh, D. and Massey, E.
Pubblicato in: Transplant International, Numero 35, 2022, Pagina/e 10621, ISSN 0934-0874
Editore: Frontiers Publishing Partnerships
DOI: 10.3389/ti.2022.10621

Generation of Prevascularized Endocrine Constructs to Treat Type 1 Diabetes

Autori: Bellofatto K, Lebreton F, Wassmer CH Fonseca L, Hanna R, Berishvili E.
Pubblicato in: Transplantation, Numero 9, 2022
Editore: Lippincott Williams & Wilkins
DOI: 10.1097/01.tp.0000885936.38573.32

Hydrogel-based, prevascularized, retrievable endocrine construct to treat Type 1 Diabetes

Autori: Bellofatto K, Lebreton F, Hanna R, Fonseca L M, Bignard J, Galvan V, Peloso A, Berney TH, Compagnon PH, VANGUARD Consortium, Berishvili E.
Pubblicato in: Transplantation, Numero 107, 2023, Pagina/e 57
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/01.tp.0000994048.59940.dd

Peer reviewed articles (28)

Mechanisms of Immunomodulation and Cytoprotection Conferred to Pancreatic Islet by Human Amniotic Epithelial Cells

Autori: Lebreton F, Hanna R, Wassmer CH, Bellofatto K, Perez L, Othenin-Girard V, de Tejada BM, Cohen M, Berishvili E.
Pubblicato in: Stem Cell Reviews and Reports, Numero 18, 2021, Pagina/e 346-359, ISSN 1550-8943
Editore: Springer Verlag
DOI: 10.1007/s12015-021-10269-w

Formation of Re-Aggregated Neonatal Porcine Islet Clusters Improves In Vitro Function and Transplantation Outcome

Autori: Honarpisheh M, Lei Y, Zhang Y, Pehl M, Kemter E, Lange A, Wolf E, Wolf-van Buerck L, VANGUARD consortium, Seissler S.
Pubblicato in: Transplant International, Numero 35, 2022, ISSN 1432-2277
Editore: Frontiers
DOI: 10.3389/ti.2022.10697

Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence

Autori: Alibashe-Ahmed M., Berney T., Giovannoni L., Berishvili E.
Pubblicato in: CellR4, Numero 8, 2020, ISSN 2329-7042
Editore: Verduci International
DOI: 10.32113/cellr4_20205_2850

Regulatory Challenges at the Intersection of Cellular and Medical Device Therapies in Europe: The Case of the Bioartificial Pancreas

Autori: Cronin AJ, Thom RL.
Pubblicato in: Law, Technology and Human, Numero 5(2), 2023, ISSN 2652-4074
Editore: QUT
DOI: 10.5204/lthj.3118

Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine

Autori: Charles-Henri Wassmer, Ekaterine Berishvili
Pubblicato in: Current Diabetes Reports, Numero 20/8, 2020, Pagina/e 31, ISSN 1534-4827
Editore: Current Science Inc.
DOI: 10.1007/s11892-020-01316-w

Generation of insulin‐secreting organoids: a step toward engineering and transplanting the bioartificial pancreas

Autori: Charles‐Henri Wassmer, Fanny Lebreton, Kevin Bellofatto, Domenico Bosco, Thierry Berney, Ekaterine Berishvili
Pubblicato in: Transplant International, Numero 33/12, 2020, Pagina/e 1577-1588, ISSN 0934-0874
Editore: Blackwell Publishing Inc.
DOI: 10.1111/tri.13721

Factor VIII, a coagulation cofactor, is a relevant survival factor in bladder cancer cell lines

Autori: Gillian E. Walker, Ester Borroni, Rida Haider, Cristina Olgasi, Chiara Borsotti, Antonia Follenzi
Pubblicato in: Journal of Thrombosis and Haemostasis, 2025, ISSN 1538-7836
Editore: Elsevier BV
DOI: 10.1016/j.jtha.2025.03.002

Organoids: a systematic review of ethical issues

Autori: Dide de Jongh, Emma K. Massey , the VANGUARD consortium*, Eline M. Bunnik
Pubblicato in: Stem Cell Research & Therapy, Numero 13, 2022, Pagina/e 337, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-022-02950-9

Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy

Autori: Ekaterine Berishvili, Laurent Kaiser, Marie Cohen, Thierry Berney, Hanne Scholz, Yngvar Floisand, Jonas Mattsson
Pubblicato in: Stem Cell Reviews and Reports, Numero 17/1, 2021, Pagina/e 63-70, ISSN 2629-3277
Editore: Springer
DOI: 10.1007/s12015-020-10004-x

