Real-time analysis of ribosomal frameshifting and its impact on immunity and disease

Project Information

T-FRAME

Grant agreement ID: 948636

DOI

10.3030/948636

EC signature date 25 November 2020

Start date 1 February 2021

End date 31 July 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 852,00

EU contribution

€ 1 499 852,00

Coordinated by

UNIVERSITAET REGENSBURG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses

Author(s): Yudi Zhang, Volker Kinast, Julie Sheldon, Nicola Frericks, Daniel Todt, Matthias Zimmer, Neva Caliskan, Richard J. P. Brown, Eike Steinmann, Thomas Pietschmann
Published in: Microbiology Spectrum, 2023, ISSN 2165-0497
Publisher: ASM Journal
DOI: 10.1128/spectrum.01284-23

Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch

Author(s): Hill, C. H.; Pekarek, L.; Napthine, S.; Kibe, A.; Firth, A. E.; Graham, S. C.; Caliskan, N.; Brierley, I.
Published in: Nature Communications, Issue 20411723, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27400-7

Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting

Author(s): Riegger, R. J.; Caliskan, N.
Published in: Frontiers in Molecular Biosciences, Issue 2296889X, 2022, ISSN 2296-889X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fmolb.2022.84226

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Author(s): Zimmer, M. M.; Kibe, A.; Rand, U.; Pekarek, L.; Ye, L.; Buck, S.; Smyth, R. P.; Cicin-Sain, L.; Caliskan N.
Published in: Nature Communications, Issue 20411723, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27431-0

Insights from structural studies of the cardiovirus 2A protein

Author(s): Caliskan, N.; Hill, C. H.
Published in: Bioscience Reports, Issue 01448463, 2022, ISSN 0144-8463
Publisher: Kluwer Academic Publishers
DOI: 10.1042/bsr20210406

Short- and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging

Author(s): Liqing Ye, Anne-Sophie Gribling-Burrer, Patrick Bohn, Anuja Kibe, Charlene Börtlein, Uddhav B. Ambi, Shazeb Ahmad, Marco Olguin-Nava, Maureen Smith, Neva Caliskan, Max von Kleist & Redmond P. Smyth
Published in: Nature Structural and Molecular Biology, 2022, ISSN 1545-9985
Publisher: Nature
DOI: 10.1038/s41594-022-00746-2

Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus

Author(s): Chris H. Hill; Georgia M. Cook; Sawsan Napthine; Anuja Kibe; Katherine A. Brown; Neva Caliskan; Andrew E. Firth; Stephen C. Graham; Ian Brierley
Published in: Nucleic Acid Research, Issue 03051048, 2021, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1101/2020.08.11.245068

Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function

Author(s): Lukas Pekarek, Matthias M Zimmer, Anne-Sophie Gribling-Burrer, Stefan Buck, Redmond Smyth, Neva Caliskan
Published in: Nucleic Acids Research, 2023, Page(s) 728-743, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkac1184

Optical Tweezers to Study RNA-Protein Interactions in Translation Regulation

Author(s): Pekarek, L.; Buck, S.; Caliskan, N.
Published in: Journal of Visualized Experiments, Issue 1940087X, 2022, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62589

POTATO: Automated pipeline for batch analysis of optical tweezers data

Author(s): Stefan Buck, Lukas Pekarek, Neva Caliskan
Published in: Biophysical Journal, 2022, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2022.06.030