Spheroids Composed of Reaggregated Neonatal Porcine Islets and Human Endothelial Cells Accelerate Development of Normoglycemia in Diabetic Mice

Autori: Mohsen Honarpisheh, Yutian Lei, Antonia Follenzi, Alessia Cucci, Cristina Olgasi, Ekaterine Berishvili, Fanny Lebreton, Kevin Bellofatto, Lorenzo Piemonti, Antonio Citro, Francesco Campo, Cataldo Pignatelli, Olivier Thaunat, Elisabeth Kemter, Martin Kraetzl, Eckhard Wolf, Jochen Seissler, Lelia Wolf-van Buerck, null null
Pubblicato in: Cells, Numero 14, 2025, Pagina/e 366, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells14050366

Early-Phase Clinical Trials of Bio-Artificial Organ Technology: A Systematic Review of Ethical Issues

Autori: de Jongh, D., Massey, E. K., Cronin, A. J., Schermer, M. H. N., Bunnik, E. M. and the VANGUARD Consortium
Pubblicato in: Transplant International, Numero 14322277, 2022, ISSN 1432-2277
Editore: Frontiers Publishing Partnership
DOI: 10.3389/ti.2022.10751

Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative Study

Autori: Charles-Henri Wassmer, Kevin Bellofatto, Lisa Perez, Vanessa Lavallard, David Cottet-Dumoulin, Sanda Ljubicic, Géraldine Parnaud, Domenico Bosco, Ekaterine Berishvili, Fanny Lebreton
Pubblicato in: Cell Transplantation, Numero 29, 2020, Pagina/e 096368972093729, ISSN 0963-6897
Editore: Cognizant Communication Corp.
DOI: 10.1177/0963689720937292

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device

Autori: Olgasi, C., Borsotti, C., Merlin, S., Bergmann, T., Bittorf, P., Adewoye, A. B., Wragg, N., Patterson, K., Calabria, A., Benedicenti, F., Cucci, A., Borchiellini, A., Pollio, B., Montini, E., Mazzuca, D. M., Zierau, M., Stolzing, A., Toleikis, P., Braspenning, J., & Follenzi, A.
Pubblicato in: Molecular Therapy - Methods & Clinical Development, Numero 23, 2021, Pagina/e 551-566, ISSN 2329-0501
Editore: Cell Press
DOI: 10.1016/j.omtm.2021.10.015

Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation

Autori: Sarah Grimus, Victoria Sarangova, Petra B. Welzel, Barbara Ludwig, Jochen Seissler, Elisabeth Kemter, Eckhard Wolf, Asghar Ali
Pubblicato in: Advanced Science, Numero 11, 2024, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202401385

Factor VIII promotes angiogenesis and vessel stability regulating extracellular matrix proteins

Autori: Cristina Olgasi, Alessia Cucci, Ivan Molineris, Simone Assanelli, Francesca Anselmi, Chiara Borsotti, Chiara Sgromo, Andrea Lauria, Simone Merlin, Gillian E. Walker, Salvatore Oliviero, Antonia Follenzi
Pubblicato in: Haematologica, Numero 109, 2024, Pagina/e 3391-3397, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.285089

The bio-artificial pancreas to treat type 1 diabetes: Perspectives from healthcare professionals in the Netherlands

Autori: Dide de Jongh, Eline Bunnik, Behiye Ozcan, Robert Zietse, Emma Massey
Pubblicato in: Journal of Clinical & Translational Endocrinology, Numero 38, 2024, Pagina/e 100372, ISSN 2214-6237
Editore: Elsevier BV
DOI: 10.1016/j.jcte.2024.100372

Legal and Regulatory Challenges for Emerging Regenerative Medicine Solutions for Diabetes

Autori: Thom RL, Cronin AJ; VANGUARD Consortium.
Pubblicato in: Transplantation, Numero 9, 2023, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000004797

Clinical Translation of Bio-Artificial Pancreas Therapies: Ethical, Legal and Psychosocial Interdisciplinary Considerations and Key Recommendations

Autori: de Jongh D, Thom RL, Cronin AJ, Bunnik EM, Massey EK.
Pubblicato in: Transplant international, 2023, ISSN 1432-2277
Editore: Frontiers
DOI: 10.3389/ti.2023.11705

From islet of Langerhans transplantation to the bioartificial pancreas

Autori: Thierry Berney; Charles H. Wassmer; Fanny Lebreton; Kevin Bellofatto; Laura Mar Fonseca; Juliette Bignard; Reine Hanna; Andrea Peloso; Ekaterine Berishvili
Pubblicato in: La Presse Médicale, Numero 9, 2022, ISSN 0755-4982
Editore: Elsevier Masson
DOI: 10.1016/j.lpm.2022.104139

Therapeutic potential of fetal liver cell transplantation in hemophilia A mice

Autori: Simone, Merlin; Saicharan, Akula; Alessia, Cottonaro; Tamara, Garcia-Leal; Luis Javier, Serrano; Ester, Borroni; Vakhtang, Kalandadze; Rocio, Galiano; Chiara, Borsotti; Antonio, Liras; María José, Sanchez; Antonia, Follenzi
Pubblicato in: Haematologica, Numero 6, 2023, Pagina/e 1544-1554, ISSN 1592-8721
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.282001

What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and Organ Xenotransplantation?

Autori: Asghar Ali, Mayuko Kurome, Barbara Kessler, Elisabeth Kemter, Eckhard Wolf
Pubblicato in: Transplant International, Numero 37, 2024, ISSN 1432-2277
Editore: Frontiers Media SA
DOI: 10.3389/ti.2024.13681

Guidelines to Analyze Preclinical Studies Using Perinatal Derivatives

Autori: Pires, Salomé; Bollini, Sveva; Botelho, Maria Filomena; Lang-Olip, Ingrid; Ponsaerts, Peter; Balbi, Carolina; Lange-Consiglio, Anna; Fénelon, Mathilde; Mojsilović, Slavko; Cremonesi, Fausto; Bugarski, Diana; Berishvili, Ekaterine; Gazouli, Maria; Gellhaus, Alexandra; Kerdjoudj, Halima; Schoeberlein, Andreina
Pubblicato in: Methods and Protocols, 2023, ISSN 2409-9279
Editore: MDPI
DOI: 10.3390/mps6030045

Bioengineering the Vascularized Endocrine Pancreas: A Fine-Tuned Interplay Between Vascularization, Extracellular-Matrix-Based Scaffold Architecture, and Insulin-Producing Cells

Autori: Pignatelli C, Campo F, Neroni A, Piemonti L and Citro A
Pubblicato in: Transplant International, Numero 14322277, 2022, ISSN 1432-2277
Editore: Frontiers
DOI: 10.3389/ti.2022.10555

Advances and challenges of endocrine pancreas bioengineering

Autori: Hanna, R., & Berishvili, E.
Pubblicato in: Current Opinion in Endocrine and Metabolic Research, Numero 23, 100320, 2022, ISSN 2451-9650
Editore: Elsevier Ltd.
DOI: 10.1016/j.coemr.2022.100320

Allogeneic Islet Transplantation: Chronicle of a Death Foretold?

Autori: Thierry Berney, Olivier Thaunat, Ekaterine Berishvili
Pubblicato in: Transplant International, Numero 38, 2025, ISSN 1432-2277
Editore: Frontiers Media SA
DOI: 10.3389/ti.2025.14598

I’ve got you under my skin

Autori: Thierry Berney, Ekaterine Berishvili
Pubblicato in: Nature Metabolism, Numero 2/10, 2020, Pagina/e 993-994, ISSN 2522-5812
Editore: Nature Research
DOI: 10.1038/s42255-020-0268-8

Bio-Engineering of Pre-Vascularized Islet Organoids for the Treatment of Type 1 Diabetes

Autori: Wassmer, C.H., Lebreton, F., Bellofatto, K., Perez, L., Cottet-Dumoulin, D., Andres, A., Bosco, D., Berney, T., Othenin-Girard, V., Martinez De Tejada, B., Cohen, M., Follenzi, A., Berishvili, E., and the VANGUARD Consortium
Pubblicato in: Transplant International, Numero 35, 2022, ISSN 1432-2277
Editore: Frontiers
DOI: 10.3389/ti.2021.10214

Clinical Translation and Implementation of a Bioartificial Pancreas Therapy: A Qualitative Study Exploring the Perspectives of People With Type 1 Diabetes

Autori: Dide de Jongh, Silke Lapré, Behiye Özcan, Robert Zietse, Eline M. Bunnik, Emma K. Massey, null null
Pubblicato in: Transplantation Direct, Numero 10, 2025, Pagina/e e1711, ISSN 2373-8731
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/txd.0000000000001711

Non-peer reviewed articles (1)

Organoïdes sécréteurs d’insuline

Autori: Fanny Lebreton, Charles-Henri Wassmer, Kevin Belofatto, Thierry Berney, Ekaterine Berishvili
Pubblicato in: médecine/sciences, Numero 36/10, 2020, Pagina/e 879-885, ISSN 0767-0974
Editore: Editions E D K
DOI: 10.1051/medsci/2020129